Back to resultsA Study of Nivolumab and Ipilimumab in Untreated Participants With Stage 3 Non-small Cell Lung Cancer (NSCLC) That is Unable or Not Planned to be Removed by Surgery (CheckMate73L)
Primary Purpose
Non-Small Cell Lung Cancer (NSCLC)
Status
Active
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
nivolumab
ipilimumab
durvalumab
Sponsored by
About this trial
This is an interventional treatment trial for Non-Small Cell Lung Cancer (NSCLC)
Eligibility Criteria
Inclusion Criteria:
- Eastern Cooperative Oncology Group (ECOG) performance status ≤1
- Locally advanced stage IIIA, IIIB, or IIIC (T1-2 N2-3 M0, T3 N1-3 M0, or T4 N0-3 M0) pathologically-confirmed NSCLC, according to 8th TNM classification. Participants who are not planned for potential curative surgical resection are eligible.
- Newly diagnosed and treatment-naïve, with no prior local or systemic anticancer therapy given as primary therapy for locally advanced disease
Exclusion Criteria:
- Any condition including medical, emotional, psychiatric, or logistical that, in the opinion of the Investigator would preclude the participant from adhering to the protocol or would increase the risk associated with study participation
- Active infection requiring systemic therapy within 14 days prior to randomization
- History of organ or tissue transplant that requires systemic use of immune suppressive agents
- Prior thoracic radiotherapy
Other protocol-defined inclusion/exclusion criteria apply
Sites / Locations
- Local Institution - 0119
- Local Institution - 0207
- Local Institution - 0166
- Local Institution - 0129
- Local Institution - 0233
- Local Institution - 0219
- Local Institution - 0039
- Local Institution - 0125
- Local Institution - 0165
- Local Institution - 0218
- Local Institution - 0108
- Local Institution - 0116
- Local Institution - 0053
- Local Institution - 0131
- Local Institution - 0188
- Local Institution - 0112
- Local Institution - 0124
- Local Institution - 0047
- Local Institution - 0123
- Local Institution - 0077
- Local Institution - 0191
- Local Institution - 0079
- Local Institution - 0130
- Local Institution - 0071
- Local Institution - 0044
- Local Institution - 0045
- Local Institution - 0043
- Local Institution - 0042
- Local Institution - 0031
- Local Institution - 0134
- Local Institution - 0033
- Local Institution - 0029
- Local Institution - 0028
- Local Institution - 0224
- Local Institution - 0052
- Local Institution
- Local Institution - 0030
- Local Institution - 0003
- Local Institution - 0001
- Local Institution - 0004
- Local Institution - 0002
- Local Institution - 0038
- Local Institution - 0234
- Local Institution - 0034
- Local Institution - 0037
- Local Institution - 0036
- Local Institution - 0035
- Local Institution - 0127
- Local Institution - 0078
- Local Institution - 0237
- Local Institution - 0070
- Local Institution - 0092
- Local Institution - 0126
- Local Institution - 0041
- Local Institution - 0040
- Local Institution - 0146
- Local Institution - 0149
- Local Institution - 0179
- Local Institution - 0164
- Local Institution - 0192
- Local Institution - 0147
- Local Institution - 0148
- Local Institution - 0150
- Local Institution - 0154
- Local Institution - 0139
- Local Institution - 0178
- Local Institution - 0170
- Local Institution - 0183
- Local Institution - 0180
- Local Institution - 0138
- Local Institution - 0145
- Local Institution - 0186
- Local Institution - 0189
- Local Institution - 0140
- Local Institution - 0184
- Local Institution - 0086
- Local Institution - 0087
- Local Institution - 0081
- Local Institution - 0082
- Local Institution - 0084
- Local Institution - 0090
- Local Institution - 0083
- Local Institution - 0227
- Local Institution - 0091
- Local Institution - 0089
- Local Institution - 0060
- Local Institution - 0063
- Local Institution - 0076
- Local Institution - 0101
- Local Institution - 0073
- Local Institution - 0061
- Local Institution - 0062
- Local Institution - 0075
- Local Institution - 0109
- Local Institution - 0072
- Local Institution - 0161
- Local Institution - 0135
- Local Institution - 0136
- Local Institution - 0162
- Local Institution - 0024
- Local Institution - 0023
- Local Institution - 0068
- Aou Policlinico V. Emanuele Di Catania
- Azienda Ospedaliero-Universitaria Mater Domini
- Ospedale San Luca
- Istituto Europeo di Oncologia IRCCS
- ASST di Monza - Azienda Ospedaliera San Gerardo
- Azienda Ospedaliera Di Perugia
- Local Institution - 0204
- Local Institution - 0212
- Local Institution - 0211
- Local Institution - 0197
- Local Institution - 0195
- Local Institution - 0206
- Local Institution - 0203
- Local Institution - 0216
- Local Institution - 0201
- Local Institution - 0217
- Local Institution - 0196
- Local Institution - 0202
- Local Institution - 0205
- Local Institution - 0210
- Local Institution - 0198
- Local Institution - 0174
- Local Institution - 0199
- Local Institution - 0200
- Local Institution - 0175
- Local Institution - 0232
- Local Institution - 0167
- Local Institution - 0152
- Local Institution - 0168
- Local Institution - 0027
- Local Institution - 0067
- Local Institution - 0080
- Local Institution - 0014
- Local Institution - 0015
- Local Institution - 0006
- Local Institution - 0025
- Local Institution - 0240
- Local Institution - 0005
- Local Institution - 0026
- Local Institution - 0107
- Local Institution - 0102
- Local Institution - 0104
- Local Institution - 0235
- Local Institution - 0120
- GCM Medical Group, PSC - Hato Rey Site
- Local Institution - 0018
- Local Institution - 0222
- Local Institution - 0019
- Local Institution - 0020
- Local Institution - 0017
- Local Institution - 0021
- Local Institution
- Local Institution
- Local Institution
- Local Institution
- Local Institution - 0171
- Local Institution - 0106
- Local Institution - 0099
- Local Institution - 0096
- Local Institution - 0095
- Local Institution - 0098
- Local Institution - 0105
- Local Institution - 0097
- Local Institution - 0100
- Local Institution - 0065
- Local Institution - 0064
- Local Institution - 0057
- Local Institution - 0058
- Local Institution - 0059
- Local Institution - 0056
- Local Institution - 0208
- Local Institution - 0214
- Local Institution - 0209
- Local Institution - 0133
- Local Institution - 0213
- Local Institution - 0143
- Local Institution - 0010
- Local Institution - 0012
- Local Institution - 0054
- Local Institution - 0007
- Local Institution - 0009
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm Type
Experimental
Experimental
Experimental
Arm Label
Arm A: nivolumab + CCRT + ipilimumab
Arm B: nivolumab + CCRT
Arm C: CCRT + durvalumab
Arm Description
Concurrent chemoradiotherapy (CCRT)
Concurrent chemoradiotherapy (CCRT)
Concurrent chemoradiotherapy (CCRT)
Outcomes
Primary Outcome Measures
Progression-free survival (PFS) by RECIST 1.1 per Blinded Independent Central Review (BICR) for Arm A vs Arm C
Secondary Outcome Measures
Overall Survival (OS) for Arm A vs Arm C
PFS by RECIST 1.1 per BICR for Arm B vs Arm C
OS for Arm B vs Arm C
PFS by RECIST 1.1 per BICR for Arm A vs Arm B
OS for Arm A vs Arm B
Objective Response Rate (ORR) by RECIST 1.1 per BICR
Duration of Response (DoR) by RECIST 1.1 per BICR
Time to Response (TTR) by RECIST 1.1 per BICR
PFS by RECIST 1.1 per Investigator assessment
ORR by RECIST 1.1 per Investigator assessment
DoR by RECIST 1.1 per Investigator assessment
TTR by RECIST 1.1 per Investigator assessment
Time to Death or Distant Metastases (TTDM) by RECIST 1.1 per Investigator assessment
Incidence of Adverse Events (AEs)
Incidence of Serious Adverse Events (SAEs)
Incidence of select AEs
Proportion of participants without symptom deterioration based on NSCLC-SAQ
Non-Small Cell Lung Cancer-Symptom Assessment Questionnaire (NSCLC-SAQ)
Full Information
1. Study Identification
Unique Protocol Identification Number
NCT04026412
Brief Title
A Study of Nivolumab and Ipilimumab in Untreated Participants With Stage 3 Non-small Cell Lung Cancer (NSCLC) That is Unable or Not Planned to be Removed by Surgery
Acronym
CheckMate73L
Official Title
A Phase 3, Randomized, Open Label Study to Compare Nivolumab Plus Concurrent Chemoradiotherapy (CCRT) Followed by Nivolumab Plus Ipilimumab or Nivolumab Plus CCRT Followed by Nivolumab vs CCRT Followed by Durvalumab in Previously Untreated, Locally Advanced Non-small Cell Lung Cancer (LA NSCLC)
Study Type
Interventional
2. Study Status
Record Verification Date
October 2023
Overall Recruitment Status
Active, not recruiting
Study Start Date
October 8, 2019 (Actual)
Primary Completion Date
July 7, 2025 (Anticipated)
Study Completion Date
December 3, 2026 (Anticipated)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Bristol-Myers Squibb
4. Oversight
Studies a U.S. FDA-regulated Drug Product
Yes
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
The primary purpose of the study is to compare the effectiveness of nivolumab plus concurrent chemoradiotherapy (CCRT) followed by nivolumab plus ipilimumab vs CCRT followed by durvalumab in participants with untreated Locally Advanced Non-small Cell Lung Cancer (LA NSCLC).
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Non-Small Cell Lung Cancer (NSCLC)
7. Study Design
Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
888 (Anticipated)
8. Arms, Groups, and Interventions
Arm Title
Arm A: nivolumab + CCRT + ipilimumab
Arm Type
Experimental
Arm Description
Concurrent chemoradiotherapy (CCRT)
Arm Title
Arm B: nivolumab + CCRT
Arm Type
Experimental
Arm Description
Concurrent chemoradiotherapy (CCRT)
Arm Title
Arm C: CCRT + durvalumab
Arm Type
Experimental
Arm Description
Concurrent chemoradiotherapy (CCRT)
Intervention Type
Biological
Intervention Name(s)
nivolumab
Intervention Description
Specified dose on specified days
Intervention Type
Biological
Intervention Name(s)
ipilimumab
Intervention Description
Specified dose on specified days
Intervention Type
Biological
Intervention Name(s)
durvalumab
Intervention Description
Specified dose on specified days
Primary Outcome Measure Information:
Title
Progression-free survival (PFS) by RECIST 1.1 per Blinded Independent Central Review (BICR) for Arm A vs Arm C
Time Frame
Up to 7 years
Secondary Outcome Measure Information:
Title
Overall Survival (OS) for Arm A vs Arm C
Time Frame
Up to 7 years
Title
PFS by RECIST 1.1 per BICR for Arm B vs Arm C
Time Frame
Up to 7 years
Title
OS for Arm B vs Arm C
Time Frame
Up to 7 years
Title
PFS by RECIST 1.1 per BICR for Arm A vs Arm B
Time Frame
Up to 7 years
Title
OS for Arm A vs Arm B
Time Frame
Up to 7 years
Title
Objective Response Rate (ORR) by RECIST 1.1 per BICR
Time Frame
Up to 7 years
Title
Duration of Response (DoR) by RECIST 1.1 per BICR
Time Frame
Up to 7 years
Title
Time to Response (TTR) by RECIST 1.1 per BICR
Time Frame
Up to 7 years
Title
PFS by RECIST 1.1 per Investigator assessment
Time Frame
Up to 7 years
Title
ORR by RECIST 1.1 per Investigator assessment
Time Frame
Up to 7 years
Title
DoR by RECIST 1.1 per Investigator assessment
Time Frame
Up to 7 years
Title
TTR by RECIST 1.1 per Investigator assessment
Time Frame
Up to 7 years
Title
Time to Death or Distant Metastases (TTDM) by RECIST 1.1 per Investigator assessment
Time Frame
Up to 7 years
Title
Incidence of Adverse Events (AEs)
Time Frame
Up to 7 years
Title
Incidence of Serious Adverse Events (SAEs)
Time Frame
Up to 7 years
Title
Incidence of select AEs
Time Frame
Up to 7 years
Title
Proportion of participants without symptom deterioration based on NSCLC-SAQ
Description
Non-Small Cell Lung Cancer-Symptom Assessment Questionnaire (NSCLC-SAQ)
Time Frame
Up to 7 years
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
Eastern Cooperative Oncology Group (ECOG) performance status ≤1
Locally advanced stage IIIA, IIIB, or IIIC (T1-2 N2-3 M0, T3 N1-3 M0, or T4 N0-3 M0) pathologically-confirmed NSCLC, according to 8th TNM classification. Participants who are not planned for potential curative surgical resection are eligible.
Newly diagnosed and treatment-naïve, with no prior local or systemic anticancer therapy given as primary therapy for locally advanced disease
Exclusion Criteria:
Any condition including medical, emotional, psychiatric, or logistical that, in the opinion of the Investigator would preclude the participant from adhering to the protocol or would increase the risk associated with study participation
Active infection requiring systemic therapy within 14 days prior to randomization
History of organ or tissue transplant that requires systemic use of immune suppressive agents
Prior thoracic radiotherapy
Other protocol-defined inclusion/exclusion criteria apply
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Bristol-Myers Squibb
Organizational Affiliation
Bristol-Myers Squibb
Official's Role
Study Director
Facility Information:
Facility Name
Local Institution - 0119
City
La Jolla
State/Province
California
ZIP/Postal Code
92093
Country
United States
Facility Name
Local Institution - 0207
City
San Francisco
State/Province
California
ZIP/Postal Code
94115
Country
United States
Facility Name
Local Institution - 0166
City
San Francisco
State/Province
California
ZIP/Postal Code
94143
Country
United States
Facility Name
Local Institution - 0129
City
Lone Tree
State/Province
Colorado
ZIP/Postal Code
80124
Country
United States
Facility Name
Local Institution - 0233
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32207
Country
United States
Facility Name
Local Institution - 0219
City
Orlando
State/Province
Florida
ZIP/Postal Code
32804
Country
United States
Facility Name
Local Institution - 0039
City
Pensacola
State/Province
Florida
ZIP/Postal Code
32504
Country
United States
Facility Name
Local Institution - 0125
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30322
Country
United States
Facility Name
Local Institution - 0165
City
Augusta
State/Province
Georgia
ZIP/Postal Code
30912
Country
United States
Facility Name
Local Institution - 0218
City
Edgewood
State/Province
Kentucky
ZIP/Postal Code
41017
Country
United States
Facility Name
Local Institution - 0108
City
Bethesda
State/Province
Maryland
ZIP/Postal Code
20817
Country
United States
Facility Name
Local Institution - 0116
City
Traverse City
State/Province
Michigan
ZIP/Postal Code
49684
Country
United States
Facility Name
Local Institution - 0053
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45220
Country
United States
Facility Name
Local Institution - 0131
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45236
Country
United States
Facility Name
Local Institution - 0188
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45267
Country
United States
Facility Name
Local Institution - 0112
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44106
Country
United States
Facility Name
Local Institution - 0124
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44106
Country
United States
Facility Name
Local Institution - 0047
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44109
Country
United States
Facility Name
Local Institution - 0123
City
Youngstown
State/Province
Ohio
ZIP/Postal Code
44501
Country
United States
Facility Name
Local Institution - 0077
City
Charleston
State/Province
South Carolina
ZIP/Postal Code
29414
Country
United States
Facility Name
Local Institution - 0191
City
Austin
State/Province
Texas
ZIP/Postal Code
78731
Country
United States
Facility Name
Local Institution - 0079
City
Bryan
State/Province
Texas
ZIP/Postal Code
77802
Country
United States
Facility Name
Local Institution - 0130
City
Dallas
State/Province
Texas
ZIP/Postal Code
75203
Country
United States
Facility Name
Local Institution - 0071
City
Burlington
State/Province
Vermont
ZIP/Postal Code
05405
Country
United States
Facility Name
Local Institution - 0044
City
Caba
State/Province
Buenos Aires
ZIP/Postal Code
C1426ANZ
Country
Argentina
Facility Name
Local Institution - 0045
City
Río Cuarto
State/Province
Cordoba
ZIP/Postal Code
5800
Country
Argentina
Facility Name
Local Institution - 0043
City
Buenos Aires
State/Province
Distrito Federal
ZIP/Postal Code
C1199ABB
Country
Argentina
Facility Name
Local Institution - 0042
City
Caba
State/Province
Distrito Federal
ZIP/Postal Code
1430
Country
Argentina
Facility Name
Local Institution - 0031
City
Darlinghurst
State/Province
New South Wales
ZIP/Postal Code
2010
Country
Australia
Facility Name
Local Institution - 0134
City
Gosford
State/Province
New South Wales
ZIP/Postal Code
2250
Country
Australia
Facility Name
Local Institution - 0033
City
Kingswood
State/Province
New South Wales
ZIP/Postal Code
2747
Country
Australia
Facility Name
Local Institution - 0029
City
Greenslopes
State/Province
Queensland
ZIP/Postal Code
4120
Country
Australia
Facility Name
Local Institution - 0028
City
Adelaide
State/Province
South Australia
ZIP/Postal Code
5000
Country
Australia
Facility Name
Local Institution - 0224
City
Ballarat Central
State/Province
Victoria
ZIP/Postal Code
3350
Country
Australia
Facility Name
Local Institution - 0052
City
Melbourne
State/Province
Victoria
ZIP/Postal Code
3004
Country
Australia
Facility Name
Local Institution
City
Melbourne
State/Province
Victoria
ZIP/Postal Code
3199
Country
Australia
Facility Name
Local Institution - 0030
City
Murdoch
State/Province
Western Australia
ZIP/Postal Code
6150
Country
Australia
Facility Name
Local Institution - 0003
City
Bruxelles
ZIP/Postal Code
1200
Country
Belgium
Facility Name
Local Institution - 0001
City
Gent
ZIP/Postal Code
9000
Country
Belgium
Facility Name
Local Institution - 0004
City
Liege
ZIP/Postal Code
4000
Country
Belgium
Facility Name
Local Institution - 0002
City
Yvoir
ZIP/Postal Code
B-5530
Country
Belgium
Facility Name
Local Institution - 0038
City
Ipatinga
State/Province
Minas Gerais
ZIP/Postal Code
35160-158
Country
Brazil
Facility Name
Local Institution - 0234
City
Ijui
State/Province
RIO Grande DO SUL
ZIP/Postal Code
98700-000
Country
Brazil
Facility Name
Local Institution - 0034
City
Porto Alegre
State/Province
RIO Grande DO SUL
ZIP/Postal Code
91350-200
Country
Brazil
Facility Name
Local Institution - 0037
City
Blumenau
State/Province
Santa Catarina
ZIP/Postal Code
89010-340
Country
Brazil
Facility Name
Local Institution - 0036
City
Barretos
State/Province
SAO Paulo
ZIP/Postal Code
14784-400
Country
Brazil
Facility Name
Local Institution - 0035
City
Rio de Janeiro
ZIP/Postal Code
20230-130
Country
Brazil
Facility Name
Local Institution - 0127
City
Kingston
State/Province
Ontario
ZIP/Postal Code
K7L 2V7
Country
Canada
Facility Name
Local Institution - 0078
City
Oshawa
State/Province
Ontario
ZIP/Postal Code
L1G 2B9
Country
Canada
Facility Name
Local Institution - 0237
City
Chicoutimi
State/Province
Quebec
ZIP/Postal Code
G7H 5H6
Country
Canada
Facility Name
Local Institution - 0070
City
Rimouski
State/Province
Quebec
ZIP/Postal Code
G5L 5T1
Country
Canada
Facility Name
Local Institution - 0092
City
Trois-Rivieres
State/Province
Quebec
ZIP/Postal Code
G8Z 3R9
Country
Canada
Facility Name
Local Institution - 0126
City
Quebec
ZIP/Postal Code
G1V 4G5
Country
Canada
Facility Name
Local Institution - 0041
City
Santiago
State/Province
Metropolitana
ZIP/Postal Code
8420383
Country
Chile
Facility Name
Local Institution - 0040
City
Vina del Mar
State/Province
Valparaiso
ZIP/Postal Code
2520598
Country
Chile
Facility Name
Local Institution - 0146
City
Beijing
State/Province
BEI
ZIP/Postal Code
100142
Country
China
Facility Name
Local Institution - 0149
City
Chongqing
State/Province
Chongqing
ZIP/Postal Code
400030
Country
China
Facility Name
Local Institution - 0179
City
Fuzhou
State/Province
Fujian
ZIP/Postal Code
350000
Country
China
Facility Name
Local Institution - 0164
City
Xiamen
State/Province
Fujian
ZIP/Postal Code
361003
Country
China
Facility Name
Local Institution - 0192
City
Guiyang
State/Province
Guizhou
ZIP/Postal Code
550002
Country
China
Facility Name
Local Institution - 0147
City
Hankou
State/Province
Hubei
ZIP/Postal Code
430023
Country
China
Facility Name
Local Institution - 0148
City
Wuhan
State/Province
Hubei
ZIP/Postal Code
210000
Country
China
Facility Name
Local Institution - 0150
City
Wuhan
State/Province
Hubei
ZIP/Postal Code
430060
Country
China
Facility Name
Local Institution - 0154
City
Changsha
State/Province
Hunan
ZIP/Postal Code
410011
Country
China
Facility Name
Local Institution - 0139
City
Nanjing
State/Province
Jiangsu
ZIP/Postal Code
210009
Country
China
Facility Name
Local Institution - 0178
City
Nanchang
State/Province
Jiangxi
ZIP/Postal Code
330006
Country
China
Facility Name
Local Institution - 0170
City
Changchun
State/Province
Jilin
ZIP/Postal Code
130012
Country
China
Facility Name
Local Institution - 0183
City
Changchun
State/Province
Jilin
ZIP/Postal Code
130021
Country
China
Facility Name
Local Institution - 0180
City
Gongzhuling
State/Province
Jilin
ZIP/Postal Code
132000
Country
China
Facility Name
Local Institution - 0138
City
Jinan
State/Province
Shandong
ZIP/Postal Code
250117
Country
China
Facility Name
Local Institution - 0145
City
Shanghai
State/Province
Shanghai
ZIP/Postal Code
200443
Country
China
Facility Name
Local Institution - 0186
City
Chengdu
State/Province
Sichuan
ZIP/Postal Code
610041
Country
China
Facility Name
Local Institution - 0189
City
Chengdu
State/Province
Sichuan
ZIP/Postal Code
610041
Country
China
Facility Name
Local Institution - 0140
City
Hangzhou
State/Province
Zhejiang
ZIP/Postal Code
310000
Country
China
Facility Name
Local Institution - 0184
City
Linhai
State/Province
Zhejiang
ZIP/Postal Code
317000
Country
China
Facility Name
Local Institution - 0086
City
Bordeaux
ZIP/Postal Code
33076
Country
France
Facility Name
Local Institution - 0087
City
Dijon
ZIP/Postal Code
21000
Country
France
Facility Name
Local Institution - 0081
City
Lyon
ZIP/Postal Code
69008
Country
France
Facility Name
Local Institution - 0082
City
Montpellier
ZIP/Postal Code
34070
Country
France
Facility Name
Local Institution - 0084
City
Nantes
ZIP/Postal Code
44000
Country
France
Facility Name
Local Institution - 0090
City
Paris Cedex 14
ZIP/Postal Code
75679
Country
France
Facility Name
Local Institution - 0083
City
Paris Cedex 5
ZIP/Postal Code
75248
Country
France
Facility Name
Local Institution - 0227
City
Paris
ZIP/Postal Code
75018
Country
France
Facility Name
Local Institution - 0091
City
Paris
ZIP/Postal Code
75020
Country
France
Facility Name
Local Institution - 0089
City
Tours Cedex 09
ZIP/Postal Code
37044
Country
France
Facility Name
Local Institution - 0060
City
Berlin
ZIP/Postal Code
14165
Country
Germany
Facility Name
Local Institution - 0063
City
Essen
ZIP/Postal Code
45136
Country
Germany
Facility Name
Local Institution - 0076
City
Grosshansdorf
ZIP/Postal Code
22927
Country
Germany
Facility Name
Local Institution - 0101
City
Hamm
ZIP/Postal Code
59063
Country
Germany
Facility Name
Local Institution - 0073
City
Heidelberg
ZIP/Postal Code
69126
Country
Germany
Facility Name
Local Institution - 0061
City
Immenhausen
ZIP/Postal Code
34376
Country
Germany
Facility Name
Local Institution - 0062
City
Kempten
ZIP/Postal Code
87439
Country
Germany
Facility Name
Local Institution - 0075
City
Loewenstein
ZIP/Postal Code
74245
Country
Germany
Facility Name
Local Institution - 0109
City
Mainz
ZIP/Postal Code
55131
Country
Germany
Facility Name
Local Institution - 0072
City
Stuttgart
ZIP/Postal Code
70376
Country
Germany
Facility Name
Local Institution - 0161
City
Athens
ZIP/Postal Code
115 22
Country
Greece
Facility Name
Local Institution - 0135
City
Athens
ZIP/Postal Code
11527
Country
Greece
Facility Name
Local Institution - 0136
City
Larissa
ZIP/Postal Code
41110
Country
Greece
Facility Name
Local Institution - 0162
City
N.Kifissia
ZIP/Postal Code
14564
Country
Greece
Facility Name
Local Institution - 0024
City
Dublin 8
State/Province
Dublin
Country
Ireland
Facility Name
Local Institution - 0023
City
Dublin
ZIP/Postal Code
00004
Country
Ireland
Facility Name
Local Institution - 0068
City
Brescia
ZIP/Postal Code
25123
Country
Italy
Facility Name
Aou Policlinico V. Emanuele Di Catania
City
Catania
ZIP/Postal Code
95100
Country
Italy
Facility Name
Azienda Ospedaliero-Universitaria Mater Domini
City
Catanzaro
ZIP/Postal Code
88100
Country
Italy
Facility Name
Ospedale San Luca
City
Lucca
ZIP/Postal Code
55100
Country
Italy
Facility Name
Istituto Europeo di Oncologia IRCCS
City
Milano
ZIP/Postal Code
20141
Country
Italy
Facility Name
ASST di Monza - Azienda Ospedaliera San Gerardo
City
Monza
ZIP/Postal Code
20900
Country
Italy
Facility Name
Azienda Ospedaliera Di Perugia
City
Perugia
ZIP/Postal Code
06129
Country
Italy
Facility Name
Local Institution - 0204
City
Nagoya
State/Province
Aichi
ZIP/Postal Code
4648681
Country
Japan
Facility Name
Local Institution - 0212
City
Fukuoka-shi
State/Province
Fukuoka
ZIP/Postal Code
8128582
Country
Japan
Facility Name
Local Institution - 0211
City
Kurume-shi
State/Province
Fukuoka
ZIP/Postal Code
8300011
Country
Japan
Facility Name
Local Institution - 0197
City
Ota
State/Province
Gunma
ZIP/Postal Code
373-8550
Country
Japan
Facility Name
Local Institution - 0195
City
Sapporo-shi
State/Province
Hokkaido
ZIP/Postal Code
0030804
Country
Japan
Facility Name
Local Institution - 0206
City
Kobe
State/Province
Hyogo
ZIP/Postal Code
6500047
Country
Japan
Facility Name
Local Institution - 0203
City
Kanazawa-shi
State/Province
Ishikawa
ZIP/Postal Code
9208641
Country
Japan
Facility Name
Local Institution - 0216
City
Yokohama-shi
State/Province
Kanagawa
ZIP/Postal Code
2210855
Country
Japan
Facility Name
Local Institution - 0201
City
Yokohama-Shi
State/Province
Kanagawa
ZIP/Postal Code
2360051
Country
Japan
Facility Name
Local Institution - 0217
City
Yokohama
State/Province
Kanagawa
ZIP/Postal Code
2418515
Country
Japan
Facility Name
Local Institution - 0196
City
Sendai-shi
State/Province
Miyagi
ZIP/Postal Code
9800873
Country
Japan
Facility Name
Local Institution - 0202
City
Niigata-shi
State/Province
Niigata
ZIP/Postal Code
9518566
Country
Japan
Facility Name
Local Institution - 0205
City
Osaka-shi
State/Province
Osaka
ZIP/Postal Code
5458586
Country
Japan
Facility Name
Local Institution - 0210
City
Osakasayama
State/Province
Osaka
ZIP/Postal Code
589-8511
Country
Japan
Facility Name
Local Institution - 0198
City
Hidaka-shi
State/Province
Saitama
ZIP/Postal Code
3501298
Country
Japan
Facility Name
Local Institution - 0174
City
Kitaadachi-gun
State/Province
Saitama
ZIP/Postal Code
3620806
Country
Japan
Facility Name
Local Institution - 0199
City
Bunkyo-ku
State/Province
Tokyo
ZIP/Postal Code
1138603
Country
Japan
Facility Name
Local Institution - 0200
City
Chuo-ku
State/Province
Tokyo
ZIP/Postal Code
1040045
Country
Japan
Facility Name
Local Institution - 0175
City
Wakayama-shi
State/Province
Wakayama
ZIP/Postal Code
641-8510
Country
Japan
Facility Name
Local Institution - 0232
City
Ube
State/Province
Yamaguchi
ZIP/Postal Code
755-0241
Country
Japan
Facility Name
Local Institution - 0167
City
Cheongju-si, Chungcheonbuk-do,
ZIP/Postal Code
361-711
Country
Korea, Republic of
Facility Name
Local Institution - 0152
City
Seoul
ZIP/Postal Code
03722
Country
Korea, Republic of
Facility Name
Local Institution - 0168
City
Seoul
ZIP/Postal Code
06351
Country
Korea, Republic of
Facility Name
Local Institution - 0027
City
La Paz
State/Province
BAJA Californa SUR
ZIP/Postal Code
23040
Country
Mexico
Facility Name
Local Institution - 0067
City
Df
State/Province
Distrito Federal
ZIP/Postal Code
06720
Country
Mexico
Facility Name
Local Institution - 0080
City
Guadalajara
State/Province
Jalisco
ZIP/Postal Code
44340
Country
Mexico
Facility Name
Local Institution - 0014
City
Monterrey
State/Province
Nuevo LEON
ZIP/Postal Code
64060
Country
Mexico
Facility Name
Local Institution - 0015
City
Culiacan
State/Province
Sinaloa
ZIP/Postal Code
80230
Country
Mexico
Facility Name
Local Institution - 0006
City
Amsterdam
ZIP/Postal Code
1081HV
Country
Netherlands
Facility Name
Local Institution - 0025
City
Arnhem
ZIP/Postal Code
6815 AD
Country
Netherlands
Facility Name
Local Institution - 0240
City
Leiden
ZIP/Postal Code
2333ZA
Country
Netherlands
Facility Name
Local Institution - 0005
City
Maastrict
ZIP/Postal Code
6229 HX
Country
Netherlands
Facility Name
Local Institution - 0026
City
Veldhoven
ZIP/Postal Code
5504 DB
Country
Netherlands
Facility Name
Local Institution - 0107
City
Bydgoszcz
ZIP/Postal Code
85796
Country
Poland
Facility Name
Local Institution - 0102
City
Gdansk
ZIP/Postal Code
80-214
Country
Poland
Facility Name
Local Institution - 0104
City
Krakow
ZIP/Postal Code
31-826
Country
Poland
Facility Name
Local Institution - 0235
City
Tomaszow Mazowiecki
ZIP/Postal Code
97-200
Country
Poland
Facility Name
Local Institution - 0120
City
Hato Rey
ZIP/Postal Code
00917
Country
Puerto Rico
Facility Name
GCM Medical Group, PSC - Hato Rey Site
City
San Juan
ZIP/Postal Code
917
Country
Puerto Rico
Facility Name
Local Institution - 0018
City
Bucharest
ZIP/Postal Code
022328
Country
Romania
Facility Name
Local Institution - 0222
City
Bucuresti
ZIP/Postal Code
022548
Country
Romania
Facility Name
Local Institution - 0019
City
Cluj-Napoca
ZIP/Postal Code
400015
Country
Romania
Facility Name
Local Institution - 0020
City
Constanta
ZIP/Postal Code
900591
Country
Romania
Facility Name
Local Institution - 0017
City
Craiova
ZIP/Postal Code
200542
Country
Romania
Facility Name
Local Institution - 0021
City
Floresti/ Cluj
ZIP/Postal Code
407280
Country
Romania
Facility Name
Local Institution
City
Moscow
ZIP/Postal Code
105229
Country
Russian Federation
Facility Name
Local Institution
City
Moscow
ZIP/Postal Code
115478
Country
Russian Federation
Facility Name
Local Institution
City
Moscow
ZIP/Postal Code
125367
Country
Russian Federation
Facility Name
Local Institution
City
St. Petersburg
ZIP/Postal Code
197758
Country
Russian Federation
Facility Name
Local Institution - 0171
City
Singapore
ZIP/Postal Code
168583
Country
Singapore
Facility Name
Local Institution - 0106
City
Barcelona
ZIP/Postal Code
8025
Country
Spain
Facility Name
Local Institution - 0099
City
Hospitalet de Llobregat
ZIP/Postal Code
08907
Country
Spain
Facility Name
Local Institution - 0096
City
Madrid
ZIP/Postal Code
28007
Country
Spain
Facility Name
Local Institution - 0095
City
Madrid
ZIP/Postal Code
28046
Country
Spain
Facility Name
Local Institution - 0098
City
Pamplona
ZIP/Postal Code
31008
Country
Spain
Facility Name
Local Institution - 0105
City
Santiago de Compostela
ZIP/Postal Code
15706
Country
Spain
Facility Name
Local Institution - 0097
City
Sevilla
ZIP/Postal Code
41013
Country
Spain
Facility Name
Local Institution - 0100
City
Zaragoza
ZIP/Postal Code
50009
Country
Spain
Facility Name
Local Institution - 0065
City
Goteborg
State/Province
Vastra Gotalands Lan
ZIP/Postal Code
41345
Country
Sweden
Facility Name
Local Institution - 0064
City
Stockholm
ZIP/Postal Code
171 76
Country
Sweden
Facility Name
Local Institution - 0057
City
Basel
ZIP/Postal Code
4031
Country
Switzerland
Facility Name
Local Institution - 0058
City
Lausanne
ZIP/Postal Code
1011
Country
Switzerland
Facility Name
Local Institution - 0059
City
St.Gallen
ZIP/Postal Code
9007
Country
Switzerland
Facility Name
Local Institution - 0056
City
Zuerich
ZIP/Postal Code
8091
Country
Switzerland
Facility Name
Local Institution - 0208
City
KaohsiungCity
ZIP/Postal Code
83301
Country
Taiwan
Facility Name
Local Institution - 0214
City
New Taipei City
ZIP/Postal Code
235
Country
Taiwan
Facility Name
Local Institution - 0209
City
Tainan
ZIP/Postal Code
704
Country
Taiwan
Facility Name
Local Institution - 0133
City
Taipei City
ZIP/Postal Code
100
Country
Taiwan
Facility Name
Local Institution - 0213
City
Taipei
ZIP/Postal Code
10099
Country
Taiwan
Facility Name
Local Institution - 0143
City
Taipei
ZIP/Postal Code
112
Country
Taiwan
Facility Name
Local Institution - 0010
City
Poole
State/Province
Dorset
ZIP/Postal Code
BH15 2JB
Country
United Kingdom
Facility Name
Local Institution - 0012
City
Swansea
State/Province
Glamorgan
ZIP/Postal Code
SA2 8QA
Country
United Kingdom
Facility Name
Local Institution - 0054
City
Aberdeen
ZIP/Postal Code
AB25 2ZN
Country
United Kingdom
Facility Name
Local Institution - 0007
City
Bebington
ZIP/Postal Code
CH63 4JY
Country
United Kingdom
Facility Name
Local Institution - 0009
City
Hull
ZIP/Postal Code
HU16 5JQ
Country
United Kingdom
12. IPD Sharing Statement
Citations:
PubMed Identifier
34489161
Citation
De Ruysscher D, Ramalingam S, Urbanic J, Gerber DE, Tan DSW, Cai J, Li A, Peters S. CheckMate 73L: A Phase 3 Study Comparing Nivolumab Plus Concurrent Chemoradiotherapy Followed by Nivolumab With or Without Ipilimumab Versus Concurrent Chemoradiotherapy Followed by Durvalumab for Previously Untreated, Locally Advanced Stage III Non-Small-Cell Lung Cancer. Clin Lung Cancer. 2022 May;23(3):e264-e268. doi: 10.1016/j.cllc.2021.07.005. Epub 2021 Jul 19.
Results Reference
derived
Links:
URL
https://www.bms.com/researchers-and-partners/clinical-trials-and-research.html
Description
BMS Clinical Trial Information
URL
https://www.bmsstudyconnect.com/s/US/English/USenHome
Description
BMS Clinical Trial Patient Recruiting
URL
https://www.fda.gov/Safety/MedWatch/SafetyInformation/default.htm
Description
FDA Safety Alerts and Recalls
URL
https://www.bms.com/researchers-and-partners/clinical-trials-and-research.html
Description
Investigator Inquiry Form
Learn more about this trial
A Study of Nivolumab and Ipilimumab in Untreated Participants With Stage 3 Non-small Cell Lung Cancer (NSCLC) That is Unable or Not Planned to be Removed by Surgery
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