RT-CGM in Young Adults at Risk of DKA (YODA)
Diabetes Mellitus, Diabetes Mellitus, Type 1, Glucose Metabolism Disorders
About this trial
This is an interventional treatment trial for Diabetes Mellitus focused on measuring Type 1 Diabetes Mellitus
Eligibility Criteria
Inclusion Criteria:
- Adolescents and young adults aged 18-25 years
- Insulin-treated diabetes >12 months (on multiple daily injections or insulin pump therapy)
- HbA1c > 75 mmol/mol (9%) or 1 or more DKA admissions in the last 12 months or 1 or more admissions with uncontrolled blood glucose levels in the last 12 months.
- Naïve to RT-CGM - except for short periods for use for diagnosis or monitoring purposes.
- Use of prior flash glucose monitoring is permittable
Exclusion Criteria:
- Chronic kidney disease eGFR <30ml/min
- Pregnant or planning pregnancy
- Breastfeeding
- Have active malignancy or under investigation for malignancy
- Severe visual impairment
- Reduced manual dexterity
- Unable to participate due to other factors, as assessed by the Chief Investigator
Sites / Locations
- Imperial College Clinical Research FacilityRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Real Time Continuous Glucose Monitoring
Standard care
Participants wear Real time continous glucose monitoring (Dexcom G6), with alarms for when their glucose is too low or too high. They will be able to view their data on the Dexcom app on their smartphones or a Dexcom receiver and share this with a nominated caregiver. Participants can chose to share data between study visits via "Dexcom clarity" with the research/clinical team, who will support them making changes to their insulin regime in light of the data.
Standard care - finger prick self monitoring of blood glucose.