International Cooperative Treatment Protocol for Children and Adolescents With Lymphoblastic Lymphoma (LBL 2018)
Lymphoblastic Lymphoma, Childhood
About this trial
This is an interventional treatment trial for Lymphoblastic Lymphoma, Childhood
Eligibility Criteria
Inclusion criteria:
- newly diagnosed lymphoblastic lymphoma
- age <18 years
- patient enrolled in a participating center
- written informed consent of patient (>14 years of age or according to local law and regulation) and parents to trial participation and transfer and processing of data
- willingness of patients and the investigator/pathologist to provide adequate slides/blocks for reference (molecular) pathology and international pathology panel and/or fresh or fresh frozen samples for genetic risk group stratification if these samples are available after standard diagnostic procedures.
Exclusion criteria:
- lymphoblastic lymphoma as secondary malignancy
non-lymphoma related relevant medical, psychiatric or social conditions incompatible with trial treatment, including among others
- prior organ transplant
- severe immunodeficiency
- demyelinating Charcot-Marie Tooth syndrome
- serious acute or chronic infections, such as HIV, VZV and tuberculosis
- urinary tract infection, cystitis, urinary outflow obstruction, severe renal impairment (creatinine clearance less than 20 ml/min)
- severe hepatic impairment (bilirubin >3 times ULN, transaminases >10 times ULN)
- myocardial insufficiency, severe arrhythmias
- ulcers of the oral cavity and known active gastrointestinal ulcer disease
- known hypersensitivity to any IMP and to any excipient (listed in section 6.1 of the respective SmPC)
- steroid pre-treatment with ≥ 1 mg/kg/d for more than two weeks during the last month before diagnosis
- vaccination with live vaccines within 2 weeks before start of protocol treatment
- treatment started according to another protocol or pre-treatment with cytostatic drugs
- participation in another clinical trial that interferes with the protocol, except NHL-BFM Registry 2012 and trials with different endpoints, involving aspects of supportive treatment, which can run parallel to LBL 2018 without influencing the outcome of this trial (e.g. trials on antiemetics, antibiotics, strategies for psychosocial support)
- evidence of pregnancy or lactation period
- sexually active adolescents not willing to use highly effective contraceptive method (pearl index < 1) until 12 months after end of cytostatic therapy
Sites / Locations
- Univ.Klinik für Kinder- und Jugendheilkunde Graz, Klin. Abteilung für pädiatrische Hämato-OnkologieRecruiting
- Univ.Klinik für Kinder- und Jugendheilkunde Innsbruck, Universitätsklinik für Pädiatrie IRecruiting
- Kepler Universitätsklinikum, Med Campus IV / OnkologieRecruiting
- LKH Salzburg, Universitätsklinik für Kinder- und Jugendheilkunde, KinderonkologieRecruiting
- St. Anna KinderspitalRecruiting
- Hôpital Universitaire des Enfants Reine Fabiola (ULB), Pédiatrie hémato-oncologieRecruiting
- University Hospital Brussels, Pediatrische oncologieRecruiting
- Cliniques Universitaires Saint-Luc (UCL), Hématologie et oncologie pédiatriqueRecruiting
- UZ Antwerpen Kinderhemato-oncologieRecruiting
- University Hospital Gent Pediatrische hemato-oncologieRecruiting
- University Hospitals Leuven, Kinderhemato-oncologieRecruiting
- CHR Citadelle Hémato - oncologie pédiatriqueRecruiting
- CHR Citadelle Hémato - oncologie pédiatriqueRecruiting
- Hong Kong Children's Hospital
- Dept. of Pediatric Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University CernopolniRecruiting
- Dept. of Pediatric Hematology and Oncology. University Hospital Motol and 2nd Medical School, Charles UniversityRecruiting
- University Hospital Aalborg, Nord, Department of PediatricsRecruiting
- Aarhus University Hospital, Department of PediatricsRecruiting
- Børneonkologisk afsnit 5054, BørneUngeKlinikken, Juliane Marie Centret, RigshospitaletRecruiting
- H.C. Andersens Children Hospital, Odense University HospitalRecruiting
- Helsinki University Hospital, Department of Pediatric Hematology and OncologyRecruiting
- Kuopio University Hospital, Department of Pediatric Hematology and OncologyRecruiting
- University Hospital of Oulu, Paediatric Haematology and OncologyRecruiting
- Tampere University Hospital, Paediatric Haematology and OncologyRecruiting
- Turku University Hospital, Paediatric and Adolescent Haematology and OncologyRecruiting
- Service d'oncolologie, Hématologie pédiatrique. CHU Amiens, Avenue René Laënnec - SALOUEL
- Pôle Femme Mère Enfant ; Unité d'Hématologie/Oncologie pédiatrique, CHU Angers
- Hématologie Oncologie pédiatrique, CHRU Besançon
- Hôpital de Enfants, Unité Onco-Hématologie Pédiatrique, Groupe Hospitalier Pellegrin
- Département de Pédiatrie et Génétique Médicale CHRU Morvan
- Unité d'hémato-immuno-oncologie pédiatrique. Centre Hospitalier Universitaire niveau 1 - bâtiment FEH
- Unité Onco- Hématologie Pédiatrique CHU Estaing 1 place Lucie-Aubrac
- Service Immuno-Hématologie Oncologie Pédiatrique
- Service onco hématologie pédiatrique CHU de Grenoble site Nord - Hôpital Couple enfant
- Unité d'hématologie pédiatrique CHRU de Lille - Hôpital Jeanne de Flandre
- Service d'Hématologie - Oncologie pédiatrique CHU Limoges - Hôpital de la mère et de l'enfant
- Service d'immuno-hématologie pédiatrique et de transplantation de moelle osseuse, CHU de Lyon HCL - GH Est-Institut d'hématologie et d'oncologie pédiatrique IHOP
- Service de Pédiatrie et hématologie pédiatrique, CHU de Marseille - Hôpital de la Timone
- UAM Hématologie et Oncologie Pédiatrique, CHU de Montpellier - Hôpital Arnaud de Villeneuve
- Service d'hématologie et oncologie pédiatriques, Hôpital enfant-adolescent, CHU NANTES
- Service d'hémato-oncologie pédiatrique CHU NICE - Hôpital l'Archet 2
- service d'oncologie pédiatrique, institut Curie
- Service Hémato-immuno- oncologie- CHU PARIS Armand Trousseau
- Service d' hémato-immunologie CHU Paris - Hôpital Robert Debré
- Service Oncologie-Hématologie pédiatrique CHU de Poitiers
- Service d'Hémato-Oncologie Pédiatrique- American Hospital
- Pôle pédiatrie Hémato-cancérologie pédiatrique- CHU RENNES - Hôpital sud
- Service d'Hemato-Oncologie Pediatrique CHU Rouen
- service d'oncologie pédiatrique, hopital Félix Guyon
- Pôle mère enfant-Unité Hématologie - Oncologie pédiatrique - CHU Hôpital NORD
- Service d'Onco-Hematologie Pediatrique CHU STRASBOURG -Hôpital de Hautepierre
- Service Pédiatrie - Hématologie Immunologie Oncologie - CHU Toulouse
- Service d'hémato-oncologie pédiatrique- CHU de Nancy - Hôpital de Brabois Enfant
- Dépt de Pédiatrie Gustave Roussy
- Universitätsklinikum Aachen .Klinik für Kinder - und Jugendmedizin Hämatologie / OnkologieRecruiting
- Klinikum Augsburg ,Schwäbisches Kinderkrebszentrum. I. Klinik für Kinder und Jugendliche Hämatologie / OnkologieRecruiting
- HELIOS Klinikum Berlin-Buch, Kinderklinik, Pädiatrische Hämatologie und OnkologieRecruiting
- Charité Campus Virchow-Klinikum, Zentrum für Kinder- und Jugendmedizin- Abt. Hämatologie / OnkologieRecruiting
- Evangelisches Krankenhaus Bielefeld GmbH, Klinik für Kinder- und Jugendmedizin, Hämatologie und OnkologieRecruiting
- Zentrum für Kinderheilkunde der Universität Bonn, Abt. Päd. Hämatologie / OnkologieRecruiting
- Städtisches Klinikum Braunschweig gGmbH, Zentrum für Kinder- und JugendmedizinRecruiting
- Klinikum Bremen-Mitte gGmbH, Prof.-Hess-Kinderklinik,Pädiatrische Onkologie und HämatologieRecruiting
- Klinikum Chemnitz gGmbH, Klinik für Kinder- und Jugendmedizin, Päd. Hämatologie und Onkologie
- Carl-Thiem-Klinikum, Kinderklinik, Station 5eRecruiting
- Vestische Kinderklinik, Universität Witten / HerdeckeRecruiting
- Klinikum Dortmund gGmbH, Klinik für Kinder- und Jugendmedizin, Station K1, Abt. Päd. Onkologie / HämatologieRecruiting
- Universitätsklinik Carl Gustav Carus der TU Dresden, Klinik für Kinder- und JugendmedizinRecruiting
- Universitätsklinikum Düsseldorf, Zentrum für Kinder- und Jugendmedizin, Klinik für Päd. Hämatologie und OnkologieRecruiting
- HELIOS Klinikum Erfurt GmbH, Klinik für Kinder- und Jugendmedizin, Päd. Onkologie / HämatologieRecruiting
- Universitätsklinikum Erlangen, Klinik für Kinder- und Jugendmedizin, Pädiatrische Onkologie / HämatologieRecruiting
- Universitätsklinikum Essen, Zentrum für Kinder- und Jugendmedizin, Hämatologie / OnkologieRecruiting
- Universitätsklinikum Frankfurt, Klinik für Kinder- und Jugendmedizin, Pädiatrische Hämatologie und OnkologieRecruiting
- Universitätsklinikum Freiburg, Zentrum für Kinder- und Jugendmedizin, Klinik IV: Päd. Hämatologie und OnkologieRecruiting
- Universitätsklinikum Gießen und Marburg, Standort Gießen, Zentrum für Kinderhämatologie und -onkologieRecruiting
- Universitätsklinikum Greifswald KdöR, Klinik und Poliklinik für Kinder- und Jugendmedizin, Abt. Pädiatrische Onkologie und HämatologieRecruiting
- Georg-August-Universität Universitäts-Kinderklinik, Pädiatrie IRecruiting
- Universitätsklinikum Halle (Saale), Klinik für Kinder- und Jugendmedizin, Pädiatrische Hämatologie / OnkologieRecruiting
- Universitätsklinikum Hamburg Eppendorf, Zentrum für Kinder- und Jugendmedizin, Abt. Pädiatrische Hämatologie und OnkologieRecruiting
- Medizinische Hochschule Hannover, Kinderheilkunde, Päd. Hämatologie / OnkologieRecruiting
- Universitäts-Kinderklinik Heidelberg, Abt. Hämatologie / OnkologieRecruiting
- Gemeinschaftskrankenhaus Herdecke, Kinder- und Jugendmedizin, Päd. Hämatologie / OnkologieRecruiting
- Universitätskliniken für Kinder- und Jugendmedizin, Päd. Hämatologie und Onkologie, Geb. 9Recruiting
- Universitätsklinikum Jena, Klinik für Kinder- und JugendmedizinRecruiting
- Städtisches Klinikum Karlsruhe gGmbH, Kinderklinik, Station S 24Recruiting
- Klinikum Kassel Gesundheit Nordhessen Holding AG, Klinik für pädiatrische Hämatologie und OnkologieRecruiting
- Universitätsklinikum Schleswig Holstein Campus Kiel, Klinik für Allgemeine Pädiatrie, Päd. Onkologie / HämatologieRecruiting
- Gemeinschaftsklinikum Mittelrhein Kemperhof, Klinik für Kinder- und Jugendmedizin, Pädiatrische Hämatologie und OnkologieRecruiting
- HELIOS Klinikum Krefeld, Zentrum für Kinder- und Jugendmedizin, Päd. Hämatologie/OnkologieRecruiting
- Klinikum der Universität zu Köln, Klinik für Kinder- und Jugendmedizin, Abt. Kinderonkologie und -hämatologie
- Universitätsklinikum Leipzig, Klinik für Kinder und Jugendliche, Abt. Päd. Hämatologie / OnkologieRecruiting
- Universitätsklinikum Schleswig Holstein Campus Lübeck, Klinik für Kinder- und Jugendmedizin, Hämatologie und OnkologieRecruiting
- Universitätsklinikum Magdeburg A. ö. R., Kinderklinik, Päd. Hämatologie / OnkologieRecruiting
- Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Zentrum für Kinder- und Jugendmedizin, Pädiatrische Hämatologie / OnkologieRecruiting
- Klinikum Mannheim gGmbH, Universitäts-Kinderklinik, Päd. Onkologie /HämatologieRecruiting
- Johannes Wesling Klinikum Minden, Klinik für Kinder- und Jugendmedizin, Päd. Hämatologie / Onkologie, Station E 22Recruiting
- Klinikum der LMU, Dr. von Haunersches Kinderspital, Pädiatrische Hämatologie / OnkologieRecruiting
- Klinikum Schwabing, Kinderklinik der TU Päd. Hämatologie / Onkologie, Station 24dRecruiting
- Universitätsklinikum Münster, Klinik für Kinder- und Jugendmedizin, Abt. Pädiatrische Hämatologie und OnkologieRecruiting
- Diakonie Neuendettelsau, Kliniken Hallerwiese / Cnopf'sche Kinderklinik, Pädiatrische Hämatologie /OnkologieRecruiting
- Klinikum Oldenburg AöR, Zentrum für Kinder- und Jugendmedizin, Abt. Hämatologie / OnkologieRecruiting
- Universitätsklinikum Regensburg, Klinik für Kinder- und Jugendmedizin, Abt. Päd. Hämatologie, Onkologie, SZTRecruiting
- Universitätsklinikum Rostock, Kinder- und Jugendklinik, Päd. Hämatologie und OnkologieRecruiting
- Asklepios Klinik St. Augustin GmbH, Kinder- und Jugendmedizin, Kinder-Hämatologie und OnkologieRecruiting
- HELIOS Kliniken Schwerin GmbH, Klinik für Kinder- und Jugendmedizin, Station A1Recruiting
- Klinikum Stuttgart, Olgahospital Zentrum für Kinder- und Jugendmedizin Pädiatrie 5 (Onkologie, Hämatologie, Immunologie)Recruiting
- Klinikum Mutterhaus der Borromäerinnen gGmbH, Pädiatrische Abteilung
- Universitätsklinik Tübingen, Klinik für Kinderheilkunde und Jugendmedizin, Päd. Hämatologie / OnkologieRecruiting
- Universitätsklinikum Ulm, Klinik für Kinder- und Jugendmedizin, Päd. Hämatologie und OnkologieRecruiting
- Universitätskinderklinik Würzburg, Päd. Onkologie und HämatologieRecruiting
- 2nd Dep. of Pediatrics, Semmelweis Univ
- Heim Pal Children Hospital
- Dep. of Pediatrics, Univ. of Debrecen
- Children's Treating Center, Miskolc
- Dep. of Pediatrics, University of Pecs
- Dep. of Pediatrics, Univ. of Szeged
- Our Lady's Children's Hospital Crumlin
- Children's Hospital at Soroka Medical Center
- Ruth Rappaport Children's Hospital, Rambam Medical Center
- Children's Hospital at Hadassah, Ein Kerem Medical Center
- Schneider Children's hospital, Rabin Medical Center
- Edmond and Lily Safra Children's Hospital, Sheba Medical Center
- Dana Children's Hospital, Tel-Aviv Sourasky Medical Center
- Clinica Pediatrica, Centro Regionale Oncoematologia Pediatrica- Ospedale dei Bambini "G. Salesi"
- Dipartimento Biomedicina Età Evolutiva- U.O. Pediatrica I Policlinico
- Dipartimento Pediatrico degli OO.RR. di Bergamo
- Dipartimento di Scienze Pediatriche Mediche Chirurgiche Ospedale Sant'Orsola Malpighi
- Clinica Pediatrica Ospedale Civile
- Istituto di Clinica Pediatrica- Ospedale Regionale Microcitemie
- Divisione Ematologia - Oncologia Pediatrica, Clinica Pediatrica
- U. O. di Pediatria- Azienda Ospedaliera Annunziata
- Dipartimento di Medicina Clinica e Sperimentale Sezione di Pediatria - Università di Ferrara
- Unità Autonoma di Oncoematologia Pediatrica, Dipartimento Pediatria - Azienda "A.Meyer"
- Dipartimento di Ematologia e Oncologia Pediatrica Istituto " G. Gaslini"
- Divisione di Oncologia Pediatrica Ist. Nazionale Studio e Cura Tumori
- U.O. di Ematologia, Oncologia e Trapianto-Azienda Policlinico di Modena
- Clinica Pediatrica Ospedale S. Gerardo Via Donizetti
- S.C. Ematologia Oncologica- Ospedale "Pausilipon"
- Clinica di Oncoematologia Pediatrica- Azienda Ospedaliera-Università di Padova
- Oncoematologia Pediatrica- Ospedale dei Bambini G. di Cristina
- U.O. di Pediatria e Oncoematologia Pediatrica. Az. Osp. di Parma
- Oncoematologia Pediatrica IRCCS, Policlinico San Matteo Piazzale Golgi
- Dipartimento di Ematologia -Ospedale Civile
- U.O. Pediatria Ospedale Infermi- Azienda USL Rimini
- Sezione Ematologia- Dipart. Biotecnico Cellulare ed Ematologia- Università "La Sapienza"
- Divisione di Ematologia Pediatrica- Ospedale "Bambino Gesù". Istituto di Ricerca Scientifica
- Divisione di Pediatria- Ospedale "Casa Sollievo della Sofferenza"
- Oncologia Pediatrica,- Ospedale "R. Silvestrini"
- Dip. Scienze Pediatriche e dell'Adolescenza Ospedale Infantile Regina Margherita
- U.O. Emato-Oncologia Pediatrica- Università degli studi di Trieste-Ospedale Infantile Burlo Garofolo
- U.O. Oncoematologia Pediatrica- Policlinico "G.B. Rossi"
- Princess Maxima Centre for Pediatric Oncology
- Haukeland University Hospital in BergenRecruiting
- University Hospital Northern NorwayRecruiting
- St Olavs Hospital in TrondheimRecruiting
- Department of Pediatric Oncology and Hematology, Medical University of Bialystok
- Department of Pediatric Hematology and Oncology, Nicolaus Copernicus University
- Department of Pediatric Hematology and Oncology, Center of Pediatrics and Oncology in Chorzów
- Department of Pediatrics, Hematology, Oncology and Endocrinology, Medical University of Gdansk
- Department of Pediatric Oncology and Hematology, Center of Pediatrics in Kielce
- Department of Pediatric Oncology/Hematology, Institute of Pediatrics, Medical College Jagiellonian University
- Department of Pediatric Hematology, Oncology and Transplantology, Medical University of Lublin
- Department of Pediatric Oncology and Hematology, Provincial Specialist Children's Hospital
- Department of Pediatric Oncology, Hematology and Transplantology, Poznan University of Medical Sciences
- Department of Paediatric Oncology and Haematology, University of Rzeszów, Department of Pediatrics
- Department of Pediatrics, Children Hematology nad Oncology, Pomeranian Medical University
- Department of Pediatrics, Hematology and Oncology, Medical University of Warsaw
- Department of Pediatric Oncology, Children's Memorial Health Institute
- Department of Bone Marrow Transplantation, Children Oncology and Hematology, Wroclaw Medical University
- Department of Pediatric Hematology and Oncology, Silesian Medical University in Katowice
- Department of Pediatrics, Oncology, Hematology and Diabetology, Institute of Pediatrics, Medical University of Lodz
- Centro Hospitalar e Universitário de Coimbra
- Instituto Português de Oncologia - Francisco Gentil - Libosa
- Instituto Português de Oncologia - Francisco Gentil - Porto
- Oncological center of regional Children's HospitalRecruiting
- National Center for Pediatric Hematology, Oncology and Immunology MoscowRecruiting
- Department of pediatric oncology and hematology, Children´s Faculty Hospital
- Department of pediatric hematology and oncology, National Institute of Children's Diseases
- Department of pediatric hematology and oncology, Children´s University Hospital
- Hospital General Universitario de AlicanteRecruiting
- Hospital Universitario TorrecárdenasRecruiting
- Hospital Materno-Infantil de BadajozRecruiting
- Hospital Universitario CrucesRecruiting
- Hospital Universitari Vall d'HebronRecruiting
- Hospital de la Santa Creu i Sant PauRecruiting
- Hospital Universitario DonostiaRecruiting
- Hospital Sant Joan de DéuRecruiting
- Hospital Universitario Virgen de las NievesRecruiting
- Complejo Hospitalario Universitario Insular Materno InfantilRecruiting
- Hospital General Universitario Gregorio MarañónRecruiting
- Hospital Infantil Universitario Niño JesúsRecruiting
- Hospital Universitario 12 de OctubreRecruiting
- Hospital Universitario La PazRecruiting
- Hospital Clínico Universitario Virgen de la ArrixacaRecruiting
- Hospital Regional Universitario de MálagaRecruiting
- Hospital Universitario Central de AsturiasRecruiting
- Hospital Universitari Son EspasesRecruiting
- Hospital Virgen del CaminoRecruiting
- Complejo Hospitalario Universitario de VigoRecruiting
- Hospital Universitario Nuestra Señora de CandelariaRecruiting
- Hospital Universitario Marqués de ValdecillaRecruiting
- Hospital Clínico Universitario de SantiagoRecruiting
- Hospital Universitario Virgen MacarenaRecruiting
- Hospital Universitario Virgen del RocíoRecruiting
- Hospital Virgen de la SaludRecruiting
- Hospital Clínico Universitario de ValenciaRecruiting
- Hospital Universitari i Politècnic La FeRecruiting
- Hospital Clínico Universitario de ValladolidRecruiting
- Hospital Universitario Miguel ServetRecruiting
- Barncancercentrum, Drottning Silvias Barn och Ungdomssjukhus, Sahlgrenska UniversitetssjukhusetRecruiting
- Barnonkologiska enheten, Barn och Ungdomsmedicinska kliniken, Universitetssjukhuset i LinköpingRecruiting
- Barnonkologi, Skåne UniversitetssjukhusRecruiting
- Barncanceravdelningen Astrid Lindgrens Barnsjukhus, Nya Karolinska UniversitetssjukhusetRecruiting
- Barnonkologiska avdelningen, Barn 3, Norrlands UniversitetssjukhusRecruiting
- Barnavdelningen för blod- och tumörsjukdomar 95A, Akademiska sjukhusetRecruiting
- Kantonsspital Aarau
- Universitäts-Kinderspital beider Basel (UKBB)
- Ospedale San Giovanni
- Inselspital Bern, University of Bern
- HUG Hôpitaux Universitaires de Genève
- CHUV - Centre Hospitalier Universitaire Vaudois
- Luzerner Kantonspital - Kinderspital Luzern
- Ostschweizer Kinderspital
- Universitäts-Kinderspital Zürich
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Arm 7
Arm 8
Other
Experimental
Other
Experimental
Other
Experimental
Experimental
Experimental
SR I/II: R1 into protocol Ia-Pred
SR I/II: R1 into protocol Ia-Dexa
SR: R1 into protocol Ia-Pred
SR: R1 into protocol Ia-Dexa
HR: R1 into "Pred" and R2 into non-HR extra-compartment phase
HR: R1 into "Dexa" and R2 into non-HR extra-compartment phase
HR: R1 into "Pred" and R2 into HR extra-compartment phase
HR: R1 into "Dexa" and R2 into HR extra-compartment phase
cytoreductive prephase with prednisone standard induction phase (protocol Ia-prednisone) consolidation phase (protocol Ib) non-HR extra-compartment phase (protocol M) maintenance therapy
cytoreductive prephase with prednisone experimental induction phase (protocol Ia-dexamethasone) consolidation phase (protocol Ib) non-HR extra-compartment Phase (protocol M) maintenance therapy
cytoreductive prephase with prednisone standard induction phase (protocol Ia-prednisone) consolidation phase (protocol Ib) non-HR extra-compartment phase (protocol M) reintensification phase (protocol II) maintenance therapy
cytoreductive prephase with prednisone experimental induction phase (protocol Ia-dexamethasone) consolidation phase (protocol Ib) non-HR extra-compartment phase (protocol M) reintensification phase (protocol II) maintenance therapy
cytoreductive prephase with prednisone standard induction phase (protocol Ia-prednisone) consolidation phase (protocol Ib) non-HR extra-compartment phase (protocol M) reintensification phase (protocol II) maintenance therapy
cytoreductive prephase with prednisone experimental induction phase (protocol Ia-dexamethasone) consolidation phase (protocol Ib) non-HR extra-compartment phase (protocol M) reintensification phase (protocol II) maintenance therapy
cytoreductive prephase with prednisone standard induction phase (protocol Ia-prednisone) consolidation phase (protocol Ib*) HR extra-compartment phase (intensified protocol M) reintensification phase (protocol II) maintenance therapy
cytoreductive prephase with prednisone experimental induction phase (protocol Ia-dexamethasone) consolidation phase (protocol Ib*) HR extra-compartment phase (intensified protocol M) reintensification phase (protocol II) maintenance therapy