Intensity of Aerobic Training and Neuroprotection in Parkinson's Disease (AEROPROTECT)
Parkinson's Disease
About this trial
This is an interventional treatment trial for Parkinson's Disease focused on measuring Parkinson's disease, Aerobic Exercises, High Intensity Training, Neuroprotection
Eligibility Criteria
Inclusion Criteria:
- Diagnosis of PD according to the UKPDSBB criteria
- Previous MRI available, to further help distinguish idiopathic PD from atypical parkinsonism Hoehn & Yahr Stage 1-3 in OFF state
- Age > 18
- Signed informed consent to participate in study
Exclusion Criteria:
- Patients lacking motivation or ability to participate in training sessions for 9 months, in the investigator's opinion
- Contra-indications to high-intensity aerobic training in the cardiologist's opinion
- Contra-indications to perchlorate de potassium or to the use of 123I-FP-CIT
- Concurrent severe co-morbidities
- Cognitive deficit limiting participation to the program in the investigator's opinion
- Montreal Cognitive Assessment test (MoCA)<23
- Uninsured patient
- Participation in another ongoing interventional clinical trial (drug therapy, surgical treatment, another rehabilitation treatment, medical device)
- Pregnancy or current lactation, or no efficacious contraception during the 9 months of intervention.
Sites / Locations
- Henri Mondor Hospital
- Sébastopol hospital
- Rangueil hospital
Arms of the Study
Arm 1
Arm 2
Arm 3
Placebo Comparator
Sham Comparator
Experimental
Conventional Physical Therapy
Medium Intensity Aerobic exercise (50% VO2 max)
High Intensity Aerobic exercise
Three sessions a week of hospital-based conventional physical therapy, all in presence and with the guidance of a registered physical therapist, for nine months
Three sessions a week of hospital-based Medium Intensity Aerobic exercise (50% VO2 max); on a stationary bicycle, all in presence and with the guidance of a physical education teacher, for nine months
Three sessions a week of hospital-based High Intensity Aerobic exercise (70% VO2 max) on a stationary bicycle, all in presence and with the guidance of a physical education teacher, for nine months