Treating Primary Progressive Aphasia (PPA) Using High-definition tDCS
Primary Progressive Aphasia
About this trial
This is an interventional treatment trial for Primary Progressive Aphasia focused on measuring non-invasive brain stimulation, transcranial direct current stimulation (tDCS), aphasia
Eligibility Criteria
Inclusion Criteria:
- Presence of aphasia attributable to nonfluent agrammatic PPA (naPPA) or logopenic variant PPA (lvPPA)
- High school education (or more)
- Must be able to understand the nature of the study, and give informed consent
- Native English speaker
Exclusion Criteria:
- Presence of additional neurological illness such as stroke or traumatic brain injury
- Diagnosis of epilepsy or reoccurening seizures
- Pacemaker or ICDs
- Craniotomy or skull breech
- Small vessel disease
Sites / Locations
- University of PennsylvaniaRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Sham Comparator
HD-tDCS+mCILT
Sham+mCILT
Participants will undergo 10 daily sessions (Monday-Friday, x2 weeks) of HD-tDCS for 20 minutes using a montage in which a central electrode (1.5mA) is placed over the left frontotemporal area and four surrounding cathodes (.375mA each). Subjects will participate in a modified constraint-induced language therapy.
Participants will undergo 10 daily sessions (Monday-Friday, x2 weeks) of sham for 20 minutes using a montage in which a central electrode is placed over the left frontotemporal area and four surrounding cathodes. Subjects will participate in a modified constraint-induced language therapy,