Antimicrobial Photodynamic Therapy in the Nasal Decolonization of Maintenance Hemodialysis Patients
Photochemotherapy, Renal Insufficiency, Chronic
About this trial
This is an interventional treatment trial for Photochemotherapy focused on measuring antimicrobial photodynamic therapy, Staphylococcus aureus, nasal decolonization, hemodialysis, chronic kidney disease, mupirocin
Eligibility Criteria
Inclusion Criteria:
- patients over 18 years of age,
- no preference for race or socioeconomic status
- who agree to participate in the study by signing the informed consent form.
Exclusion Criteria:
- presence of active S.aureus infection at the time of randomization,
- history of mupirocin allergy,
- pregnancy or breastfeeding,
- previous use of mupirocin in the last 04 weeks,
- presence of nasal foreign body,
- history of systemic antibiotic use at that time of randomization.
Sites / Locations
- University of Nove de Julho (UNINOVE)
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
experimental aPDT group
control mupirocin group
Application of 0.01% methylene blue with enough sterile swab to cover the inner nostril extension with a 10 minute pre-irradiation time. The irradiations were carried out with a red light-emitting diode (LED) (λ = 660 nm), for 300 seconds, irradiance of 400 mW / cm2, radiant exposure 124 J / cm2, with uniform application in each anterior nostril.
A standard treatment will be performed conventionally with topical mupirocin. Will be performed with 2% Mupirocin Ointment, to be applied to the anterior nostrils twice a day for 5 days.