Biomarkers in Urine for Children With Monosymptomatic Nocturnal Enuresis and Nocturnal Polyuria
Nocturnal Enuresis
About this trial
This is an interventional diagnostic trial for Nocturnal Enuresis
Eligibility Criteria
Inclusion Criteria:
- Monosymptomatic nocturnal enuresis with at least one dry night per week.
- Nocturnal polyuria defined as nocturnal urine production on wet nights greater than 130 % of expected bladder capacity for age.
- Normal bladder capacity defined as maximum voided volume excluding first morning voided volume bigger than expected bladder capacity for age.
Exclusion Criteria:
- Recurrent urinary tract infections.
- Anamnestic, clinical or laboratory findings that can be related to diseases or conditions that might affect the parameters investigated.
- Neurological and/or known clinically significant anatomical abnormalities of the urinary tract.
- Former operations in the urinary tract.
- Ongoing medication that may interfere with the parameters tested.
If the child is receiving treatment for nocturnal enuresis (desmopressin, alarm or anticholinergics), the treatment has to be paused 1 week before urine collection.
Sites / Locations
- Department of Paediatrics and Adolescent Medicine, Aarhus University Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Urine collection, children with nocturnal enuresis
Urine collection, healthy children
The child ́s weight and height will be registered. The children's urine will be tested for infection with a dipstick urinalysis. The child will be asked to perform home recordings for seven days consisting of measurements of diaper weight and first morning voided volume and a two-day frequency-volume chart.
The child ́s weight and height will be registered. The children's urine will be tested for infection with a dipstick urinalysis.