Influence of Smoking on Clinical, Microbiological and Immunologic Parameters in Patients With Aggressive Periodontitis.
Periodontal Diseases, Aggressive Periodontitis
About this trial
This is an interventional treatment trial for Periodontal Diseases
Eligibility Criteria
Inclusion Criteria:
- diagnosis of generalized aggressive periodontitis, according to the American Academy of Periodontology-AAP, 1999;
- presence of at least 15 teeth;
- presence of at least 6 teeth containing 6 deep sites (≥ 7 mm), which are not located in bifurcation areas and
- present less than 20% of plaque index (PI) and bleeding on probing (BoP).
Exclusion Criteria:
- presence of periapical or pulpar alteration;
- presence of systemic alteration or use of medications (6 months prior to the study) that may influence the response to periodontal treatment;
- pregnant and lactating women;
- performing periodontal treatment including subgingival instrumentation in the 6 weeks preceding the study;
- teeth with bifurcation involvement;
- teeth with marked mobility;
- oral pathology;
- history of allergy to any component of the study, and
- previous periodontal surgery in the region of interest.
Sites / Locations
- University of Campinas, UNICAMP
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Smokers aggressive periodontits
Non-smokers aggressive periodontits
The patients were treated by a single-session of periodontal debridement under local anaesthesia during 45 minutes, using an ultrasonic instrument#, using subgingival tips* and irrigation with sterile saline solution, by the same operator (MGC, Paulista University, São Paulo, Brazil). After the debridement, all patients has prescribed with Amoxicillin 500 mg and Metronidazole 400 mg, every 8 hours, for 10 days (Casarin et al., 2012). Subjects were extensively informed about the intake of the prescribed medication. Subjects were clinically and microbiologically monitored at baseline (before therapy) and at 3 and 6 months post-therapy. During the monitored sessions, oral hygiene was evaluated and home care instructions were re-emphasized. Additionally, all subjects were recalled monthly for oral hygiene instructions.
The patients were treated by a single-session of periodontal debridement under local anaesthesia during 45 minutes, using an ultrasonic instrument#, using subgengival tips* and irrigation with sterile saline solution, by the same operator (MGC, Paulista University, São Paulo, Brazil). After the debridement, all patients was prescribed with Amoxicillin 500 mg and Metronidazole 400 mg, every 8 hours, for 10 days (Casarin et al., 2012). Subjects were extensively informed about the intake of the prescribed medication. Subjects were clinically and microbiologically monitored at baseline (before therapy) and at 3 and 6 months post-therapy. During the monitored sessions, oral hygiene was evaluated and home care instructions were re-emphasized. Additionally, all subjects were recalled monthly for oral hygiene instructions.