A Clinical Trial Into the Efficacy of rTMS Treatment for Treating Anorexia Nervosa and Bulimia Nervosa
Eating Disorders, Anorexia Nervosa, Bulimia Nervosa
About this trial
This is an interventional treatment trial for Eating Disorders focused on measuring rTMS
Eligibility Criteria
Inclusion Criteria:
- Confirmed diagnosis of Anorexia Nervosa or Bulimia Nervosa, must pass rTMS screening questionnaire
Exclusion Criteria:
- Diagnosis of another psychiatric disorder, except MDD.
- Any rTMS counter-indications:
- History of seizures
- Metal in head
- Currently pregnant
- Having received rTMS for any reason in the past as this would interfere with participant blinding.
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Sham Comparator
Sham Comparator
Active rTMS (Anorexia Nervosa)
Active rTMS (Bulimia Nervosa)
Sham rTMS (Anorexia Nervosa)
Sham rTMS (Bulimia Nervosa)
Patients in this arm will receive 40 sessions of active rTMS. Every day, the first session of rTMS for both groups will be applied to the left DLPFC using intermittent Theta Burst Stimulation (iTBS). For the second session each day the patients in the anorexia group will receive low-frequency treatment (1 Hz, 60 second cycles, 30 second inter-train interval, 20 trains, 1200 total pulses) at 120% of the resting motor threshold to the orbitofrontal cortex
Patients in this arm will receive 40 sessions of active rTMS. Every day, the first session of rTMS for both groups will be applied to the left DLPFC using intermittent Theta Burst Stimulation (iTBS). For the second session each day the patients in the bulimia group will receive high-frequency (10 Hz, 5 second cycles, 50 pulses, 25 second inter-train interval, 60 trains, 3000 total) at 120% of the resting motor threshold treatment to the left dorsomedial prefrontal cortex
Patients in this arm will receive 40 sessions of sham rTMS. They will be set up the same as the active Anorexia Nervosa group however their will be no actual brain stimulation.
Patients in this arm will receive 40 sessions of sham rTMS. They will be set up the same as the active Bulimia Nervosa group however their will be no actual brain stimulation.