Optimal Antibiotics for Operated Diabetic Foot Infections
Diabetic Foot Infection, Surgical Wound, Antibiotic Side Effect
About this trial
This is an interventional treatment trial for Diabetic Foot Infection focused on measuring diabetic foot; osteomyelitis; amputation; antibiotics
Eligibility Criteria
Inclusion Criteria:
- Age ≥ 18 years
- Diabetic foot infections or ischemia/necrosis with surgical amputation/disarticulation level in vicinity of MRI signs of infection
- At least two months of follow-up from hospitalization
- Patient signing to participate, including acceptance of local wound care, -off-loading and arterial re-vascularization (if clinically indicated).
Exclusion Criteria:
- At least 5 cm of distance between amputation level and infection.
- Any concomitant infection requiring more than 5 days of systemic antibiotic therapy
- Eventual osteosynthesis material not removed
Sites / Locations
- Balgrist University HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Arm 7
Arm 8
Experimental
Active Comparator
Experimental
Active Comparator
Experimental
Active Comparator
Experimental
Active Comparator
1. Trial (Amputation) Soft tissue - short antibiotic arm
1. Trial (Amputation) Soft tissue - long antibiotic arm
1. Trial (Amputation) Bone - short antibiotic arm
1. Trial (Amputation) Bone - long antibiotic arm
2.Trial (soft tissue infection) - short antibiotic arm
2. Trial (soft tissue infection) - long antibiotic arm
2. Trial (osteomyelitis) - short antibiotic arm
2. Trial (osteomyelitis) - long antibiotic arm
The intervention group consists of 1 day of postoperative antibiotic therapy for eventual residual soft tissue infection after amputation.
The control group consists of 4 days duration of postoperative antibiotic therapy for eventual residual soft tissue infection after amputation.
The intervention group consists of 1 week of postoperative antibiotic therapy for eventual residual bone infection / contamination in the proximal bone stump after amputation.
The intervention group consists of 3 weeks of postoperative antibiotic therapy for eventual residual bone infection / contamination in the proximal bone stump after amputation.
The intervention group consists of 10 days of post-debridement antibiotic therapy for non-amputated diabetic foot soft tissue infection.
The control group consists of 20 days of post-debridement antibiotic therapy for non-amputated diabetic foot soft tissue infection.
The intervention group consists of 3 weeks of post-debridement antibiotic therapy for non-amputated diabetic foot osteomyelitis.
The control group consists of 6 weeks of post-debridement antibiotic therapy for non-amputated diabetic foot osteomyelitis.