Efficacy of Short Pulsed 1064 nm Nd-YAG Laser Versus 10600 nm Fractional CO2 Laser in Treatment of Striae Alba
Striae Distensae, Striae; Albicantes, Striae Alba
About this trial
This is an interventional treatment trial for Striae Distensae focused on measuring Striae Distensae, Striae; Albicantes, Striae Alba, Nd-YAG Laser, Fractional CO2 Laser, High Frequency Skin Ultrasound, Short Pulsed Nd-YAG, Carbon Dioxide Laser, Neodymium-Doped Yttrium Aluminum Garnet Laser
Eligibility Criteria
Inclusion Criteria:
- Patients with striae alba.
- Ages between 14 years - 50 years.
- Both sexes.
- Skin types I-IV
- Bilateral striae.
Exclusion Criteria:
- Patients with striae rubra, striae nigra, striae caerulea or striae atrophicans.
- History of diseases associated with SD (cushing disease or Marfan syndrome).
- History of drugs associated with development of SD (topical or systemic glucocorticoids, Indinavir or protease inhibitors).
- History of conditions with abnormal dermal connective tissue structure (Ehler-Danlos syndrome, cutis laxa, pseudoxanthoma elasticum, elastolysis, elastomas, hyaline fibromatosis, keloidal tendencies, skin atrophy, poikiloderma or anetoderma).
- Current state of pregnancy in female patients.
- Relative contraindications to laser therapy (photosensitive dermatoses or burns).
- History of any therapeutic procedure for striae in the past 6 months before enrollment in the study.
- History of conditions associated with dermal edema or lymphedema.
Sites / Locations
- Cairo UniversityRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
Short pulsed Nd-YAG laser treatment side
Fractional ablative CO2 laser treatment side
Neodymium-Doped Yttrium Aluminum Garnet (Nd-YAG) (Fotona XP®) laser is a successful therapeutic modality and is characterized by its safe profile compared to other lasers. Short pulsed Nd-YAG laser (Fotona XP® Accelera mode) results in a non-ablative dermal heating with intact overlying epidermis which has shown a potential for dermal collagen remodeling in histological sections.
Carbon dioxide (CO2) (Deka SmartXide DOT®) laser is one of the well-tolerated therapeutic modalities used for treatment of different skin disorders including striae alba. CO2 laser targets mainly water content in both epidermis and dermis causing vaporization of target cells. Fractional ablative CO2 laser creates columns of focal dermo-epidermal tissue loss known as (microablative columns) with thermal damage, hemostatic effect and incomplete coagulation of tissues. This ablation of dermal tissues (including collagen and elastin) has the potential for stimulation of new tissue formation in striae distensae.