Function Following Laser for Anal Intraepithelial Neoplasia (FLAN) (FLAN)
Anus Cancer, Fecal Incontinence, Anal Intraepithelial Neoplasia
About this trial
This is an interventional prevention trial for Anus Cancer focused on measuring laser ablation, anal intraepithelial neoplasia, AIN, fecal incontinence, anal function
Eligibility Criteria
Inclusion Criteria:
MSM >18 years of age if HIV positive, CD4 count of over 350; if less, been on highly active antiretroviral treatment for at least 3 months Histologically proven high-grade squamous anal intraepithelial neoplasia lesion (HSIL) Anal canal disease with or without perianal disease Written informed consent
Exclusion Criteria:
Previous laser or other ablative treatment for HSIL (previous topical treatment is not excluded) Any treatment for HSIL in the previous six months Previous or current diagnosis of anal cancer Concurrent or previous (if severe) perianal inflammatory bowel disease, complex fistula or other significant perianal condition requiring surgery including fissures, current fistula in ano and Grade III or IV haemorrhoids Perianal sepsis Perianal disease only without anal canal HSIL
Sites / Locations
- Homerton University Hospital NHS Foundation TrustRecruiting
Arms of the Study
Arm 1
Experimental
Anorectal function post anal laser
Intervention: Device: laser