Left Bundle Branch Pacing Versus Biventricular Pacing for Cardiac Resynchronization Therapy (LBBP-RESYNC)
Chronic Heart Failure
About this trial
This is an interventional treatment trial for Chronic Heart Failure focused on measuring cardiac resynchronization therapy, chronic heart failure, left bundle branch pacing, biventricular pacing
Eligibility Criteria
Inclusion Criteria:
- LVEF≤35% as assessed by echocardiography and NYHA class II-IV despite optimal medical therapy for at lest 3 months;
- Sinus rhythm, complete left bundle branch block (QRS duration ≥130ms);
- Between the ages of 18 and 80;
- With informed consent signed.
Exclusion Criteria:
- After mechanical tricuspid valve replacement;
- Unstable angina, acute MI, CABG or PCI within the past 3 months;
- Persistent atrial fibrillation without atrioventricular block, the expected percentage of ventricular pacing below 95%;
- Enrollment in any other study;
- A life expectancy of less than 12 months;
- Pregnant or with child-bearing potential;
- History of heart transplantation.
Sites / Locations
- The First Affiliated Hospital with Nanjing Medical University
- Fu Wai Hospital, Beijing, China
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
LBBP group
BivP group
In this arm, An right artrial (RA) lead and an implantable cardioverter defibrillator (ICD) lead are conventionally implanted. A left bundle branch pacing(LBBP) lead is attempted to be placed. If LBBP failed, a left ventricular(LV) pacing lead is implanted instead.
In this arm, an RA lead , an ICD lead and a LV pacing lead are placed. If the implantation of LV pacing lead is unsuccessful due to unavailable coronary sinus branches(venae cordis magna or venae cordis media is not recommended), capture above 3.5V/0.5ms or refractory phrenic nerve stimulation,a LBBP lead is placed instead.