Magnesium and Ketamine in Postoperative Analgesia
Postoperative Analgesia
About this trial
This is an interventional supportive care trial for Postoperative Analgesia focused on measuring Magnisum sulfate, Ketamine, Analgesia, Breast Cancer Surgeries
Eligibility Criteria
Inclusion Criteria:
- Patients with class II physical status (American Society of Anaesthesiologists) ,
- Age between 18-65 years,
- Scheduled for breast cancer surgery (e.g. modified radical mastectomy and conservative mastectomy)
Exclusion Criteria:
- Patient refusal,
- Cardiac dysfunction (ejection fraction <45%),
- Diabetic patients
- Patients with uncontrolled hypertension
- Patients have any degree of heart block
- Patients have renal impairment (creatinine > 2 mg/dl),
- Patients have hepatic dysfunction (transaminases > 2 times normal),
- Patients with preexisting neurological or psychiatric disease,
- Patients who are allergic to one of the study drugs,
- Patients with communication difficulties,
- Inability to use the patient controlled analgesia (PCA) device,
- Female patients who are pregnant
- Patients who use preoperative calcium channel blockers or narcotic drugs.
Sites / Locations
- National Cancer Institute
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
ketamine group : group (k)
ketamine and magnesium group: group (KM)
-Ketamine group (group K): will receive a bolus of 0.5 mg/kg ketamine during induction of anaesthesia diluted in 100 ml normal saline, followed by ketamine infusion 0.12 mg/kg/hour continued till 24 hours after surgery. The infusion pump concentration will be 0.6mg/ml and the rate of infusion will be 0.2 ml/kg/hour
- Ketamine and magnesium group (group KM): will receive a bolus of 0.5 mg/kg ketamine added to 50mg/kg magnesium sulfate diluted in 100 ml normal saline over 30 minutes after induction of anaesthesia, followed by ketamine infusion 0.12 mg/kg/hour added to 8mg/kg/hour of magnesium sulfate continued till 24 hours after surgery. Each ml of the administered infusion will contain 0.6mg ketamine and 40mg magnesium and the rate of infusion will be 0.2 ml/kg/hour.