Hyperbaric Oxygen for Carbon Monoxide Induced Chronic Encephalopathy (HACMICE)
Carbon Monoxide Poisoning, Chronic Encephalopathy
About this trial
This is an interventional treatment trial for Carbon Monoxide Poisoning
Eligibility Criteria
Inclusion Criteria:
- CO induced neurological or cognitive sequelae assessed as at least mild (e.g. UPDRS part 3 (motor)>15).
- chronicity- signs or symptoms present for greater than one year after exposure.
Exclusion Criteria:
- age >90 or less than 10 years
- other morbidities which may contribute to chronic neurocognitive deficits (such as traumatic brain injury, poisoning by other toxins, other neurodegenerative diseases)
- pregnancy (if a subject becomes pregnant she will be removed from the study)
- routine contraindications to hyperbaric oxygen
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Sham Comparator
Active Comparator
sham1st
sham second
40 sham HBO2 treatments (air at near normal pressure (1.2 ATA)). Treatments will be done once daily for 2 hours, Monday through Friday. The second block will be treated similarly except that they will receive sham treatments in the first block and oxygen treatments in the second block.
iii. We will divide the subjects into two groups of five. One group will receive 40 Hyperbaric Oxygen (HBO2) treatments (100% oxygen at twice normal air pressure (2 ATA)) followed by 40 sham HBO2 treatments (air at near normal pressure (1.2 ATA)). Treatments will be done once daily for 2 hours, Monday through Friday. The second block will be treated similarly except that they will receive sham treatments in the first block and oxygen treatments in the second block. iv. Neurological and psychologic assessments will be done prior to starting treatments, after the first block of 40 and again after the second block of 40.