When the Kidney Reacts to Nutritional Changes
Prehypertension
About this trial
This is an interventional other trial for Prehypertension focused on measuring inpatient, nutrition
Eligibility Criteria
Inclusion Criteria:
- any gender, 18-60 years of age
- self described as White or Black individuals
- prehypertensives (=stage 1 hypertension) defined as sustolic blood pressure of 130-159 mmHG and/or diastolic blood pressure between 80-100.
- adequate dentition to consume fruits and vegetables as described for DASH -
Exclusion Criteria:
- Preexisting kidney disease structural or parenchymal including APCKD (adult polycystic kidney disease), single kidney (as assessed by ultrasound including size differences >3 cm in diameter between kidneys), or evidence of RAS (renal artery stenosis)
- Pregnant
- HIV
- taking medications for diabetes, hyperlipidemia, cardiac disease, Medications for birth control, psychiatirc conditions, and sleep are Ok. Vitamins and herbs are Ok if continued throughout the study. Thyroid meds are acceptable if the TSH is within normal limits.
- Diabetes as defined by hemoglobin A1c > 6.5% and/or fasting glucose > 125 mg/dl
- Hyperlipidemia as defined by triglycerides >200 and/or LDL > 150
- Hematuria on screening
- RAAS (Renin-Angiotensin-Aldosterone) axis deviation - Aldosterone and Renin should be within normal ranges upon screening.
- BUN > 40mg/dL corrected to body surface area
- Creatinine > 1.3 mg/dL corrected to body surface area
- BMI > 29.9 or < 19
- Current smoker
- Currently, a vegetarian (who does not consume fish and dairy) or a vegan
- Based on medical history, any evidence of an autoimmune disease
- Use of any of the following - ACEi, ARB, spironolactone, diuretics of any class, beta blockers, alpha blockers, nsaids, within the past two weeks
- Any medical, psychological or social condition that, in the opinion of the Investigator, would jeopardize the health or well-being of the participant during any study procedures or the integrity of the data
Sites / Locations
- The Rockefeller University
Arms of the Study
Arm 1
Experimental
nutrition implementation
Volunteers with prehypertension, but otherwise healthy, will complete a screening visit, then be admitted to the In-Patient Unit for fourteen (14) days. Participants will be admitted for 5 days during the week and then go on pass for 2 weekend days each week with packed DASH diet meals. During hospitalization we will: 1) collect samples of blood and urine daily 2) monitor blood pressure, weight and pulse twice daily 3) collect 24-hour urine, twice during the period of two weeks 4) serve participants a menu based on DASH principles, namely low in sodium and high in potassium.