Dexmedetomidine and Propofol in the Treatment of Emergence Agitation
Emergence Agitation
About this trial
This is an interventional treatment trial for Emergence Agitation
Eligibility Criteria
Inclusion Criteria:
- Adult patients aged 18-65 years old after general anesthesia
- with informed consent provided.
Exclusion Criteria:
- age younger than 18 years or older than 65 years;
- American Society of Anesthesiologists classification ≥Ⅲ;
- preoperative lung dysfunction(including pneumonia,atelectasis,adult respiratory distress syndrome,acute lung injury and so on);
- preoperative heart dysfunction(including sever cardiac coronary disease,unstable angina,LVEF≤30%,sick sinus syndrome,bradycardia:heart rate≤50bpm,second or third degree A-V block);
- history of mental disease;
- no informed consent provided;
- uncontrolled hypertension(baseline blood pressure:SBP≥160mmHg or DBP≥110mmHg);
- cancers;
- enrolled in other researches within 90 days;
- allergic to intervening medicine.
- BMI less than 18 or more than 30 kg/m2.
Sites / Locations
- Renji Hospital,Shanghai Jiao Tong University,School of MedicineRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Dexmedetomidine Group
Propofol Group
General anesthesia will be maintained by sevoflurane and remifentanil. End-tidal carbon dioxide will be controlled between 35 mmHg to 40 mmHg.Mean blood pressure(MAP) will be administrated between 80% and 120% of the baseline.Heart rate is going to be maintained between 50-100 beats per minute. In consultation with the surgeons and 5 minutes prior to the departure of the operating room,all the anesthesia agents are discontinued and the patient will be transferred to the post-anaesthesia care unit.And reversal agents are given to antagonize the residual muscular relaxant.Once emergence agitation occurs,the patient assigned to the dexmedetomidine group will be infused with a single dose of 0.7ug/kg dexmedetomidine.
General anesthesia will be maintained by sevoflurane and remifentanil. End-tidal carbon dioxide will be controlled between 35 mmHg to 40 mmHg.Mean blood pressure(MAP) will be administrated between 80% and 120% of the baseline.Heart rate is going to be maintained between 50-100 beats per minute. In consultation with the surgeons and 5 minutes prior to the departure of the operating room,all the anesthesia agents are discontinued and the patient will be transferred to the post-anaesthesia care unit.And reversal agents are given to antagonize the residual muscular relaxant.Once emergence agitation occurs,the patient assigned to the propofol group will be infused with a single dose of 0.5mg/kg propofol.