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House Dust Mite Allergy Trial In Children (MATIC)

Primary Purpose

Allergic Rhinitis Due to Dermatophagoides Farinae, Allergic Rhinitis Due to Dermatophagoides Pteronyssinus, Allergic Rhinitis Due to House Dust Mite

Status
Active
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Sublingual allergy immunotherapy tablet
Placebo
Sponsored by
ALK-Abelló A/S
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Allergic Rhinitis Due to Dermatophagoides Farinae focused on measuring Allergic rhinitis, HDM, pediatric

Eligibility Criteria

5 Years - 11 Years (Child)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • Male or female subjects aged 5-11 years
  • A clinical history of HDM AR/C (with or without asthma) and with allergic rhinitis symptoms despite having received allergy pharmacotherapy during the previous year prior to screening
  • Have a certain level of AR symptoms on at least 8 of the last 14 days of the baseline period
  • Use symptomatic medication for treatment of HDM allergic rhinitis during at least 8 of the last 14 days of the baseline period
  • Positive skin prick test (SPT) and IgE to D. pteronyssinus or D. farinae at screening
  • Lung function ≥ 70% of predicted value

Exclusion Criteria:

  • Sensitised and regularly exposed to perennial allergens
  • Any nasal or pharyngeal condition that could interfere with the safety or efficacy evaluation
  • Asthma requiring treatment with high dose of inhaled corticosteroid
  • A relevant history of systemic allergic reaction

Sites / Locations

  • Kern Research, Inc
  • Allergy & Asthma Specialists Medical Group and Research Center
  • California Allergy and Asthma Medical Group
  • Allergy & Asthma Medical Group and Research Center, A P.C.
  • Miami Clinical Research
  • Pensacola Research Consultants, Inc. d.b.a. Avanza Medical Research Center
  • GCP, Global Clinical Professionals
  • Sarasota Clinical Research
  • Aeroallergy Research Labs of Savannah, Inc.
  • Clinical Research Atlanta
  • Deaconess Clinic Allergy
  • PMG Research of McFarland Clinic
  • Clinical Research Institute
  • University of Missouri
  • Clinical Research of The Ozarks Inc
  • Summit Medical Group
  • Allergy & Asthma Associates of Monmouth City
  • Allergy Partners of Western North Carolina
  • The Children's Research Institute, Department of Pediatrics, University of North Carolina Children's Hospital
  • UNC Children's Raleigh
  • Bernstein Clinical Research Center
  • Allergy, Asthma & Clinical Research Center
  • Oklahoma Institute of Allergy & Asthma Clinical Research, LLC
  • Vital Prospects Clinical Research Institute, P.C.
  • The Corvallis Clinic
  • West Ashley office: Charleston Allergy & Asthma
  • ADAC Research, PA
  • Charleston Allergy & Asthma
  • Biogenics Research Institute
  • Allergy, Asthma & Sinus Center, S.C.
  • Multiprofile Hospital for active treatment, Department of Pediatrics
  • Multiprofile Hospital for Active Treatment, Department of Pediatrics
  • University Multiprofile Hospital for Active Treatment Sveti Georgi EAD
  • University Multiprofile Hospital for Active Treatment "Sveti Georgi" EAD
  • Multiprofile Hospital for Active Treatment, Department of pneumology and phthisiatrics
  • Outpatient Clinic for individual practice for specialized outpatient medical care in Allergology
  • Specialized Hospital For Active Treatment of Pneumo - Phtisiatric Diseases Dr Dimitar Gramatikov - Ruse
  • Acibadem City Clinic Multiprofile Hospital for Active Treatment Tokuda, EAD, Clinic in Pediatrics
  • Sv. Vratch and Sv.Sv. Kuzma i Damian
  • Alitea-Med-Medical-Center
  • Diagnostic-Consultative center Ritam TR
  • Halton Pediatric Allergy
  • Triple A Lab
  • Kingston General Hospital - Division of Allergy & Immunology
  • Cheema Research Inc
  • CHU Ste-Justine
  • The Montreal Children's Hospital
  • Niagara Clinical Research
  • Gordon Sussman Clinical Research, Inc.
  • Clinique spécialisée en allergie de la capitale
  • Hospital for Sick Children
  • Joel Liem Medicine Professional Corporation
  • Hôpital Morvan - Service de Pédiatrie
  • CHU de Montpellier - Service Pneumologie et Addictologie
  • Kinderarztpraxis Bramsche
  • HNO praxis - Dr Yury Yarin
  • Universitätsklinikum Düsseldorf - Zentrum f. Kinder- u. Jugendmedizin
  • Klinikum der Johann-Wolfgang-Goethe Universität - Zentrum f. Kinder- u. Jugendmedizin
  • GMAP/HNO am Neckar
  • CD8 klinika
  • Vilnius Centro Outpatient Clinic
  • JSC Seimos gydytojas
  • Center of Allergy Diagnosis and Treatment
  • Inlita JSC, Santara KTC
  • Siauliai Republican Hospital
  • Indywidualna Specjalistyczna Praktyka Lekarska Elzbieta Matusz
  • Specjalistyczna Praktyka Lekarska Dr n. med. Joanna Orlicz-Widawska
  • Centrum Medyczne ALL-MED
  • Centrum Medyczne Plejady
  • Alergotest s.c. Specjalistyczne Centrum Medyczne Andrzej Emeryk
  • Centrum Alergologii Teresa Hofman Sp. z o.o.
  • Podkarpacki Ośrodek Pulmonologii i Alergologii Sp. z o.o.
  • Prywatny Gabinet Lekarski Malgorzata Pawlukiewicz
  • IRMED Irena Wojciechowska
  • All-Med" Specjalistyczna Opieka Medyczna, Medyczny Instytut Badawczy Marek Jutel
  • Poradnia Alergologiczna
  • Poradnia Alergologiczna
  • City Children's Hospital
  • Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University
  • NRC Institute of Immunology
  • Moscow City Children's Hospital No 9
  • City Сhildren's Сlinical Polyclinic No5
  • I.P. Pavlov Ryazan State Medical University
  • Medical Technologies" Ltd.
  • City Children's Polyclinic No44
  • ArsVitae Severo-Zapad LLC
  • North-Western State Medical University named after I.I. Mechnikov, Ministry of Public Health of Russian Federation
  • Сurator LLC
  • City Children's Polyclinic No45
  • Сity Children's Polyclinic No 35
  • Smolensk State Medical University
  • Scientific Medical Center for General Therapy and Pharmacology
  • Regional Children's Hospital
  • Alersa, s.r.o, Ambulancia klinickej alergológie a imunológie
  • Ambulancia klinickej imunologie a alergologie
  • ALFA EL, Imunoalergologická ambulancia
  • Ambulancia klinickej imunologie a alergologie
  • Hospital Vall d'Hebron
  • Hospital Sant Joan de Deu
  • Hospital Universitario de Jerez de la Frontera
  • Hospital de Sagunto
  • Hospital de Sagunto
  • Hospital la Plana
  • Chernivtsi Regional Children's Clinical Hospital, Department of Pediatrics and Children's Infectious Diseases
  • Clinical Emergency Hospital" of Dnipro City Council, Department of Pediatric Allergology at the Allergology Center
  • Dnipro City Children's Municipal Clinical Hospital #2
  • City Children's Clinic № 16" of Kharkiv City Council
  • City Children's Clinical Hospital # 19" of Kharkiv City Council
  • Kryvyi Rih City Clinical Hospital #8'' of Kryvyi Rih City Council, Department of Pediatric Pulmonology; State Institution "Dnipropetrovsk Medical Academy of the Ministry of Health of Ukraine
  • O.S. Kolomiychenko Institute, Center of Allergic Diseases of Upper Respiratory Ways and Ear
  • State Institution Phthisiology and Pulmonology Institute named after F.G. Yanovskyy of NAMS of Ukraine
  • Institute of Pediatrics, Obstetrics and Gynecology named after Academician O. M. Lukianova of the National Academy of Medical Sciences of Ukraine
  • Communal Nonprofit Enterprise "Lviv City Children's Clinical Hospital", Allergology Department, Lviv City Children's Allergology Center
  • Children's Clinical Hospital of Poltava Regional Council
  • Regional Children Clinical Hospital, Infectious-Diagnostic Department
  • Regional Children's Clinical Hospital of Vinnytsia Regional Council
  • City Children's Hospital #5" of Zaporizhzhya City Council, Allergology Department

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Placebo Comparator

Arm Label

Active treatment

Placebo

Arm Description

HDM SLIT-tablet plus allergy and asthma rescue medication

Placebo oral tablet plus allergy and asthma rescue medication

Outcomes

Primary Outcome Measures

Combined rhinitis symptoms and medication use
The average daily sum of a rhinitis symptoms score and rhinitis medication score measured on a common scale

Secondary Outcome Measures

Rhinitis symptoms
The average of a daily rhinitis symptoms score
Rhinitis medication
The average of a daily rhinitis medication score
Combined rhinoconjunctivitis symptoms and medication use
The average daily sum of a rhinoconjunctivitis symptoms score and rhinoconjunctivitis medication score measured on a common scale
Safety and tolerability
Adverse events and assessment of lung function

Full Information

First Posted
October 11, 2019
Last Updated
December 8, 2022
Sponsor
ALK-Abelló A/S
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1. Study Identification

Unique Protocol Identification Number
NCT04145219
Brief Title
House Dust Mite Allergy Trial In Children
Acronym
MATIC
Official Title
A One-year Placebo-controlled Phase III Trial Evaluating the Efficacy and Safety of the House Dust Mite (HDM) SLIT-tablet in Children (5-11 Years of Age) With HDM Allergic Rhinitis/Rhinoconjunctivitis With or Without Asthma
Study Type
Interventional

2. Study Status

Record Verification Date
December 2022
Overall Recruitment Status
Active, not recruiting
Study Start Date
October 12, 2019 (Actual)
Primary Completion Date
April 1, 2023 (Anticipated)
Study Completion Date
April 2023 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
ALK-Abelló A/S

4. Oversight

Studies a U.S. FDA-regulated Drug Product
Yes
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes

5. Study Description

Brief Summary
A research study of how house dust mite tablets work compared to placebo in children aged between 5 and 11 years and who have allergy to house dust mites (MATIC)
Detailed Description
The trial aims to demonstrate efficacy of the House Dust Mite SLIT-tablet compared to placebo in children (5-11 years of age) with House Dust Mite allergic rhinitis based on the total combined rhinitis symptoms and medication score during the last 8 weeks of treatment. In addition, the trial will evaluate safety and tolerability of the treatment, and assess whether treatment has an impact on asthma symptoms and medication use, immunological parameters, and rhinoconjunctivitis quality of life (QoL). The trial is a randomised, parallel-group, double-blind, placebo-controlled multi-national phase III trial conducted in Europe and North America. The treatment period will be approximately 1 year.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Allergic Rhinitis Due to Dermatophagoides Farinae, Allergic Rhinitis Due to Dermatophagoides Pteronyssinus, Allergic Rhinitis Due to House Dust Mite
Keywords
Allergic rhinitis, HDM, pediatric

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
ParticipantInvestigator
Masking Description
Double-blind
Allocation
Randomized
Enrollment
1459 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Active treatment
Arm Type
Experimental
Arm Description
HDM SLIT-tablet plus allergy and asthma rescue medication
Arm Title
Placebo
Arm Type
Placebo Comparator
Arm Description
Placebo oral tablet plus allergy and asthma rescue medication
Intervention Type
Biological
Intervention Name(s)
Sublingual allergy immunotherapy tablet
Other Intervention Name(s)
Acarizax, Odactra
Intervention Description
For daily administration (1 tablet per day)
Intervention Type
Other
Intervention Name(s)
Placebo
Other Intervention Name(s)
Placebo sublingual tablet
Intervention Description
For daily administration (1 tablet per day)
Primary Outcome Measure Information:
Title
Combined rhinitis symptoms and medication use
Description
The average daily sum of a rhinitis symptoms score and rhinitis medication score measured on a common scale
Time Frame
The last 8 weeks of approximately 12 months of treatment
Secondary Outcome Measure Information:
Title
Rhinitis symptoms
Description
The average of a daily rhinitis symptoms score
Time Frame
The last 8 weeks of approximately 12 months of treatment
Title
Rhinitis medication
Description
The average of a daily rhinitis medication score
Time Frame
The last 8 weeks of approximately 12 months of treatment
Title
Combined rhinoconjunctivitis symptoms and medication use
Description
The average daily sum of a rhinoconjunctivitis symptoms score and rhinoconjunctivitis medication score measured on a common scale
Time Frame
The last 8 weeks of approximately 12 months of treatment
Title
Safety and tolerability
Description
Adverse events and assessment of lung function
Time Frame
From first subject screened until last subject last visit

10. Eligibility

Sex
All
Minimum Age & Unit of Time
5 Years
Maximum Age & Unit of Time
11 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Male or female subjects aged 5-11 years A clinical history of HDM AR/C (with or without asthma) and with allergic rhinitis symptoms despite having received allergy pharmacotherapy during the previous year prior to screening Have a certain level of AR symptoms on at least 8 of the last 14 days of the baseline period Use symptomatic medication for treatment of HDM allergic rhinitis during at least 8 of the last 14 days of the baseline period Positive skin prick test (SPT) and IgE to D. pteronyssinus or D. farinae at screening Lung function ≥ 70% of predicted value Exclusion Criteria: Sensitised and regularly exposed to perennial allergens Any nasal or pharyngeal condition that could interfere with the safety or efficacy evaluation Asthma requiring treatment with high dose of inhaled corticosteroid A relevant history of systemic allergic reaction
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Antje Schuster, MD
Organizational Affiliation
Professor of Pediatrics, Düsseldorf University Hospital
Official's Role
Principal Investigator
Facility Information:
Facility Name
Kern Research, Inc
City
Bakersfield
State/Province
California
ZIP/Postal Code
93301
Country
United States
Facility Name
Allergy & Asthma Specialists Medical Group and Research Center
City
Huntington Beach
State/Province
California
ZIP/Postal Code
92647
Country
United States
Facility Name
California Allergy and Asthma Medical Group
City
Los Angeles
State/Province
California
ZIP/Postal Code
90025
Country
United States
Facility Name
Allergy & Asthma Medical Group and Research Center, A P.C.
City
San Diego
State/Province
California
ZIP/Postal Code
92123
Country
United States
Facility Name
Miami Clinical Research
City
Miami
State/Province
Florida
ZIP/Postal Code
33155
Country
United States
Facility Name
Pensacola Research Consultants, Inc. d.b.a. Avanza Medical Research Center
City
Pensacola
State/Province
Florida
ZIP/Postal Code
32503
Country
United States
Facility Name
GCP, Global Clinical Professionals
City
Saint Petersburg
State/Province
Florida
ZIP/Postal Code
33705
Country
United States
Facility Name
Sarasota Clinical Research
City
Sarasota
State/Province
Florida
ZIP/Postal Code
34239
Country
United States
Facility Name
Aeroallergy Research Labs of Savannah, Inc.
City
Savannah
State/Province
Georgia
ZIP/Postal Code
31406
Country
United States
Facility Name
Clinical Research Atlanta
City
Stockbridge
State/Province
Georgia
ZIP/Postal Code
30281
Country
United States
Facility Name
Deaconess Clinic Allergy
City
Evansville
State/Province
Indiana
ZIP/Postal Code
47715
Country
United States
Facility Name
PMG Research of McFarland Clinic
City
Ames
State/Province
Iowa
ZIP/Postal Code
50010
Country
United States
Facility Name
Clinical Research Institute
City
Minneapolis
State/Province
Minnesota
ZIP/Postal Code
55402
Country
United States
Facility Name
University of Missouri
City
Columbia
State/Province
Missouri
ZIP/Postal Code
65201
Country
United States
Facility Name
Clinical Research of The Ozarks Inc
City
Warrensburg
State/Province
Missouri
ZIP/Postal Code
64093
Country
United States
Facility Name
Summit Medical Group
City
Berkeley Heights
State/Province
New Jersey
ZIP/Postal Code
07922
Country
United States
Facility Name
Allergy & Asthma Associates of Monmouth City
City
Little Silver
State/Province
New Jersey
ZIP/Postal Code
07739
Country
United States
Facility Name
Allergy Partners of Western North Carolina
City
Asheville
State/Province
North Carolina
ZIP/Postal Code
28801
Country
United States
Facility Name
The Children's Research Institute, Department of Pediatrics, University of North Carolina Children's Hospital
City
Chapel Hill
State/Province
North Carolina
ZIP/Postal Code
27599
Country
United States
Facility Name
UNC Children's Raleigh
City
Raleigh
State/Province
North Carolina
ZIP/Postal Code
27607
Country
United States
Facility Name
Bernstein Clinical Research Center
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45231
Country
United States
Facility Name
Allergy, Asthma & Clinical Research Center
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73120
Country
United States
Facility Name
Oklahoma Institute of Allergy & Asthma Clinical Research, LLC
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73131
Country
United States
Facility Name
Vital Prospects Clinical Research Institute, P.C.
City
Tulsa
State/Province
Oklahoma
ZIP/Postal Code
74136
Country
United States
Facility Name
The Corvallis Clinic
City
Corvallis
State/Province
Oregon
ZIP/Postal Code
97330
Country
United States
Facility Name
West Ashley office: Charleston Allergy & Asthma
City
Charleston
State/Province
South Carolina
ZIP/Postal Code
29414
Country
United States
Facility Name
ADAC Research, PA
City
Greenville
State/Province
South Carolina
ZIP/Postal Code
29607
Country
United States
Facility Name
Charleston Allergy & Asthma
City
Summerville
State/Province
South Carolina
ZIP/Postal Code
29485
Country
United States
Facility Name
Biogenics Research Institute
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78229
Country
United States
Facility Name
Allergy, Asthma & Sinus Center, S.C.
City
Greenfield
State/Province
Wisconsin
ZIP/Postal Code
53228
Country
United States
Facility Name
Multiprofile Hospital for active treatment, Department of Pediatrics
City
Gabrovo
ZIP/Postal Code
5300
Country
Bulgaria
Facility Name
Multiprofile Hospital for Active Treatment, Department of Pediatrics
City
Kyustendil
ZIP/Postal Code
2500
Country
Bulgaria
Facility Name
University Multiprofile Hospital for Active Treatment Sveti Georgi EAD
City
Plovdiv
ZIP/Postal Code
4002
Country
Bulgaria
Facility Name
University Multiprofile Hospital for Active Treatment "Sveti Georgi" EAD
City
Plovdiv
Country
Bulgaria
Facility Name
Multiprofile Hospital for Active Treatment, Department of pneumology and phthisiatrics
City
Razgrad
ZIP/Postal Code
7200
Country
Bulgaria
Facility Name
Outpatient Clinic for individual practice for specialized outpatient medical care in Allergology
City
Razgrad
ZIP/Postal Code
7200
Country
Bulgaria
Facility Name
Specialized Hospital For Active Treatment of Pneumo - Phtisiatric Diseases Dr Dimitar Gramatikov - Ruse
City
Ruse
ZIP/Postal Code
7002
Country
Bulgaria
Facility Name
Acibadem City Clinic Multiprofile Hospital for Active Treatment Tokuda, EAD, Clinic in Pediatrics
City
Sofia
ZIP/Postal Code
1407
Country
Bulgaria
Facility Name
Sv. Vratch and Sv.Sv. Kuzma i Damian
City
Sofia
ZIP/Postal Code
1408
Country
Bulgaria
Facility Name
Alitea-Med-Medical-Center
City
Sofia
ZIP/Postal Code
1618
Country
Bulgaria
Facility Name
Diagnostic-Consultative center Ritam TR
City
Stara Zagora
ZIP/Postal Code
6000
Country
Bulgaria
Facility Name
Halton Pediatric Allergy
City
Burlington
ZIP/Postal Code
L7L 6W6
Country
Canada
Facility Name
Triple A Lab
City
Hamilton
ZIP/Postal Code
L8S 1G5
Country
Canada
Facility Name
Kingston General Hospital - Division of Allergy & Immunology
City
Kingston
ZIP/Postal Code
K7L 2V7
Country
Canada
Facility Name
Cheema Research Inc
City
Mississauga
ZIP/Postal Code
L5A 3V4
Country
Canada
Facility Name
CHU Ste-Justine
City
Montréal
ZIP/Postal Code
H3T1C5
Country
Canada
Facility Name
The Montreal Children's Hospital
City
Montréal
ZIP/Postal Code
H4A 3J1
Country
Canada
Facility Name
Niagara Clinical Research
City
Niagara Falls
ZIP/Postal Code
L2G 1J4
Country
Canada
Facility Name
Gordon Sussman Clinical Research, Inc.
City
North York
Country
Canada
Facility Name
Clinique spécialisée en allergie de la capitale
City
Québec
ZIP/Postal Code
G1V 4W2
Country
Canada
Facility Name
Hospital for Sick Children
City
Toronto
ZIP/Postal Code
M5G 1X8
Country
Canada
Facility Name
Joel Liem Medicine Professional Corporation
City
Windsor
ZIP/Postal Code
N8X 2G1
Country
Canada
Facility Name
Hôpital Morvan - Service de Pédiatrie
City
Brest
Country
France
Facility Name
CHU de Montpellier - Service Pneumologie et Addictologie
City
Montpellier
ZIP/Postal Code
34090
Country
France
Facility Name
Kinderarztpraxis Bramsche
City
Bramsche
ZIP/Postal Code
49565
Country
Germany
Facility Name
HNO praxis - Dr Yury Yarin
City
Dresden
ZIP/Postal Code
01139
Country
Germany
Facility Name
Universitätsklinikum Düsseldorf - Zentrum f. Kinder- u. Jugendmedizin
City
Düsseldorf
ZIP/Postal Code
40235
Country
Germany
Facility Name
Klinikum der Johann-Wolfgang-Goethe Universität - Zentrum f. Kinder- u. Jugendmedizin
City
Frankfurt
Country
Germany
Facility Name
GMAP/HNO am Neckar
City
Heidelberg
ZIP/Postal Code
68120
Country
Germany
Facility Name
CD8 klinika
City
Kaunas
ZIP/Postal Code
LT-44191
Country
Lithuania
Facility Name
Vilnius Centro Outpatient Clinic
City
Vilnius
ZIP/Postal Code
LT-01117
Country
Lithuania
Facility Name
JSC Seimos gydytojas
City
Vilnius
ZIP/Postal Code
LT-01118
Country
Lithuania
Facility Name
Center of Allergy Diagnosis and Treatment
City
Vilnius
ZIP/Postal Code
LT-08109
Country
Lithuania
Facility Name
Inlita JSC, Santara KTC
City
Vilnius
Country
Lithuania
Facility Name
Siauliai Republican Hospital
City
Šiauliai
ZIP/Postal Code
LT-76231
Country
Lithuania
Facility Name
Indywidualna Specjalistyczna Praktyka Lekarska Elzbieta Matusz
City
Gryfice
ZIP/Postal Code
72-300
Country
Poland
Facility Name
Specjalistyczna Praktyka Lekarska Dr n. med. Joanna Orlicz-Widawska
City
Katowice
ZIP/Postal Code
40-338
Country
Poland
Facility Name
Centrum Medyczne ALL-MED
City
Kraków
ZIP/Postal Code
30-033
Country
Poland
Facility Name
Centrum Medyczne Plejady
City
Kraków
ZIP/Postal Code
30-363
Country
Poland
Facility Name
Alergotest s.c. Specjalistyczne Centrum Medyczne Andrzej Emeryk
City
Lublin
ZIP/Postal Code
20-050
Country
Poland
Facility Name
Centrum Alergologii Teresa Hofman Sp. z o.o.
City
Poznań
ZIP/Postal Code
60-214
Country
Poland
Facility Name
Podkarpacki Ośrodek Pulmonologii i Alergologii Sp. z o.o.
City
Rzeszow
ZIP/Postal Code
35-612
Country
Poland
Facility Name
Prywatny Gabinet Lekarski Malgorzata Pawlukiewicz
City
Rzeszów
Country
Poland
Facility Name
IRMED Irena Wojciechowska
City
Warszawa
ZIP/Postal Code
01-157
Country
Poland
Facility Name
All-Med" Specjalistyczna Opieka Medyczna, Medyczny Instytut Badawczy Marek Jutel
City
Wrocław
ZIP/Postal Code
53-201
Country
Poland
Facility Name
Poradnia Alergologiczna
City
Łódź
ZIP/Postal Code
90-141
Country
Poland
Facility Name
Poradnia Alergologiczna
City
Łódź
ZIP/Postal Code
90-329
Country
Poland
Facility Name
City Children's Hospital
City
Kolpino
ZIP/Postal Code
196657
Country
Russian Federation
Facility Name
Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University
City
Krasnoyarsk
ZIP/Postal Code
660022
Country
Russian Federation
Facility Name
NRC Institute of Immunology
City
Moscow
ZIP/Postal Code
115478
Country
Russian Federation
Facility Name
Moscow City Children's Hospital No 9
City
Moscow
ZIP/Postal Code
123317
Country
Russian Federation
Facility Name
City Сhildren's Сlinical Polyclinic No5
City
Perm
ZIP/Postal Code
614066
Country
Russian Federation
Facility Name
I.P. Pavlov Ryazan State Medical University
City
Ryazan'
ZIP/Postal Code
390026
Country
Russian Federation
Facility Name
Medical Technologies" Ltd.
City
Saint Petersburg
ZIP/Postal Code
191025
Country
Russian Federation
Facility Name
City Children's Polyclinic No44
City
Saint Petersburg
ZIP/Postal Code
191144
Country
Russian Federation
Facility Name
ArsVitae Severo-Zapad LLC
City
Saint Petersburg
ZIP/Postal Code
194223
Country
Russian Federation
Facility Name
North-Western State Medical University named after I.I. Mechnikov, Ministry of Public Health of Russian Federation
City
Saint Petersburg
ZIP/Postal Code
194291
Country
Russian Federation
Facility Name
Сurator LLC
City
Saint Petersburg
ZIP/Postal Code
196240
Country
Russian Federation
Facility Name
City Children's Polyclinic No45
City
Saint Petersburg
Country
Russian Federation
Facility Name
Сity Children's Polyclinic No 35
City
Saint Petersburg
Country
Russian Federation
Facility Name
Smolensk State Medical University
City
Smolensk
ZIP/Postal Code
214019
Country
Russian Federation
Facility Name
Scientific Medical Center for General Therapy and Pharmacology
City
Stavropol'
ZIP/Postal Code
355000
Country
Russian Federation
Facility Name
Regional Children's Hospital
City
Tomsk
ZIP/Postal Code
634009
Country
Russian Federation
Facility Name
Alersa, s.r.o, Ambulancia klinickej alergológie a imunológie
City
Košice
Country
Slovakia
Facility Name
Ambulancia klinickej imunologie a alergologie
City
Levice
ZIP/Postal Code
93501
Country
Slovakia
Facility Name
ALFA EL, Imunoalergologická ambulancia
City
Poprad
ZIP/Postal Code
05801
Country
Slovakia
Facility Name
Ambulancia klinickej imunologie a alergologie
City
Šurany
ZIP/Postal Code
94201
Country
Slovakia
Facility Name
Hospital Vall d'Hebron
City
Barcelona
ZIP/Postal Code
08035
Country
Spain
Facility Name
Hospital Sant Joan de Deu
City
Esplugues De Llobregat
ZIP/Postal Code
08950
Country
Spain
Facility Name
Hospital Universitario de Jerez de la Frontera
City
Jerez De La Frontera
ZIP/Postal Code
11407
Country
Spain
Facility Name
Hospital de Sagunto
City
Sagunto
ZIP/Postal Code
46520
Country
Spain
Facility Name
Hospital de Sagunto
City
Valencia
Country
Spain
Facility Name
Hospital la Plana
City
Villarreal
ZIP/Postal Code
12540
Country
Spain
Facility Name
Chernivtsi Regional Children's Clinical Hospital, Department of Pediatrics and Children's Infectious Diseases
City
Chernivtsi
ZIP/Postal Code
58023
Country
Ukraine
Facility Name
Clinical Emergency Hospital" of Dnipro City Council, Department of Pediatric Allergology at the Allergology Center
City
Dnipro
ZIP/Postal Code
49006
Country
Ukraine
Facility Name
Dnipro City Children's Municipal Clinical Hospital #2
City
Dnipro
Country
Ukraine
Facility Name
City Children's Clinic № 16" of Kharkiv City Council
City
Kharkiv
ZIP/Postal Code
61000
Country
Ukraine
Facility Name
City Children's Clinical Hospital # 19" of Kharkiv City Council
City
Kharkiv
ZIP/Postal Code
61000
Country
Ukraine
Facility Name
Kryvyi Rih City Clinical Hospital #8'' of Kryvyi Rih City Council, Department of Pediatric Pulmonology; State Institution "Dnipropetrovsk Medical Academy of the Ministry of Health of Ukraine
City
Kryvyi Rih
ZIP/Postal Code
50082
Country
Ukraine
Facility Name
O.S. Kolomiychenko Institute, Center of Allergic Diseases of Upper Respiratory Ways and Ear
City
Kyiv
ZIP/Postal Code
03057
Country
Ukraine
Facility Name
State Institution Phthisiology and Pulmonology Institute named after F.G. Yanovskyy of NAMS of Ukraine
City
Kyiv
ZIP/Postal Code
03680
Country
Ukraine
Facility Name
Institute of Pediatrics, Obstetrics and Gynecology named after Academician O. M. Lukianova of the National Academy of Medical Sciences of Ukraine
City
Kyiv
ZIP/Postal Code
04050
Country
Ukraine
Facility Name
Communal Nonprofit Enterprise "Lviv City Children's Clinical Hospital", Allergology Department, Lviv City Children's Allergology Center
City
Lviv
ZIP/Postal Code
79000
Country
Ukraine
Facility Name
Children's Clinical Hospital of Poltava Regional Council
City
Poltava
ZIP/Postal Code
36011
Country
Ukraine
Facility Name
Regional Children Clinical Hospital, Infectious-Diagnostic Department
City
Sumy
ZIP/Postal Code
40031
Country
Ukraine
Facility Name
Regional Children's Clinical Hospital of Vinnytsia Regional Council
City
Vinnytsya
ZIP/Postal Code
21029
Country
Ukraine
Facility Name
City Children's Hospital #5" of Zaporizhzhya City Council, Allergology Department
City
Zaporizhzhya
ZIP/Postal Code
69076
Country
Ukraine

12. IPD Sharing Statement

Plan to Share IPD
No
Citations:
PubMed Identifier
32548677
Citation
Field K, Blaiss MS. Sublingual Versus Subcutaneous Immunotherapy for Allergic Rhinitis: What Are the Important Therapeutic and Real-World Considerations? Curr Allergy Asthma Rep. 2020 Jun 16;20(9):45. doi: 10.1007/s11882-020-00934-4.
Results Reference
derived

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House Dust Mite Allergy Trial In Children

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