Conservative Endometrioma Surgery (BLAST)
Endometriosis Ovary, Endometrioma
About this trial
This is an interventional treatment trial for Endometriosis Ovary
Eligibility Criteria
Population: patients planned for laparoscopic CO2 laser surgery for endometriotic cysts.
Inclusion Criteria:
- Age: 18 - 40 years (both inclusive)
- Unilateral endometriotic cysts with a mean diameter of >=2.5cm and ≤8 cm, measured in 3 dimensions.
- Presence of a contralateral endometrioma of ≤ 2cm is allowed
- Complaining of infertility and/or pain
- BMI ≤35
- Use of contraception (combined or Progesteron only) for at least 4 weeks before surgery
Exclusion Criteria:
- Incomplete surgery for the pelvis
- Contra-indication for the use of contraception (combined or Progesteron only)
- Use of GnRH analogues preoperatively and in the first 3 months postoperatively
- (History of) hysterectomy
- Prior unilateral oophorectomy
- Pituitary/hypothalamic disorders
- Suspected malignancy
- Contralateral endometrioma of >2 cm
- AMH <0.7 preoperatively
- Pregnancy
Sites / Locations
- GZA Sint-AugustinusRecruiting
- Cliniques universitaires Saint-LUC (UCL)Recruiting
- UZLeuvenRecruiting
- CHR La CitadelleRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
The combined technique
CO2 laser vaporization only
First step consisting of stripping the cyst wall for 80% of the surface, followed by a second step consisting of ablation of the remaining 20% cyst surface.
CO2 laser vaporization only of the complete inner cystic wall after drainage of the cyst content, irrigation and inspection of its inner wall. Ablation of the inner cyst wall using the CO2 laser (Lumenis). Power settings of 30-55W for CO2 laser beam and 6-10W for CO2 fibre are used. The laser should be on the ablate function to widen the beam (e.g. Surgitouch modus). The laser should be applied in Surgitouch modus so that it can ablate the cyst surface while preserving the underlying healthy tissue.