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Effect of Aerobic Training and Moringa Oleifera on Dyslipidemia and Cardiac Endurance

Primary Purpose

Dyslipidemias

Status
Unknown status
Phase
Not Applicable
Locations
Study Type
Interventional
Intervention
Aerobic training and Moringa Oleifera
Sponsored by
Aga Khan University
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional health services research trial for Dyslipidemias focused on measuring Aerobic training, Moringa, Cardioprotection

Eligibility Criteria

20 Years - 50 Years (Adult)MaleAccepts Healthy Volunteers

Inclusion Criteria:

  • Healthy and no medical conditions.
  • LDL level should be 160-189 mg/dl
  • HDL level should be < 40 mg/dl
  • Tri glyceride level should be 200-499 mg/dl
  • Total cholesterol level should be > 200 mg/dl).
  • Beep Test score should be less than 10.5 or less than 40% vo2 max

Exclusion Criteria:

  • Any disease condition as anemia, physical injuries, chronic disease
  • Not capable of doing aerobic training

Sites / Locations

    Arms of the Study

    Arm 1

    Arm 2

    Arm 3

    Arm 4

    Arm Type

    Experimental

    Experimental

    Experimental

    No Intervention

    Arm Label

    Moringa Group

    Aerobic training Group

    Moringa and Aerobic training

    Control Group (T4)

    Arm Description

    Participants will receive 5-7g of moringa diet daily for 6 weeks.

    Participants will receive 5-7g of moringa diet daily and will do 30 minutes of aerobic training daily for 6 weeks.

    Participants will do 30 minutes of aerobic training daily for 6 weeks

    Participants will not recieve any treatment

    Outcomes

    Primary Outcome Measures

    Positive effect of aerobic training and Moringa Oleifera on dyslipidemia and cardiac endurance
    Change in level of HDL, LDL and triglyceride, impact on cardiac endurance

    Secondary Outcome Measures

    Full Information

    First Posted
    November 7, 2019
    Last Updated
    December 16, 2019
    Sponsor
    Aga Khan University
    Collaborators
    Muhammad Safdar Ali
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    1. Study Identification

    Unique Protocol Identification Number
    NCT04164771
    Brief Title
    Effect of Aerobic Training and Moringa Oleifera on Dyslipidemia and Cardiac Endurance
    Official Title
    Effect of Aerobic Training and Moringa Oleifera on Dyslipidemia and Cardiac Endurance
    Study Type
    Interventional

    2. Study Status

    Record Verification Date
    December 2019
    Overall Recruitment Status
    Unknown status
    Study Start Date
    February 2020 (Anticipated)
    Primary Completion Date
    April 2020 (Anticipated)
    Study Completion Date
    July 2020 (Anticipated)

    3. Sponsor/Collaborators

    Responsible Party, by Official Title
    Principal Investigator
    Name of the Sponsor
    Aga Khan University
    Collaborators
    Muhammad Safdar Ali

    4. Oversight

    Studies a U.S. FDA-regulated Drug Product
    No
    Studies a U.S. FDA-regulated Device Product
    No
    Data Monitoring Committee
    No

    5. Study Description

    Brief Summary
    Aerobic training is essential for maintaining and improving physical performance and has a positive effect on physiological functions as well as anthropometric characteristics. It also has positive effect on cardiovascular health and carries a number of beneficial effects on the whole body functions and systems. Aerobic training can also decrease the risk of heart disease in the individual's life.The Moringa leaves are the rich source of minerals, vitamins and other essential phytochemicals. Moringa leave have found to be very effective in many disease particularly diabetic, blood pressure, dyslipidemia and cancer.
    Detailed Description
    Aerobic training is an important component for health in daily life as well as sports performance. Aerobic training improves overall health, reduces body fat, maintain body weight, resting blood pressure (systolic and diastolic), maximal oxygen consumption adequate blood supply and provision of oxygen to the body muscles .The studies reveal that aerobic training is valuable for improving cardiovascular health, fitness and quality of life. On account of lack of aerobic engagement around 17 % of the population suffer from heart related ailment, 12 % from diabetes and 10 % from breast cancer. American College of Sports Medicine suggested that 30 minutes of aerobic workout has progressive effects on physical fitness and especially on chronic diseases. Physically fit individuals have got the potential to affectively cope with stress and anxiety and coronary arteries diseases. Aerobic training can raise maximal oxygen uptake, which means body adapts to use oxygen more efficiently during physical activities. Resultantly, the heart becomes efficient and stronger; meaning that the heart doesn't have to work hard to pump blood in resting position. Aerobic training decreases resting heart rate and may increase blood volume and blood plasma. Moringa Oleifera a plant from the family Moringacea, its products are used as a health supplement introduced in Africa and south Asian countries to cure many diseases and improve health status . Moringa leaves are rich source of vitamins and protein. The Moringa oleifera leaves, flowers, seeds and pods are commonly used as vegetables diet in different regions of south Asia. Moringa plant products are sources of vitamin A, b, C and proteins, including the essential amino acids. Moringa Oleifera leaves can be merged in the feed of birds, animals and human which provide wonderful source of protein other than expensive ingredients. The Moringa oil is used in cooking products as well as for lubrication. There are scientific indications that Moringa Oleifera holds therapeutic potential for hyperlipidemia, diabetes and cardiovascular diseases. The use of herbal supplements has increased rapidly during the first decade of the twentieth century. The nutrients of Moringa are considered to be useful for disorders including skin disease, malnutrition and sexual problem.Different experimental studies has described that Moringa oleifera leaves have therapeutic potential for chronic hyperglycemia and dyslipidemia . Moringa Oleifera is used as a hypolipidemic medication to improve the lipid profile of rats fed on atherogenic diet. Moringa Oleifera intake is more effective in prevention than in treatment of hyperlipidemia.It is documented that overuse of Moringa supplements can cause high increase of iron. Hence, a daily 70 g quantity of Moringa is recommended to be batter and preventive for accumulation of nutrients.This research study is due to be conducted to determine the effect of aerobic training and Moringa Oleifera on dyslipidemia and cardiac endurance

    6. Conditions and Keywords

    Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
    Dyslipidemias
    Keywords
    Aerobic training, Moringa, Cardioprotection

    7. Study Design

    Primary Purpose
    Health Services Research
    Study Phase
    Not Applicable
    Interventional Study Model
    Parallel Assignment
    Masking
    None (Open Label)
    Allocation
    Randomized
    Enrollment
    120 (Anticipated)

    8. Arms, Groups, and Interventions

    Arm Title
    Moringa Group
    Arm Type
    Experimental
    Arm Description
    Participants will receive 5-7g of moringa diet daily for 6 weeks.
    Arm Title
    Aerobic training Group
    Arm Type
    Experimental
    Arm Description
    Participants will receive 5-7g of moringa diet daily and will do 30 minutes of aerobic training daily for 6 weeks.
    Arm Title
    Moringa and Aerobic training
    Arm Type
    Experimental
    Arm Description
    Participants will do 30 minutes of aerobic training daily for 6 weeks
    Arm Title
    Control Group (T4)
    Arm Type
    No Intervention
    Arm Description
    Participants will not recieve any treatment
    Intervention Type
    Other
    Intervention Name(s)
    Aerobic training and Moringa Oleifera
    Intervention Description
    Aerobic exercises/training refers to any type of rhythmic, continuous physical activities that use large group of muscles like walking, running, cycling, and swimming consuming additional amount of energy while Moringa Oleifera a plant from the family Moringacea, its products are used as a health supplement introduced in Africa and south Asian countries to cure many diseases and improve health status
    Primary Outcome Measure Information:
    Title
    Positive effect of aerobic training and Moringa Oleifera on dyslipidemia and cardiac endurance
    Description
    Change in level of HDL, LDL and triglyceride, impact on cardiac endurance
    Time Frame
    6 weeks

    10. Eligibility

    Sex
    Male
    Gender Based
    Yes
    Minimum Age & Unit of Time
    20 Years
    Maximum Age & Unit of Time
    50 Years
    Accepts Healthy Volunteers
    Accepts Healthy Volunteers
    Eligibility Criteria
    Inclusion Criteria: Healthy and no medical conditions. LDL level should be 160-189 mg/dl HDL level should be < 40 mg/dl Tri glyceride level should be 200-499 mg/dl Total cholesterol level should be > 200 mg/dl). Beep Test score should be less than 10.5 or less than 40% vo2 max Exclusion Criteria: Any disease condition as anemia, physical injuries, chronic disease Not capable of doing aerobic training
    Central Contact Person:
    First Name & Middle Initial & Last Name or Official Title & Degree
    Naseer Ahmed, Ph.D
    Phone
    03333382013
    Ext
    4465
    Email
    dr.naseer99@gmail.com
    First Name & Middle Initial & Last Name or Official Title & Degree
    Javeria Farooq, M.Phil
    Phone
    03343585849
    Email
    javeria.farooq@aku.edu
    Overall Study Officials:
    First Name & Middle Initial & Last Name & Degree
    Naseer Ahmed, Ph.D
    Organizational Affiliation
    Agha Khan Hospital
    Official's Role
    Principal Investigator

    12. IPD Sharing Statement

    Plan to Share IPD
    No

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    Effect of Aerobic Training and Moringa Oleifera on Dyslipidemia and Cardiac Endurance

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