EEG Monitoring for Refractory Status Epilepticus
Status Epilepticus
About this trial
This is an interventional other trial for Status Epilepticus
Eligibility Criteria
Inclusion Criteria:
• Patients aged > 16 years
- Consent obtained according to Mental Capacity Act 2005
- Patients admitted to ICU for treatment of status epilepticus or admitted for another reason and diagnosed with SE during their admission
Convulsive Status epilepticus defined by either:
- Tonic-clonic SE lasting longer than 5 minutes,
- Focal SE with impaired consciousness lasting longer than 10 minutes
- or Non-Convulsive SE according to Salzburg consensus criteria
- Status epilepticus that continues despite treatment with benzodiazepine and one antiepileptic medication
Exclusion Criteria:
- Anoxic brain injury
Sites / Locations
- Royal London Hospital
Arms of the Study
Arm 1
Arm 2
No Intervention
Experimental
control
cEEG
The standard medical care (Control) group will receive sequential portable EEGs, performed according to clinical demand. These patients usually have 2 recordings of 20-30 minutes each within 24 or 48 hours. The studies include baseline recoding and recording after auditory, tactile and nociceptive stimulation. The EEGs will be visually reviewed and reported within 4 hours after the recording completion by a Consultant Clinical Neurophysiologist or other doctor with equivalent qualifications.
The treatment (cEEG) group will have cEEG applied within 12 hours of RSE diagnosis, which will continue until 24 hours after cessation of clinical and electrical seizure activity. Reactivity testing with auditory, tactile and nociceptive stimulation will be repeated at least once daily. The cEEG will be visually interpreted twice daily by a Consultant Clinical Neurophysiologist and the results will be communicated within two hours of their completion to the treating clinical team.