Efficacy of Deep Anaesthesia With Isoflurane as a Fast-response Antidepressant Agent (ISORADAR)
Depressive Disorder, Major, Treatment Resistant Depression, Depressive Episode
About this trial
This is an interventional treatment trial for Depressive Disorder, Major focused on measuring Isoflurane, Anesthesia, Treatment resistant depression, Deep anesthesia, Burst suppression, Depressive episode
Eligibility Criteria
Inclusion Criteria:
- Patients with Treatment resistant depression on depressive state with or without psychiatric comorbidities for anxious features
- moderate to severe condition measured by Montgomery Asperger Depression Rating Scale and Hamilton Depression rating scale - 17
- be between 18 and 60 years old
- IF female, do not be pregnant and use a trustable contraceptive method
- can read and write in Portuguese language
- will to be in all the phases of the study
- have agreed with free will to participate
- classified as American Society of Anesthesiologists - Physical Status 1 or 2 by a certified anesthesiologist
- Suicide ideation measured by Montgomery Asperger Depression Rating Scale on item 10 less than 4
Exclusion Criteria:
- drug abusers in the last 6 months, except for nicotine
- use of benzodiazepines or lamotrigine less then 15 days from the first session
- family history of malignant hyperthermia Suicidal ideation on item 10 of Montgomery Asperger Depression Rating Scale more than 4
- Suicide attempt one month prior the study begins
Sites / Locations
- Insitute of Psychiatry of the University of São Paulo
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Experimental
ISO
ISOAD
ISOPOT
Patients not taking oral medications for depression. They will receive the study intervention consisting in general anesthesia with the volatile anesthetic gas Isoflurane until burst suppression is detected in electroencephalogram more than 80% of the time for 15 minutes.
Patients in treatment with oral medications for depression, will receive intervention consisting in general anesthesia with the volatile anesthetic gas Isoflurane until burst suppression is detected in electroencephalogram more than 80% of the time for 15 minutes
Patients that where from ISO arm, that did not respond to intervention consisting in general anesthesia with the volatile anesthetic gas Isoflurane until burst suppression is detected in electroencephalogram more than 80% of the time for 15 minutes They will now, start taking sertraline as oral medication for depression to asset the enhancement of oral treatment after Isoflurane challenge.