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Treatment of Breakpoint Cluster Region-Abelson (BCR-ABL) Negative ALL in Adults

Primary Purpose

Acute Lymphoblastic Leukemia

Status
Recruiting
Phase
Not Applicable
Locations
Spain
Study Type
Interventional
Intervention
Pediatric-type of chemotherapy
allogeneic HSCT
Sponsored by
PETHEMA Foundation
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Acute Lymphoblastic Leukemia focused on measuring ALL, adult, Ph-negative, minimal residual disease, transplantation

Eligibility Criteria

18 Years - 60 Years (Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • Patients 18-60 yr with de novo Ph-neg ALL
  • Eastern Cooperative Oncology Group (ECOG) 0-2 (or >2 if due to ALL)
  • Informed consent

Exclusion Criteria:

  • Mature B-ALL, Ph+ ALL or blast crisis of chronic myeloid leukemia (CML), ALL of ambiguous lineage
  • ECOG >2 not due to ALL
  • Impaired cardiac, respiratory, hepatic or renal function not due to ALL
  • Pregnancy
  • HIV positivity
  • Severe psychiatric disease
  • Negative to sign informed consent.

Sites / Locations

  • Ico-HugtipRecruiting
  • H Albacete
  • H. General Univ. de AlicanteRecruiting
  • H. General Univ. de Alicante
  • Clínica Teknon
  • H del Mar
  • H. Clínic de BarcelonaRecruiting
  • H. del Mar
  • H. Sant PauRecruiting
  • H. Vall d'HebronRecruiting
  • H. Vall d'Hebron
  • ICO-Duran i Reynals
  • H Basurto
  • Hu BasurtoRecruiting
  • H. Jerez
  • H. Puerta del Mar
  • H. General de Castellón
  • H. San Pedro de Alcántara
  • H. Reina Sofía
  • H. Fuenlabrada
  • H Galdakao
  • H. Univ. De Getafe
  • ICO-Dr.Josep TruetaRecruiting
  • H. Guadalajara
  • H Juan Ramón Jiménez
  • Complejo Hospitalario Ciudad de JaénRecruiting
  • H. Jerez de la FronteraRecruiting
  • H. A Coruña
  • H. General Lanzarote
  • H Dr. NegrínRecruiting
  • Hospital Insular de Gran Canaria
  • Hu Gran Canarias Dr Negrin
  • H. Arnau De VilanovaRecruiting
  • H. Lucus Augusti
  • H. Lucus Augusti
  • H. Lucus Augusti
  • Fundación Jiménez Díaz
  • H La Zarzuela
  • H Puerta de HierroRecruiting
  • H Puerta de Hierro
  • H. 12 de Octubre
  • H. 12 de Octubre
  • H. 12 de Octubre
  • H. 12 de Octubre
  • H. 12 de Octubre
  • H. Clínico de Madrid
  • H. Clínico de Madrid
  • H. Gregorio Marañón
  • H. Gregorio Marañón
  • H. Infanta Sofía
  • H. Madrid-Norte SanchinarroRecruiting
  • H. Ramón y CajalRecruiting
  • H. Ramón y Cajal
  • H. Univ La Paz
  • Hu Infanta Leonor
  • Hu La Princesa
  • H. Morales Meseguer
  • H. Virgen de la Arrixaca
  • H. Virgen de la Arrixaca
  • H. Virgen de la Arrixaca
  • H. Carlos Haya
  • H. Clínico Univ. Virgen de la VictoriaRecruiting
  • H. Regional de MálagaRecruiting
  • Complejo Hosp. Univ. de Orense
  • Complejo Hosp. Univ. de Orense
  • Complejo Hosp. Univ. de Orense
  • Complejo Hosp. Univ. de Orense
  • H. Central de AsturiasRecruiting
  • H Río Carrión
  • H. Son EspasesRecruiting
  • H. Son Llàtzer
  • Complejo Hospitalario NavarraRecruiting
  • H. Clínico Univ. de Navarra
  • H. Virgen del Camino
  • Complejo Hospitalario Pontevedra - Hospital Montecelo
  • H. Parc Taulí
  • H. Clínico Univ. de Salamanca
  • H. Clínico Univ. de Salamanca
  • H Donostia
  • H Donostia
  • H Donostia
  • H Donostia
  • H. Univ. de Canarias
  • H. Marqués de Valdecilla
  • H. Marqués de Valdecilla
  • Complejo Hosp. Univ. Santiago de Compostela
  • Complejo Hosp. Univ. Santiago de CompostelaRecruiting
  • H. General de Segovia
  • H. Universitario de Valme
  • H. Virgen del RocíoRecruiting
  • ICO-Joan XXIII
  • Mútua de Terrassa
  • H Torrejón
  • H. Verge de la Cinta
  • H. Arnau de Vilanova
  • H. Clínico Univ. de Valencia
  • H. Dr. Peset
  • H. Dr. Peset
  • H. General Univ. de Valencia
  • H. la FeRecruiting
  • H. Clínico Universitario de Valladolid
  • H. Río Hortega
  • H. Xeral-Cíes Vigo
  • H. Xeral-Cíes Vigo
  • H. Virgen de la Concha
  • H. Lozano Blesa
  • H. Miguel Servet
  • Hospital Nuestra Señora de SonsolesRecruiting

Arms of the Study

Arm 1

Arm 2

Arm Type

Other

Other

Arm Label

CHEMOTHERAPY

allogeneic HSCT

Arm Description

Pediatric-type of chemotherapy

allogeneic HSCT

Outcomes

Primary Outcome Measures

Overall survival
Time from diagnosis to death or last follow-up

Secondary Outcome Measures

Complete remission (CR) rate
Proportion of patients who achieve CR with or 2 induction therapy lines
MRD status after induction and consolidation
Proportion of patients who achieve and maintain the negative MRD status (<10-4)

Full Information

First Posted
November 20, 2019
Last Updated
February 17, 2022
Sponsor
PETHEMA Foundation
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1. Study Identification

Unique Protocol Identification Number
NCT04179929
Brief Title
Treatment of Breakpoint Cluster Region-Abelson (BCR-ABL) Negative ALL in Adults
Official Title
Treatment of BCR-ABL Negative ALL in Adults According to MRD and Genetics
Study Type
Interventional

2. Study Status

Record Verification Date
February 2022
Overall Recruitment Status
Recruiting
Study Start Date
November 25, 2019 (Actual)
Primary Completion Date
November 2026 (Anticipated)
Study Completion Date
February 2027 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
PETHEMA Foundation

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No

5. Study Description

Brief Summary
After consolidation therapy adult patients (≥18 yr) with Ph-negative ALL will be treated with continuation chemotherapy or allogeneic hematopoietic stem cell transplantation (alloHSCT) according to both measurable residual disease (MRD) and results of genetic study performed at baseline.
Detailed Description
Patients will be uniformly treated with four drug-induction: vincristine (VCR), prednisone (PDN), pegylated asparaginase (PegASP), daunorubicin (DNR). Resistant patients will receive a second induction with fludarabine, Ara-C, G-Colony-Stimulating Factor (G-CSF) and idarubicin (FLAG-IDA). Patients with adequate MRD clearance after induction will receive 3 blocks of early consolidation. If adequate MRD clearance and good genetic background, the patients will proceed to delayed intensification, reinduction and maintenance. The remaining patients will receive early or delayed alloHSCT.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Acute Lymphoblastic Leukemia
Keywords
ALL, adult, Ph-negative, minimal residual disease, transplantation

7. Study Design

Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Non-Randomized
Enrollment
300 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
CHEMOTHERAPY
Arm Type
Other
Arm Description
Pediatric-type of chemotherapy
Arm Title
allogeneic HSCT
Arm Type
Other
Arm Description
allogeneic HSCT
Intervention Type
Drug
Intervention Name(s)
Pediatric-type of chemotherapy
Intervention Description
Pediatric type chemotherapy (induction, early and delayed consolidation, reinduction, maintenance). Induction (VCR,PDN,PegASP,DNR). Early and delayed consolidation (high-dose Methotrexate, high-dose Cytarabine, PegASP). Reinduction (VCR, PDN, PegASP, DNR). Maintenance (Methotrexate, Mercaptopurine)
Intervention Type
Procedure
Intervention Name(s)
allogeneic HSCT
Intervention Description
allogeneic HSCT
Primary Outcome Measure Information:
Title
Overall survival
Description
Time from diagnosis to death or last follow-up
Time Frame
3 years
Secondary Outcome Measure Information:
Title
Complete remission (CR) rate
Description
Proportion of patients who achieve CR with or 2 induction therapy lines
Time Frame
4 or 8 weeks after treatment onset
Title
MRD status after induction and consolidation
Description
Proportion of patients who achieve and maintain the negative MRD status (<10-4)
Time Frame
After induction (4-8 weeks) and consolidation (16-20 weeks)
Other Pre-specified Outcome Measures:
Title
alloSCT realization
Description
Proportion of patients who receive early or delayed alloHSCT
Time Frame
Early alloHSCT: 15-20 weeks from diagnosis. Delayed: 30-35 weeks from diagnosis.

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
60 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Patients 18-60 yr with de novo Ph-neg ALL Eastern Cooperative Oncology Group (ECOG) 0-2 (or >2 if due to ALL) Informed consent Exclusion Criteria: Mature B-ALL, Ph+ ALL or blast crisis of chronic myeloid leukemia (CML), ALL of ambiguous lineage ECOG >2 not due to ALL Impaired cardiac, respiratory, hepatic or renal function not due to ALL Pregnancy HIV positivity Severe psychiatric disease Negative to sign informed consent.
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Josep Maria Ribera, Ph
Phone
934978987
Email
jribera@iconcologia.net
Facility Information:
Facility Name
Ico-Hugtip
City
Badalona
State/Province
Barcelona
ZIP/Postal Code
08916
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jose Maria Ribera Santasusana
Phone
934978987
Email
jribera@iconcologia.net
Facility Name
H Albacete
City
Albacete
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
José Santiago Bermón
Facility Name
H. General Univ. de Alicante
City
Alicante
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Cristina Gil
Facility Name
H. General Univ. de Alicante
City
Alicante
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Pascual Fernández Abellán
Facility Name
Clínica Teknon
City
Barcelona
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Pilar Vivancos
Facility Name
H del Mar
City
Barcelona
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Eva Gimeno
Facility Name
H. Clínic de Barcelona
City
Barcelona
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jordi Esteve
Facility Name
H. del Mar
City
Barcelona
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Eugènia Abella Monreal
Facility Name
H. Sant Pau
City
Barcelona
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Irene García-Cadenas
Facility Name
H. Vall d'Hebron
City
Barcelona
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Pere Barba
Facility Name
H. Vall d'Hebron
City
Barcelona
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Pau Abrisqueta
Facility Name
ICO-Duran i Reynals
City
Bellvitge
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Santiago Mercadal
Facility Name
H Basurto
City
Bilbao
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Olga Arce Fernández
Facility Name
Hu Basurto
City
Bilbao
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Cristina Barrenetxea
Facility Name
H. Jerez
City
Cadiz
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Carmen Muñoz García
Facility Name
H. Puerta del Mar
City
Cadiz
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Victoria Martín Reina
Facility Name
H. General de Castellón
City
Castelló
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Raimundo García Boyero
Facility Name
H. San Pedro de Alcántara
City
Cáceres
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Juan Bergua
Facility Name
H. Reina Sofía
City
Córdoba
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Josefina Serrano López
Facility Name
H. Fuenlabrada
City
Fuenlabrada
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Pilar Bravo
Facility Name
H Galdakao
City
Galdakao
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Matxalen Olivares
Facility Name
H. Univ. De Getafe
City
Getafe
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Carmen Monteserín
Facility Name
ICO-Dr.Josep Trueta
City
Girona
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Nazly Santos
Facility Name
H. Guadalajara
City
Guadalajara
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Miguel Díaz Morfa
Facility Name
H Juan Ramón Jiménez
City
Huelva
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Encarni Gil Espárraga
Facility Name
Complejo Hospitalario Ciudad de Jaén
City
Jaén
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Angela Baena
Facility Name
H. Jerez de la Frontera
City
Jerez De La Frontera
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Lourdes Hermosín
Facility Name
H. A Coruña
City
La Coruña
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Víctor Noriega Concepción
Facility Name
H. General Lanzarote
City
Lanzarote
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Azueg Hong
Facility Name
H Dr. Negrín
City
Las Palmas De Gran Canaria
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Carlos Rodríguez
Facility Name
Hospital Insular de Gran Canaria
City
Las Palmas De Gran Canaria
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Rosa Fernández
Facility Name
Hu Gran Canarias Dr Negrin
City
Las Palmas De Gran Canaria
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Carlos Rodríguez Medina
Facility Name
H. Arnau De Vilanova
City
Lleida
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Antoni García Guiñón
Facility Name
H. Lucus Augusti
City
Lugo
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Esperanza Lavilla
Facility Name
H. Lucus Augusti
City
Lugo
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Maria José Sánchez Sánchez
Facility Name
H. Lucus Augusti
City
Lugo
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jesús Arias Sampedro
Facility Name
Fundación Jiménez Díaz
City
Madrid
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
José Luis López Lorenzo
Facility Name
H La Zarzuela
City
Madrid
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Daniel García Belmonte
Facility Name
H Puerta de Hierro
City
Madrid
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Irene Romera
Facility Name
H Puerta de Hierro
City
Madrid
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Rafael Forés
Facility Name
H. 12 de Octubre
City
Madrid
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Carlos Grande
Facility Name
H. 12 de Octubre
City
Madrid
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Pilar Martínez Sánchez
Facility Name
H. 12 de Octubre
City
Madrid
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
José María Sánchez Pina
Facility Name
H. 12 de Octubre
City
Madrid
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
María Calbacho
Facility Name
H. 12 de Octubre
City
Madrid
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mario Rodríguez Rodríguez
Facility Name
H. Clínico de Madrid
City
Madrid
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Eloy del Potro
Facility Name
H. Clínico de Madrid
City
Madrid
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mónica Sánchez
Facility Name
H. Gregorio Marañón
City
Madrid
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Silvia Monsalvo
Facility Name
H. Gregorio Marañón
City
Madrid
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mariana Bastos Oreiro
Facility Name
H. Infanta Sofía
City
Madrid
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Pilar Massó
Facility Name
H. Madrid-Norte Sanchinarro
City
Madrid
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alfons Serrano
Facility Name
H. Ramón y Cajal
City
Madrid
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alberto González
Facility Name
H. Ramón y Cajal
City
Madrid
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Anabelle Chinea
Facility Name
H. Univ La Paz
City
Madrid
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Dolores Hernández Maraver
Facility Name
Hu Infanta Leonor
City
Madrid
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
María José Penalva Moreno
Facility Name
Hu La Princesa
City
Madrid
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Reyes Arranz
Facility Name
H. Morales Meseguer
City
Murcia
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Maria Luz Amigo Lozano
Facility Name
H. Virgen de la Arrixaca
City
Murcia
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
José Maria Moraleda
Facility Name
H. Virgen de la Arrixaca
City
Murcia
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Andrés Sánchez Salinas
Facility Name
H. Virgen de la Arrixaca
City
Murcia
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Maria Carmen Garcia Garay
Facility Name
H. Carlos Haya
City
Málaga
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Concha Bethencourt
Facility Name
H. Clínico Univ. Virgen de la Victoria
City
Málaga
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
MªPaz Queipo de Llano
Facility Name
H. Regional de Málaga
City
Málaga
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alejandro Contento
Facility Name
Complejo Hosp. Univ. de Orense
City
Orense
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
María Elsa López Ansoar
Facility Name
Complejo Hosp. Univ. de Orense
City
Orense
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Manuel Albors Ferreiro
Facility Name
Complejo Hosp. Univ. de Orense
City
Orense
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Marta Rodríguez
Facility Name
Complejo Hosp. Univ. de Orense
City
Orense
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
José Angel Méndez Sánchez
Facility Name
H. Central de Asturias
City
Oviedo
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Teresa Bernal
Facility Name
H Río Carrión
City
Palencia
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
José María Alonso Alonso
Facility Name
H. Son Espases
City
Palma De Mallorca
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Andrés Novo
Facility Name
H. Son Llàtzer
City
Palma De Mallorca
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Antònia Cladera
Facility Name
Complejo Hospitalario Navarra
City
Pamplona
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
M Carmen Mateos
Facility Name
H. Clínico Univ. de Navarra
City
Pamplona
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
José Rifón
Facility Name
H. Virgen del Camino
City
Pamplona
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Maria Carmen Mateos Rodríguez
Facility Name
Complejo Hospitalario Pontevedra - Hospital Montecelo
City
Pontevedra
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Maria Lourdes Amador
Facility Name
H. Parc Taulí
City
Sabadell
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sonia Piernas
Facility Name
H. Clínico Univ. de Salamanca
City
Salamanca
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mónica Cabrero
Facility Name
H. Clínico Univ. de Salamanca
City
Salamanca
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jesús Mª Hernández Rivas
Facility Name
H Donostia
City
San Sebastián
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Maria Teresa Artola
Facility Name
H Donostia
City
San Sebastián
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Nerea Caminos Uresandi
Facility Name
H Donostia
City
San Sebastián
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Izaskun Ceberio
Facility Name
H Donostia
City
San Sebastián
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Maialen Sirvent Auzmendi
Facility Name
H. Univ. de Canarias
City
Santa Cruz De Tenerife
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Beatriz Soria Santa Bárbara
Facility Name
H. Marqués de Valdecilla
City
Santander
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mercedes Colorado
Facility Name
H. Marqués de Valdecilla
City
Santander
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Arancha Bermúdez
Facility Name
Complejo Hosp. Univ. Santiago de Compostela
City
Santiago De Compostela
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Maria José Rabuñal Martínez
Facility Name
Complejo Hosp. Univ. Santiago de Compostela
City
Santiago De Compostela
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Natalia Alonso
Facility Name
H. General de Segovia
City
Segovia
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
José Antonio Queizán Hernández
Facility Name
H. Universitario de Valme
City
Sevilla
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Carmen Couto
Facility Name
H. Virgen del Rocío
City
Sevilla
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
José González Campos
Facility Name
ICO-Joan XXIII
City
Tarragona
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Marta Cervera
Facility Name
Mútua de Terrassa
City
Terrassa
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ferran Vall-Llovera Calmet
Facility Name
H Torrejón
City
Torrejón De Ardoz
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ana Sebrango Sadia
Facility Name
H. Verge de la Cinta
City
Tortosa
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xavier Ortin Font
Facility Name
H. Arnau de Vilanova
City
Valencia
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Aurelio López
Facility Name
H. Clínico Univ. de Valencia
City
Valencia
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mar Tormo
Facility Name
H. Dr. Peset
City
Valencia
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
María José Sayas
Facility Name
H. Dr. Peset
City
Valencia
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
María Pedreño
Facility Name
H. General Univ. de Valencia
City
Valencia
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Magdalena Sánchez
Facility Name
H. la Fe
City
Valencia
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Pau Montesinos
Facility Name
H. Clínico Universitario de Valladolid
City
Valladolid
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
María Jesús Peñarrubia
Facility Name
H. Río Hortega
City
Valladolid
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alberto Cantalapiedra
Facility Name
H. Xeral-Cíes Vigo
City
Vigo
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ángeles Fernández Fernández
Facility Name
H. Xeral-Cíes Vigo
City
Vigo
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Esmeralda Benítez
Facility Name
H. Virgen de la Concha
City
Zamora
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Magdalena Sierra Pacho
Facility Name
H. Lozano Blesa
City
Zaragoza
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mayte Olave
Facility Name
H. Miguel Servet
City
Zaragoza
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Beatriz de Rueda
Facility Name
Hospital Nuestra Señora de Sonsoles
City
Ávila
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Miguel Cabezudo

12. IPD Sharing Statement

Plan to Share IPD
No
Links:
URL
https://www.fundacionpethema.es
Description
Web page of the sponsor of the study

Learn more about this trial

Treatment of Breakpoint Cluster Region-Abelson (BCR-ABL) Negative ALL in Adults

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