LITT Followed by Hypofractionated RT for Recurrent Gliomas (GCCC 19140)
Glioblastoma, Brain Tumor, Glioma
About this trial
This is an interventional treatment trial for Glioblastoma focused on measuring Gliomas, Laser Interstitial Thermal Therapy, Brain, Brain Tumor, Radiotherapy, Proton Therapy, Hypofractionated Radiation Therapy, Malignant, Glioblastoma
Eligibility Criteria
Inclusion Criteria:
Patients with history of a WHO Grade II-IV glioma with radiographic evidence of recurrent or progressive tumor
- Patient must have received prior radiation therapy for initial treatment of glioma
- Patients with any number of recurrences are allowed as long as the patient has not undergone re-irradiation
- Brain MRI with contrast demonstrates an enhancing tumor ≤ 6 cm in largest diameter within 60 days prior to registration
- History and physical including neurological exam within 30 days prior to registration
- Karnofsky performance status ≥ 60% within 30 days prior to registration
- Age ≥ 22 years old
Minimum interval since completion of prior radiation treatment is 8 weeks
- Patients will only receive re-irradiation if pathology from LITT is consistent with recurrent tumor
- Patients must have signed an approved informed consent
- Patients with the potential for pregnancy or impregnating their partner must agree to practice effective contraceptive methods to avoid conception while on study and for 6 months after study completion.
- Female patients of child-bearing potential must have a negative pregnancy test within 28 days prior to study registration.
Exclusion Criteria:
- Patients that are not surgical candidates for stereotactic biopsy or laser ablation
Patients with impaired cardiac function or clinically significant cardiac diseases, including any of the following:
- History or presence of serious uncontrolled ventricular or significant arrhythmias.
- Any of the following within 6 months prior to registration: myocardial infarction, severe/unstable angina, coronary artery bypass graft, congestive heart failure, cerebrovascular accident, transient ischemic attack , pulmonary embolism
- Infratentorial tumor or evidence of leptomeningeal spread
- Inability to undergo a MRI
- Pregnant or breast-feeding women
Sites / Locations
- University of Maryland Greenebaum Cancer CenterRecruiting
- UCH Kaufman Cancer CenterRecruiting
- Central Maryland Radiation OncologyRecruiting
- Baltimore Washington Medical CenterRecruiting
Arms of the Study
Arm 1
Experimental
Experimental: LITT with Hypofractionated radiation therapy
Laser interstitial thermal therapy (LITT) followed by hypo-fractionated radiation therapy, 35Gy/10 fractions.