Effects of Paired Associative Nerve Stimulation on Spinal Cord Injury Subjects
Spinal Cord Injuries
About this trial
This is an interventional treatment trial for Spinal Cord Injuries focused on measuring Spinal Cord Injuries, Trans-cranial magnetic stimulation, Trans-spinal direct current stimulation
Eligibility Criteria
Inclusion Criteria:
- Age 20 to 65 years incomplete SCI (American Spinal Injury Association Impairment Scale (ASIA) B to D)
- Lesion area above the tenth thoracic vertebra (T10)
- Injury time more than one year
- Without range of motion (ROM) limitation
- Medical condition stable
Exclusion Criteria:
- Having pacemaker, cochlear implants, metal in the brain or skull, open wound of brain, or history of epilepsy.
- Having seizure history
- Having other neurological, mental, medical problems affect this study
Sites / Locations
- Taipei Medical university HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Experimental
Experimental
Experimental
Experimental
Sham Comparator
rTMS (Brain) + tsES (Spinal)
rTMS (Brain) + tsES (Spinal) or sham stimulation
iTBS rTMS or sham (Brain) + tsES or sham (Spinal)
iTBS rTMS or sham (Brain) + iTBS or sham (Spinal)
sham (no stimulation on brain nor spinal)
First part 20 Hz rTMS (Brain) + Anode tsDCS (Spinal) Brain: Train pulse: 2 sec Inter-train: 28 sec Total time: 1200 sec Spinal: Continuous direct current (DC): 1200 sec Second part iTBS rTMS(Brain) + 2.5-mA tsDCS (Spinal) Brain: Train pulse: 2 sec Inter-train: 8 sec Total time: 200 sec Spinal: Continuous direct current (DC): 600 sec
First part 20 Hz rTMS (Brain) + 20 Hz current square-wave pulses (Spinal) Brain and spinal: Train pulse: 2 sec Inter-train: 28 sec Total time: 1200 sec Second part iTBS rTMS(Brain) + sham 2.5-mA tsDCS (Spinal) Brain: Train pulse: 2 sec Inter-train: 8 sec Total time: 200 sec Spinal: Sham direct current (DC) stimulation
First part Brain: Train pulse: 2 sec Inter-train: 8 sec Total time: 200 sec Spinal: Continuous direct current (DC): 190 sec Second part Sham iTBS rTMS (Brain) + 2.5-mA tsDCS (Spinal) Sham iTBS rTMS Brain: Spinal: Continuous direct current (DC): 600 sec
First part Brain and spinal: Train pulse: 2 sec Inter-train: 8 sec Total time: 200 sec Second part Sham iTBS rTMS (Brain) + Sham 2.5-mA tsDCS (Spinal) Brain: Sham iTBS rTMS Spinal: Sham direct current (DC) stimulation
First part Sham stimulation. No second part