search
Back to results

Thrombus Aspiration in STEMI Patients With High Thrombus Burden

Primary Purpose

ST-segment Elevation Myocardial Infarction (STEMI)

Status
Recruiting
Phase
Not Applicable
Locations
China
Study Type
Interventional
Intervention
Thrombus aspiration
PCI Alone
Sponsored by
Guangdong Provincial People's Hospital
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for ST-segment Elevation Myocardial Infarction (STEMI) focused on measuring Thrombus Aspiration, Coronary Intervention, Thrombus Burden, ST-segment Elevation Myocardial Infarction

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  1. Age ≥ 18 years;
  2. STEMI patients undergoing primary PCI within 12 hours after the onset of symptoms;
  3. High thrombus burden after guidewire passes the lesion (TIMI thrombus grade ≥3);
  4. Informed consent must be voluntary;

Exclusion Criteria:

  1. Haemodynamic instability or cardiogenic shock;
  2. After thrombolytic therapy;
  3. The predicted survival time is less than 6 months due to non-cardiac disease;
  4. History of coronary artery bypass grafting;
  5. Participate in other researches within 30 days;
  6. Preoperative gastrointestinal bleeding or contraindications to dual antiplatelet therapy;
  7. Patients were considered unsuitable by other researchers.

Sites / Locations

  • Fujian Provincial Hospital
  • First People's Hospital of Foshan
  • The Second People's Hospital of Nanhai DistrictRecruiting
  • First People's Hospital of Shunde (Affiliated Hospital at Shunde, Southern Medical University)
  • Guangdong Provincial People's Hospital
  • Guangzhou Panyu Central Hospital
  • Guangzhou General Hospital of Guangzhou Military Command
  • The first Affiliated Hospital, Sun Yat-Sen University
  • Guangdong Provincial Hospital of traditional Chinese Medicine
  • The First Affiliated Hospital of Guangzhou Medical University
  • The Second Affiliated Hospital, Sun Yat-Sen University
  • Zhujiang Hospital of Southern Medical University
  • Nanfang Hospital
  • Huangpu Division of The First Affiliated Hospital, Sun Yat-sen University
  • Huadu District People's Hospital of Guangzhou
  • Huizhou Third People's Hospital
  • Jiangmen Central Hospital
  • Kaiping Central HospitalRecruiting
  • Maoming People's Hospital
  • Nanxiong people's Hospital
  • The Second Affiliated Hospital of Shantou university Medical CollegeRecruiting
  • Yue Bei People's Hospital
  • Shenzhen People's Hospital
  • The Eighth Affiliated Hospital, Sun Yat-Sen University
  • Peking University Shenzhen Hospital
  • Shenzhen Bao'an District People's Hospital
  • Taishan people's Hospital
  • People's Hospital of Yangjiang CityRecruiting
  • The Second Affiliated Hospital of Guangdong Medical University
  • Sihui people's HospitalRecruiting
  • Zhongshan People's Hospital
  • The Fifth Affiliated Hospital, Sun Yat-Sen University
  • Zhuhai people's Hospital
  • Guilin people's Hospital
  • The Second Clinical College of Hainan Medical University
  • Hainan People's Hospital
  • Wuhan Asia Heart Hospital
  • The Third Xiangya Hospital of Central South University
  • The Second Xiangya Hospital of Central South University
  • GanZhou Municopal Hospital
  • Shangyou Hospital
  • Affiliated Hospital, Weifang Medical University
  • The first Affiliated Hospital of Xi'an Jiaotong University
  • West China Hospital
  • Sichuan Provincial People's Hospital
  • Kashgar first people's Hospital
  • The First Affilicated Hospital of Xinjiang Medical University
  • Yan'an Hospital of Kunming City
  • Shaoxing people's Hospital
  • The First Affiliated Hospital of Wenzhou Medical University

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Active Comparator

Arm Label

Thrombus aspiration

PCI Alone

Arm Description

Upfront manual thrombus aspiration followed by PCI

PCI without upfront manual thrombus aspiration

Outcomes

Primary Outcome Measures

Major adverse cardiovascular events
The first occurrence of cardiovascular death, recurrent myocardial infarction, stent thrombosis or target vessel revascularization

Secondary Outcome Measures

Stroke
The symptoms continuing for more than 24 hours or leading to death with no apparent cause other than vascular
Composite adverse cardiocerebrovascular events
The first occurence of cardiovascular death, recurrent myocardial infarction, stent thrombosis, target vessel revascularization or stroke.

Full Information

First Posted
December 24, 2019
Last Updated
September 14, 2023
Sponsor
Guangdong Provincial People's Hospital
Collaborators
Fujian Provincial Hospital, Jiangmen Central Hospital, Shenzhen People's Hospital, ZhuHai Hospital, First People's Hospital of Foshan, Peking University Shenzhen Hospital, West China Hospital, Sichuan Provincial People's Hospital, Wuhan Asia Heart Hospital, Central South University, First Affiliated Hospital of Guangxi Medical University, Hainan People's Hospital, Fifth Affiliated Hospital, Sun Yat-Sen University
search

1. Study Identification

Unique Protocol Identification Number
NCT04212494
Brief Title
Thrombus Aspiration in STEMI Patients With High Thrombus Burden
Official Title
Thrombus Aspiration in Primary Percutaneous Coronary Intervention for STEMI Patients With High Thrombus Burden
Study Type
Interventional

2. Study Status

Record Verification Date
September 2023
Overall Recruitment Status
Recruiting
Study Start Date
August 30, 2020 (Actual)
Primary Completion Date
August 31, 2025 (Anticipated)
Study Completion Date
February 28, 2026 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Guangdong Provincial People's Hospital
Collaborators
Fujian Provincial Hospital, Jiangmen Central Hospital, Shenzhen People's Hospital, ZhuHai Hospital, First People's Hospital of Foshan, Peking University Shenzhen Hospital, West China Hospital, Sichuan Provincial People's Hospital, Wuhan Asia Heart Hospital, Central South University, First Affiliated Hospital of Guangxi Medical University, Hainan People's Hospital, Fifth Affiliated Hospital, Sun Yat-Sen University

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes

5. Study Description

Brief Summary
This is a prospective, multicenter, open-label, randomized, controlled, parallel group study, in which ST-segment Elevation Myocardial Infarction (STEMI) patients with high thrombus burden(TIMI thrombus grade ≥3) are included. Patients are randomized to be treated with or without manual thrombus aspiration(TA) during primary percutaneous coronary intervention(PPCI) by a ratio of 1:1.
Detailed Description
This study is intended to explore the efficacy of thrombus aspiration (TA) in ST-Segment Elevation Myocardial Infarction (STEMI) patients with high thrombus burden who received primary PCI within 12 hours after the onset of symptoms, reducing the incidence of cardiovascular death, recurrent myocardial infarction, stent thrombosis, target vessel revascularization within 180 days or stroke in 30 days.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
ST-segment Elevation Myocardial Infarction (STEMI)
Keywords
Thrombus Aspiration, Coronary Intervention, Thrombus Burden, ST-segment Elevation Myocardial Infarction

7. Study Design

Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
3838 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
Thrombus aspiration
Arm Type
Experimental
Arm Description
Upfront manual thrombus aspiration followed by PCI
Arm Title
PCI Alone
Arm Type
Active Comparator
Arm Description
PCI without upfront manual thrombus aspiration
Intervention Type
Procedure
Intervention Name(s)
Thrombus aspiration
Intervention Description
Percutaneous Coronary Intervention with manual aspiration thrombectomy
Intervention Type
Procedure
Intervention Name(s)
PCI Alone
Intervention Description
Percutaneous Coronary Intervention without manual aspiration thrombectomy
Primary Outcome Measure Information:
Title
Major adverse cardiovascular events
Description
The first occurrence of cardiovascular death, recurrent myocardial infarction, stent thrombosis or target vessel revascularization
Time Frame
up to180 days
Secondary Outcome Measure Information:
Title
Stroke
Description
The symptoms continuing for more than 24 hours or leading to death with no apparent cause other than vascular
Time Frame
up to 30 days
Title
Composite adverse cardiocerebrovascular events
Description
The first occurence of cardiovascular death, recurrent myocardial infarction, stent thrombosis, target vessel revascularization or stroke.
Time Frame
up to 1 year

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Age ≥ 18 years; STEMI patients undergoing primary PCI within 12 hours after the onset of symptoms; High thrombus burden after guidewire passes the lesion (TIMI thrombus grade ≥3); Informed consent must be voluntary; Exclusion Criteria: Haemodynamic instability or cardiogenic shock; After thrombolytic therapy; The predicted survival time is less than 6 months due to non-cardiac disease; History of coronary artery bypass grafting; Participate in other researches within 30 days; Preoperative gastrointestinal bleeding or contraindications to dual antiplatelet therapy; Patients were considered unsuitable by other researchers.
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Pengchen He, MD
Phone
86-13829730152
Email
drhepengcheng@aliyun.co
Facility Information:
Facility Name
Fujian Provincial Hospital
City
Fuzhou
State/Province
Fujian
ZIP/Postal Code
350001
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Wei Chen
Phone
13950394772
Email
hpscw@sina.com
Facility Name
First People's Hospital of Foshan
City
Foshan
State/Province
Guangdong
ZIP/Postal Code
528000
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xili Yang
Phone
18038863836
Email
Yannihu@126.com
Facility Name
The Second People's Hospital of Nanhai District
City
Foshan
State/Province
Guangdong
ZIP/Postal Code
528251
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Pengcheng He, MD
Phone
13829730152
Email
drhepengcheng@aliyun.com
Facility Name
First People's Hospital of Shunde (Affiliated Hospital at Shunde, Southern Medical University)
City
Foshan
State/Province
Guangdong
ZIP/Postal Code
528300
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yunzhao Hu
Phone
13702832088
Facility Name
Guangdong Provincial People's Hospital
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510000
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Pengcheng He, MD
Phone
86-13829730152
Email
drhepengcheng@aliyun.com
Facility Name
Guangzhou Panyu Central Hospital
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510000
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jianhao Li
Phone
13928838806
Facility Name
Guangzhou General Hospital of Guangzhou Military Command
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510010
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Dingcheng Xiang, MD
Phone
13609008024
Email
dcxiang@foxmail.com
Facility Name
The first Affiliated Hospital, Sun Yat-Sen University
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510080
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yi Li, MD
Phone
13822285813
Facility Name
Guangdong Provincial Hospital of traditional Chinese Medicine
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510120
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xia Wang
Phone
13825133223
Facility Name
The First Affiliated Hospital of Guangzhou Medical University
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510120
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Zheng Huang, MD
Phone
13802503802
Email
13802503802@163.com
Facility Name
The Second Affiliated Hospital, Sun Yat-Sen University
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510235
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ruqiong Nie
Facility Name
Zhujiang Hospital of Southern Medical University
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510280
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hua Xiao
Phone
13889900264
Facility Name
Nanfang Hospital
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510515
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jianping Bin, MD
Phone
18680488488
Facility Name
Huangpu Division of The First Affiliated Hospital, Sun Yat-sen University
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510700
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Qing Xu
Phone
13609648852
Facility Name
Huadu District People's Hospital of Guangzhou
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510800
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Junhui Xiao
Phone
15011888377
Facility Name
Huizhou Third People's Hospital
City
Huizhou
State/Province
Guangdong
ZIP/Postal Code
516002
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sigan Zhong
Phone
13502428918
Facility Name
Jiangmen Central Hospital
City
Jiangmen
State/Province
Guangdong
ZIP/Postal Code
529030
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Gaoxing Zhang, MD
Phone
13322889844
Email
5886970@qq.com
Facility Name
Kaiping Central Hospital
City
Kaiping
State/Province
Guangdong
ZIP/Postal Code
529300
Country
China
Individual Site Status
Recruiting
Facility Name
Maoming People's Hospital
City
Maoming
State/Province
Guangdong
ZIP/Postal Code
525000
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Chunbo Chen, MD
Phone
13922745788
Facility Name
Nanxiong people's Hospital
City
Nanxiong
State/Province
Guangdong
ZIP/Postal Code
512400
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Foyuan Fan
Phone
15914844979
Facility Name
The Second Affiliated Hospital of Shantou university Medical College
City
Shantou
State/Province
Guangdong
ZIP/Postal Code
515041
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jilin Li, MD
Phone
13592852807
Facility Name
Yue Bei People's Hospital
City
Shaoguan
State/Province
Guangdong
ZIP/Postal Code
512026
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Liangqiu Tang
Phone
13509056589
Facility Name
Shenzhen People's Hospital
City
Shenzhen
State/Province
Guangdong
ZIP/Postal Code
518020
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Huadong Liu, MD
Phone
13724397998
Email
lhd2578@163.com
Facility Name
The Eighth Affiliated Hospital, Sun Yat-Sen University
City
Shenzhen
State/Province
Guangdong
ZIP/Postal Code
518033
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Guifu Wu, PD
Phone
15989893111
Facility Name
Peking University Shenzhen Hospital
City
Shenzhen
State/Province
Guangdong
ZIP/Postal Code
518035
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Chun Wu, MM
Phone
13923748673
Email
2508257466@qq.com
Facility Name
Shenzhen Bao'an District People's Hospital
City
Shenzhen
State/Province
Guangdong
ZIP/Postal Code
518101
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Zhiming Shen
Phone
13632772238
Facility Name
Taishan people's Hospital
City
Taishan
State/Province
Guangdong
ZIP/Postal Code
529200
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yan Chen
Phone
13580014030
Facility Name
People's Hospital of Yangjiang City
City
Yangjiang
State/Province
Guangdong
ZIP/Postal Code
529500
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jiaman Ou
Phone
13829810048
Email
297122698@qq.com
Facility Name
The Second Affiliated Hospital of Guangdong Medical University
City
Zhanjiang
State/Province
Guangdong
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Can Chen
Phone
13902502296
Facility Name
Sihui people's Hospital
City
Zhaoqing
State/Province
Guangdong
ZIP/Postal Code
526200
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yuehua Huang
Phone
13929832932
Facility Name
Zhongshan People's Hospital
City
Zhongshan
State/Province
Guangdong
ZIP/Postal Code
528403
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Li Feng
Facility Name
The Fifth Affiliated Hospital, Sun Yat-Sen University
City
Zhuhai
State/Province
Guangdong
ZIP/Postal Code
519000
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jian Chen, MD
Phone
13926931713
Email
chenjn@mail.sysu.edu.cn
Facility Name
Zhuhai people's Hospital
City
Zhuhai
State/Province
Guangdong
ZIP/Postal Code
519000
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jun Li
Phone
13709686461
Facility Name
Guilin people's Hospital
City
Guilin
State/Province
Guangxi
ZIP/Postal Code
541002
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Bin Li
Phone
18978320601
Facility Name
The Second Clinical College of Hainan Medical University
City
Haikou
State/Province
Hainan
ZIP/Postal Code
460106
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yuewu Chen
Phone
13518085982
Email
576157175@qq.com
Facility Name
Hainan People's Hospital
City
Haikou
State/Province
Hainan
ZIP/Postal Code
570311
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Bin Li
Phone
13907698311
Facility Name
Wuhan Asia Heart Hospital
City
Wuhan
State/Province
Hubei
ZIP/Postal Code
430022
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hua Yan, MD
Phone
13100659066
Email
Yanhua0807@aliyun.com
Facility Name
The Third Xiangya Hospital of Central South University
City
Changsha
State/Province
Hunan
ZIP/Postal Code
13787318063
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yu Cao, MD
Phone
13787318063
Email
13787318063@139.com
Facility Name
The Second Xiangya Hospital of Central South University
City
Changsha
State/Province
Hunan
ZIP/Postal Code
410008
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xinqun Hu, MD
Phone
13307313627
Email
huxinqungs@163.com
Facility Name
GanZhou Municopal Hospital
City
Ganzhou
State/Province
Jiangxi
ZIP/Postal Code
341000
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Zhonghan Ni
Phone
13889908239
Facility Name
Shangyou Hospital
City
Ganzhou
State/Province
Jiangxi
ZIP/Postal Code
341200
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Shuo Sun
Phone
15018788144
Facility Name
Affiliated Hospital, Weifang Medical University
City
Weifang
State/Province
Shandong
ZIP/Postal Code
261031
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jingtian Li
Facility Name
The first Affiliated Hospital of Xi'an Jiaotong University
City
Xi'an
State/Province
Shanxi
ZIP/Postal Code
710061
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ning Guo
Phone
13991229101
Facility Name
West China Hospital
City
Chengdu
State/Province
Sichuan
ZIP/Postal Code
610041
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yong He, MD
Phone
18980602038
Email
happensky@163.com
Facility Name
Sichuan Provincial People's Hospital
City
Chengdu
State/Province
Sichuan
ZIP/Postal Code
610072
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jianhong Tao
Phone
18981838875
Email
taojianhong06@medmail.com
Facility Name
Kashgar first people's Hospital
City
Kashgar
State/Province
Xinjiang
ZIP/Postal Code
844000
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yuying Hu
Phone
13579061010
Facility Name
The First Affilicated Hospital of Xinjiang Medical University
City
Urumqi
State/Province
Xinjiang
ZIP/Postal Code
830054
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yining Yang, MD
Phone
13199860611
Facility Name
Yan'an Hospital of Kunming City
City
Kunming
State/Province
Yunnan
ZIP/Postal Code
65005
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Qiang Xue, MD
Facility Name
Shaoxing people's Hospital
City
Shaoxing
State/Province
Zhejiang
ZIP/Postal Code
312000
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yangjian Liu
Phone
13570786812
Facility Name
The First Affiliated Hospital of Wenzhou Medical University
City
Wenzhou
State/Province
Zhejiang
ZIP/Postal Code
325000
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hao Zhou

12. IPD Sharing Statement

Plan to Share IPD
No
Citations:
PubMed Identifier
6350634
Citation
Herrick JB. Landmark article (JAMA 1912). Clinical features of sudden obstruction of the coronary arteries. By James B. Herrick. JAMA. 1983 Oct 7;250(13):1757-65. No abstract available.
Results Reference
background
PubMed Identifier
7412821
Citation
DeWood MA, Spores J, Notske R, Mouser LT, Burroughs R, Golden MS, Lang HT. Prevalence of total coronary occlusion during the early hours of transmural myocardial infarction. N Engl J Med. 1980 Oct 16;303(16):897-902. doi: 10.1056/NEJM198010163031601.
Results Reference
background
PubMed Identifier
17692740
Citation
Sianos G, Papafaklis MI, Daemen J, Vaina S, van Mieghem CA, van Domburg RT, Michalis LK, Serruys PW. Angiographic stent thrombosis after routine use of drug-eluting stents in ST-segment elevation myocardial infarction: the importance of thrombus burden. J Am Coll Cardiol. 2007 Aug 14;50(7):573-83. doi: 10.1016/j.jacc.2007.04.059. Epub 2007 Jul 30.
Results Reference
background
PubMed Identifier
12021220
Citation
Beran G, Lang I, Schreiber W, Denk S, Stefenelli T, Syeda B, Maurer G, Glogar D, Siostrzonek P. Intracoronary thrombectomy with the X-sizer catheter system improves epicardial flow and accelerates ST-segment resolution in patients with acute coronary syndrome: a prospective, randomized, controlled study. Circulation. 2002 May 21;105(20):2355-60. doi: 10.1161/01.cir.0000016350.02669.1d.
Results Reference
background
PubMed Identifier
16022970
Citation
Burzotta F, Trani C, Romagnoli E, Mazzari MA, Rebuzzi AG, De Vita M, Garramone B, Giannico F, Niccoli G, Biondi-Zoccai GG, Schiavoni G, Mongiardo R, Crea F. Manual thrombus-aspiration improves myocardial reperfusion: the randomized evaluation of the effect of mechanical reduction of distal embolization by thrombus-aspiration in primary and rescue angioplasty (REMEDIA) trial. J Am Coll Cardiol. 2005 Jul 19;46(2):371-6. doi: 10.1016/j.jacc.2005.04.057.
Results Reference
background
PubMed Identifier
18539223
Citation
Vlaar PJ, Svilaas T, van der Horst IC, Diercks GF, Fokkema ML, de Smet BJ, van den Heuvel AF, Anthonio RL, Jessurun GA, Tan ES, Suurmeijer AJ, Zijlstra F. Cardiac death and reinfarction after 1 year in the Thrombus Aspiration during Percutaneous coronary intervention in Acute myocardial infarction Study (TAPAS): a 1-year follow-up study. Lancet. 2008 Jun 7;371(9628):1915-20. doi: 10.1016/S0140-6736(08)60833-8.
Results Reference
background
PubMed Identifier
23991656
Citation
Frobert O, Lagerqvist B, Olivecrona GK, Omerovic E, Gudnason T, Maeng M, Aasa M, Angeras O, Calais F, Danielewicz M, Erlinge D, Hellsten L, Jensen U, Johansson AC, Karegren A, Nilsson J, Robertson L, Sandhall L, Sjogren I, Ostlund O, Harnek J, James SK; TASTE Trial. Thrombus aspiration during ST-segment elevation myocardial infarction. N Engl J Med. 2013 Oct 24;369(17):1587-97. doi: 10.1056/NEJMoa1308789. Epub 2013 Aug 31. Erratum In: N Engl J Med. 2014 Aug 21;371(8):786.
Results Reference
background
PubMed Identifier
25853743
Citation
Jolly SS, Cairns JA, Yusuf S, Meeks B, Pogue J, Rokoss MJ, Kedev S, Thabane L, Stankovic G, Moreno R, Gershlick A, Chowdhary S, Lavi S, Niemela K, Steg PG, Bernat I, Xu Y, Cantor WJ, Overgaard CB, Naber CK, Cheema AN, Welsh RC, Bertrand OF, Avezum A, Bhindi R, Pancholy S, Rao SV, Natarajan MK, ten Berg JM, Shestakovska O, Gao P, Widimsky P, Dzavik V; TOTAL Investigators. Randomized trial of primary PCI with or without routine manual thrombectomy. N Engl J Med. 2015 Apr 9;372(15):1389-98. doi: 10.1056/NEJMoa1415098. Epub 2015 Mar 16.
Results Reference
background
PubMed Identifier
26498666
Citation
Levine GN, Bates ER, Blankenship JC, Bailey SR, Bittl JA, Cercek B, Chambers CE, Ellis SG, Guyton RA, Hollenberg SM, Khot UN, Lange RA, Mauri L, Mehran R, Moussa ID, Mukherjee D, Ting HH, O'Gara PT, Kushner FG, Ascheim DD, Brindis RG, Casey DE Jr, Chung MK, de Lemos JA, Diercks DB, Fang JC, Franklin BA, Granger CB, Krumholz HM, Linderbaum JA, Morrow DA, Newby LK, Ornato JP, Ou N, Radford MJ, Tamis-Holland JE, Tommaso CL, Tracy CM, Woo YJ, Zhao DX. 2015 ACC/AHA/SCAI Focused Update on Primary Percutaneous Coronary Intervention for Patients With ST-Elevation Myocardial Infarction: An Update of the 2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention and the 2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction. J Am Coll Cardiol. 2016 Mar 15;67(10):1235-1250. doi: 10.1016/j.jacc.2015.10.005. Epub 2015 Oct 21. No abstract available. Erratum In: J Am Coll Cardiol. 2016 Mar 29;67(12):1506.
Results Reference
background
PubMed Identifier
27941066
Citation
Jolly SS, James S, Dzavik V, Cairns JA, Mahmoud KD, Zijlstra F, Yusuf S, Olivecrona GK, Renlund H, Gao P, Lagerqvist B, Alazzoni A, Kedev S, Stankovic G, Meeks B, Frobert O. Thrombus Aspiration in ST-Segment-Elevation Myocardial Infarction: An Individual Patient Meta-Analysis: Thrombectomy Trialists Collaboration. Circulation. 2017 Jan 10;135(2):143-152. doi: 10.1161/CIRCULATIONAHA.116.025371. Epub 2016 Dec 9.
Results Reference
background
PubMed Identifier
28886621
Citation
Ibanez B, James S, Agewall S, Antunes MJ, Bucciarelli-Ducci C, Bueno H, Caforio ALP, Crea F, Goudevenos JA, Halvorsen S, Hindricks G, Kastrati A, Lenzen MJ, Prescott E, Roffi M, Valgimigli M, Varenhorst C, Vranckx P, Widimsky P; ESC Scientific Document Group. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2018 Jan 7;39(2):119-177. doi: 10.1093/eurheartj/ehx393. No abstract available.
Results Reference
background

Learn more about this trial

Thrombus Aspiration in STEMI Patients With High Thrombus Burden

We'll reach out to this number within 24 hrs