Mechanisms and Innovations in Cardiac Resynchronisation Therapy (MIC)
Heart Failure, Left Ventricular Systolic Dysfunction, Left Bundle-Branch Block
About this trial
This is an interventional treatment trial for Heart Failure focused on measuring Cardiac resynchronization therapy, His bundle pacing, Haemodynamics, ECGI
Eligibility Criteria
Inclusion Criteria:
- Patients referred for conventional CRT
- Severe heart failure (LVEF, a measure of heart pumping, < 35% - severe)
- Prolonged QRS duration (>120ms)
- Adults willing to take part (age > 18 years)
- Able to give consent
Exclusion Criteria:
- Unable to give consent
- Children (age < 18 years)
- Pregnant women
Sites / Locations
- Hammersmith Hospital Imperial College NHS trust
Arms of the Study
Arm 1
Experimental
Heart failure and abnormal cardiac conduction
Subjects will have an attempt at His-bundle pacing, left bundle pacing and biventricular pacing. Pacing at the His bundle and the left bundle will be attempted using a Medtronic SelectSecure™, Model 3830 lead. Delivery of the lead utilizes a deflectable sheath, the Medtronic SelectSite™, Model C304. Biventricular pacing will utilise a left ventricular lead placed in the coronary sinus using any of the 5 manufactures of CS leads Biotronik, Boston Scientific, Medtronic, Sorin, and St. Jude Medical or in participants receiving permanent conduction system pacing left ventricular pacing will be achieved using a Cordis ATW™ wire placed in the coronary sinus.