Cerebellar rTMS Theta Burst for Postural Instability in Progressive Supranuclear Palsy (CerTI-PSP)
Progressive Supranuclear Palsy, Fall, Gait, Rigid
About this trial
This is an interventional treatment trial for Progressive Supranuclear Palsy focused on measuring repetitive Transcranial Magnetic stimulation, cerebellum, wearing sensors, static balance
Eligibility Criteria
Inclusion Criteria:
- probable PSP diagnosis
- ability to stand alone without support for at least 5 seconds
- ability to walk without aid for at least three meters
Exclusion Criteria:
- dementia or behavioral alterations
- contraindications of stimulation
Sites / Locations
- Parkinson's disease Rehabilitation Centre - FERB ONLUS
Arms of the Study
Arm 1
Arm 2
Active Comparator
Sham Comparator
Real Stimulation
Sham Stimulation
Cerebellar Repetitive theta burst stimulation will be performed using a 3 pulses at 50-Hz repeated at a rate of 5-Hz; 20 trains of 10 bursts given with 8-s intervals for a total of 600 pulses. Intensity of rTMS was set at the 80% of Amplitude of Motor Threshold (RMT) obtained in the left motor cortex for each subject.
The rTMS coil stimulation will be applied in the same position of the real stimulation. The Stimulation will be performed like in the real arm with the difference that the coil will be masked and thus will be inactive. The patient will hear the same sound of real stimulation, which will be only functionally inactive but will be completely performed (for the whole time of duration of stimulation)