Comparing Intravenous Magnesium Sulfate With Dexamethasone as Adjuvants to Ultrasound Guided TAPblock (TAPblock)
Postoperative Pain

About this trial
This is an interventional prevention trial for Postoperative Pain
Eligibility Criteria
Inclusion Criteria:
- singleton full term pregnancy ( completed 37 weeks)
- undergoing elective cesarean section
- ASA I, II
Exclusion Criteria:
- patients with ASA physical status class III-IV,
- morbid obesity with BMI > 35 kg.m-2 at initial hospital visit
- neuro-axial anaesthesia
- severe pre-eclampsia,
- diabetes mellitus,
- cardiovascular disease,
- renal disease,
- hypermagnesemia,
- history of analgesic administration or intake during past 24 hours,
- chronic use of steroids therapy,
- urgent cesarean sections,
- multiple gestations,
- history of relevant drug allergy,
- any possibility of anticipated difficult intubation.
Sites / Locations
- AinShams University, Faculty of medicine
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Active Comparator
Placebo Comparator
Magnesium sulfate group(M)
Dexamethasone group(D)
Placebo group(C)
Participants in group (M) will receive 50 mg/kg MgSO4 in 100 ml isotonic saline intravenous (I.V) over 20 minutes prior to induction of general anesthesia by 30 minutes then ultrasound guided TAPblock after closure of the abdomen
participants in group (D) will receive 2 mg Dexamethasone in 100 ml isotonic saline IV then ultrasound guided TAPblock after closure of the abdomen
participants in group (C) will receive 100 ml isotonic saline IV (placebo) by the same route and over the same duration as control then ultrasound guided TAPblock after closure of the abdomen