Reverse Remodeling After PTSMA in Severe But Asymptomatic LVOT Obstruction (RASTA)
HOCM, Hypertrophic Obstructive Cardiomyopathy, LVOTO - Left Ventricular Outflow Tract Obstruction, Remodeling, Ventricular
About this trial
This is an interventional treatment trial for HOCM, Hypertrophic Obstructive Cardiomyopathy focused on measuring HOCM, Hypertrophic Obstructive Cardiomyopathy, Left Ventricular Outflow Tract Obstruction, Adverse Remodeling, Reverse Remodeling, Alcohol Septal Ablation, Percutaneous Transluminal Septal Myocardial Ablation, PTSMA, Extracellular Volume Fraction, Global Longitudinal Strain, Deformation Imaging, 4D Velocity Mapping
Eligibility Criteria
Inclusion Criteria:
- Age > 40 yrs
- HOCM diagnosed by experienced cardiologists (European Society of Cardiology (ESC)-certified imaging cardiologists and/or finalized fellowship imaging)
- LVOT obstruction >30 mmHg pressure gradient in rest, or >50 mmHg during exercise by TTE and/or invasive measurement, performed experienced (imaging) cardiologists
- Symptomatic (NYHA class >2 or CCS class >2)
- Asymptomatic: free of any dyspnea/chest pain or discomfort associated with LVOT obstruction
Exclusion Criteria:
- LV wall thickness <15 mm
- Other conditions responsible for hypertrophy (e.g. hypertension, aortic valve disease)
- Moderate to severe mitral valve regurgitation
- Systolic anterior motion of the mitral valve
- Coronary artery disease requiring intervention
- Pregnancy
Sites / Locations
- St. Antonius Hospital
- St. Antonius HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Experimental
No Intervention
Reference Group
Study Group
Observation Group
Five symptomatic HOCM patients with severe LVOT obstruction will undergo PTSMA
Five asymptomatic HOCM patients with severe LVOT obstruction will undergo PTSMA
Five asymptomatic HOCM patients with severe LVOT obstruction will not undergo PTSMA