Comparing Two Methods to Follow Patients With Pancreatic Cysts
Pancreatic Carcinoma
About this trial
This is an interventional supportive care trial for Pancreatic Carcinoma
Eligibility Criteria
- Patient must be ≥ 50 years and ≤ 75 years of age.
- Patient must not have acute pancreatitis or a history of chronic pancreatitis.
- Patient must have received a CT, MRI, or EUS within 6 months prior to randomization that revealed one or more ≥ 1 cm pancreatic cyst (s).
- Patients of childbearing potential must not be known to be pregnant.
- Patient must not have a prior diagnosis of pancreatic malignancy of any type.
- Patient must not have a history of pancreatic resection.
- Patients with only pancreatic lesions without malignant risk (pancreatic pseudocyst or classic serous cystic lesion) are not eligible.
- Patient must not have a family history of pancreatic adenocarcinoma in one or more first degree relatives(biological parents, full siblings or children).
- Patient must not have pancreatic cyst morphology that would prompt immediate surgical consideration (enhancing mural nodule, solid component in cyst, pancreatic duct ≥10mm, cyst causing obstructive jaundice).
- Patient must not have a comorbid illness that precludes pancreatic cyst resection.
- Patient must not be participating in any form of pancreatic cyst surveillance.
Sites / Locations
- University of Alabama at Birmingham Cancer CenterRecruiting
- University of South Alabama Mitchell Cancer InstituteRecruiting
- Anchorage Associates in Radiation MedicineRecruiting
- Anchorage Radiation Therapy CenterRecruiting
- Alaska Breast Care and Surgery LLCRecruiting
- Alaska Oncology and Hematology LLCRecruiting
- Alaska Women's Cancer CareRecruiting
- Anchorage Oncology CentreRecruiting
- Katmai Oncology GroupRecruiting
- Providence Alaska Medical CenterRecruiting
- Mayo Clinic Hospital in ArizonaRecruiting
- Mayo Clinic in ArizonaRecruiting
- University of Arkansas for Medical SciencesRecruiting
- Providence Saint Joseph Medical Center/Disney Family Cancer CenterRecruiting
- Enloe Medical CenterRecruiting
- UC San Diego Health System - Encinitas
- UC San Diego Moores Cancer CenterRecruiting
- UCLA / Jonsson Comprehensive Cancer CenterRecruiting
- UC San Diego Medical Center - Hillcrest
- UCSF Medical Center-Mount ZionRecruiting
- UCSF Medical Center-ParnassusRecruiting
- UCSF Medical Center-Mission BayRecruiting
- Smilow Cancer Hospital-Derby Care CenterRecruiting
- Smilow Cancer Hospital Care Center-FairfieldRecruiting
- Smilow Cancer Hospital Care Center at GlastonburyRecruiting
- Smilow Cancer Hospital Care Center at GreenwichRecruiting
- Smilow Cancer Hospital Care Center - GuilfordRecruiting
- Smilow Cancer Hospital-Hamden Care CenterRecruiting
- Smilow Cancer Hospital Care Center at Saint FrancisRecruiting
- Smilow Cancer Center/Yale-New Haven HospitalRecruiting
- Yale-New Haven Hospital Saint Raphael CampusRecruiting
- Yale UniversityRecruiting
- Yale-New Haven Hospital North Haven Medical CenterRecruiting
- Smilow Cancer Hospital-Orange Care CenterRecruiting
- Smilow Cancer Hospital-Torrington Care CenterRecruiting
- Smilow Cancer Hospital Care Center-TrumbullRecruiting
- Smilow Cancer Hospital-Waterbury Care CenterRecruiting
- Smilow Cancer Hospital Care Center - WaterfordRecruiting
- Veterans Affairs Connecticut Healthcare System-West Haven CampusRecruiting
- MedStar Georgetown University HospitalRecruiting
- Regional Cancer Center-Lee Memorial Health SystemRecruiting
- Emory University Hospital MidtownRecruiting
- Emory University Hospital/Winship Cancer InstituteRecruiting
- Emory Saint Joseph's HospitalRecruiting
- Saint Luke's Cancer Institute - BoiseRecruiting
- Saint Luke's Cancer Institute - FruitlandRecruiting
- Saint Luke's Cancer Institute - MeridianRecruiting
- Saint Luke's Cancer Institute - NampaRecruiting
- Saint Luke's Cancer Institute - Twin FallsRecruiting
- Advocate Good Shepherd HospitalRecruiting
- Bromenn Lifecare CenterRecruiting
- Illinois CancerCare-BloomingtonRecruiting
- Illinois CancerCare-CantonRecruiting
- Memorial Hospital of CarbondaleRecruiting
- SIH Cancer InstituteRecruiting
- Illinois CancerCare-CarthageRecruiting
- Centralia Oncology ClinicRecruiting
- Northwestern UniversityRecruiting
- Advocate Illinois Masonic Medical CenterRecruiting
- AMG Crystal Lake - OncologyRecruiting
- Carle at The RiverfrontRecruiting
- Cancer Care Specialists of Illinois - DecaturRecruiting
- Decatur Memorial HospitalRecruiting
- Northwestern Medicine Cancer Center KishwaukeeRecruiting
- Illinois CancerCare-DixonRecruiting
- Advocate Good Samaritan HospitalRecruiting
- Carle Physician Group-EffinghamRecruiting
- Crossroads Cancer CenterRecruiting
- Advocate Sherman HospitalRecruiting
- Elmhurst Memorial HospitalRecruiting
- Illinois CancerCare-EurekaRecruiting
- NorthShore University HealthSystem-Evanston Hospital
- Illinois CancerCare-GalesburgRecruiting
- Western Illinois Cancer Treatment CenterRecruiting
- Northwestern Medicine Cancer Center DelnorRecruiting
- NorthShore University HealthSystem-Glenbrook Hospital
- Ingalls Memorial Hospital
- Advocate South Suburban HospitalRecruiting
- NorthShore University HealthSystem-Highland Park Hospital
- Illinois CancerCare-Kewanee ClinicRecruiting
- Northwestern Medicine Lake Forest Hospital
- AMG Libertyville - OncologyRecruiting
- Condell Memorial HospitalRecruiting
- Illinois CancerCare-MacombRecruiting
- Carle Physician Group-Mattoon/CharlestonRecruiting
- Edward Hospital/Cancer CenterRecruiting
- Bromenn Regional Medical CenterRecruiting
- Carle Cancer Institute NormalRecruiting
- Cancer Care Center of O'FallonRecruiting
- Advocate Christ Medical CenterRecruiting
- Illinois CancerCare-Ottawa ClinicRecruiting
- Advocate Lutheran General HospitalRecruiting
- Illinois CancerCare-PekinRecruiting
- Illinois CancerCare-PeoriaRecruiting
- Methodist Medical Center of IllinoisRecruiting
- Illinois CancerCare-PeruRecruiting
- Valley Radiation OncologyRecruiting
- Edward Hospital/Cancer Center?PlainfieldRecruiting
- Illinois CancerCare-PrincetonRecruiting
- Southern Illinois University School of MedicineRecruiting
- Springfield ClinicRecruiting
- Memorial Medical CenterRecruiting
- Southwest Illinois Health Services LLP
- Carle Cancer CenterRecruiting
- The Carle Foundation HospitalRecruiting
- Northwestern Medicine Cancer Center WarrenvilleRecruiting
- Illinois CancerCare - WashingtonRecruiting
- Reid HealthRecruiting
- Medical Oncology and Hematology Associates-West Des MoinesRecruiting
- Mercy Cancer Center-West LakesRecruiting
- Greater Regional Medical CenterRecruiting
- Mercy Medical Center - Des MoinesRecruiting
- Mission Cancer and Blood - LaurelRecruiting
- University of Iowa/Holden Comprehensive Cancer CenterRecruiting
- Mercy Medical Center-West LakesRecruiting
- LSU Health Baton Rouge-North ClinicRecruiting
- Our Lady of The LakeRecruiting
- Mary Bird Perkins Cancer Center
- Our Lady of the Lake Physicians Group - Medical OncologyRecruiting
- UM Baltimore Washington Medical Center/Tate Cancer CenterRecruiting
- University of Michigan Comprehensive Cancer CenterRecruiting
- Bronson Battle CreekRecruiting
- Beaumont Hospital - DearbornRecruiting
- Beaumont Hospital - Farmington HillsRecruiting
- Helen DeVos Children's Hospital at Spectrum HealthRecruiting
- Spectrum Health at Butterworth CampusRecruiting
- Trinity Health Grand Rapids HospitalRecruiting
- Bronson Methodist HospitalRecruiting
- West Michigan Cancer CenterRecruiting
- Ascension Borgess Cancer CenterRecruiting
- Borgess Medical CenterRecruiting
- Trinity Health Muskegon HospitalRecruiting
- Lakeland Hospital NilesRecruiting
- Cancer and Hematology Centers of Western Michigan - Norton ShoresRecruiting
- Spectrum Health Reed City HospitalRecruiting
- Oakland Colon Rectal AssociatesRecruiting
- Cancer Care Associates PCRecruiting
- Comprehensive Medical Center PLLCRecruiting
- Hematology Oncology Consultants PCRecruiting
- Oakland Medical GroupRecruiting
- William Beaumont Hospital-Royal OakRecruiting
- Lakeland Medical Center Saint JosephRecruiting
- Marie Yeager Cancer CenterRecruiting
- Munson Medical CenterRecruiting
- Michigan Institute of Urology-Town CenterRecruiting
- William Beaumont Hospital - TroyRecruiting
- Hematology Oncology Consultants PC-TroyRecruiting
- Metro Health HospitalRecruiting
- Sanford Joe Lueken Cancer CenterRecruiting
- Sanford Thief River Falls Medical CenterRecruiting
- Sanford Cancer Center WorthingtonRecruiting
- Saint Francis Medical CenterRecruiting
- Southeast Cancer CenterRecruiting
- Parkland Health Center - FarmingtonRecruiting
- Capital Region Southwest CampusRecruiting
- Washington University School of MedicineRecruiting
- Missouri Baptist Medical CenterRecruiting
- Sainte Genevieve County Memorial HospitalRecruiting
- Missouri Baptist Sullivan HospitalRecruiting
- Missouri Baptist Outpatient Center-Sunset HillsRecruiting
- Saint Patrick Hospital - Community HospitalRecruiting
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
- CentraState Medical CenterRecruiting
- Morristown Medical CenterRecruiting
- Saint Peter's University HospitalRecruiting
- Capital Health Medical Center-Hopewell
- Penn Medicine Princeton HealthRecruiting
- Overlook HospitalRecruiting
- University of New Mexico Cancer CenterRecruiting
- Montefiore Medical Center-Einstein CampusRecruiting
- Montefiore Medical Center-Weiler HospitalRecruiting
- Montefiore Medical Center - Moses CampusRecruiting
- Roswell Park Cancer InstituteRecruiting
- Northwell Health/Center for Advanced MedicineRecruiting
- Laura and Isaac Perlmutter Cancer Center at NYU LangoneRecruiting
- Lenox Hill HospitalRecruiting
- Stony Brook University Medical CenterRecruiting
- UNC Lineberger Comprehensive Cancer CenterRecruiting
- East Carolina UniversityRecruiting
- Wake Forest University Health SciencesRecruiting
- Sanford Bismarck Medical CenterRecruiting
- Sanford South University Medical CenterRecruiting
- Southpointe-Sanford Medical Center FargoRecruiting
- Sanford Medical Center FargoRecruiting
- Sanford Broadway Medical CenterRecruiting
- Sanford Roger Maris Cancer CenterRecruiting
- Indu and Raj Soin Medical CenterRecruiting
- Saint Elizabeth Boardman HospitalRecruiting
- Dayton Physicians LLC-Miami Valley SouthRecruiting
- Miami Valley Hospital South
- Oncology Hematology Care Inc-KenwoodRecruiting
- MetroHealth Medical CenterRecruiting
- Ohio State University Comprehensive Cancer CenterRecruiting
- Miami Valley Hospital
- Dayton Physician LLC-Miami Valley Hospital NorthRecruiting
- Miami Valley Hospital North
- Armes Family Cancer CenterRecruiting
- Blanchard Valley HospitalRecruiting
- Orion Cancer CareRecruiting
- Atrium Medical Center-Middletown Regional Hospital
- Dayton Physicians LLC-AtriumRecruiting
- Dayton Physicians LLC-WayneRecruiting
- Wayne HospitalRecruiting
- Greater Dayton Cancer CenterRecruiting
- Kettering Medical CenterRecruiting
- Springfield Regional Cancer Center
- Springfield Regional Medical Center
- Dayton Physicians LLC - TroyRecruiting
- Upper Valley Medical Center
- Saint Joseph Warren HospitalRecruiting
- Saint Elizabeth Youngstown HospitalRecruiting
- University of Oklahoma Health Sciences CenterRecruiting
- Saint Charles Health SystemRecruiting
- Clackamas Radiation Oncology CenterRecruiting
- Providence Cancer Institute Clackamas ClinicRecruiting
- Bay Area HospitalRecruiting
- Providence Newberg Medical CenterRecruiting
- Providence Willamette Falls Medical CenterRecruiting
- Providence Portland Medical CenterRecruiting
- Providence Saint Vincent Medical CenterRecruiting
- Oregon Health and Science UniversityRecruiting
- Saint Charles Health System-RedmondRecruiting
- Saint Luke's Cancer Center - AllentownRecruiting
- Saint Luke's University Hospital-Bethlehem CampusRecruiting
- Bryn Mawr HospitalRecruiting
- Main Line Health Center-CollegevilleRecruiting
- Geisinger Medical CenterRecruiting
- Saint Luke's Hospital-Anderson CampusRecruiting
- Main Line Health Center-ExtonRecruiting
- Riddle Memorial HospitalRecruiting
- Paoli Memorial HospitalRecruiting
- University of Pennsylvania/Abramson Cancer CenterRecruiting
- Thomas Jefferson University HospitalRecruiting
- Fox Chase Cancer CenterRecruiting
- Saint Luke's Hospital-Quakertown CampusRecruiting
- Geisinger Wyoming Valley/Henry Cancer CenterRecruiting
- Lankenau Medical CenterRecruiting
- Smilow Cancer Hospital Care Center - WesterlyRecruiting
- Prisma Health Cancer Institute - Spartanburg
- Roper HospitalRecruiting
- Bon Secours Saint Francis HospitalRecruiting
- Prisma Health Cancer Institute - Laurens
- Prisma Health Richland HospitalRecruiting
- Prisma Health Baptist HospitalRecruiting
- Prisma Health Cancer Institute - Easley
- Tidelands Georgetown Memorial Hospital
- Prisma Health Cancer Institute - Butternut
- Prisma Health Cancer Institute - Faris
- Prisma Health Greenville Memorial HospitalRecruiting
- Prisma Health Cancer Institute - Eastside
- Prisma Health Cancer Institute - Greer
- Prisma Health Cancer Institute - Seneca
- Sanford Cancer Center Oncology ClinicRecruiting
- Sanford USD Medical Center - Sioux FallsRecruiting
- University of Tennessee - KnoxvilleRecruiting
- Baptist Memorial Hospital and Cancer Center-MemphisRecruiting
- Vanderbilt University/Ingram Cancer CenterRecruiting
- UT Southwestern/Simmons Cancer Center-DallasRecruiting
- Baylor College of Medicine/Dan L Duncan Comprehensive Cancer CenterRecruiting
- Huntsman Cancer Institute/University of UtahRecruiting
- University of Virginia Cancer CenterRecruiting
- Inova Schar Cancer InstituteRecruiting
- Inova Fairfax HospitalRecruiting
- VCU Massey Cancer Center at Stony PointRecruiting
- Virginia Commonwealth University/Massey Cancer CenterRecruiting
- Valley Health / Winchester Medical CenterRecruiting
- Providence Regional Cancer System-AberdeenRecruiting
- PeaceHealth Saint Joseph Medical CenterRecruiting
- Providence Regional Cancer System-CentraliaRecruiting
- Swedish Cancer Institute-EdmondsRecruiting
- Providence Regional Cancer PartnershipRecruiting
- Swedish Cancer Institute-IssaquahRecruiting
- Kadlec Clinic Hematology and OncologyRecruiting
- Providence Regional Cancer System-LaceyRecruiting
- PeaceHealth Saint John Medical CenterRecruiting
- Virginia Mason Medical Center
- Pacific Gynecology Specialists
- Swedish Medical Center-Ballard CampusRecruiting
- Swedish Medical Center-Cherry HillRecruiting
- Swedish Medical Center-First HillRecruiting
- PeaceHealth United General Medical CenterRecruiting
- Providence Regional Cancer System-SheltonRecruiting
- PeaceHealth Southwest Medical CenterRecruiting
- Providence Saint Mary Regional Cancer CenterRecruiting
- North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
- Providence Regional Cancer System-YelmRecruiting
- United Hospital Center
- WVUH-Berkely Medical Center
- West Virginia University HealthcareRecruiting
- Camden Clark Medical Center
- Aurora Cancer Care-Southern Lakes VLCCRecruiting
- Marshfield Medical Center-EC Cancer CenterRecruiting
- Aurora Health Care Germantown Health CenterRecruiting
- Aurora Cancer Care-GraftonRecruiting
- Aurora BayCare Medical CenterRecruiting
- Mercyhealth Hospital and Cancer Center - Janesville
- Aurora Cancer Care-Kenosha SouthRecruiting
- University of Wisconsin Carbone Cancer CenterRecruiting
- Aurora Bay Area Medical Group-MarinetteRecruiting
- Marshfield Medical Center-MarshfieldRecruiting
- Aurora Cancer Care-MilwaukeeRecruiting
- Aurora Saint Luke's Medical CenterRecruiting
- Aurora Sinai Medical CenterRecruiting
- Marshfield Clinic-Minocqua CenterRecruiting
- Vince Lombardi Cancer Clinic - OshkoshRecruiting
- Aurora Cancer Care-RacineRecruiting
- Marshfield Medical Center-Rice LakeRecruiting
- Vince Lombardi Cancer Clinic-SheboyganRecruiting
- Marshfield Medical Center-River Region at Stevens PointRecruiting
- Aurora Medical Center in SummitRecruiting
- Vince Lombardi Cancer Clinic-Two RiversRecruiting
- Aurora Cancer Care-Milwaukee WestRecruiting
- Aurora West Allis Medical CenterRecruiting
- Marshfield Medical Center - WestonRecruiting
- Juravinski Cancer Centre at Hamilton Health SciencesRecruiting
- Kingston Health Sciences CentreRecruiting
- Odette Cancer Centre- Sunnybrook Health Sciences CentreRecruiting
- National Cancer Center-KoreaRecruiting
- Yonsei University Health System-Severance HospitalRecruiting
- Cancer Center-Metro Medical Center BayamonRecruiting
- HIMA San Pablo Oncologic Hospital
- Doctors Cancer CenterRecruiting
- Instituto Oncologia Moderna Ponce
- San Juan Community Oncology GroupRecruiting
- Primary Care Physician Group
- Centro Comprensivo de Cancer de UPRRecruiting
- PROncologyRecruiting
- San Juan City HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Arm I (low intensity surveillance)
Arm II (high intensity surveillance)
Patients undergo MRI or CT at the beginning of the trial and again in 1 year. Following the first year, patients with no abnormalities repeat MRI or CT every 2 years. Patients with positive imaging features on MRI and CT at 1 or 2 years and with negative EUS, repeat MRI or CT in 1 year. Patients with negative imaging repeat MRI or CT in 2 years.
Patients undergo MRI or CT. Patients with 1-2 cm cyst undergo MRI or CT every 6 months for 1 year, then every 12 months for 2 years, and then every 24 months thereafter. Patients with 2-3 cm cyst undergo EUS within 6 months, and if EUS is negative, patients repeat MRI or CT in 1 year. If second EUS is negative, patients undergo alternate MRI or CT and EUS every 12 months. Patients with cyst > 3 cm undergo EUS within 6 months, and if EUS is negative, patients undergo alternate MRI or CT with EUS every 3-6 months.