Back to resultsInterrupting Prolonged Sitting With Periodic Interval Exercise: Effect on Postprandial Lipemia
Primary Purpose
Sedentary Behavior, Hypertriglyceridemia
Status
Unknown status
Phase
Not Applicable
Locations
United States
Study Type
Interventional
Intervention
Interrupting Prolonged Sitting with Periodic Interval Exercise: Effect on Postprandial Lipemia
Sponsored by
About this trial
This is an interventional treatment trial for Sedentary Behavior
Eligibility Criteria
Inclusion Criteria:
- Inactive or recreational healthy adults aged 18-65 years old.
Exclusion Criteria:
- Lactose intolerance, cardiovascular or metabolic diagnoses, medications for cardiovascular or metabolic diagnoses, orthopedic issues barring cycling.
Sites / Locations
- University of Texas, Austin
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm Type
No Intervention
Experimental
Experimental
Arm Label
Control group-no exercise
Exercise intervention 1
Exercise intervention 2
Arm Description
A no-exercise control. Must maintain <4,500 steps per day for 3 consecutive days followed by a high fat tolerance test on day 4.
Two consecutive days of <4,500 steps per day followed by an intervention day on day 3. Intervention day consists of interrupting 8-hour sit with bike sprint protocol every 2 hours. Participants must aim to maintain <2,500 steps on intervention day. A high fat tolerance test will be performed the following day on day 4.
Two consecutive days of <4,500 steps per day followed by an intervention day. Intervention day consists of interrupting 8-hour sit with bike sprint protocol every 6 hours. Participants must aim to maintain <2,500 steps on intervention day. A high fat tolerance test will be performed the following day on day 4.
Outcomes
Primary Outcome Measures
Triglyceride area under the curve
Blood measurements baseline and every hour during a high fat tolerance test.
Secondary Outcome Measures
Whole body fat oxidation
Expired gas collection and measurement of expired gas concentrations in mass spectrometer, baseline and every two hours during high fat tolerance test.
Full Information
NCT ID
NCT04241081
First Posted
January 21, 2020
Last Updated
January 21, 2020
Sponsor
University of Texas at Austin
1. Study Identification
Unique Protocol Identification Number
NCT04241081
Brief Title
Interrupting Prolonged Sitting With Periodic Interval Exercise: Effect on Postprandial Lipemia
Official Title
Interrupting Prolonged Sitting With Periodic Interval Exercise: Effect on Postprandial Lipemia
Study Type
Interventional
2. Study Status
Record Verification Date
January 2020
Overall Recruitment Status
Unknown status
Study Start Date
January 2020 (Anticipated)
Primary Completion Date
May 2020 (Anticipated)
Study Completion Date
May 2020 (Anticipated)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
University of Texas at Austin
4. Oversight
Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No
5. Study Description
Brief Summary
Investigating the effects of interrupting various lengths of prolonged sitting with bike sprints on post prandial lipemia the next day. We will conduct three trials, one control, one with two-hour sitting intervals (total of 4 bouts of bike sprints) and one with 6-hour sitting intervals I total of two bouts of bike sprints). A milkshake high fat tolerance test will be conducted the next day and whole body fat oxidation as well as triglyceride area under the curve will be measured every hour for the duration of the 6-hour test.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Sedentary Behavior, Hypertriglyceridemia
7. Study Design
Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Crossover Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
15 (Anticipated)
8. Arms, Groups, and Interventions
Arm Title
Control group-no exercise
Arm Type
No Intervention
Arm Description
A no-exercise control. Must maintain <4,500 steps per day for 3 consecutive days followed by a high fat tolerance test on day 4.
Arm Title
Exercise intervention 1
Arm Type
Experimental
Arm Description
Two consecutive days of <4,500 steps per day followed by an intervention day on day 3. Intervention day consists of interrupting 8-hour sit with bike sprint protocol every 2 hours. Participants must aim to maintain <2,500 steps on intervention day. A high fat tolerance test will be performed the following day on day 4.
Arm Title
Exercise intervention 2
Arm Type
Experimental
Arm Description
Two consecutive days of <4,500 steps per day followed by an intervention day. Intervention day consists of interrupting 8-hour sit with bike sprint protocol every 6 hours. Participants must aim to maintain <2,500 steps on intervention day. A high fat tolerance test will be performed the following day on day 4.
Intervention Type
Behavioral
Intervention Name(s)
Interrupting Prolonged Sitting with Periodic Interval Exercise: Effect on Postprandial Lipemia
Intervention Description
This is a behavioral intervention designed to determine the effect of breaking up prolonged bouts of sitting every 2 hours and every 6 hours with 5 sets of 4 second bouts of maximum effort bicycle ergometer accelerations compared to sitting alone on the blood triglyceride response and whole body fat oxidation after a high fat meal.
Primary Outcome Measure Information:
Title
Triglyceride area under the curve
Description
Blood measurements baseline and every hour during a high fat tolerance test.
Time Frame
6 hour long high fat tolerance test
Secondary Outcome Measure Information:
Title
Whole body fat oxidation
Description
Expired gas collection and measurement of expired gas concentrations in mass spectrometer, baseline and every two hours during high fat tolerance test.
Time Frame
10 min, baseline, 2 hours post ingestion of shake, 4 hours, 6 hours.
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
65 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria:
Inactive or recreational healthy adults aged 18-65 years old.
Exclusion Criteria:
Lactose intolerance, cardiovascular or metabolic diagnoses, medications for cardiovascular or metabolic diagnoses, orthopedic issues barring cycling.
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Rebecca braden, BS
Phone
4422156656
Email
rebecca.braden@utexas.edu
First Name & Middle Initial & Last Name or Official Title & Degree
Edward Coyle, PhD
Phone
512 471 8596
Email
coyle@austin.utexas.edu
Facility Information:
Facility Name
University of Texas, Austin
City
Austin
State/Province
Texas
ZIP/Postal Code
78705
Country
United States
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Rebecca Braden, BS
Phone
442-215-6656
Email
rebecca.braden@utexas.edu
First Name & Middle Initial & Last Name & Degree
Edward Coyle, PhD
Phone
512 471 8596
Email
coyle@austin.utexas.edu
12. IPD Sharing Statement
Plan to Share IPD
Undecided
Learn more about this trial
Interrupting Prolonged Sitting With Periodic Interval Exercise: Effect on Postprandial Lipemia
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