Racial Differences in Serum Sodium and Blood Pressure Regulation
Sodium Excess, Racial Disparities, Blood Pressure
About this trial
This is an interventional prevention trial for Sodium Excess focused on measuring blood pressure, racial disparities, cardiovascular health, physical fitness, sleep, dietary sodium, dietary salt, diet
Eligibility Criteria
Inclusion Criteria:
- Are between the ages of 19-75.
- Have blood pressure no higher than 150/90 mmHg.
- Have a BMI below 35 Kg/m2 (otherwise healthy)
- Free from metabolic disease (diabetes or renal disease), pulmonary disorders (e.g., COPD & cystic fibrosis), and cardiovascular disease (peripheral vascular, cardiac, or cerebrovascular).
- Do not have any precluding medical issues that prevent participants from exercising (i.e., cardiovascular issues, or muscle/joint issues including painful arthritis) or giving blood (e.g., blood thinners).
- Are not currently smoking, using smokeless tobacco, nor smoked within the past 12 months.
Exclusion Criteria:
- High blood pressure - greater the 150/90 mmHg
- Low blood pressure - less than 90/50 mmHg
- History of cardiovascular disease
- History of cancer
- History of diabetes
- History of kidney disease
- Obesity (BMI > 30 kg/m2)
- Smoking or tobacco use
- Current pregnancy
- Nursing mothers
- Communication barriers
Sites / Locations
- Auburn UniversityRecruiting
- Kinesiology BuildingRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
High Sodium Meal (2500 mg sodium)
Low Sodium Meal (140 mg sodium)
Participants will have sympathetic nerve activity, vascular function, blood pressure and blood samples (from intravenous catheters) assessed before and after a high sodium meal (2500 mg sodium).
Participants will have sympathetic nerve activity, vascular function, blood pressure and blood samples (from intravenous catheters) assessed before and after a low sodium meal (140 mg sodium) which will serve as the control condition to demonstrate whether or not observed changes are due to high sodium or occur irrespective of sodium in the postprandial state.