Threat Interpretation Bias as Cognitive Marker and Treatment Target in Pediatric Anxiety
Anxiety Disorders
About this trial
This is an interventional treatment trial for Anxiety Disorders focused on measuring Child, Adolescent, Pediatric, Youth, Anxiety, Separation anxiety, Social phobia, Social anxiety, Generalized anxiety, Interpretation bias, Cognitive bias, Cognitive bias modification, Interpretation bias modification, Randomized controlled trial, Threat bias, Threat interpretation, Intervention, Randomized, Cognitive training, National Institute of Mental Health, Personalized
Eligibility Criteria
Inclusion Criteria:
- youth aged 10 to 17
- diagnosed at study baseline with a primary "big three" anxiety disorder (Separation, Social, Generalized)
- standard score greater than or equal to 85 on the Wide Range Achievement Test - Word Reading Subtest (to ensure ability to read stimuli during interpretation bias assessment and CBM-I/ICC), and estimated IQ standard score of at least 80 on the Wechsler Abbreviated Scale of Intelligence
- youth and consenting parent/legal guardian speak sufficient English to complete consent/assent and study procedures
- no concurrent psychosocial services during study participation to reduce likelihood that other interventions are responsible for change in primary or secondary outcomes
- no psychotropic medications with no plans to start medications during study, or six weeks stable on SSRI or psychostimulant medication and dose with no plans to change medication/dose during study
Exclusion Criteria:
- severe anxiety indicting that youth requires higher level of care (e.g., intensive treatment such as psychiatric hospitalization), significant diagnostic comorbidity (e.g., presence of psychosis or significant mood disorder), or another primary diagnosis that warrants alternate intervention
- significant uncorrected vision impairment (e.g., uncorrected blindness) that precludes participation in CBM-I/ICC
- safety concerns due to recent or acute suicidality with plan, intent, and/or attempt that warrants alternate intervention
Sites / Locations
- BRAVE Lab, Department of Psychology, University of Denver
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Cognitive Bias Modification for Interpretations (CBM-I)
Interpretation Control Condition (ICC)
Computerized 16-session intervention aimed at reducing interpretation bias. In this study, CBM-I is personalized to youth anxiety symptoms. During CBM-I sessions, youth indicate whether word-sentence pairs are related, and are provided with feedback aimed to reduce bias.
Computerized 16-session intervention that is not believed to significantly modify bias. In this study, youth see stimuli personalized to their anxiety symptoms. During ICC sessions, youth see word-sentence pairs and are required to indicate whether word and sentence are related, but are not provided with feedback that aims to "train" a reduction in interpretation bias.