Fatty Acid Taste Rating With or Without Sour Taste Adaptation
Primary Purpose
Taste, Altered
Status
Completed
Phase
Not Applicable
Locations
United States
Study Type
Interventional
Intervention
Taste Intensity
Sponsored by
About this trial
This is an interventional basic science trial for Taste, Altered
Eligibility Criteria
Inclusion Criteria:
-
Exclusion Criteria:
- taste disorder no allergy to alcohol
Sites / Locations
- Purdue University
Arms of the Study
Arm 1
Arm 2
Arm Type
No Intervention
Experimental
Arm Label
Fatty Acid Taste
Fatty Acid Taste after sour adaptation
Arm Description
Fatty acid taste without sour adaptation
Fatty Acid Taste after sour adaptation
Outcomes
Primary Outcome Measures
Taste Intensity
two sets of taste intensity ratings without (Test A) or with (Test B) sour taste adaptation. For test A, participants will taste one of the eight solutions or one of solid fatty acids, and rate its intensity before and after expectorating it.
Secondary Outcome Measures
Full Information
1. Study Identification
Unique Protocol Identification Number
NCT04248374
Brief Title
Fatty Acid Taste Rating With or Without Sour Taste Adaptation
Official Title
Fatty Acid Taste Rating With or Without Sour Taste Adaptation
Study Type
Interventional
2. Study Status
Record Verification Date
January 2021
Overall Recruitment Status
Completed
Study Start Date
October 7, 2019 (Actual)
Primary Completion Date
September 8, 2020 (Actual)
Study Completion Date
December 30, 2020 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
Purdue University
4. Oversight
Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No
5. Study Description
Brief Summary
We are trying to figure out whether the fatty acid taste is differentiated from sour taste.
Detailed Description
Participants will be asked to provide general demographic information such as gender, age and ethnicity. Their height and weight will be measured. Then, they will be trained with one of the sample solutions for intensity rating and adaptation to sour taste. There will be eight different sample solutions containing sucrose esters, xanthan gums to help fatty acids stay dissolved, and either acetic acid for sour compounds or, butyric acid, caproic acid, caprylic acid, capric acid, lauric acid, oleic acid, or linoleic acid for fatty acid taste. 2 g of each palmitic acid and stearic acids in solid form (their melting points are above body temperature) will also be placed in participants' mouth. All of these compounds are common in the commercial food supply.
The study procedure entails two sets of taste intensity ratings without (Test A) or with (Test B) sour taste adaptation. For test A, participants will taste one of the eight solutions or one of solid fatty acids, and rate its intensity before and after expectorating it. They will not swallow any samples and they will rinse their tongues thoroughly with 1% ethanol solution and water after expectorating the solution. They will consume one piece of unsalted cracker and rinse their tongues thoroughly again. Before moving to the next step, they will be asked to describe the taste quality of the sample solution they just tasted. They will repeat this procedure with the rest of the sample solutions.
For test B, participants will follow the same procedure of taste intensity ratings but with sour taste adaptation. For sour taste adaptation, the participants will hold sour taste solutions in their mouth for 5 seconds and rate its taste intensity. They will repeat rating the sourness until they rate its intensity as less than weak. When they feel the sour taste solution weak, they will taste one of the eight solutions and repeat the intensity rating with one of the sample solutions. After the taste intensity rating, the participants will be asked to describe the taste quality of the sample solution they just tasted. They will repeat this procedure with the rest of the sample solutions.
The participants will do both test A and B twice in random order on two separate days. Taste testing is expected to take 1 hour each day. They will receive $20 at the end of the two test days as compensation for their participation.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Taste, Altered
7. Study Design
Primary Purpose
Basic Science
Study Phase
Not Applicable
Interventional Study Model
Crossover Assignment
Model Description
Fatty Acid taste with and without sour adaptation
Masking
Participant
Masking Description
three random number and covered sample cup[
Allocation
Randomized
Enrollment
35 (Actual)
8. Arms, Groups, and Interventions
Arm Title
Fatty Acid Taste
Arm Type
No Intervention
Arm Description
Fatty acid taste without sour adaptation
Arm Title
Fatty Acid Taste after sour adaptation
Arm Type
Experimental
Arm Description
Fatty Acid Taste after sour adaptation
Intervention Type
Other
Intervention Name(s)
Taste Intensity
Intervention Description
Taste intensity with and without sour adaptation
Primary Outcome Measure Information:
Title
Taste Intensity
Description
two sets of taste intensity ratings without (Test A) or with (Test B) sour taste adaptation. For test A, participants will taste one of the eight solutions or one of solid fatty acids, and rate its intensity before and after expectorating it.
Time Frame
4 hours
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
65 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria:
-
Exclusion Criteria:
taste disorder no allergy to alcohol
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Richard D Mattes, PhD
Organizational Affiliation
Purdue University
Official's Role
Principal Investigator
Facility Information:
Facility Name
Purdue University
City
West Lafayette
State/Province
Indiana
ZIP/Postal Code
47907
Country
United States
12. IPD Sharing Statement
Plan to Share IPD
No
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Fatty Acid Taste Rating With or Without Sour Taste Adaptation
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