Impact of Interval Training on Sympathetic Hyperactivity and Vascular Function
Heart Failure
About this trial
This is an interventional other trial for Heart Failure
Eligibility Criteria
Inclusion Criteria:
- Functional Class II to III of New York Heart Association
- Left ventricular ejection fraction ≤40%
- Peak oxygen uptake (V̇O2) <20 ml•kg-1•min-1
Exclusion Criteria:
- Myocardial infarction within three months
- Unstable angina
- Acute heart failure
- Pacemaker
- Pulmonary disease
- Chronic renal disease
- Peripheral neuropathy
- History of stroke
- Untreated hypo/hyperthyroidism
- Body mass index (BMI) >30 kg/m2
- History of smoking
Sites / Locations
- Heart Institute
- Heart Institute (InCor)
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Sham Comparator
High-intensity interval training (HIIT)
Moderate-intensity continuous training (MICT)
No training
High-intensity interval training (HIIT) = the exercise of high intensity perform on a cycle ergometer, three times per week for 12 weeks, and training sessions were matched for energy expenditure (i.e., an isocaloric energy expenditure of 200 Kcal/session). The intensity of the HIIT session was established based on the HR and workload levels corresponding to 5% above the respiratory compensation point.
Moderate-intensity continuous training (MICT) = the exercise of moderate intensity perform on a cycle ergometer, three times per week for 12 weeks, and training sessions were matched for energy expenditure (i.e., an isocaloric energy expenditure of 200 Kcal/session). The intensity of the MICT session was established based on the HR and workload levels corresponding to anaerobic threshold and respiratory compensation point
The patients are instructed to avoid any regular exercise program or any non-supervised exercise protocol during the study.