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Lung Ultrasound for Infants' Swallowing Disorders (LUNCH)

Primary Purpose

Cerebral Palsy, Pediatric Neurological Disorder, Developmental Disability

Status
Recruiting
Phase
Not Applicable
Locations
Italy
Study Type
Interventional
Intervention
Lung Ultrasound (LUS)-monitored feeding trial
Sponsored by
IRCCS Fondazione Stella Maris
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional diagnostic trial for Cerebral Palsy focused on measuring abnormal swallowing, infants and young children with neurological impairment, lung ultrasound, apparent aspiration, silent aspiration

Eligibility Criteria

3 Weeks - 6 Years (Child)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • cerebral palsy or abnormal muscular tone at any age between 0-3 years of life due disorders other than cerebral palsy;
  • motor developmental delay assessed by a quantitative scale for infants and young children development (<5 sd according to age)
  • in absence of the previous clinical indices, if there is the clinical suspicion of GERD or dysphagia based on clinical symptoms
  • a brain MRI acquisition done before or programmed prior the end of the study period as part of their diagnostic procedure.

Exclusion Criteria:

  • epileptic spasm
  • drugs for muscle tone abnormalities or GERD introduced or modified less than 3 weeks before potential enrollment

Sites / Locations

  • IRCCS Fondazione Stella MarisRecruiting
  • IRCCS Fondazione Stella Maris

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Sham Comparator

Arm Label

LUS-monitored management (LUS-m)

Standard care management (SC-m)

Arm Description

In the first 3 months, participants will be evaluated a minimum of 1 time per month, in-hospital, for a total of 3 evaluations (T1, T2 and T3), plus baseline (T0). At any time point, they will undergo at least one LUS-monitored (before and after) feeding trial (different consistencies might be tested in separate repeated trials according to clinical evaluation). A further LUS evaluation will be performed at a distance of 3 hours, before the next meal to check for resolution of after-meal abnormalities.

Sham protocol with LUS performed at the same timepoints. LUS results in the SC-m group will be available only at the time of data analyses for comparison by investigators. They will not be used for clinical decisions.

Outcomes

Primary Outcome Measures

respiratory
respiratory illness rate (including pneumonia, wheezing, chronic cough, and apnoea rate)
respiratory
respiratory illness rate (including pneumonia, wheezing, chronic cough, and apnoea rate)
growth
growth rate
growth
growth rate
invasive diagnostic
VFSS/FEES execution rates
invasive diagnostic
VFSS/FEES execution rates

Secondary Outcome Measures

change from baseline laboratory exam at 6 months
blood cells count
change from baseline laboratory exam at 6 months
reticulocytes count
change from baseline laboratory exam at 6 months
total serum protein
change from baseline laboratory exam at 6 months
ferritin
chronic pain assessment
parents-report measure (Non-communicating Children's Pain Checklist, NCCPC), with scores ranging from 0 to 90, with higher scores corresponding to worse outcome
chronic pain assessment
parents-report measure (Non-communicating Children's Pain Checklist, NCCPC), with scores ranging from 0 to 90, with higher scores corresponding to worse outcome
parents' stress
Parenting Stress Index questionnaire (PSI), with scores ranging from 0 to 120 including 4 domains, with higher scores corresponding to worse outcome

Full Information

First Posted
January 30, 2020
Last Updated
June 20, 2022
Sponsor
IRCCS Fondazione Stella Maris
Collaborators
Ministry of Health, Italy, University of Pisa, Fondazione C.N.R./Regione Toscana "G. Monasterio", Pisa, Italy
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1. Study Identification

Unique Protocol Identification Number
NCT04253951
Brief Title
Lung Ultrasound for Infants' Swallowing Disorders
Acronym
LUNCH
Official Title
Lung Ultrasound for Early Detection of Silent and Apparent aspiratioN in Infants and Young CHildren With Cerebral Palsy and Other Developmental Disabilities: a New Fast, Safe, Cost-effective Infant-friendly Imaging Tool to Easily Monitor Feeding , Improve Outcomes and Reduce Morbidities (LUNCH)
Study Type
Interventional

2. Study Status

Record Verification Date
June 2022
Overall Recruitment Status
Recruiting
Study Start Date
April 1, 2021 (Actual)
Primary Completion Date
September 15, 2023 (Anticipated)
Study Completion Date
December 15, 2023 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
IRCCS Fondazione Stella Maris
Collaborators
Ministry of Health, Italy, University of Pisa, Fondazione C.N.R./Regione Toscana "G. Monasterio", Pisa, Italy

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes

5. Study Description

Brief Summary
The aim is to test the effectiveness of lung ultrasound (LUS) in the dynamic assessment of aspiration related to abnormal swallowing in infants and young children with neurological impairment (cerebral palsy/developmental disabilities). Neither standardized measure is available, nor protocols for invasive fibre-optic endoscopic examination of swallowing (FEES) and x-Ray videofluoroscopic swallowing study (VFSS) to be used in such population. LUS offers several advantages: time saving for aspiration diagnosis; safeness (neither invasiveness nor radiation); repeatability with different meal consistencies or to monitor interventions efficacy; cost-effectiveness; savings of x-Ray exposition (compared to VFSS). All these advantages may lead infants to improve clinical behavioural and neurological outcomes and reduce stressful interactions with caregivers, and to reduce morbidities and hospitalization costs for respiratory and non-respiratory complications related to swallowing disorders.
Detailed Description
The dynamic use of LUS for monitoring feeding related aspiration can be effective in detecting meal-related pulmonary abnormalities in neurologically impaired infants and that LUS-management will improve medical/neurological/behavioural status, and reduce chronic pain/discomfort and stress for caregivers. LUS effectiveness is expected to reduce the need for x-Ray, invasive and more expensive techniques (VFSS and FEES). Results may be translated into clinical practice in the management of swallowing disorders in a very vulnerable population, by reducing invasiveness, possible x-Ray early exposition risks, costs, medical complications, and by assessing risk categories based on neuroimaging MRI markers, to rationalize prevention and intervention. Preliminary data. LUS examinations have been performed on 6 infants with neurological impairment (mean age 15 ± 8 months; Gross Motor Function Classification System (GMFCS) range 2-5, median=4) and in 3 healthy infants (mean age 25 ± 3 months) before and right after a meal. A LUS score ranging from 0 to 18 was established, according to previous literature (0= normal pattern, 1= separated B-lines, 2= confluent B-lines or B-lines with pleural alterations, 3= consolidations; the score 0-3 was then calculated in all 6 thoracic scanning areas and summed up). In the 6 infants with neurological impairment, at paired sample t test, LUS score changed before and after meal (pre-meal 2.50±2.95 vs post-meal 5.17±3.25, p=0.01), with very large effect size (Cohen d=1.6). No change was detected in the control group. Changes in LUS score pre and post-meal correlated with GMFCS (p=0.03, r=0.64) and with adapted Eating and Drinking Ability Classification System (EDACS) scores (p=0.04, r=0.59), as more severe clinical pictures resulted in worse LUS scores. The LUS score pre- meal was worse in infants with neurological impairment compared to controls (2.50±2.95 vs 0.67±0.58, p=0.14). Results make LUS extremely promising as a tool to monitor pulmonary aeration changes in infants with neurological impairment. Feasibility of dorsal and ventral oromotor tract reconstruction has been tested in an infant with neurological impairment. Specific Aim 1: To establish the feasibility and effectiveness of LUS-guided management in the detection of aspiration related to swallowing disorders in children with cerebral palsy and other developmental disabilities, determining advantages of LUS-guided management over standard care on medical (respiratory illness and growth rate) LUS findings themselves and behavioural/neurological outcomes To compare diagnostic accuracy of LUS versus X-ray VFSS and invasive FEES Specific Aim 2: - To determine specific parameters to estimate aspiration entity by LUS (eg cut-off values for the diagnosis of clinically significant silent or overt aspiration, responsiveness of LUS monitoring to medical, postural or food consistencies adaptation) and their relationship with standardised clinical feeding evaluation and medical/behavioural/neurological measures in order to define risk groups for aspiration Specific Aim 3: To evaluate other applications/potentialities of LUS in children with cerebral palsy and other developmental disabilities. To uncover the impact of brain abnormalities detected by brain MRI on LUS findings, for establishing risk categories for unsafe swallowing disorders on early imaging markers, and potential clinical recommendations for early management. Experimental Design Aim 1: Double-blinded randomized parallel-designed controlled trial (Consort checklist), with block randomization (blocks of size 4), in one of 2 groups: 1) LUS-monitored management (LUS-m); 2) Standard care management (SC-m). Both groups will undergo an experimental 6-months follow-up. In the first 3 months, participants will be evaluated a minimum of 1 time per month, in-hospital, for a total of 3 evaluations (T1, T2 and T3), plus baseline (T0). At any time point, they will undergo at least one LUS-monitored (before and after) feeding trial (different consistencies might be tested in separate repeated trials according to clinical evaluation). A further LUS evaluation will be performed at a distance of 3 hours, before the next meal to check for resolution of after-meal abnormalities. Both the clinicians who will perform and score LUS, and the patients' family will be blinded to randomization. The child neurologist and the speech and language pathologist (SLP) will be informed of the result of LUS only in the LUS-m group and will include that result to impact on feeding care (postural, thickening fluids or with drugs available for GERD). LUS results in the SC-m group will be available only at the time of data analyses. All meals will be monitored by pulse-oximetry and video recording. A further 6-months LUS-monitored and clinical assessment (T4) will be delivered for collecting outcome measures in both treatment groups. At T0, T3 and T4 time points, infants will perform standardized medical/behavioural/neurological, chronic pain/discomfort assessments. At T0 and T4, a blood sample will be collected, to evaluate general and nutritional status, and a quantitative ultrasound (QUS) will be performed to evaluate bone density. A parent stress questionnaire (Parenting Stress Index (PSI)) will be delivered (T0, T3 and T4). Between T0 and T4, parents will be asked to fill a respiratory infection-diary for respiratory illness rate calculation. VFSS and FEES data will be collected, compared in frequency of execution between groups, and their results will be compared to LUS findings. Primary and secondary outcome measures will be collected at both T3 (short-term) and T4 (long-term). Experimental Design Aim 2: Aim 2 is based on the same design as Aim 1. We will explore the frequency, severity and distribution of basal and feeding related LUS parameters and their relationship with clinical (feeding assessment/medical/behavioural/neurological/chronic pain) measures, interventions (postural, thickening fluids or with drugs available for GERD), inter- and intra- group at any time point. Other possible applications of LUS in the enrolled population will be collected (e.g. pneumonia detection and monitoring). Experimental Design Aim 3: Brain MRI is a clinical procedure in the diagnostic approach to children with neurological impairment. Brain abnormalities and corticobulbar tract integrity for lips, tongue, larynx motor and sensory control will be checked to uncover the neural circuits that may underlay swallowing problems leading to silent or overt aspiration and pulmonary risk estimated by LUS. Brain lesions topography and severity will be assessed by using a standardized MRI acquisition protocol according to the diagnostic procedure in use at Stella Maris Scientific Institute MRI Lab. Diffusion-weighted Imaging (DWI) will be used with the aim of revealing structural integrity and connectivity along white matter tracts involved in swallowing. Expected outcomes: the LUS-m group having better outcomes, at short- and long-term, including: having lower rate of pulmonary illness, better growth curve, reduction of execution rate of VFSS/FEES. Also, better results at blood sample and bone metabolism, lower pain indices, better scores at neurological/behavioural clinical measures, and less stressful interaction with caregivers.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Cerebral Palsy, Pediatric Neurological Disorder, Developmental Disability
Keywords
abnormal swallowing, infants and young children with neurological impairment, lung ultrasound, apparent aspiration, silent aspiration

7. Study Design

Primary Purpose
Diagnostic
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Model Description
Double-blinded randomized parallel-designed controlled trial (Consort checklist, 21), with block randomization (blocks of size 4), in one of 2 groups: 1) LUS-monitored management (LUS-m); 2) Standard care management (SC-m). Both groups will undergo an experimental 6-months follow-up. In the first 3 months, participants will be evaluated a minimum of 1 time per month, in-hospital, for a total of 3 evaluations (T1, T2 and T3), plus baseline (T0).
Masking
ParticipantInvestigatorOutcomes Assessor
Masking Description
Both the clinicians who will perform and score LUS, and the patients' family will be blinded to randomization. The care providers (child neurologist and speech and language pathologist (SLP) will be informed of the result of LUS only in the LUS-m group and will include that result to impact on feeding care (postural, thickening fluids or with drugs available for GERD). LUS results in the SC-m group will be available only at the time of data analyses.
Allocation
Randomized
Enrollment
150 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
LUS-monitored management (LUS-m)
Arm Type
Experimental
Arm Description
In the first 3 months, participants will be evaluated a minimum of 1 time per month, in-hospital, for a total of 3 evaluations (T1, T2 and T3), plus baseline (T0). At any time point, they will undergo at least one LUS-monitored (before and after) feeding trial (different consistencies might be tested in separate repeated trials according to clinical evaluation). A further LUS evaluation will be performed at a distance of 3 hours, before the next meal to check for resolution of after-meal abnormalities.
Arm Title
Standard care management (SC-m)
Arm Type
Sham Comparator
Arm Description
Sham protocol with LUS performed at the same timepoints. LUS results in the SC-m group will be available only at the time of data analyses for comparison by investigators. They will not be used for clinical decisions.
Intervention Type
Diagnostic Test
Intervention Name(s)
Lung Ultrasound (LUS)-monitored feeding trial
Intervention Description
LUS-monitored (before and after) feeding trial (different consistencies might be tested in separate repeated trials according to clinical evaluation). A further LUS evaluation will be performed at a distance of 3 hours, before the next meal to check for resolution of after-meal abnormalities. All pulmonary fields will be explored according to semeiotics and previous literature.
Primary Outcome Measure Information:
Title
respiratory
Description
respiratory illness rate (including pneumonia, wheezing, chronic cough, and apnoea rate)
Time Frame
long term (T4, at 6 months)
Title
respiratory
Description
respiratory illness rate (including pneumonia, wheezing, chronic cough, and apnoea rate)
Time Frame
short term (T3, at 3 months)
Title
growth
Description
growth rate
Time Frame
long term (T4, at 6 months)
Title
growth
Description
growth rate
Time Frame
short term (T3, at 3 months)
Title
invasive diagnostic
Description
VFSS/FEES execution rates
Time Frame
long term (T4, at 6 months)
Title
invasive diagnostic
Description
VFSS/FEES execution rates
Time Frame
short term (T3, at 3 months)
Secondary Outcome Measure Information:
Title
change from baseline laboratory exam at 6 months
Description
blood cells count
Time Frame
baseline-long term (T4, at 6 months)
Title
change from baseline laboratory exam at 6 months
Description
reticulocytes count
Time Frame
baseline-long term (T4, at 6 months)
Title
change from baseline laboratory exam at 6 months
Description
total serum protein
Time Frame
baseline- long term (T4, at 6 months)
Title
change from baseline laboratory exam at 6 months
Description
ferritin
Time Frame
baseline- long term (T4, at 6 months)
Title
chronic pain assessment
Description
parents-report measure (Non-communicating Children's Pain Checklist, NCCPC), with scores ranging from 0 to 90, with higher scores corresponding to worse outcome
Time Frame
short term (T3, at 3 months)
Title
chronic pain assessment
Description
parents-report measure (Non-communicating Children's Pain Checklist, NCCPC), with scores ranging from 0 to 90, with higher scores corresponding to worse outcome
Time Frame
long term (T4, at 6 months)
Title
parents' stress
Description
Parenting Stress Index questionnaire (PSI), with scores ranging from 0 to 120 including 4 domains, with higher scores corresponding to worse outcome
Time Frame
long term (T4, at 6 months)
Other Pre-specified Outcome Measures:
Title
neurological outcome
Description
Hammersmith Infant Neurological Examination (HINE), with scores ranging from 0 to 78, with higher scores corresponding to better outcome
Time Frame
short term (T3, at 3 months) and long term (T4, at 6 months)

10. Eligibility

Sex
All
Minimum Age & Unit of Time
3 Weeks
Maximum Age & Unit of Time
6 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: cerebral palsy or abnormal muscular tone at any age between 0-3 years of life due disorders other than cerebral palsy; motor developmental delay assessed by a quantitative scale for infants and young children development (<5 sd according to age) in absence of the previous clinical indices, if there is the clinical suspicion of GERD or dysphagia based on clinical symptoms a brain MRI acquisition done before or programmed prior the end of the study period as part of their diagnostic procedure. Exclusion Criteria: epileptic spasm drugs for muscle tone abnormalities or GERD introduced or modified less than 3 weeks before potential enrollment
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Simona Fiori, MD, PhD
Phone
0039 050886310
Email
s.fiori@fsm.unipi.it
First Name & Middle Initial & Last Name or Official Title & Degree
Elena Moretti, SLP
Phone
0039 050886310
Email
e.moretti@fsm.unipi.it
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Simona Fiori, MD, PhD
Organizational Affiliation
IRCCS Fondazione Stella Maris
Official's Role
Principal Investigator
Facility Information:
Facility Name
IRCCS Fondazione Stella Maris
City
Marina di Pisa-Tirrenia-Calambrone
State/Province
Toscana
ZIP/Postal Code
56128
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Giovanni Cioni
Phone
050886233
Email
gcioni@fsm.unipi.it
First Name & Middle Initial & Last Name & Degree
Giuseppina Sgandurra
Email
gsgandurra@fsm.unipi.it
Facility Name
IRCCS Fondazione Stella Maris
City
Pisa
ZIP/Postal Code
56128
Country
Italy
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Simona Fiori, MD, PhD
Phone
0039 050886310
Email
s.fiori@fsm.unipi.it
First Name & Middle Initial & Last Name & Degree
Giovanni Cioni, MD
Phone
0039 050886229
Email
dirscient@fsm.unipi.it

12. IPD Sharing Statement

Plan to Share IPD
No
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Lung Ultrasound for Infants' Swallowing Disorders

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