Back to resultsA Study of Tirzepatide (LY3298176) Compared With Dulaglutide on Major Cardiovascular Events in Participants With Type 2 Diabetes (SURPASS-CVOT)
Primary Purpose
Type 2 Diabetes Mellitus
Status
Active
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Tirzepatide
Dulaglutide
Sponsored by
About this trial
This is an interventional treatment trial for Type 2 Diabetes Mellitus focused on measuring Diabetes Mellitus, Diabetes Mellitus, Type 2, Glucose Metabolism Disorders, Metabolic Diseases, Endocrine System Diseases, Hypoglycemic Agents, Physiological Effects of Drugs, Tirzepatide, Incretins, Glucagon-Like Peptide 1, Gastric Inhibitory Polypeptide, Hormones, Hormones, Hormone Substitutes, and Hormone Antagonists
Eligibility Criteria
Inclusion Criteria:
- Have a diagnosis of type 2 diabetes
- Have confirmed atherosclerotic cardiovascular disease
- HbA1c ≥7.0% to ≤10.5%
- Body mass index (BMI) ≥25 kilograms per meter squared (kg/m²)
Exclusion Criteria:
- Have had a major cardiovascular event within the last 60 days
- Have type 1 diabetes mellitus
- Have a history of severe hypoglycemia and/or hypoglycemia unawareness within the last 6 months
- Are currently planning treatment for diabetic retinopathy and/or macular edema
- Currently planning a coronary, carotid, or peripheral artery revascularization
- Have a history of pancreatitis
- Have a history of ketoacidosis or hyperosmolar state/coma
- Have a known clinically significant gastric emptying abnormality, have undergone or currently planning any gastric outlet obstruction, or have undergone or currently planning any gastric bypass (bariatric) surgery or restrictive bariatric surgery
- Have a history of an active or untreated malignancy or are in remission from a clinically significant malignancy for less than 5 years
- Have a family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN-2)
- Have had a blood transfusion or severe blood loss within 90 days prior to screening or have known hematological conditions that may interfere with HbA1c measurement
Sites / Locations
- University of Alabama at Birmingham Medical Center
- John Muir Medical Center - Concord Campus
- Valley Clinical Trials, Inc.
- AMCR Institute
- Valley Research
- UCSD - Altman Clinical and Translational Research Institute (ACTRI)
- Diabetes and Endocrine Associates
- Monterey Endocrine & Diabetes Institute, Inc.
- Riverside University Health System - Medical Center
- Diabetes Associates Medical Group
- Pasadena Clinical Research
- LCGK Research
- Norcal Endocrinology & Internal Medicine
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
- Coastal Metabolic Research Centre
- CMR of Greater New Haven, LLC
- Chase Medical Research, LLC
- Orlando Heart & Vascular Institute, LLC
- Excel Medical Clinical Trials
- Encore Medical Research
- East Coast Institute for Research, LLC
- Encore Research Group- Jacksonville Center for Clinical Research
- Ocala Caridovascular Research
- Cardiology Partners Clinical Research Institute - Palm Beach Gardens
- Peace River Cardiovascular Center
- Professional Health Care of Pinellas
- Cardiology Partners Clinical Research Institute - Wellington
- Clinical Research of Central Florida
- Atlanta Diabetes Associates
- Kaiser Permanente - Dutluth, GA
- NSC Research
- Physicians Research Associates
- East Coast Institute for Research, LLC
- Atlanta Heart Specialists
- East-West Medical Research Institute
- Rocky Mountain Clinical Research
- Northwest Heart Clinical Research
- Cedar-Crosse Research Center
- Clinical Investigation Specialists
- Central Illinois Diabetes and Clinical Research a Division of Prairie Education and Research Cooperative
- University of Iowa
- Iowa Diabetes and Endocrinology Research Center
- The University of Kansas - Clinical Research Center
- Cotton O'Neil Clinical Research Center - Central Office
- Cotton O'Neil Clinical Research Center
- Qualmedica Research
- L-MARC Research Center
- Maryland Cardiovascular Specialists
- MD Medical Research
- Endocrine and Metabolic Consultants
- Joslin Diabetes Center
- ActivMed Practices and Research
- Infinity Medical Research
- Arcturus Healthcare , PLC, Troy Internal Medicine Research Division
- St. John's Hospital
- M Health Fairview St. John's Hospital
- CentraCare Heart & Vascular Center
- StudyMetrix Research
- Mercy Research - Smith Glynn Callaway
- Clinvest Research LLC
- Billings Clinic
- Mercury Street Medical Group, PLLC
- VA Nebraska-Western Iowa Health Care System
- Southern Nh Diabetes and Endocrinology
- Albany Medical College, Division of Community Endocrinology
- Great Lakes Medical Research, LLC
- Duke University
- PMG Research Inc., d/b/a PMG of Piedmont Healthcare
- PMG Research of Wilmington, LLC
- Lillestol Research
- Cleveland Clinic Foundation
- Alliance for Multispecialty Research, LLC
- Heritage Valley Medical Group, Inc.
- Decpa, Llc
- Office 18
- Cardiology Consultants of Philadelphia Yardley
- Ralph H. Johnson VA Medical Center
- Tribe Clinical Research, LLC
- PMG Research, Inc. d/b/a PMG Research of Knoxville
- Private Practice - Dr. Osvaldo A. Brusco
- Dallas Diabetes Research Center
- North Texas Endocrine Center
- Research Institute of Dallas
- Texas Health Physicians Group
- Galenos Research
- Academy of Diabetes, Thyroid and Endocrine
- Diabetes and Thyroid Center of Ft. Worth
- Northwest Houston Cardiology - Cypress
- North Hills Family Medicine/North Hills Medical Research
- Audie L Murphy VA Hospital
- Northwest Houston Heart Center
- Physicians' Research Options
- Advanced Research Institute
- Alpine Medical Group
- Kalo Clinical Research
- MultiCare Good Samaritan Hospital
- VA Puget Sound Health Care System
- Clinical Investigation Specialists
- Instituto de Investigaciones Clínicas Bahia Blanca
- Organizacion Medica de Investigacion
- CEDIC
- Stat Research S.A.
- Centro de Investigaciones Metabólicas (CINME)
- DIM Clínica Privada
- Go Centro Medico San Nicolás
- Centro Médico Viamonte
- Mautalen Salud e Investigación
- CEMEDIAB
- Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada
- Centro Medico Privado CEMAIC
- Centro Medico Privado San Vicente Diabetes
- Instituto Médico Catamarca IMEC
- Instituto Médico Fundación Grupo Colaborativo Rosario Investigación y Prevención Medica
- Instituto de Investigaciones Clinicas Rosario
- Centro de Investigaciones Médicas Tucuman
- Clínica Mayo de Urgencias Médicas Cruz Blanca S.R.L
- Investigaciones Clínicas Tucumán
- CEMEDIC
- Glenny Corp
- CIPREC
- Asociación de Beneficencia Hospital Sirio Libanés
- Centro Universitario de Investigación en Farmacologia Clínic
- Instituto de Cardiología "Juana F. Cabral"
- CIDIM-Centro Integral de Diagnostico por Imagenes Marchegiani
- Centro Diabetológico Dr. Waitman
- Instituto Médico Alas
- Sanatorio Norte
- The AIM Centre / Hunter Diabetes Centre
- Core Research Group
- Gold Coast University Hospital
- The Townsville Hospital
- School of Medicine, Fremantle Hospital
- GenesisCare
- GenesisCare
- Uniklinikum Salzburg
- Klinik Landstraße
- Zentrum für klinische Studien Dr Hanusch Gmbh
- Université Libre de Bruxelles - Hôpital Erasme
- ZNA Jan Palfijn
- AZ Sint-Jan Brugge-Oostende AV
- Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman
- CEDOES
- Pesquisa Clínica em Diabetes - Dra Rosângela Réa
- Núcleo de Pesquisa Clínica do Rio Grande do Sul
- Loema Instituto de Pesquisa Clinica
- CPCLIN
- ISPEM - Instituto São José dos Campos em Pesquisas Médicas
- IBPClin - Instituto Brasil de Pesquisa Clínica
- CPQuali Pesquisa Clínica
- LMC Diabetes & Endocrinology
- BC Diabetes Office
- Dr. M.B. Jones Inc.
- Winnipeg Clinic
- LMC Clinical Research Inc. (Barrie)
- LMC Diabetes & Endocrinology
- Aggarwal and Associates Limited
- Cambridge Cardiac Care Centre
- LMC Clinical Research Inc. (Thornhill)
- Milestone Research Inc.
- North York Diagnostic and Cardiac Centre
- LMC Clinical Research Inc. (Oakville)
- Private Practice - Dr. James Cha
- LMC Manna Research
- Kawartha Cardiology Clinical Trials
- Bluewater Clinical Research Group Inc.
- Diabetes Clinic
- Janik Research Corporation
- Canadian Phase Onward
- LMC Clinical Research Inc. (Bayview)
- Diabetes Heart Research Centre
- Dr. Anil K. Gupta Medicine Professional Corporation
- Viacar Recherche Clinique
- Centre de Recherche Clinique de Laval
- Manna Research
- Clinique Sante Cardio MC
- Peking University First Hospital
- Beijing Friendship Hospital
- The First Hospital of Lanzhou University
- Lanzhou university second hospital
- First Huai'an Hospital Affiliated to Nanjing Medical University
- Nanjing First Hospital
- Zhongda Hospital Southeast University
- The Second Affiliated Hospital of Nanjing Medical University
- The First Affiliated Hospital of Nanchang University
- General Hospital of Ningxia Medical University
- The First Affiliated Hospital of Xi'an Jiaotong University
- Jinan Central Hospital
- Tianjin Medical University General Hospital
- Milan Kvapil s.r.o., Diabetologicka ambulance
- Centre Hospitalier Sud Francilien
- Gemeinschaftspraxis Dres. Jung
- Marienhospital Stuttgart
- Gemeinschaftspraxis Prof. Dr. med. Stephan Jacob, Dr. med. Frohmut Jacob
- Praxis Sauter & Sauter & Vorbach
- Studienzentrum Aschaffenburg
- CIMS Studienzentrum Bamberg
- Private Practice - Dr. Ilka Simon-Wagner
- CDG Studienambulanz Hartard
- Medizinisches Versorgungszentrum am Bahnhof Spandau
- ZKS Suedbrandenburg
- ClinPhenomics GmbH & Co KG
- Diabetes Zentrum Dr. Tews
- Diabetologische Schwerpunktpraxis und Praxis für Allgemeinmedizin Dr. Veronika Wenzl-Bauer null Josef Wenzl
- Herz - und Diabeteszentrum Nordrhein - Westfalen, Bad Oeynhausen
- Diabetes- und Stoffwechselpraxis Bochum
- Private Practice - Dr. Claus Busch, Dr. Christian Busch & Dr. Christopher Cramer
- InnoDiab Forschung Gmbh
- Medizentrum Essen Borbeck
- Private Practice - Dr. Bernd Becker
- Institut für Diabetesforschung GmbH Münster
- Diabetologische Schwerpunktpraxis Diabetologikum Speyer
- Practice Dr.med. Denger and Dr.med. Pfitzner
- Zentrum für klinische Studien
- Hausarzt- und Diabetologische Schwerpunktpraxis Hohenmölsen - Weiβenfels
- SMO.MD GmbH
- Hausärztlich-Kardiologisches MVZ am Felsenkeller GmbH/Zentrum für klinische Studien
- SIBAmed GmbH
- Gemeinschaftspraxis Dr. Taeschner/Dr. Bonigut
- AmBeNet GmbH
- Private Practice - Dr. Christine Kosch
- MVZ Riesa am Klinikum Döbeln GmbH
- Praxis für Inner Medizin - Diabetologische Schwerpunktpraxis
- Universität zu Lübeck - Institut für Endokrinologie und Diabetes
- RED-Institut GmbH
- Private Practice - Dr. Joachim Weimer
- Gemeinschaftspraxis für Diabetologie
- Diabetespraxis Prenzlauer Alle
- Institut für klinische Forschung und Entwicklung
- Diabetologische Schwerpunktpraxis Harburg
- Diabetes Zentrum Wilhelmsburg
- Diabeteszentrum Hamburg West
- St. Josefskrankenhaus Heidelberg
- Athens Euroclinic
- Studium Egeszseghaz Kft
- Markhot Ferenc Oktatókórház
- Pharma 4 Trial
- CLINFAN Szolgáltató Kft
- DRC Gyógyszervizsgáló Központ
- ClinDiab Kft.
- Strazsahegy Medicina Bt.
- G.B. Pant Institute of Postgraduate Medical Education & Research
- All India Institute of Medical Sciences
- Sir Ganga Ram Hospital
- Batra Hospital and Medical Research Centre
- CIMS Hospital - Care Institute of Medical Sciences
- Bangalore Diabetes Centre
- CHL Hospital Indore
- Topiwala National Medical College & B. Y. L. Nair Charitable Hospital
- Madras Diabetes Research Foundation
- Care Hospitals Hyderabad- Banjara Hills
- Apollo Gleneagles Hospitals Kolkata
- Sourasky Medical Center
- Clalit Health Services Diabetes and Endocrinology Clinic Jerusalem
- Clalit Health Services - Atlit
- "Fatebenefratelli Isola Tiberina - Gemelli Isola"
- Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico
- A.O.U.C. Policlinico di Bari
- A.O.U. Policlinico Paolo Giaccone
- Azienda Ospedaliera Universitaria Pisana
- Azienda Ospedaliera Mater Domini
- Università degli Studi Gabriele D' Annunzio
- Centro Cardiologico Monzino
- Fondazione Salvatore Maugeri Clinica del lavoro
- Uji-Tokushukai Medical Center
- Takatsuki Red Cross Hospital
- The Institute for Adult Disease, Asahi Life Foundation
- Tokyo-Eki Center-building Clinic
- Fukuwa Clinic
- Medical Corporation Sato Medical clinic
- Jinnouchi Hospital
- AMC Nishiumeda Clinic
- Sakurabashi Watanabe Hospital
- Yonsei University-Wonju Severance Christian Hospital
- Korea University Anam Hospital
- Severance Hospital, Yonsei University Health System
- Kyung Hee University Hospital at Gangdong
- Asan Medical Center
- The Catholic Univ. of Korea Seoul St. Mary's Hospital
- Hallym University Kangnam Sacred Heart Hospital
- Keimyung University Dongsan Hospital
- Ulsan University Hospital
- Centro de Investigacion Cardiovascular y Metabólica
- Centro Especializado En Diabetes, Obesidad Y Prevencion De Enfermedades Cardiovasculares
- Centro de Investigacion Medica Integral
- Private Practice - Dr. Arechavaleta Granell Maria del Rosario
- Instituto de Diabetes, Obesidad y Nutricion
- Cardiolink Clin Trials
- Unidad Médica para la Salud Integral
- Medical Care and Research SA de CV
- Centro de Investigacion Medica Aguascalientes
- Fundación Cardiovascular de Aguascalientes A.C.
- Hospital Cardiologica Aguescalientes
- Investigacion En Salud Y Metabolismo S.C / Nutricion Clinica / Unidad de Base de Datos
- Lahoja. Asociacion Para La Investigacion Y La Farmacovigilancia
- Centro de Estudios Clínicos de Querétaro (CECLIQ)
- EB Utrecht
- Ziekenhuis Rijnstate
- Slingeland Ziekenhuis
- Jeroen Bosch ziekenhuis
- Reinier de Graaf Ziekenhuis, locatie Delft
- Universitair Medisch Centrum Utrecht
- Wojewódzki Zespól Specjalistycznej Opieki Zdrowotnej
- CenterMed Lublin NZOZ
- Gabinety TERPA
- NZOZ Medica
- Instytut Diabetologii
- ETG Warszawa
- Centrum Medyczne AMED
- NZOZ Diab-Endo-Met
- SN ZOZ Lege Artis Poradnia Diabetologiczna
- Niepubliczny Specjalistyczny Zaklad Opieki Zdrowotnej Osrodek Diabetologiczny Popula Spolka Cywilna
- Centrum Badan Klinicznych PI-House sp. z o.o.
- OMEDICA Medical Center
- Gaja Poradnie Lekarskie Maciej Wiza
- Private Practice - Dr. Ewa Krzyzagorska
- NZOZ Salvia CM
- NZOZ Przychodnia Specjalistyczna Andrzej Wittek, Henryk Rudzki
- Advanced Clinical Research, LLC
- Manati Center for Clinical Research
- Research and Cardiovascular Corp.
- GCM Medical Group, PSC - Hato Rey Site
- Arkhangelsk Regional Clinical Hospital
- First City Clinical Hospital E.E. Volosevich
- Advisory Diagnostic Centre
- National Medical Research Center for therapy and preventive medicine
- Endocrinology Research Center of Rosmedtechnologies
- Pirogov Russian National Research Medical University
- First Moscow State Medical University I.M. Sechenov
- Russian Cardiology Research and Production Complex
- Moscow City Clinical Hospital Number 52
- M. F. Vladimirskiy Moscow Regional Research Clinical Institute
- Moscow City Clinical Hospital Number 52
- Novosibirsk State Medical University
- Rostov State Medical University
- Ryazan Regional Clinical Cardiological Dispensary
- S.M. Kirov Military Medical Academy
- Astarta Clinic
- Regional Clinical Hospital of the Saratov Region
- Tomsk Regional Clinical Hospital
- Sibneyromed Urban Neurological Center
- Research & Practice
- Yaroslavl State Med Acad Clinical Hospital
- IN-DIA
- Sin Azucar
- Diacrin .s.ro.
- Funkystuff
- Diabetol
- MED-DIA s.r.o
- Diacrin .s.ro.
- Diabetes Centrum
- Hospital Unviersitario Virgen Nieves
- Clínica nuevas Tecnologías en Diabetes y Endocrinología (NTDE)
- Dalecarlia Clinical Research Center
- Östersunds Sjukhus
- ProbarE
- Citydiabetes
- Sahlgrenska Universitetssjukhuset Mölndal
- Universitetssjukhuset Örebro
- Changhua Christian Hospital
- Mackay Memorial Hospital-Hsinchu
- Hualien Tzu Chi Medical Center
- Chang Gung Memorial Hospital at Kaohsiung
- Chi Mei Medical Center
- National Cheng Kung University Hospital
- Taipei Veterans General Hospital
- Taichung Veterans General Hospital
- Chang Gung Medical Foundation-Linkou Branch
- Eskisehir Osmangazi University
- Mersin University Medical Faculty
- Ankara University Medicine Hospital
- Koç Üniversitesi Hastanesi
- Dr. Sadi Konuk Egitim ve Arastirma Hastanesi
- Göztepe Eitim Ve Aratrma Hastanesi
- Ege Universitesi Hastanesi
- İnönü Üniversitesi Turgut Özal Tıp Merkezi
- Chernivetsky Oblasny Endokrynologichny Centr, Oblasna Komunalna Ustanova
- Dnipropetrovsk City Clinical Hospital No. 9
- L.T. Mala National Institute of Therapy of NAMS of Ukraine
- Municipal Non-Profit Enterprise "City clinical hospital №8" of Kharkiv city council
- ARTEM
- Institute of Endocrinology and Metabolism named after Komissarenko
- Institute of Endocrinology and Metabolism named after Komissarenko
- Lviv Regional Endocrinology Dispensary
- Lviv City Clinical Hospital #4
- Municipal non-profit enterprise'Odesa Regional Clinical Hospital'of Odesa Regional Council
- Poltova Oblast Clinical Hospital IM.M.V.Sklifosovskoho
- Vinnytsia Regional Clinical Endocrinology Dispensary
- Ukrainian State Research Institute Of Medical And Social Problems Of Disability
- Medical Center Ok!Clinic+
- Aberdeen Royal Infirmary
- Southmead Hospital
- The Royal Cornwall Hospital
- Glasgow Royal Infirmary
- Hull and East Yorkshire Hospitals NHS Trust
- Ipswich Hospital
- Morriston Hospital
- University Hospital Aintree
Arms of the Study
Arm 1
Arm 2
Arm Type
Experimental
Active Comparator
Arm Label
Tirzepatide
Dulaglutide
Arm Description
Tirzepatide administered subcutaneously (SC) once a week.
Dulaglutide administered SC once a week.
Outcomes
Primary Outcome Measures
Time to First Occurrence of Death from Cardiovascular (CV) Causes, Myocardial Infarction (MI), or Stroke (MACE-3)
Time to First Occurrence of a component event of MACE-3
Secondary Outcome Measures
Time to Death from Any Cause
Time to Death from Any Cause
Time to CV Death
Time to CV Death
Time to First Occurrence of MI
Time to First Occurrence of MI
Time to First Occurrence of Stroke
Time to First Occurrence of Stroke
Time to First Occurrence of the Expanded Composite of CV Death, MI, Stroke, Coronary Revascularization, or Hospitalization for Unstable Angina
Time to First Occurrence of the Expanded Composite of CV Death, MI, Stroke, Coronary Revascularization, or Hospitalization for Unstable Angina
Cumulative Number of CV Deaths and Total (First and Recurrent) Heart Failure Events Requiring Hospitalization and/or Urgent Heart Failure Visits
Cumulative Number of CV Deaths and Total (First and Recurrent) Heart Failure Events Requiring Hospitalization and/or Urgent Heart Failure Visits
Percentage of Participants with More than 10% Weight Loss
Percentage of Participants with More than 10% Weight Loss
Change from Baseline in Body Weight
Change from Baseline in Body Weight
Change from Baseline in Hemoglobin A1c (HbA1c)
Change from Baseline in HbA1c
Change from Baseline in Urinary Albumin to Creatinine Ratio
Change from Baseline in Urinary Albumin to Creatinine Ratio
Change from Baseline in Blood Lipids
Change from Baseline in Blood Lipids (Total Cholesterol, Low-Density Lipoprotein Cholesterol, High-Density Lipoprotein Cholesterol, and Triglycerides)
Time to First Occurrence of Revascularization
Time to First Occurrence of Revascularization
Time to First Occurrence of Hospitalization Due to Unstable Angina
Time to First Occurrence of Hospitalization Due to Unstable Angina
Time to First Occurrence of New or Worsening Nephropathy
Time to First Occurrence of New or Worsening Nephropathy
Cumulative Number of Primary Composite Events of CV Death and Total (First and Recurrent) MI and/or Stroke
Cumulative Number of Primary Composite Events of CV Death and Total (First and Recurrent) MI and/or Stroke
Full Information
NCT ID
NCT04255433
First Posted
February 3, 2020
Last Updated
October 18, 2023
Sponsor
Eli Lilly and Company
1. Study Identification
Unique Protocol Identification Number
NCT04255433
Brief Title
A Study of Tirzepatide (LY3298176) Compared With Dulaglutide on Major Cardiovascular Events in Participants With Type 2 Diabetes
Acronym
SURPASS-CVOT
Official Title
The Effect of Tirzepatide Versus Dulaglutide on Major Adverse Cardiovascular Events in Patients With Type 2 Diabetes (SURPASS-CVOT)
Study Type
Interventional
2. Study Status
Record Verification Date
October 2023
Overall Recruitment Status
Active, not recruiting
Study Start Date
May 29, 2020 (Actual)
Primary Completion Date
October 17, 2024 (Anticipated)
Study Completion Date
October 17, 2024 (Anticipated)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Eli Lilly and Company
4. Oversight
Studies a U.S. FDA-regulated Drug Product
Yes
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
The purpose of the trial is to assess the efficacy and safety of tirzepatide to dulaglutide in participants with type 2 diabetes and increased cardiovascular risk.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Type 2 Diabetes Mellitus
Keywords
Diabetes Mellitus, Diabetes Mellitus, Type 2, Glucose Metabolism Disorders, Metabolic Diseases, Endocrine System Diseases, Hypoglycemic Agents, Physiological Effects of Drugs, Tirzepatide, Incretins, Glucagon-Like Peptide 1, Gastric Inhibitory Polypeptide, Hormones, Hormones, Hormone Substitutes, and Hormone Antagonists
7. Study Design
Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
ParticipantInvestigator
Allocation
Randomized
Enrollment
13299 (Actual)
8. Arms, Groups, and Interventions
Arm Title
Tirzepatide
Arm Type
Experimental
Arm Description
Tirzepatide administered subcutaneously (SC) once a week.
Arm Title
Dulaglutide
Arm Type
Active Comparator
Arm Description
Dulaglutide administered SC once a week.
Intervention Type
Drug
Intervention Name(s)
Tirzepatide
Other Intervention Name(s)
LY3298176
Intervention Description
Administered SC
Intervention Type
Drug
Intervention Name(s)
Dulaglutide
Other Intervention Name(s)
LY2189265
Intervention Description
Administered SC
Primary Outcome Measure Information:
Title
Time to First Occurrence of Death from Cardiovascular (CV) Causes, Myocardial Infarction (MI), or Stroke (MACE-3)
Description
Time to First Occurrence of a component event of MACE-3
Time Frame
Randomization up to Study Completion (Approximate Maximum 54 Months)
Secondary Outcome Measure Information:
Title
Time to Death from Any Cause
Description
Time to Death from Any Cause
Time Frame
Randomization up to Study Completion (Approximate Maximum 54 Months)
Title
Time to CV Death
Description
Time to CV Death
Time Frame
Randomization up to Study Completion (Approximate Maximum 54 Months)
Title
Time to First Occurrence of MI
Description
Time to First Occurrence of MI
Time Frame
Randomization up to Study Completion (Approximate Maximum 54 Months)
Title
Time to First Occurrence of Stroke
Description
Time to First Occurrence of Stroke
Time Frame
Randomization up to Study Completion (Approximate Maximum 54 Months)
Title
Time to First Occurrence of the Expanded Composite of CV Death, MI, Stroke, Coronary Revascularization, or Hospitalization for Unstable Angina
Description
Time to First Occurrence of the Expanded Composite of CV Death, MI, Stroke, Coronary Revascularization, or Hospitalization for Unstable Angina
Time Frame
Randomization up to Study Completion (Approximate Maximum 54 Months)
Title
Cumulative Number of CV Deaths and Total (First and Recurrent) Heart Failure Events Requiring Hospitalization and/or Urgent Heart Failure Visits
Description
Cumulative Number of CV Deaths and Total (First and Recurrent) Heart Failure Events Requiring Hospitalization and/or Urgent Heart Failure Visits
Time Frame
End of Study (Approximate Maximum 54 Months)
Title
Percentage of Participants with More than 10% Weight Loss
Description
Percentage of Participants with More than 10% Weight Loss
Time Frame
36 Months
Title
Change from Baseline in Body Weight
Description
Change from Baseline in Body Weight
Time Frame
Baseline, End of Study (Approximate Maximum 54 Months)
Title
Change from Baseline in Hemoglobin A1c (HbA1c)
Description
Change from Baseline in HbA1c
Time Frame
Baseline, End of Study (Approximate Maximum 54 Months)
Title
Change from Baseline in Urinary Albumin to Creatinine Ratio
Description
Change from Baseline in Urinary Albumin to Creatinine Ratio
Time Frame
Baseline, End of Study (Approximate Maximum 54 Months)
Title
Change from Baseline in Blood Lipids
Description
Change from Baseline in Blood Lipids (Total Cholesterol, Low-Density Lipoprotein Cholesterol, High-Density Lipoprotein Cholesterol, and Triglycerides)
Time Frame
Baseline, End of Study (Approximate Maximum 54 Months)
Title
Time to First Occurrence of Revascularization
Description
Time to First Occurrence of Revascularization
Time Frame
Randomization up to Study Completion (Approximate Maximum 54 Months)
Title
Time to First Occurrence of Hospitalization Due to Unstable Angina
Description
Time to First Occurrence of Hospitalization Due to Unstable Angina
Time Frame
Randomization up to Study Completion (Approximate Maximum 54 Months)
Title
Time to First Occurrence of New or Worsening Nephropathy
Description
Time to First Occurrence of New or Worsening Nephropathy
Time Frame
Randomization up to Study Completion (Approximate Maximum 54 Months)
Title
Cumulative Number of Primary Composite Events of CV Death and Total (First and Recurrent) MI and/or Stroke
Description
Cumulative Number of Primary Composite Events of CV Death and Total (First and Recurrent) MI and/or Stroke
Time Frame
End of Study (Approximate Maximum 54 Months)
10. Eligibility
Sex
All
Minimum Age & Unit of Time
40 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
Have a diagnosis of type 2 diabetes
Have confirmed atherosclerotic cardiovascular disease
HbA1c ≥7.0% to ≤10.5%
Body mass index (BMI) ≥25 kilograms per meter squared (kg/m²)
Exclusion Criteria:
Have had a major cardiovascular event within the last 60 days
Have type 1 diabetes mellitus
Have a history of severe hypoglycemia and/or hypoglycemia unawareness within the last 6 months
Are currently planning treatment for diabetic retinopathy and/or macular edema
Currently planning a coronary, carotid, or peripheral artery revascularization
Have a history of pancreatitis
Have a history of ketoacidosis or hyperosmolar state/coma
Have a known clinically significant gastric emptying abnormality, have undergone or currently planning any gastric outlet obstruction, or have undergone or currently planning any gastric bypass (bariatric) surgery or restrictive bariatric surgery
Have a history of an active or untreated malignancy or are in remission from a clinically significant malignancy for less than 5 years
Have a family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN-2)
Have had a blood transfusion or severe blood loss within 90 days prior to screening or have known hematological conditions that may interfere with HbA1c measurement
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST)
Organizational Affiliation
Eli Lilly and Company
Official's Role
Study Director
Facility Information:
Facility Name
University of Alabama at Birmingham Medical Center
City
Birmingham
State/Province
Alabama
ZIP/Postal Code
35294
Country
United States
Facility Name
John Muir Medical Center - Concord Campus
City
Concord
State/Province
California
ZIP/Postal Code
94520
Country
United States
Facility Name
Valley Clinical Trials, Inc.
City
Covina
State/Province
California
ZIP/Postal Code
91723
Country
United States
Facility Name
AMCR Institute
City
Escondido
State/Province
California
ZIP/Postal Code
92025
Country
United States
Facility Name
Valley Research
City
Fresno
State/Province
California
ZIP/Postal Code
93720
Country
United States
Facility Name
UCSD - Altman Clinical and Translational Research Institute (ACTRI)
City
La Jolla
State/Province
California
ZIP/Postal Code
92037
Country
United States
Facility Name
Diabetes and Endocrine Associates
City
La Mesa
State/Province
California
ZIP/Postal Code
91942
Country
United States
Facility Name
Monterey Endocrine & Diabetes Institute, Inc.
City
Monterey
State/Province
California
ZIP/Postal Code
93940
Country
United States
Facility Name
Riverside University Health System - Medical Center
City
Moreno Valley
State/Province
California
ZIP/Postal Code
92555
Country
United States
Facility Name
Diabetes Associates Medical Group
City
Orange
State/Province
California
ZIP/Postal Code
92868
Country
United States
Facility Name
Pasadena Clinical Research
City
Pasadena
State/Province
California
ZIP/Postal Code
91105
Country
United States
Facility Name
LCGK Research
City
San Carlos
State/Province
California
ZIP/Postal Code
94070
Country
United States
Facility Name
Norcal Endocrinology & Internal Medicine
City
San Ramon
State/Province
California
ZIP/Postal Code
94583
Country
United States
Facility Name
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
City
Torrance
State/Province
California
ZIP/Postal Code
90502
Country
United States
Facility Name
Coastal Metabolic Research Centre
City
Ventura
State/Province
California
ZIP/Postal Code
93003
Country
United States
Facility Name
CMR of Greater New Haven, LLC
City
Hamden
State/Province
Connecticut
ZIP/Postal Code
06517
Country
United States
Facility Name
Chase Medical Research, LLC
City
Waterbury
State/Province
Connecticut
ZIP/Postal Code
06708
Country
United States
Facility Name
Orlando Heart & Vascular Institute, LLC
City
Altamonte Springs
State/Province
Florida
ZIP/Postal Code
32714
Country
United States
Facility Name
Excel Medical Clinical Trials
City
Boca Raton
State/Province
Florida
ZIP/Postal Code
33434
Country
United States
Facility Name
Encore Medical Research
City
Hollywood
State/Province
Florida
ZIP/Postal Code
33021
Country
United States
Facility Name
East Coast Institute for Research, LLC
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32204
Country
United States
Facility Name
Encore Research Group- Jacksonville Center for Clinical Research
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32216
Country
United States
Facility Name
Ocala Caridovascular Research
City
Ocala
State/Province
Florida
ZIP/Postal Code
34474
Country
United States
Facility Name
Cardiology Partners Clinical Research Institute - Palm Beach Gardens
City
Palm Beach Gardens
State/Province
Florida
ZIP/Postal Code
33410
Country
United States
Facility Name
Peace River Cardiovascular Center
City
Port Charlotte
State/Province
Florida
ZIP/Postal Code
33952
Country
United States
Facility Name
Professional Health Care of Pinellas
City
Saint Petersburg
State/Province
Florida
ZIP/Postal Code
33713
Country
United States
Facility Name
Cardiology Partners Clinical Research Institute - Wellington
City
Wellington
State/Province
Florida
ZIP/Postal Code
33449
Country
United States
Facility Name
Clinical Research of Central Florida
City
Winter Haven
State/Province
Florida
ZIP/Postal Code
33880
Country
United States
Facility Name
Atlanta Diabetes Associates
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30318
Country
United States
Facility Name
Kaiser Permanente - Dutluth, GA
City
Duluth
State/Province
Georgia
ZIP/Postal Code
30096
Country
United States
Facility Name
NSC Research
City
Johns Creek
State/Province
Georgia
ZIP/Postal Code
30024
Country
United States
Facility Name
Physicians Research Associates
City
Lawrenceville
State/Province
Georgia
ZIP/Postal Code
30045
Country
United States
Facility Name
East Coast Institute for Research, LLC
City
Macon
State/Province
Georgia
ZIP/Postal Code
31210
Country
United States
Facility Name
Atlanta Heart Specialists
City
Tucker
State/Province
Georgia
ZIP/Postal Code
30084
Country
United States
Facility Name
East-West Medical Research Institute
City
Honolulu
State/Province
Hawaii
ZIP/Postal Code
96814
Country
United States
Facility Name
Rocky Mountain Clinical Research
City
Idaho Falls
State/Province
Idaho
ZIP/Postal Code
83404
Country
United States
Facility Name
Northwest Heart Clinical Research
City
Arlington Heights
State/Province
Illinois
ZIP/Postal Code
60005
Country
United States
Facility Name
Cedar-Crosse Research Center
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60607
Country
United States
Facility Name
Clinical Investigation Specialists
City
Gurnee
State/Province
Illinois
ZIP/Postal Code
60031
Country
United States
Facility Name
Central Illinois Diabetes and Clinical Research a Division of Prairie Education and Research Cooperative
City
Springfield
State/Province
Illinois
ZIP/Postal Code
62711
Country
United States
Facility Name
University of Iowa
City
Iowa City
State/Province
Iowa
ZIP/Postal Code
52242
Country
United States
Facility Name
Iowa Diabetes and Endocrinology Research Center
City
West Des Moines
State/Province
Iowa
ZIP/Postal Code
50265
Country
United States
Facility Name
The University of Kansas - Clinical Research Center
City
Fairway
State/Province
Kansas
ZIP/Postal Code
66205
Country
United States
Facility Name
Cotton O'Neil Clinical Research Center - Central Office
City
Topeka
State/Province
Kansas
ZIP/Postal Code
66606
Country
United States
Facility Name
Cotton O'Neil Clinical Research Center
City
Topeka
State/Province
Kansas
ZIP/Postal Code
66606
Country
United States
Facility Name
Qualmedica Research
City
Bowling Green
State/Province
Kentucky
ZIP/Postal Code
42101
Country
United States
Facility Name
L-MARC Research Center
City
Louisville
State/Province
Kentucky
ZIP/Postal Code
40213
Country
United States
Facility Name
Maryland Cardiovascular Specialists
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21229
Country
United States
Facility Name
MD Medical Research
City
Oxon Hill
State/Province
Maryland
ZIP/Postal Code
20745
Country
United States
Facility Name
Endocrine and Metabolic Consultants
City
Rockville
State/Province
Maryland
ZIP/Postal Code
20852
Country
United States
Facility Name
Joslin Diabetes Center
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02215
Country
United States
Facility Name
ActivMed Practices and Research
City
Methuen
State/Province
Massachusetts
ZIP/Postal Code
01844
Country
United States
Facility Name
Infinity Medical Research
City
North Dartmouth
State/Province
Massachusetts
ZIP/Postal Code
02747
Country
United States
Facility Name
Arcturus Healthcare , PLC, Troy Internal Medicine Research Division
City
Troy
State/Province
Michigan
ZIP/Postal Code
48098
Country
United States
Facility Name
St. John's Hospital
City
Edina
State/Province
Minnesota
ZIP/Postal Code
55435
Country
United States
Facility Name
M Health Fairview St. John's Hospital
City
Maplewood
State/Province
Minnesota
ZIP/Postal Code
55109
Country
United States
Facility Name
CentraCare Heart & Vascular Center
City
Saint Cloud
State/Province
Minnesota
ZIP/Postal Code
56303
Country
United States
Facility Name
StudyMetrix Research
City
Saint Peters
State/Province
Missouri
ZIP/Postal Code
63303
Country
United States
Facility Name
Mercy Research - Smith Glynn Callaway
City
Springfield
State/Province
Missouri
ZIP/Postal Code
65807
Country
United States
Facility Name
Clinvest Research LLC
City
Springfield
State/Province
Missouri
ZIP/Postal Code
65810
Country
United States
Facility Name
Billings Clinic
City
Billings
State/Province
Montana
ZIP/Postal Code
59101
Country
United States
Facility Name
Mercury Street Medical Group, PLLC
City
Butte
State/Province
Montana
ZIP/Postal Code
59701
Country
United States
Facility Name
VA Nebraska-Western Iowa Health Care System
City
Omaha
State/Province
Nebraska
ZIP/Postal Code
68105
Country
United States
Facility Name
Southern Nh Diabetes and Endocrinology
City
Nashua
State/Province
New Hampshire
ZIP/Postal Code
03060
Country
United States
Facility Name
Albany Medical College, Division of Community Endocrinology
City
Albany
State/Province
New York
ZIP/Postal Code
12203
Country
United States
Facility Name
Great Lakes Medical Research, LLC
City
Westfield
State/Province
New York
ZIP/Postal Code
14787
Country
United States
Facility Name
Duke University
City
Durham
State/Province
North Carolina
ZIP/Postal Code
27710
Country
United States
Facility Name
PMG Research Inc., d/b/a PMG of Piedmont Healthcare
City
Mooresville
State/Province
North Carolina
ZIP/Postal Code
28117
Country
United States
Facility Name
PMG Research of Wilmington, LLC
City
Wilmington
State/Province
North Carolina
ZIP/Postal Code
24801
Country
United States
Facility Name
Lillestol Research
City
Fargo
State/Province
North Dakota
ZIP/Postal Code
58104
Country
United States
Facility Name
Cleveland Clinic Foundation
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44195
Country
United States
Facility Name
Alliance for Multispecialty Research, LLC
City
Norman
State/Province
Oklahoma
ZIP/Postal Code
73069
Country
United States
Facility Name
Heritage Valley Medical Group, Inc.
City
Beaver
State/Province
Pennsylvania
ZIP/Postal Code
15009
Country
United States
Facility Name
Decpa, Llc
City
Feasterville
State/Province
Pennsylvania
ZIP/Postal Code
19053
Country
United States
Facility Name
Office 18
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15236
Country
United States
Facility Name
Cardiology Consultants of Philadelphia Yardley
City
Yardley
State/Province
Pennsylvania
ZIP/Postal Code
19067
Country
United States
Facility Name
Ralph H. Johnson VA Medical Center
City
Charleston
State/Province
South Carolina
ZIP/Postal Code
29401
Country
United States
Facility Name
Tribe Clinical Research, LLC
City
Greenville
State/Province
South Carolina
ZIP/Postal Code
29607
Country
United States
Facility Name
PMG Research, Inc. d/b/a PMG Research of Knoxville
City
Knoxville
State/Province
Tennessee
ZIP/Postal Code
37938
Country
United States
Facility Name
Private Practice - Dr. Osvaldo A. Brusco
City
Corpus Christi
State/Province
Texas
ZIP/Postal Code
78414
Country
United States
Facility Name
Dallas Diabetes Research Center
City
Dallas
State/Province
Texas
ZIP/Postal Code
75230
Country
United States
Facility Name
North Texas Endocrine Center
City
Dallas
State/Province
Texas
ZIP/Postal Code
75231
Country
United States
Facility Name
Research Institute of Dallas
City
Dallas
State/Province
Texas
ZIP/Postal Code
75231
Country
United States
Facility Name
Texas Health Physicians Group
City
Dallas
State/Province
Texas
ZIP/Postal Code
75231
Country
United States
Facility Name
Galenos Research
City
Dallas
State/Province
Texas
ZIP/Postal Code
75251
Country
United States
Facility Name
Academy of Diabetes, Thyroid and Endocrine
City
El Paso
State/Province
Texas
ZIP/Postal Code
79935
Country
United States
Facility Name
Diabetes and Thyroid Center of Ft. Worth
City
Fort Worth
State/Province
Texas
ZIP/Postal Code
76132
Country
United States
Facility Name
Northwest Houston Cardiology - Cypress
City
Houston
State/Province
Texas
ZIP/Postal Code
77070
Country
United States
Facility Name
North Hills Family Medicine/North Hills Medical Research
City
North Richland Hills
State/Province
Texas
ZIP/Postal Code
76180
Country
United States
Facility Name
Audie L Murphy VA Hospital
City
San Antonio
State/Province
Texas
ZIP/Postal Code
75231
Country
United States
Facility Name
Northwest Houston Heart Center
City
Tomball
State/Province
Texas
ZIP/Postal Code
77375-4536
Country
United States
Facility Name
Physicians' Research Options
City
Draper
State/Province
Utah
ZIP/Postal Code
84020
Country
United States
Facility Name
Advanced Research Institute
City
Ogden
State/Province
Utah
ZIP/Postal Code
84405
Country
United States
Facility Name
Alpine Medical Group
City
Salt Lake City
State/Province
Utah
ZIP/Postal Code
84102
Country
United States
Facility Name
Kalo Clinical Research
City
West Valley City
State/Province
Utah
ZIP/Postal Code
84120
Country
United States
Facility Name
MultiCare Good Samaritan Hospital
City
Puyallup
State/Province
Washington
ZIP/Postal Code
98372
Country
United States
Facility Name
VA Puget Sound Health Care System
City
Seattle
State/Province
Washington
ZIP/Postal Code
98108
Country
United States
Facility Name
Clinical Investigation Specialists
City
Kenosha
State/Province
Wisconsin
ZIP/Postal Code
53144
Country
United States
Facility Name
Instituto de Investigaciones Clínicas Bahia Blanca
City
Bahía Blanca
State/Province
Buenos Aires
ZIP/Postal Code
8000
Country
Argentina
Facility Name
Organizacion Medica de Investigacion
City
Caba
State/Province
Buenos Aires
ZIP/Postal Code
C1015
Country
Argentina
Facility Name
CEDIC
City
Caba
State/Province
Buenos Aires
ZIP/Postal Code
C1060ABN
Country
Argentina
Facility Name
Stat Research S.A.
City
Capital Federal
State/Province
Buenos Aires
ZIP/Postal Code
1023
Country
Argentina
Facility Name
Centro de Investigaciones Metabólicas (CINME)
City
Ciudad Autónoma de Buenos Aires
State/Province
Buenos Aires
ZIP/Postal Code
1056
Country
Argentina
Facility Name
DIM Clínica Privada
City
Ramos Mejía
State/Province
Buenos Aires
ZIP/Postal Code
1704
Country
Argentina
Facility Name
Go Centro Medico San Nicolás
City
San Nicolas
State/Province
Buenos Aires
ZIP/Postal Code
2900
Country
Argentina
Facility Name
Centro Médico Viamonte
City
Buenos Aires
State/Province
Ciudad Autónoma De Buenos Aires
ZIP/Postal Code
C1120AAC
Country
Argentina
Facility Name
Mautalen Salud e Investigación
City
Buenos Aires
State/Province
Ciudad Autónoma De Buenos Aires
ZIP/Postal Code
C1128AAF
Country
Argentina
Facility Name
CEMEDIAB
City
C.a.b.a.
State/Province
Ciudad Autónoma De Buenos Aires
ZIP/Postal Code
C1205AAO
Country
Argentina
Facility Name
Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada
City
Ciudad Autonoma de Buenos Aires
State/Province
Ciudad Autónoma De Buenos Aires
ZIP/Postal Code
C1425AGC
Country
Argentina
Facility Name
Centro Medico Privado CEMAIC
City
Capital
State/Province
Córdoba
ZIP/Postal Code
X5008HHW
Country
Argentina
Facility Name
Centro Medico Privado San Vicente Diabetes
City
Cordoba
State/Province
Córdoba
ZIP/Postal Code
5006
Country
Argentina
Facility Name
Instituto Médico Catamarca IMEC
City
Rosario
State/Province
Santa Fe
ZIP/Postal Code
2000
Country
Argentina
Facility Name
Instituto Médico Fundación Grupo Colaborativo Rosario Investigación y Prevención Medica
City
Rosario
State/Province
Santa Fe
ZIP/Postal Code
2000
Country
Argentina
Facility Name
Instituto de Investigaciones Clinicas Rosario
City
Rosario
State/Province
Santa Fe
ZIP/Postal Code
S2000CVD
Country
Argentina
Facility Name
Centro de Investigaciones Médicas Tucuman
City
SAN M. DE Tucuman
State/Province
Tucumán
ZIP/Postal Code
T4000AXL
Country
Argentina
Facility Name
Clínica Mayo de Urgencias Médicas Cruz Blanca S.R.L
City
San Miguel de Tucuman
State/Province
Tucumán
ZIP/Postal Code
4000
Country
Argentina
Facility Name
Investigaciones Clínicas Tucumán
City
San Miguel de Tucuman
State/Province
Tucumán
ZIP/Postal Code
4000
Country
Argentina
Facility Name
CEMEDIC
City
Buenos Aires
ZIP/Postal Code
1407
Country
Argentina
Facility Name
Glenny Corp
City
Buenos Aires
ZIP/Postal Code
1430
Country
Argentina
Facility Name
CIPREC
City
Buenos aires
ZIP/Postal Code
C1061
Country
Argentina
Facility Name
Asociación de Beneficencia Hospital Sirio Libanés
City
Buenos Aires
ZIP/Postal Code
C1419AHN
Country
Argentina
Facility Name
Centro Universitario de Investigación en Farmacologia Clínic
City
Corrientes
ZIP/Postal Code
3400
Country
Argentina
Facility Name
Instituto de Cardiología "Juana F. Cabral"
City
Corrientes
ZIP/Postal Code
3400
Country
Argentina
Facility Name
CIDIM-Centro Integral de Diagnostico por Imagenes Marchegiani
City
Córdoba
ZIP/Postal Code
X5000AVE
Country
Argentina
Facility Name
Centro Diabetológico Dr. Waitman
City
Córdoba
ZIP/Postal Code
X5000JJS
Country
Argentina
Facility Name
Instituto Médico Alas
City
Salta
ZIP/Postal Code
4400
Country
Argentina
Facility Name
Sanatorio Norte
City
Santiago del Estero
ZIP/Postal Code
4200
Country
Argentina
Facility Name
The AIM Centre / Hunter Diabetes Centre
City
Merewether
State/Province
New South Wales
ZIP/Postal Code
2291
Country
Australia
Facility Name
Core Research Group
City
Brisbane
State/Province
Queensland
ZIP/Postal Code
4064
Country
Australia
Facility Name
Gold Coast University Hospital
City
Southport
State/Province
Queensland
ZIP/Postal Code
4215
Country
Australia
Facility Name
The Townsville Hospital
City
Townsville
State/Province
Queensland
ZIP/Postal Code
4814
Country
Australia
Facility Name
School of Medicine, Fremantle Hospital
City
Fremantle
State/Province
Western Australia
ZIP/Postal Code
6160
Country
Australia
Facility Name
GenesisCare
City
Joondalup
State/Province
Western Australia
ZIP/Postal Code
6027
Country
Australia
Facility Name
GenesisCare
City
Murdoch
State/Province
Western Australia
ZIP/Postal Code
6150
Country
Australia
Facility Name
Uniklinikum Salzburg
City
Salzburg
ZIP/Postal Code
5020
Country
Austria
Facility Name
Klinik Landstraße
City
Wien
ZIP/Postal Code
1030
Country
Austria
Facility Name
Zentrum für klinische Studien Dr Hanusch Gmbh
City
Wien
ZIP/Postal Code
1060
Country
Austria
Facility Name
Université Libre de Bruxelles - Hôpital Erasme
City
Brussels
State/Province
Bruxelles-Capitale, Région De
ZIP/Postal Code
1070
Country
Belgium
Facility Name
ZNA Jan Palfijn
City
Merksem
State/Province
Vlaams Gewest
ZIP/Postal Code
2170
Country
Belgium
Facility Name
AZ Sint-Jan Brugge-Oostende AV
City
Brugge
State/Province
West-Vlaanderen
ZIP/Postal Code
8000
Country
Belgium
Facility Name
Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman
City
Liège
ZIP/Postal Code
4000
Country
Belgium
Facility Name
CEDOES
City
Vitória
State/Province
Espírito Santo
ZIP/Postal Code
29055450
Country
Brazil
Facility Name
Pesquisa Clínica em Diabetes - Dra Rosângela Réa
City
Curitiba
State/Province
Paraná
ZIP/Postal Code
80045170
Country
Brazil
Facility Name
Núcleo de Pesquisa Clínica do Rio Grande do Sul
City
Porto Alegre
State/Province
Rio Grande Do Sul
ZIP/Postal Code
90430-001
Country
Brazil
Facility Name
Loema Instituto de Pesquisa Clinica
City
Campinas
State/Province
São Paulo
ZIP/Postal Code
13092-133
Country
Brazil
Facility Name
CPCLIN
City
Sao Paulo
State/Province
São Paulo
ZIP/Postal Code
01228-200
Country
Brazil
Facility Name
ISPEM - Instituto São José dos Campos em Pesquisas Médicas
City
São José dos Campos
State/Province
São Paulo
ZIP/Postal Code
12243-280
Country
Brazil
Facility Name
IBPClin - Instituto Brasil de Pesquisa Clínica
City
Rio de Janeiro
ZIP/Postal Code
22241-180
Country
Brazil
Facility Name
CPQuali Pesquisa Clínica
City
São Paulo
ZIP/Postal Code
01228-000
Country
Brazil
Facility Name
LMC Diabetes & Endocrinology
City
Calgary
State/Province
Alberta
ZIP/Postal Code
T2H 2G4
Country
Canada
Facility Name
BC Diabetes Office
City
Vancouver
State/Province
British Columbia
ZIP/Postal Code
V5Y 3W2
Country
Canada
Facility Name
Dr. M.B. Jones Inc.
City
Victoria
State/Province
British Columbia
ZIP/Postal Code
V8V 4A1
Country
Canada
Facility Name
Winnipeg Clinic
City
Winnipeg
State/Province
Manitoba
ZIP/Postal Code
MB R3C 0N2
Country
Canada
Facility Name
LMC Clinical Research Inc. (Barrie)
City
Barrie
State/Province
Ontario
ZIP/Postal Code
L4N 7L3
Country
Canada
Facility Name
LMC Diabetes & Endocrinology
City
Brampton
State/Province
Ontario
ZIP/Postal Code
L6S 0C9
Country
Canada
Facility Name
Aggarwal and Associates Limited
City
Brampton
State/Province
Ontario
ZIP/Postal Code
L6T 0G1
Country
Canada
Facility Name
Cambridge Cardiac Care Centre
City
Cambridge
State/Province
Ontario
ZIP/Postal Code
N1R 6V6
Country
Canada
Facility Name
LMC Clinical Research Inc. (Thornhill)
City
Concord
State/Province
Ontario
ZIP/Postal Code
L4K 4M2
Country
Canada
Facility Name
Milestone Research Inc.
City
London
State/Province
Ontario
ZIP/Postal Code
N5W 6A2
Country
Canada
Facility Name
North York Diagnostic and Cardiac Centre
City
North York
State/Province
Ontario
ZIP/Postal Code
M6B 3H7
Country
Canada
Facility Name
LMC Clinical Research Inc. (Oakville)
City
Oakville
State/Province
Ontario
ZIP/Postal Code
L6M 1M1
Country
Canada
Facility Name
Private Practice - Dr. James Cha
City
Oshawa
State/Province
Ontario
ZIP/Postal Code
L1G 2K1
Country
Canada
Facility Name
LMC Manna Research
City
Ottawa
State/Province
Ontario
ZIP/Postal Code
K2J 0V2
Country
Canada
Facility Name
Kawartha Cardiology Clinical Trials
City
Peterborough
State/Province
Ontario
ZIP/Postal Code
K9J 0B2
Country
Canada
Facility Name
Bluewater Clinical Research Group Inc.
City
Sarnia
State/Province
Ontario
ZIP/Postal Code
N7T 4X3
Country
Canada
Facility Name
Diabetes Clinic
City
Smiths Falls
State/Province
Ontario
ZIP/Postal Code
K7A 4W8
Country
Canada
Facility Name
Janik Research Corporation
City
Sudbury
State/Province
Ontario
ZIP/Postal Code
P3B 4H5
Country
Canada
Facility Name
Canadian Phase Onward
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M3J 0K2
Country
Canada
Facility Name
LMC Clinical Research Inc. (Bayview)
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M4G 3E8
Country
Canada
Facility Name
Diabetes Heart Research Centre
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M6G 1M2
Country
Canada
Facility Name
Dr. Anil K. Gupta Medicine Professional Corporation
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M9V 4B4
Country
Canada
Facility Name
Viacar Recherche Clinique
City
Greenfield Park
State/Province
Quebec
ZIP/Postal Code
J4V 2G8
Country
Canada
Facility Name
Centre de Recherche Clinique de Laval
City
Laval
State/Province
Quebec
ZIP/Postal Code
H7T 2P5
Country
Canada
Facility Name
Manna Research
City
Lévis
State/Province
Quebec
ZIP/Postal Code
G6W 0M5
Country
Canada
Facility Name
Clinique Sante Cardio MC
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H1T 3Y7
Country
Canada
Facility Name
Peking University First Hospital
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100034
Country
China
Facility Name
Beijing Friendship Hospital
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100050
Country
China
Facility Name
The First Hospital of Lanzhou University
City
Lanzhou
State/Province
Gansu
ZIP/Postal Code
730000
Country
China
Facility Name
Lanzhou university second hospital
City
Lanzhou
State/Province
Gansu
ZIP/Postal Code
730030
Country
China
Facility Name
First Huai'an Hospital Affiliated to Nanjing Medical University
City
Huai'an
State/Province
Jiangsu
ZIP/Postal Code
223300
Country
China
Facility Name
Nanjing First Hospital
City
Nanjing Shi
State/Province
Jiangsu
ZIP/Postal Code
210012
Country
China
Facility Name
Zhongda Hospital Southeast University
City
Nanjing
State/Province
Jiangsu
ZIP/Postal Code
210009
Country
China
Facility Name
The Second Affiliated Hospital of Nanjing Medical University
City
Nanjing
State/Province
Jiangsu
ZIP/Postal Code
210011
Country
China
Facility Name
The First Affiliated Hospital of Nanchang University
City
Nanchang
State/Province
Jiangxi
ZIP/Postal Code
330006
Country
China
Facility Name
General Hospital of Ningxia Medical University
City
Yinchuan
State/Province
Ningxia
ZIP/Postal Code
750004
Country
China
Facility Name
The First Affiliated Hospital of Xi'an Jiaotong University
City
Xi'an
State/Province
Shaanxi
ZIP/Postal Code
710061
Country
China
Facility Name
Jinan Central Hospital
City
Jinan
State/Province
Shandong
ZIP/Postal Code
250013
Country
China
Facility Name
Tianjin Medical University General Hospital
City
Tianjin
State/Province
Tianjin
ZIP/Postal Code
300052
Country
China
Facility Name
Milan Kvapil s.r.o., Diabetologicka ambulance
City
Praha 4
ZIP/Postal Code
14900
Country
Czechia
Facility Name
Centre Hospitalier Sud Francilien
City
Corbeil-Essonnes
State/Province
Île-de-France
ZIP/Postal Code
91106
Country
France
Facility Name
Gemeinschaftspraxis Dres. Jung
City
Deggingen
State/Province
Baden-Württemberg
ZIP/Postal Code
73326
Country
Germany
Facility Name
Marienhospital Stuttgart
City
Stuttgart
State/Province
Baden-Württemberg
ZIP/Postal Code
70199
Country
Germany
Facility Name
Gemeinschaftspraxis Prof. Dr. med. Stephan Jacob, Dr. med. Frohmut Jacob
City
Villingen-Schwenningen
State/Province
Baden-Württemberg
ZIP/Postal Code
78048
Country
Germany
Facility Name
Praxis Sauter & Sauter & Vorbach
City
Wangen
State/Province
Baden-Württemberg
ZIP/Postal Code
88239
Country
Germany
Facility Name
Studienzentrum Aschaffenburg
City
Aschaffenburg
State/Province
Bayern
ZIP/Postal Code
63739
Country
Germany
Facility Name
CIMS Studienzentrum Bamberg
City
Bamberg
State/Province
Bayern
ZIP/Postal Code
96049
Country
Germany
Facility Name
Private Practice - Dr. Ilka Simon-Wagner
City
Lichtenfels
State/Province
Bayern
ZIP/Postal Code
96215
Country
Germany
Facility Name
CDG Studienambulanz Hartard
City
München
State/Province
Bayern
ZIP/Postal Code
80809
Country
Germany
Facility Name
Medizinisches Versorgungszentrum am Bahnhof Spandau
City
Spandau
State/Province
Berlin
ZIP/Postal Code
13597
Country
Germany
Facility Name
ZKS Suedbrandenburg
City
Elsterwerda
State/Province
Brandenburg
ZIP/Postal Code
4910
Country
Germany
Facility Name
ClinPhenomics GmbH & Co KG
City
Frankfurt
State/Province
Hessen
ZIP/Postal Code
60596
Country
Germany
Facility Name
Diabetes Zentrum Dr. Tews
City
Gelnhausen
State/Province
Hessen
ZIP/Postal Code
63571
Country
Germany
Facility Name
Diabetologische Schwerpunktpraxis und Praxis für Allgemeinmedizin Dr. Veronika Wenzl-Bauer null Josef Wenzl
City
Rehlingen
State/Province
Niedersachsen
ZIP/Postal Code
66780
Country
Germany
Facility Name
Herz - und Diabeteszentrum Nordrhein - Westfalen, Bad Oeynhausen
City
Bad Oeynhausen
State/Province
Nordrhein-Westfalen
ZIP/Postal Code
32545
Country
Germany
Facility Name
Diabetes- und Stoffwechselpraxis Bochum
City
Bochum
State/Province
Nordrhein-Westfalen
ZIP/Postal Code
44869
Country
Germany
Facility Name
Private Practice - Dr. Claus Busch, Dr. Christian Busch & Dr. Christopher Cramer
City
Dortmund
State/Province
Nordrhein-Westfalen
ZIP/Postal Code
44137
Country
Germany
Facility Name
InnoDiab Forschung Gmbh
City
Essen
State/Province
Nordrhein-Westfalen
ZIP/Postal Code
45136
Country
Germany
Facility Name
Medizentrum Essen Borbeck
City
Essen
State/Province
Nordrhein-Westfalen
ZIP/Postal Code
45355
Country
Germany
Facility Name
Private Practice - Dr. Bernd Becker
City
Essen
State/Province
Nordrhein-Westfalen
ZIP/Postal Code
45355
Country
Germany
Facility Name
Institut für Diabetesforschung GmbH Münster
City
Münster
State/Province
Nordrhein-Westfalen
ZIP/Postal Code
48145
Country
Germany
Facility Name
Diabetologische Schwerpunktpraxis Diabetologikum Speyer
City
Speyer
State/Province
Rheinland-Pfalz
ZIP/Postal Code
67346
Country
Germany
Facility Name
Practice Dr.med. Denger and Dr.med. Pfitzner
City
Friedrichsthal
State/Province
Saarland
ZIP/Postal Code
66299
Country
Germany
Facility Name
Zentrum für klinische Studien
City
Saint Ingbert
State/Province
Saarland
ZIP/Postal Code
66386
Country
Germany
Facility Name
Hausarzt- und Diabetologische Schwerpunktpraxis Hohenmölsen - Weiβenfels
City
Hohenmölsen
State/Province
Sachsen-Anhalt
ZIP/Postal Code
06679
Country
Germany
Facility Name
SMO.MD GmbH
City
Magdeburg
State/Province
Sachsen-Anhalt
ZIP/Postal Code
39120
Country
Germany
Facility Name
Hausärztlich-Kardiologisches MVZ am Felsenkeller GmbH/Zentrum für klinische Studien
City
Dresden
State/Province
Sachsen
ZIP/Postal Code
1277
Country
Germany
Facility Name
SIBAmed GmbH
City
Leipzig
State/Province
Sachsen
ZIP/Postal Code
04103
Country
Germany
Facility Name
Gemeinschaftspraxis Dr. Taeschner/Dr. Bonigut
City
Leipzig
State/Province
Sachsen
ZIP/Postal Code
04249
Country
Germany
Facility Name
AmBeNet GmbH
City
Leipzig
State/Province
Sachsen
ZIP/Postal Code
4107
Country
Germany
Facility Name
Private Practice - Dr. Christine Kosch
City
Pirna
State/Province
Sachsen
ZIP/Postal Code
1796
Country
Germany
Facility Name
MVZ Riesa am Klinikum Döbeln GmbH
City
Riesa
State/Province
Sachsen
ZIP/Postal Code
1589
Country
Germany
Facility Name
Praxis für Inner Medizin - Diabetologische Schwerpunktpraxis
City
Zwenkau
State/Province
Sachsen
ZIP/Postal Code
04442
Country
Germany
Facility Name
Universität zu Lübeck - Institut für Endokrinologie und Diabetes
City
Lübeck
State/Province
Schleswig-Holstein
ZIP/Postal Code
23562
Country
Germany
Facility Name
RED-Institut GmbH
City
Oldenburg
State/Province
Schleswig-Holstein
ZIP/Postal Code
23758
Country
Germany
Facility Name
Private Practice - Dr. Joachim Weimer
City
Reinfeld
State/Province
Schleswig-Holstein
ZIP/Postal Code
23858
Country
Germany
Facility Name
Gemeinschaftspraxis für Diabetologie
City
Eisenach
State/Province
Thüringen
ZIP/Postal Code
99817
Country
Germany
Facility Name
Diabetespraxis Prenzlauer Alle
City
Berlin
ZIP/Postal Code
10409
Country
Germany
Facility Name
Institut für klinische Forschung und Entwicklung
City
Berlin
ZIP/Postal Code
10437
Country
Germany
Facility Name
Diabetologische Schwerpunktpraxis Harburg
City
Hamburg
ZIP/Postal Code
21073
Country
Germany
Facility Name
Diabetes Zentrum Wilhelmsburg
City
Hamburg
ZIP/Postal Code
21109
Country
Germany
Facility Name
Diabeteszentrum Hamburg West
City
Hamburg
ZIP/Postal Code
22607
Country
Germany
Facility Name
St. Josefskrankenhaus Heidelberg
City
Heidelberg
ZIP/Postal Code
69115
Country
Germany
Facility Name
Athens Euroclinic
City
Athens
State/Province
Attikí (Region)
ZIP/Postal Code
115 21
Country
Greece
Facility Name
Studium Egeszseghaz Kft
City
Kalocsa
State/Province
Bács-Kiskun
ZIP/Postal Code
6300
Country
Hungary
Facility Name
Markhot Ferenc Oktatókórház
City
Eger
State/Province
Heves
ZIP/Postal Code
3300
Country
Hungary
Facility Name
Pharma 4 Trial
City
Gyöngyös
State/Province
Heves
ZIP/Postal Code
3200
Country
Hungary
Facility Name
CLINFAN Szolgáltató Kft
City
Szekszárd
State/Province
Tolna
ZIP/Postal Code
7100
Country
Hungary
Facility Name
DRC Gyógyszervizsgáló Központ
City
Balatonfüred
State/Province
Veszprém
ZIP/Postal Code
8230
Country
Hungary
Facility Name
ClinDiab Kft.
City
Budapest
ZIP/Postal Code
1089
Country
Hungary
Facility Name
Strazsahegy Medicina Bt.
City
Budapest
ZIP/Postal Code
H1171
Country
Hungary
Facility Name
G.B. Pant Institute of Postgraduate Medical Education & Research
City
New Delhi
State/Province
Delhi
ZIP/Postal Code
110002
Country
India
Facility Name
All India Institute of Medical Sciences
City
New Delhi
State/Province
Delhi
ZIP/Postal Code
110029
Country
India
Facility Name
Sir Ganga Ram Hospital
City
New Delhi
State/Province
Delhi
ZIP/Postal Code
110060
Country
India
Facility Name
Batra Hospital and Medical Research Centre
City
New Delhi
State/Province
Delhi
ZIP/Postal Code
110062
Country
India
Facility Name
CIMS Hospital - Care Institute of Medical Sciences
City
Ahmedabad
State/Province
Gujarat
ZIP/Postal Code
380060
Country
India
Facility Name
Bangalore Diabetes Centre
City
Bangalore
State/Province
Karnataka
ZIP/Postal Code
560043
Country
India
Facility Name
CHL Hospital Indore
City
Indore
State/Province
Madhya Pradesh
ZIP/Postal Code
452008
Country
India
Facility Name
Topiwala National Medical College & B. Y. L. Nair Charitable Hospital
City
Mumbai
State/Province
Maharashtra
ZIP/Postal Code
400008
Country
India
Facility Name
Madras Diabetes Research Foundation
City
Chennai
State/Province
Tamil Nadu
ZIP/Postal Code
600086
Country
India
Facility Name
Care Hospitals Hyderabad- Banjara Hills
City
Hyderabad
State/Province
Telangana
ZIP/Postal Code
500034
Country
India
Facility Name
Apollo Gleneagles Hospitals Kolkata
City
Kolkata
State/Province
West Bengal
ZIP/Postal Code
700054
Country
India
Facility Name
Sourasky Medical Center
City
Tel Aviv
State/Province
Tell Abīb
ZIP/Postal Code
6423906
Country
Israel
Facility Name
Clalit Health Services Diabetes and Endocrinology Clinic Jerusalem
City
Jerusalem
State/Province
Yerushalayim
ZIP/Postal Code
93106
Country
Israel
Facility Name
Clalit Health Services - Atlit
City
Atlit
State/Province
Ḥeifā
ZIP/Postal Code
30300
Country
Israel
Facility Name
"Fatebenefratelli Isola Tiberina - Gemelli Isola"
City
Rome
State/Province
Lazio
ZIP/Postal Code
186
Country
Italy
Facility Name
Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico
City
Milano
State/Province
Lombardia
ZIP/Postal Code
20122
Country
Italy
Facility Name
A.O.U.C. Policlinico di Bari
City
Bari
State/Province
Puglia
ZIP/Postal Code
70124
Country
Italy
Facility Name
A.O.U. Policlinico Paolo Giaccone
City
Palermo
State/Province
Sicilia
ZIP/Postal Code
90129
Country
Italy
Facility Name
Azienda Ospedaliera Universitaria Pisana
City
Pisa
State/Province
Toscana
ZIP/Postal Code
56124
Country
Italy
Facility Name
Azienda Ospedaliera Mater Domini
City
Catanzaro
ZIP/Postal Code
88100
Country
Italy
Facility Name
Università degli Studi Gabriele D' Annunzio
City
Chieti
ZIP/Postal Code
66100
Country
Italy
Facility Name
Centro Cardiologico Monzino
City
MIlano
ZIP/Postal Code
20138
Country
Italy
Facility Name
Fondazione Salvatore Maugeri Clinica del lavoro
City
Pavia
ZIP/Postal Code
27100
Country
Italy
Facility Name
Uji-Tokushukai Medical Center
City
Uji
State/Province
Kyoto
ZIP/Postal Code
611-0041
Country
Japan
Facility Name
Takatsuki Red Cross Hospital
City
Takatsuki
State/Province
Osaka
ZIP/Postal Code
569-1045
Country
Japan
Facility Name
The Institute for Adult Disease, Asahi Life Foundation
City
Chuo-ku
State/Province
Tokyo
ZIP/Postal Code
103-0002
Country
Japan
Facility Name
Tokyo-Eki Center-building Clinic
City
Chuo-ku
State/Province
Tokyo
ZIP/Postal Code
103-0027
Country
Japan
Facility Name
Fukuwa Clinic
City
Chuo-ku
State/Province
Tokyo
ZIP/Postal Code
104-0031
Country
Japan
Facility Name
Medical Corporation Sato Medical clinic
City
Ootaku
State/Province
Tokyo
ZIP/Postal Code
143-0015
Country
Japan
Facility Name
Jinnouchi Hospital
City
Kumamoto
ZIP/Postal Code
862-0976
Country
Japan
Facility Name
AMC Nishiumeda Clinic
City
Osaka
ZIP/Postal Code
530-0001
Country
Japan
Facility Name
Sakurabashi Watanabe Hospital
City
Osaka
ZIP/Postal Code
530-0001
Country
Japan
Facility Name
Yonsei University-Wonju Severance Christian Hospital
City
Wonju
State/Province
Kang-won-do
ZIP/Postal Code
26426
Country
Korea, Republic of
Facility Name
Korea University Anam Hospital
City
Seoul
State/Province
Seoul-teukbyeolsi [Seoul]
ZIP/Postal Code
2841
Country
Korea, Republic of
Facility Name
Severance Hospital, Yonsei University Health System
City
Seoul
State/Province
Seoul-teukbyeolsi [Seoul]
ZIP/Postal Code
3722
Country
Korea, Republic of
Facility Name
Kyung Hee University Hospital at Gangdong
City
Seoul
State/Province
Seoul-teukbyeolsi [Seoul]
ZIP/Postal Code
5278
Country
Korea, Republic of
Facility Name
Asan Medical Center
City
Seoul
State/Province
Seoul-teukbyeolsi [Seoul]
ZIP/Postal Code
5505
Country
Korea, Republic of
Facility Name
The Catholic Univ. of Korea Seoul St. Mary's Hospital
City
Seoul
State/Province
Seoul-teukbyeolsi [Seoul]
ZIP/Postal Code
6591
Country
Korea, Republic of
Facility Name
Hallym University Kangnam Sacred Heart Hospital
City
Seoul
State/Province
Seoul-teukbyeolsi [Seoul]
ZIP/Postal Code
7441
Country
Korea, Republic of
Facility Name
Keimyung University Dongsan Hospital
City
Daegu
State/Province
Taegu-Kwangyǒkshi
ZIP/Postal Code
42601
Country
Korea, Republic of
Facility Name
Ulsan University Hospital
City
Ulsan
State/Province
Ulsan-Kwangyǒkshi
ZIP/Postal Code
44033
Country
Korea, Republic of
Facility Name
Centro de Investigacion Cardiovascular y Metabólica
City
Tijuana
State/Province
Baja California
ZIP/Postal Code
22500
Country
Mexico
Facility Name
Centro Especializado En Diabetes, Obesidad Y Prevencion De Enfermedades Cardiovasculares
City
Mexico City
State/Province
Distrito Federal
ZIP/Postal Code
11650
Country
Mexico
Facility Name
Centro de Investigacion Medica Integral
City
Guadalajara
State/Province
Jalisco
ZIP/Postal Code
44160
Country
Mexico
Facility Name
Private Practice - Dr. Arechavaleta Granell Maria del Rosario
City
Guadalajara
State/Province
Jalisco
ZIP/Postal Code
44670
Country
Mexico
Facility Name
Instituto de Diabetes, Obesidad y Nutricion
City
Cuernavaca
State/Province
Morelos
ZIP/Postal Code
62250
Country
Mexico
Facility Name
Cardiolink Clin Trials
City
Monterrey
State/Province
Nuevo León
ZIP/Postal Code
64060
Country
Mexico
Facility Name
Unidad Médica para la Salud Integral
City
San Nicolás de los Garza
State/Province
Nuevo León
ZIP/Postal Code
66465
Country
Mexico
Facility Name
Medical Care and Research SA de CV
City
Merida
State/Province
Yucatán
ZIP/Postal Code
97070
Country
Mexico
Facility Name
Centro de Investigacion Medica Aguascalientes
City
Aguascalientes
ZIP/Postal Code
20116
Country
Mexico
Facility Name
Fundación Cardiovascular de Aguascalientes A.C.
City
Aguascalientes
ZIP/Postal Code
20230
Country
Mexico
Facility Name
Hospital Cardiologica Aguescalientes
City
Aguascalientes
ZIP/Postal Code
20230
Country
Mexico
Facility Name
Investigacion En Salud Y Metabolismo S.C / Nutricion Clinica / Unidad de Base de Datos
City
Chihuahua
ZIP/Postal Code
31110
Country
Mexico
Facility Name
Lahoja. Asociacion Para La Investigacion Y La Farmacovigilancia
City
Durango
ZIP/Postal Code
34000
Country
Mexico
Facility Name
Centro de Estudios Clínicos de Querétaro (CECLIQ)
City
Querétaro
ZIP/Postal Code
76000
Country
Mexico
Facility Name
EB Utrecht
City
Almere
State/Province
Flevoland
ZIP/Postal Code
1311RL
Country
Netherlands
Facility Name
Ziekenhuis Rijnstate
City
Arnhem
State/Province
Gelderland
ZIP/Postal Code
6815 AD
Country
Netherlands
Facility Name
Slingeland Ziekenhuis
City
Doetinchem
State/Province
Gelderland
ZIP/Postal Code
7009 BL
Country
Netherlands
Facility Name
Jeroen Bosch ziekenhuis
City
s-Hertogenbosch
State/Province
Noord-Brabant
ZIP/Postal Code
5223 GZ
Country
Netherlands
Facility Name
Reinier de Graaf Ziekenhuis, locatie Delft
City
Delft
ZIP/Postal Code
2625 AD
Country
Netherlands
Facility Name
Universitair Medisch Centrum Utrecht
City
Utrecht
ZIP/Postal Code
3584 CX
Country
Netherlands
Facility Name
Wojewódzki Zespól Specjalistycznej Opieki Zdrowotnej
City
Wrocław
State/Province
Dolnośląskie
ZIP/Postal Code
50-403
Country
Poland
Facility Name
CenterMed Lublin NZOZ
City
Lublin
State/Province
Lubelskie
ZIP/Postal Code
20-044
Country
Poland
Facility Name
Gabinety TERPA
City
Lublin
State/Province
Lubelskie
ZIP/Postal Code
20-333
Country
Poland
Facility Name
NZOZ Medica
City
Lublin
State/Province
Lubelskie
ZIP/Postal Code
20-538
Country
Poland
Facility Name
Instytut Diabetologii
City
Warsaw
State/Province
Mazowieckie
ZIP/Postal Code
02-117
Country
Poland
Facility Name
ETG Warszawa
City
Warszawa
State/Province
Mazowieckie
ZIP/Postal Code
02-793
Country
Poland
Facility Name
Centrum Medyczne AMED
City
Warszawa
State/Province
Mazowiecki
ZIP/Postal Code
00-215
Country
Poland
Facility Name
NZOZ Diab-Endo-Met
City
Krakow
State/Province
Małopolskie
ZIP/Postal Code
31-261
Country
Poland
Facility Name
SN ZOZ Lege Artis Poradnia Diabetologiczna
City
Bialystok
State/Province
Podlaskie
ZIP/Postal Code
15-404
Country
Poland
Facility Name
Niepubliczny Specjalistyczny Zaklad Opieki Zdrowotnej Osrodek Diabetologiczny Popula Spolka Cywilna
City
Bialystok
State/Province
Podlaskie
ZIP/Postal Code
15445
Country
Poland
Facility Name
Centrum Badan Klinicznych PI-House sp. z o.o.
City
Gdynia
State/Province
Pomorskie
ZIP/Postal Code
81-553
Country
Poland
Facility Name
OMEDICA Medical Center
City
Poznan
State/Province
Wielkopolskie
ZIP/Postal Code
60-111
Country
Poland
Facility Name
Gaja Poradnie Lekarskie Maciej Wiza
City
Poznan
State/Province
Wielkopolskie
ZIP/Postal Code
61-251
Country
Poland
Facility Name
Private Practice - Dr. Ewa Krzyzagorska
City
Poznan
State/Province
Wielkopolskie
ZIP/Postal Code
61-655
Country
Poland
Facility Name
NZOZ Salvia CM
City
Katowice
State/Province
Śląskie
ZIP/Postal Code
40-772
Country
Poland
Facility Name
NZOZ Przychodnia Specjalistyczna Andrzej Wittek, Henryk Rudzki
City
Ruda Slaska
State/Province
Śląskie
ZIP/Postal Code
41-709
Country
Poland
Facility Name
Advanced Clinical Research, LLC
City
Bayamon
ZIP/Postal Code
00960
Country
Puerto Rico
Facility Name
Manati Center for Clinical Research
City
Manati
ZIP/Postal Code
00674
Country
Puerto Rico
Facility Name
Research and Cardiovascular Corp.
City
Ponce
ZIP/Postal Code
00717
Country
Puerto Rico
Facility Name
GCM Medical Group, PSC - Hato Rey Site
City
San Juan
ZIP/Postal Code
00917
Country
Puerto Rico
Facility Name
Arkhangelsk Regional Clinical Hospital
City
Arkhangelsk
State/Province
Arkhangel'skaya Oblast'
ZIP/Postal Code
163045
Country
Russian Federation
Facility Name
First City Clinical Hospital E.E. Volosevich
City
Arkhangelsk
State/Province
Arkhangel'skaya Oblast'
ZIP/Postal Code
163045
Country
Russian Federation
Facility Name
Advisory Diagnostic Centre
City
Syktyvkar
State/Province
Komi, Respublika
ZIP/Postal Code
167000
Country
Russian Federation
Facility Name
National Medical Research Center for therapy and preventive medicine
City
Moscow
State/Province
Moskva
ZIP/Postal Code
101990
Country
Russian Federation
Facility Name
Endocrinology Research Center of Rosmedtechnologies
City
Moscow
State/Province
Moskva
ZIP/Postal Code
117036
Country
Russian Federation
Facility Name
Pirogov Russian National Research Medical University
City
Moscow
State/Province
Moskva
ZIP/Postal Code
117997
Country
Russian Federation
Facility Name
First Moscow State Medical University I.M. Sechenov
City
Moscow
State/Province
Moskva
ZIP/Postal Code
119991
Country
Russian Federation
Facility Name
Russian Cardiology Research and Production Complex
City
Moscow
State/Province
Moskva
ZIP/Postal Code
121552
Country
Russian Federation
Facility Name
Moscow City Clinical Hospital Number 52
City
Moscow
State/Province
Moskva
ZIP/Postal Code
123182
Country
Russian Federation
Facility Name
M. F. Vladimirskiy Moscow Regional Research Clinical Institute
City
Moscow
State/Province
Moskva
ZIP/Postal Code
129110
Country
Russian Federation
Facility Name
Moscow City Clinical Hospital Number 52
City
Moscow
State/Province
Moskva
Country
Russian Federation
Facility Name
Novosibirsk State Medical University
City
Novosibirsk
State/Province
Novosibirskaya Oblast'
ZIP/Postal Code
630087
Country
Russian Federation
Facility Name
Rostov State Medical University
City
Rostov-on-Don
State/Province
Rostovskaya Oblast'
ZIP/Postal Code
344022
Country
Russian Federation
Facility Name
Ryazan Regional Clinical Cardiological Dispensary
City
Ryazan
State/Province
Ryazanskaya Oblast'
ZIP/Postal Code
390026
Country
Russian Federation
Facility Name
S.M. Kirov Military Medical Academy
City
Saint Petersburg
State/Province
Sankt-Peterburg
ZIP/Postal Code
194044
Country
Russian Federation
Facility Name
Astarta Clinic
City
Saint-Petersburg
State/Province
Sankt-Peterburg
ZIP/Postal Code
199226
Country
Russian Federation
Facility Name
Regional Clinical Hospital of the Saratov Region
City
Saratov
State/Province
Saratovskaya Oblast'
ZIP/Postal Code
410053
Country
Russian Federation
Facility Name
Tomsk Regional Clinical Hospital
City
Tomsk
State/Province
Tomskaya Oblast'
ZIP/Postal Code
634063
Country
Russian Federation
Facility Name
Sibneyromed Urban Neurological Center
City
Tomsk
State/Province
Tomskaya Oblast'
Country
Russian Federation
Facility Name
Research & Practice
City
Yaroslavl
State/Province
Yaroslavskaya Oblast'
ZIP/Postal Code
150003
Country
Russian Federation
Facility Name
Yaroslavl State Med Acad Clinical Hospital
City
Yaroslavl
State/Province
Yaroslavskaya Oblast'
ZIP/Postal Code
150010
Country
Russian Federation
Facility Name
IN-DIA
City
Lučenec
State/Province
Banskobystrický Kraj
ZIP/Postal Code
984 01
Country
Slovakia
Facility Name
Sin Azucar
City
Malacky
State/Province
Bratislavský Kraj
ZIP/Postal Code
901 01
Country
Slovakia
Facility Name
Diacrin .s.ro.
City
Puchov
State/Province
Bratislavský Kraj
ZIP/Postal Code
020 01
Country
Slovakia
Facility Name
Funkystuff
City
Nove Zamky
State/Province
Nitriansky Kraj
ZIP/Postal Code
940 01
Country
Slovakia
Facility Name
Diabetol
City
Prešov
State/Province
Prešovský Kraj
ZIP/Postal Code
080 01
Country
Slovakia
Facility Name
MED-DIA s.r.o
City
Sabinov
State/Province
Prešovský Kraj
ZIP/Postal Code
8301
Country
Slovakia
Facility Name
Diacrin .s.ro.
City
Bratiislava
State/Province
Trenčiansky Kraj
ZIP/Postal Code
020 01
Country
Slovakia
Facility Name
Diabetes Centrum
City
Trencin
State/Province
Trenčiansky Kraj
ZIP/Postal Code
911 01
Country
Slovakia
Facility Name
Hospital Unviersitario Virgen Nieves
City
Granada
ZIP/Postal Code
18012
Country
Spain
Facility Name
Clínica nuevas Tecnologías en Diabetes y Endocrinología (NTDE)
City
Sevilla
ZIP/Postal Code
41003
Country
Spain
Facility Name
Dalecarlia Clinical Research Center
City
Rättvik
State/Province
Dalarnas Län [se-20]
ZIP/Postal Code
795 30
Country
Sweden
Facility Name
Östersunds Sjukhus
City
Östersund
State/Province
Jämtlands Län [se-23]
ZIP/Postal Code
831 31
Country
Sweden
Facility Name
ProbarE
City
Lund
State/Province
Skåne Län [se-12]
ZIP/Postal Code
222 22
Country
Sweden
Facility Name
Citydiabetes
City
Stockholm
State/Province
Stockholms Län [se-01]
ZIP/Postal Code
112 21
Country
Sweden
Facility Name
Sahlgrenska Universitetssjukhuset Mölndal
City
Mölndal
State/Province
Västra Götalands Län [se-14]
ZIP/Postal Code
431 80
Country
Sweden
Facility Name
Universitetssjukhuset Örebro
City
Örebro
State/Province
Örebro Län [se-18]
ZIP/Postal Code
701 85
Country
Sweden
Facility Name
Changhua Christian Hospital
City
Changhua County
State/Province
Changhua
ZIP/Postal Code
50006
Country
Taiwan
Facility Name
Mackay Memorial Hospital-Hsinchu
City
Hsinchu City
State/Province
Hsinchu
ZIP/Postal Code
300
Country
Taiwan
Facility Name
Hualien Tzu Chi Medical Center
City
Hualien City
State/Province
Hualien
ZIP/Postal Code
970
Country
Taiwan
Facility Name
Chang Gung Memorial Hospital at Kaohsiung
City
Kaohsiung Niao Sung Dist
State/Province
Kaohsiung
ZIP/Postal Code
83301
Country
Taiwan
Facility Name
Chi Mei Medical Center
City
Tainan City
State/Province
Tainan
ZIP/Postal Code
71004
Country
Taiwan
Facility Name
National Cheng Kung University Hospital
City
Tainan
ZIP/Postal Code
704
Country
Taiwan
Facility Name
Taipei Veterans General Hospital
City
Taipei
ZIP/Postal Code
11217
Country
Taiwan
Facility Name
Taichung Veterans General Hospital
City
Taipei
Country
Taiwan
Facility Name
Chang Gung Medical Foundation-Linkou Branch
City
Taoyuan
ZIP/Postal Code
333
Country
Taiwan
Facility Name
Eskisehir Osmangazi University
City
Eskisehir
State/Province
Eskişehir
ZIP/Postal Code
26040
Country
Turkey
Facility Name
Mersin University Medical Faculty
City
Yenişehir
State/Province
Mersin
ZIP/Postal Code
33343
Country
Turkey
Facility Name
Ankara University Medicine Hospital
City
Ankara
ZIP/Postal Code
06230
Country
Turkey
Facility Name
Koç Üniversitesi Hastanesi
City
Istanbul
ZIP/Postal Code
34010
Country
Turkey
Facility Name
Dr. Sadi Konuk Egitim ve Arastirma Hastanesi
City
İstanbul
ZIP/Postal Code
34147
Country
Turkey
Facility Name
Göztepe Eitim Ve Aratrma Hastanesi
City
Istanbul
ZIP/Postal Code
34722
Country
Turkey
Facility Name
Ege Universitesi Hastanesi
City
Izmir
ZIP/Postal Code
35100
Country
Turkey
Facility Name
İnönü Üniversitesi Turgut Özal Tıp Merkezi
City
Malatya
ZIP/Postal Code
44280
Country
Turkey
Facility Name
Chernivetsky Oblasny Endokrynologichny Centr, Oblasna Komunalna Ustanova
City
Chernivtsi
State/Province
Chernivetska Oblast
ZIP/Postal Code
58000
Country
Ukraine
Facility Name
Dnipropetrovsk City Clinical Hospital No. 9
City
Dnipro
State/Province
Dnipropetrovska Oblast
ZIP/Postal Code
49023
Country
Ukraine
Facility Name
L.T. Mala National Institute of Therapy of NAMS of Ukraine
City
Kharkiv
State/Province
Kharkivska Oblast
ZIP/Postal Code
61039
Country
Ukraine
Facility Name
Municipal Non-Profit Enterprise "City clinical hospital №8" of Kharkiv city council
City
Kharkiv
State/Province
Kharkivska Oblast
ZIP/Postal Code
61176
Country
Ukraine
Facility Name
ARTEM
City
Kiev
State/Province
Kyivska Oblast
ZIP/Postal Code
04050
Country
Ukraine
Facility Name
Institute of Endocrinology and Metabolism named after Komissarenko
City
Kiev
State/Province
Kyiv
ZIP/Postal Code
04114
Country
Ukraine
Facility Name
Institute of Endocrinology and Metabolism named after Komissarenko
City
Kiev
State/Province
Kyiv
ZIP/Postal Code
4114
Country
Ukraine
Facility Name
Lviv Regional Endocrinology Dispensary
City
Lviv
State/Province
Lvivska Oblast
ZIP/Postal Code
79000
Country
Ukraine
Facility Name
Lviv City Clinical Hospital #4
City
Lviv
State/Province
Lvivska Oblast
ZIP/Postal Code
79011
Country
Ukraine
Facility Name
Municipal non-profit enterprise'Odesa Regional Clinical Hospital'of Odesa Regional Council
City
Odesa
State/Province
Odeska Oblast
ZIP/Postal Code
65025
Country
Ukraine
Facility Name
Poltova Oblast Clinical Hospital IM.M.V.Sklifosovskoho
City
Poltava
State/Province
Poltavska Oblast
ZIP/Postal Code
36011
Country
Ukraine
Facility Name
Vinnytsia Regional Clinical Endocrinology Dispensary
City
Vinnytsia
State/Province
Vinnytska Oblast
ZIP/Postal Code
21010
Country
Ukraine
Facility Name
Ukrainian State Research Institute Of Medical And Social Problems Of Disability
City
Dnipro
ZIP/Postal Code
49000
Country
Ukraine
Facility Name
Medical Center Ok!Clinic+
City
Kyiv
ZIP/Postal Code
02091
Country
Ukraine
Facility Name
Aberdeen Royal Infirmary
City
Aberdeen
State/Province
Aberdeen City
ZIP/Postal Code
AB25 2ZN
Country
United Kingdom
Facility Name
Southmead Hospital
City
Bristol
State/Province
Bristol, City Of
ZIP/Postal Code
BS10 5NB
Country
United Kingdom
Facility Name
The Royal Cornwall Hospital
City
Truro
State/Province
England
ZIP/Postal Code
TR1 3LJ
Country
United Kingdom
Facility Name
Glasgow Royal Infirmary
City
Glasgow
State/Province
Glasgow City
ZIP/Postal Code
G4 0SF
Country
United Kingdom
Facility Name
Hull and East Yorkshire Hospitals NHS Trust
City
Hull
State/Province
Kingston Upon Hull
ZIP/Postal Code
HU3 2JZ
Country
United Kingdom
Facility Name
Ipswich Hospital
City
Ipswich
State/Province
Suffolk
ZIP/Postal Code
IP4 5PD
Country
United Kingdom
Facility Name
Morriston Hospital
City
Swansea
State/Province
Swansea [Abertawe Gb-ata]
ZIP/Postal Code
SA6 6SG
Country
United Kingdom
Facility Name
University Hospital Aintree
City
Liverpool
ZIP/Postal Code
L9 7AL
Country
United Kingdom
12. IPD Sharing Statement
Plan to Share IPD
Yes
IPD Sharing Plan Description
Anonymized individual patient level data will be provided in a secure access environment upon approval of a research proposal and a signed data sharing agreement.
IPD Sharing Time Frame
Data are available 6 months after the primary publication and approval of the indication studied in the US and EU, whichever is later. Data will be indefinitely available for requesting.
IPD Sharing Access Criteria
A research proposal must be approved by an independent review panel and researchers must sign a data sharing agreement.
IPD Sharing URL
http://vivli.org/
Citations:
PubMed Identifier
35949358
Citation
Kaneko S. Tirzepatide: A Novel, Once-weekly Dual GIP and GLP-1 Receptor Agonist for the Treatment of Type 2 Diabetes. touchREV Endocrinol. 2022 Jun;18(1):10-19. doi: 10.17925/EE.2022.18.1.10. Epub 2022 Jun 16.
Results Reference
derived
Links:
URL
https://trials.lillytrialguide.com/en-US/trial/7Hobv37NARjOCQyknTYfRZ
Description
A Study of Tirzepatide (LY3298176) Compared With Dulaglutide on Major Cardiovascular Events in Participants With Type 2 Diabetes
Learn more about this trial
A Study of Tirzepatide (LY3298176) Compared With Dulaglutide on Major Cardiovascular Events in Participants With Type 2 Diabetes
We'll reach out to this number within 24 hrs