Study on the Effect of Transcranial Magnetic Stimulation in Mild to Moderate Alzheimer's Disease

This is an interventional treatment trial for Mild to Moderate Alzheimer Disease Read More

Inclusion Criteria:

• patients who visited memory clinic of Samsung Medical Center
• aged 55 ~ 90
• diagnosed as probable Alzheimer dementia according to NIA-AA guideline 2011, or MCI patiens with amyloid PET positivity
• below -1SD in SVLTdelayed recall test and RCFT delayed recall test
• K-MMSE >=18
• no epileptic discharge in EEG
• no history of epilepsy
• no arrhythmia or MI in ECG
• can read and write Korean (literate)
• volunteer and agree to the registration

Exclusion Criteria:

• no other neurologic deficit which can cause dementia except for Alzheimer's disease
• paitient who has severe cerebral white matter hyperintensities. (deep white matter >=2.5cm and caps or band >=1.0 cm)
• patients with severe medical disease including caner and ishemic heart disease
• claustrophobia or allergic to contrast of MRI
• medical deviced which is not removable (e.g pacemaker, cochlear implantation, dental prosthesis)
• history of brain surgery, and intervension or surgery of intra/extracranial artery(e.g. carotid artery stent insertion, CEA)
• patient with dyspnea during resting
• history of loss of consciousness for more than 1 hour except for general anesthesia
• patients who cannot read written material because of poor visual acuity
• patients who cannot communicate because of severe hearing difficulty
• history of ototoxicity medication or exposure severe noises
• determined as inapropriate to participate clinical trial