Heart Failure Worsens Muscle Strength in COPD
COPD, CHF, Muscle Weakness
About this trial
This is an interventional basic science trial for COPD
Eligibility Criteria
Inclusion Criteria:
- non-cachectic sedentary patients
- moderate-to-severe COPD according to GOLD classification (FEV1/ FVC <0.7 and predicted post-bronchodilator FEV1 between 30% and 80%)
- no clinical or echocardiographic evidence of HF for the COPD group
- echocardiographic evidence of HF with reduced left ventricular ejection fraction (<40%) for the overlap group
- chronic dyspnoea (MRC scale score 2-4)
- NYHA class 2 or 3.
Exclusion Criteria:
- long-term O2 therapy
- recent (within a year) rehabilitation program
- osteomuscular limitation
- type I or non-controlled type II diabetes mellitus
- peripheral arterial disease associated with claudication
- Patients with preserved ejection fraction HF
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Other
Other
COPD
Overlap
Body composition was assessed using a body composition. The same medical doctor performed all echocardiograms and all patients underwent comprehensive M-mode echocardiography. Spirometry, gas transfer and static lung volumes were measured in all patients. Resting blood gases were obtained by samples from the radial artery. The six-minute walk test and the four-minute step test were performed. All CPET tests were performed on an electronically braked cycle ergometer and standard metabolic and ventilatory responses were measured breath-by-breath using a calibrated, computer-based system. Knee flexors and extensors muscles were analysed by an isokinetic dynamometer. All patients performed two maximal isokinetic tests: 6 repetitions at 60°/s and 20 repetitions at 300°/s.
Body composition was assessed using a body composition. The same medical doctor performed all echocardiograms and all patients underwent comprehensive M-mode echocardiography. Spirometry, gas transfer and static lung volumes were measured in all patients. Resting blood gases were obtained by samples from the radial artery. The six-minute walk test and the four-minute step test were performed. All CPET tests were performed on an electronically braked cycle ergometer and standard metabolic and ventilatory responses were measured breath-by-breath using a calibrated, computer-based system. Knee flexors and extensors muscles were analysed by an isokinetic dynamometer. All patients performed two maximal isokinetic tests: 6 repetitions at 60°/s and 20 repetitions at 300°/s.