CompassHER2-pCR: Decreasing Chemotherapy for Breast Cancer Patients After Pre-surgery Chemo and Targeted Therapy
Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIA Breast Cancer AJCC v8, Anatomic Stage IIB Breast Cancer AJCC v8
About this trial
This is an interventional treatment trial for Anatomic Stage II Breast Cancer AJCC v8
Eligibility Criteria
Inclusion Criteria:
- Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
- Patient must have histologically confirmed HER2-positive primary invasive breast carcinoma, determined by local testing. The tumor must have either HER2 IHC result of 3+ or HER2/CEP17 ratio > 2 with > 4.0 HER2 signals per cell by ISH. Tumors with HER2/CEP17 ISH ratio < 2 are ineligible, even if HER2 copy number is > 6, unless HER2 IHC result is 3+.
- Patients hormone receptor (estrogen receptor [ER] and progesterone receptor [PR]) status must be known and will be determined by local testing. Patients with either hormone receptor -positive or hormone receptor- negative HER2-positive breast cancer are eligible
Patients must have AJCC 8th Edition stage II or IIIa according to anatomic staging table at diagnosis
- Patients without nodal involvement (cN0) are eligible if T size > 2.0 cm (T2-3)
- Patients with nodal involvement (cN1-2) are eligible if T1-3
- Patients with clinical T4 or N3 disease are not eligible
- Patient must be willing and able (i.e., have no contraindication) to receive standard adjuvant therapy, consisting of HER2-directed therapy, radiation (if indicated) and endocrine therapy (if ER+) if achieving pCR at surgery
- Patient with bilateral invasive breast cancers are eligible if both cancers are HER2-positive (as defined in 3.1.3) at least one meets protocol eligibility and neither cancer renders the patient ineligible (i.e. per eligibility 3.1.5)
- Patients with multiple ipsilateral invasive tumors are eligible as long as all tumors are HER2-positive, and at least one tumor focus meets eligibility criteria (per eligibility 3.1.5). Multiple lesions that appear part of the same index tumor do not require additional biopsy/HER2 testing. Multiple lesions that appear part of the same index tumor do not require additional biopsy/HER2 testing. However, even if biopsy is not deemed necessary, consideration should be given to placing a clip in any lesion that is 1 cm or further from the primary tumor to ensure that all tumor is removed at surgery AND that the pathologist can locate all primary sites of tumor to assess pathologic response at surgery.
Patients with a history of other non-breast malignancies are eligible if they have been disease-free for at least 5 years, and are deemed by the investigator to be at low risk for recurrence of that malignancy.
- Patients with the following cancers are eligible if diagnosed and treated within the past 5 years: cervical cancer in situ, basal cell or squamous cell carcinoma of the skin, and localized papillary or follicular thyroid cancer who have completed recommended treatment including surgery. Patients with any other cancers within the last 5 years are ineligible.
- Patents must have a left ventricular ejection fraction (LVEF) within normal institutional parameters (or > 50%)
- Patients must not have > grade 1 peripheral neuropathy of any etiology.
- Patients must have a bilateral mammogram and a diagnostic breast ultrasound [on the side of the cancer(s)] (with or without breast MRI) performed at screening. An axillary ultrasound on the side of the cancer(s) is also required. However, if a patient has a negative axillary physical exam and a baseline MRI without suspicious lymph nodes performed before axillary ultrasound, axillary ultrasound may be omitted. Comprehensive breast and axillary imaging must be performed within 42 days of registration (i.e. the patient's mammogram/ breast ultrasound /axillary ultrasound OR their breast MRI).
- Baseline imaging of the ipsilateral axilla by ultrasound or breast MRI is mandatory. For subjects with axillary lymph node(s) suspicious on clinical exam or imaging, patient must be willing to have a needle aspiration or core biopsy to determine the presence of metastatic disease in the lymph nodes. A clip must be placed in the involved axillary lymph node. (If there are more than 1 suspicious axillary nodes, only one clipped node is required).
- Patient of childbearing potential and sexually active patients must use accepted and effective method(s) of contraception or to abstain from sexual intercourse for the duration of their participation in the study and for 7 months after the last dose of study treatment.
- Patient must be willing and able to sign informed consent
- Leukocytes >= 3,000/mcL (obtained =< 28 days prior to protocol registration)
- Absolute neutrophil count >= 1,500/mcL (obtained =< 28 days prior to protocol registration)
- Platelets >= 100,000/mcL (obtained =< 28 days prior to protocol registration)
- Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) (obtained =< 28 days prior to protocol registration)
- Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 2.5 x institutional ULN (obtained =< 28 days prior to protocol registration)
- Creatinine =< 1.5 x institutional ULN (obtained =< 28 days prior to protocol registration)
- Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial
- For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated
- Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load
Exclusion Criteria:
- Patients must not have impaired decision-making capacity
Patient must not have a history of any prior (ipsilateral or contralateral) invasive breast cancer
- One exception: a patient with a history of T1N0 triple negative breast cancer diagnosed more than 10 years earlier, who remains disease free is eligible
Patient must not have prior ipsilateral ductal breast carcinoma in situ (DCIS). Patients with prior lobular breast carcinoma in situ (LCIS), atypical hyperplasia, other high risk benign lesions or contralateral DCIS (without evidence of microinvasion) are eligible
- NOTE: Patients currently receiving endocrine therapy for prior contralateral DCIS are eligible
Patient must not have stage IV (metastatic) breast cancer
- Staging studies (computed tomography [CT] chest/abdomen/pelvis and a bone scan or positron emission tomography [PET]-CT scan) are required for stage III disease or those with abnormal baseline liver function tests (LFTs), symptoms (e.g. new bone pain) or abnormal physical exam findings (National Comprehensive Cancer Network [NCCN] guidelines version [V]1.2019)
- Patient must not have T4 and/or N3 disease, including inflammatory breast cancer
- Patient must not have any prior treatment for the current breast cancer, including surgery, chemotherapy, hormonal therapy, radiation or experimental therapy
- Patients must not have > grade 1 peripheral neuropathy of any etiology
- Patient must not have a concurrent serious medical condition that would preclude completion of study therapy. For example, uncontrolled hypertension (systolic > 180 mm Hg and/or diastolic > 100 mm Hg) or clinically significant (i.e. active) cardiovascular disease: cerebrovascular accident/stroke or myocardial infarction within 6 months prior to registration, unstable angina, congestive heart failure (CHF) or serious cardiac arrhythmia requiring medication and other concurrent serious diseases that may interfere with planned treatment
Patient must not be pregnant or breast-feeding due to the potential harm to an unborn fetus and possible risk for adverse events in nursing infants with the treatment regimens being used. Patients must also not expect to conceive from the time of registration, while on study treatment, and until at least 7 months after the last dose of study treatment. All patients of childbearing potential must have a blood test or urine study within 14 days prior to registration to rule out pregnancy
- All patients of childbearing potential is anyone, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy; or 3) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
Sites / Locations
- University of Alabama at Birmingham Cancer CenterRecruiting
- Anchorage Associates in Radiation MedicineRecruiting
- Anchorage Radiation Therapy CenterRecruiting
- Alaska Breast Care and Surgery LLCRecruiting
- Alaska Oncology and Hematology LLCRecruiting
- Alaska Women's Cancer CareRecruiting
- Anchorage Oncology CentreRecruiting
- Katmai Oncology GroupRecruiting
- Providence Alaska Medical CenterRecruiting
- Fairbanks Memorial HospitalRecruiting
- Kingman Regional Medical CenterRecruiting
- Cancer Center at Saint Joseph'sRecruiting
- University of Arizona Cancer Center-Orange Grove CampusRecruiting
- Banner University Medical Center - TucsonRecruiting
- University of Arizona Cancer Center-North CampusRecruiting
- Mercy Hospital Fort SmithRecruiting
- CHI Saint Vincent Cancer Center Hot Springs
- NEA Baptist Memorial Hospital and Fowler Family Cancer Center - JonesboroRecruiting
- Mission Hope Medical Oncology - Arroyo GrandeRecruiting
- PCR OncologyRecruiting
- Sutter Auburn Faith HospitalRecruiting
- Sutter Cancer Centers Radiation Oncology Services-AuburnRecruiting
- Alta Bates Summit Medical Center-Herrick CampusRecruiting
- Providence Saint Joseph Medical Center/Disney Family Cancer CenterRecruiting
- Mills-Peninsula Medical CenterRecruiting
- Marshall Cancer CenterRecruiting
- Sutter Cancer Centers Radiation Oncology Services-Cameron ParkRecruiting
- Mercy Cancer Center �� CarmichaelRecruiting
- Mercy San Juan Medical CenterRecruiting
- Eden Hospital Medical CenterRecruiting
- John Muir Medical Center-Concord CampusRecruiting
- Sutter Davis HospitalRecruiting
- Epic Care-DublinRecruiting
- Mercy Cancer Center - Elk GroveRecruiting
- Bay Area Breast Surgeons IncRecruiting
- Epic Care Partners in Cancer CareRecruiting
- Palo Alto Medical Foundation-FremontRecruiting
- Washington HospitalRecruiting
- Keck Medicine of USC Huntington Beach
- Los Angeles County-USC Medical Center
- USC / Norris Comprehensive Cancer Center
- Contra Costa Regional Medical CenterRecruiting
- Fremont - Rideout Cancer CenterRecruiting
- Memorial Medical CenterRecruiting
- Palo Alto Medical Foundation-Camino DivisionRecruiting
- Palo Alto Medical Foundation-Gynecologic OncologyRecruiting
- USC Norris Oncology/Hematology-Newport Beach
- Sutter Cancer Research ConsortiumRecruiting
- Alta Bates Summit Medical Center - Summit Campus
- Bay Area Tumor InstituteRecruiting
- Saint Joseph Hospital - OrangeRecruiting
- Desert Regional Medical CenterRecruiting
- Palo Alto Medical Foundation Health CareRecruiting
- Stanford Cancer Institute Palo AltoRecruiting
- Keck Medical Center of USC Pasadena
- Mercy Cancer Center - RocklinRecruiting
- Sutter Cancer Centers Radiation Oncology Services-RosevilleRecruiting
- Sutter Roseville Medical CenterRecruiting
- Mercy Cancer Center - SacramentoRecruiting
- Sutter Medical Center SacramentoRecruiting
- Saint Helena HospitalRecruiting
- Salinas Valley MemorialRecruiting
- Zuckerberg San Francisco General HospitalRecruiting
- California Pacific Medical Center-Pacific CampusRecruiting
- Stanford Cancer Center South BayRecruiting
- Pacific Central Coast Health Center-San Luis ObispoRecruiting
- Palo Alto Medical Foundation-Santa CruzRecruiting
- Mission Hope Medical Oncology - Santa MariaRecruiting
- Sutter Pacific Medical FoundationRecruiting
- Palo Alto Medical Foundation-SunnyvaleRecruiting
- Gene Upshaw Memorial Tahoe Forest Cancer CenterRecruiting
- Sutter Cancer Centers Radiation Oncology Services-VacavilleRecruiting
- Sutter Solano Medical Center/Cancer CenterRecruiting
- Epic Care Cyberknife CenterRecruiting
- John Muir Medical Center-Walnut CreekRecruiting
- Woodland Memorial HospitalRecruiting
- Rocky Mountain Cancer Centers-AuroraRecruiting
- The Medical Center of Aurora
- University of Colorado HospitalRecruiting
- Boulder Community Foothills HospitalRecruiting
- Rocky Mountain Cancer Centers-BoulderRecruiting
- Rocky Mountain Cancer Centers - CentennialRecruiting
- Penrose-Saint Francis HealthcareRecruiting
- Rocky Mountain Cancer Centers-PenroseRecruiting
- UCHealth Memorial Hospital CentralRecruiting
- Memorial Hospital NorthRecruiting
- Saint Francis Cancer CenterRecruiting
- UCHealth - Cherry CreekRecruiting
- The Women's Imaging CenterRecruiting
- Porter Adventist HospitalRecruiting
- Colorado Blood Cancer InstituteRecruiting
- Presbyterian - Saint Lukes Medical Center - Health OneRecruiting
- Rocky Mountain Cancer Centers-MidtownRecruiting
- Rocky Mountain Cancer Centers-RoseRecruiting
- Rose Medical CenterRecruiting
- Western Surgical Care
- Mercy Medical CenterRecruiting
- Southwest Oncology PCRecruiting
- Mountain Blue Cancer Care Center - SwedishRecruiting
- Rocky Mountain Cancer Centers - SwedishRecruiting
- Swedish Medical CenterRecruiting
- The Melanoma and Skin Cancer InstituteRecruiting
- Poudre Valley HospitalRecruiting
- Cancer Care and Hematology-Fort CollinsRecruiting
- Grand Valley OncologyRecruiting
- North Colorado Medical Center
- UCHealth Greeley HospitalRecruiting
- UCHealth Highlands Ranch HospitalRecruiting
- Rocky Mountain Cancer Centers-LakewoodRecruiting
- Saint Anthony HospitalRecruiting
- Rocky Mountain Cancer Centers-LittletonRecruiting
- Littleton Adventist HospitalRecruiting
- Rocky Mountain Cancer Centers-Sky RidgeRecruiting
- Sky Ridge Medical Center
- UCHealth Lone Tree Health CenterRecruiting
- Longmont United HospitalRecruiting
- Rocky Mountain Cancer Centers-Longmont
- Medical Center of the RockiesRecruiting
- McKee Medical Center
- Parker Adventist HospitalRecruiting
- Saint Mary Corwin Medical CenterRecruiting
- Rocky Mountain Cancer Centers-ThorntonRecruiting
- Hartford HealthCare - Saint Vincent's Medical CenterRecruiting
- Smilow Cancer Hospital-Derby Care CenterRecruiting
- Smilow Cancer Hospital Care Center-FairfieldRecruiting
- Smilow Cancer Hospital Care Center at GlastonburyRecruiting
- Smilow Cancer Hospital Care Center at GreenwichRecruiting
- Smilow Cancer Hospital Care Center - GuifordRecruiting
- Hartford HospitalRecruiting
- Smilow Cancer Hospital Care Center at Saint FrancisRecruiting
- Midstate Medical CenterRecruiting
- The Hospital of Central ConnecticutRecruiting
- Smilow Cancer Center/Yale-New Haven HospitalRecruiting
- Yale UniversityRecruiting
- Yale-New Haven Hospital North Haven Medical CenterRecruiting
- Smilow Cancer Hospital-Orange Care CenterRecruiting
- Smilow Cancer Hospital Care Center at Long RidgeRecruiting
- Stamford Hospital/Bennett Cancer CenterRecruiting
- Smilow Cancer Hospital-Torrington Care CenterRecruiting
- Smilow Cancer Hospital Care Center-TrumbullRecruiting
- Smilow Cancer Hospital-Waterbury Care CenterRecruiting
- Smilow Cancer Hospital Care Center - WaterfordRecruiting
- Beebe South Coastal Health CampusRecruiting
- Beebe Medical CenterRecruiting
- Delaware Clinical and Laboratory Physicians PARecruiting
- Helen F Graham Cancer CenterRecruiting
- Medical Oncology Hematology Consultants PARecruiting
- Christiana Care Health System-Christiana HospitalRecruiting
- Beebe Health CampusRecruiting
- TidalHealth Nanticoke / Allen Cancer Center
- Christiana Care Health System-Wilmington HospitalRecruiting
- Kaiser Permanente-Capitol Hill Medical CenterRecruiting
- Sibley Memorial HospitalRecruiting
- AdventHealth AltamonteRecruiting
- Mount Sinai Comprehensive Cancer Center at AventuraRecruiting
- UM Sylvester Comprehensive Cancer Center at AventuraRecruiting
- AdventHealth CelebrationRecruiting
- Morton Plant HospitalRecruiting
- UM Sylvester Comprehensive Cancer Center at Coral GablesRecruiting
- UM Sylvester Comprehensive Cancer Center at Deerfield BeachRecruiting
- University of Florida Health Science Center - GainesvilleRecruiting
- Memorial Regional Hospital/Joe DiMaggio Children's HospitalRecruiting
- Mayo Clinic in Florida
- AdventHealth Kissimmee
- Mount Sinai Medical CenterRecruiting
- University of Miami Miller School of Medicine-Sylvester Cancer CenterRecruiting
- UM Sylvester Comprehensive Cancer Center at KendallRecruiting
- AdventHealth Medical Group Urology at Orlando
- AdventHealth OrlandoRecruiting
- AdventHealth East Orlando
- Memorial Hospital WestRecruiting
- UM Sylvester Comprehensive Cancer Center at PlantationRecruiting
- Mease Countryside HospitalRecruiting
- Winter Haven HospitalRecruiting
- AdventHealth Winter Park
- Grady Health SystemRecruiting
- Emory University Hospital MidtownRecruiting
- Emory University Hospital/Winship Cancer InstituteRecruiting
- Emory Saint Joseph's HospitalRecruiting
- Northside HospitalRecruiting
- Hamilton Medical Center - Peeples Cancer InstituteRecruiting
- Northside Hospital - DuluthRecruiting
- Northside Hospital - GwinnettRecruiting
- Lewis Cancer and Research Pavilion at Saint Joseph's/CandlerRecruiting
- Suburban Hematology Oncology Associates - SnellvilleRecruiting
- Lewis Hall Singletary Oncology CenterRecruiting
- Saint Alphonsus Cancer Care Center-BoiseRecruiting
- Saint Luke's Cancer Institute - BoiseRecruiting
- Saint Alphonsus Cancer Care Center-CaldwellRecruiting
- Kootenai Health - Coeur d'AleneRecruiting
- Walter Knox Memorial HospitalRecruiting
- Saint Luke's Cancer Institute - FruitlandRecruiting
- Idaho Urologic Institute-MeridianRecruiting
- Saint Luke's Cancer Institute - MeridianRecruiting
- Saint Luke's Cancer Institute - NampaRecruiting
- Saint Alphonsus Cancer Care Center-NampaRecruiting
- Kootenai Clinic Cancer Services - Post FallsRecruiting
- Kootenai Cancer ClinicRecruiting
- Saint Luke's Cancer Institute - Twin FallsRecruiting
- Saint Anthony's HealthRecruiting
- Rush - Copley Medical CenterRecruiting
- Advocate Good Shepherd HospitalRecruiting
- Illinois CancerCare-BloomingtonRecruiting
- Illinois CancerCare-CantonRecruiting
- Memorial Hospital of CarbondaleRecruiting
- SIH Cancer InstituteRecruiting
- Illinois CancerCare-CarthageRecruiting
- Centralia Oncology ClinicRecruiting
- Saint Mary's HospitalRecruiting
- Mount Sinai Hospital Medical CenterRecruiting
- Northwestern UniversityRecruiting
- Rush University Medical CenterRecruiting
- University of IllinoisRecruiting
- Swedish Covenant HospitalRecruiting
- University of Chicago Comprehensive Cancer CenterRecruiting
- Advocate Illinois Masonic Medical CenterRecruiting
- AMG Crystal Lake - OncologyRecruiting
- Carle on VermilionRecruiting
- Cancer Care Specialists of Illinois - DecaturRecruiting
- Decatur Memorial HospitalRecruiting
- Northwestern Medicine Cancer Center KishwaukeeRecruiting
- Illinois CancerCare-DixonRecruiting
- Advocate Good Samaritan HospitalRecruiting
- Carle Physician Group-EffinghamRecruiting
- Crossroads Cancer CenterRecruiting
- Advocate Sherman HospitalRecruiting
- Illinois CancerCare-EurekaRecruiting
- NorthShore University HealthSystem-Evanston HospitalRecruiting
- Illinois CancerCare-GalesburgRecruiting
- Western Illinois Cancer Treatment CenterRecruiting
- Northwestern Medicine Cancer Center DelnorRecruiting
- NorthShore University HealthSystem-Glenbrook HospitalRecruiting
- Ingalls Memorial HospitalRecruiting
- Advocate South Suburban HospitalRecruiting
- NorthShore University HealthSystem-Highland Park HospitalRecruiting
- Duly Health and Care JolietRecruiting
- Illinois CancerCare-Kewanee ClinicRecruiting
- Northwestern Medicine Lake Forest HospitalRecruiting
- AMG Libertyville - OncologyRecruiting
- Condell Memorial HospitalRecruiting
- Illinois CancerCare-MacombRecruiting
- Carle Physician Group-Mattoon/CharlestonRecruiting
- Good Samaritan Regional Health CenterRecruiting
- UC Comprehensive Cancer Center at Silver CrossRecruiting
- Cancer Care Center of O'FallonRecruiting
- Advocate Christ Medical CenterRecruiting
- University of Chicago Medicine-Orland ParkRecruiting
- Illinois CancerCare-Ottawa ClinicRecruiting
- Advocate Lutheran General HospitalRecruiting
- Illinois CancerCare-PekinRecruiting
- Illinois CancerCare-PeoriaRecruiting
- Methodist Medical Center of IllinoisRecruiting
- Illinois CancerCare-PeruRecruiting
- Valley Radiation OncologyRecruiting
- Illinois CancerCare-PrincetonRecruiting
- SwedishAmerican Regional Cancer Center/ACTRecruiting
- Genesis Cancer Center - SilvisRecruiting
- North Shore Medical CenterRecruiting
- Southern Illinois University School of MedicineRecruiting
- Springfield ClinicRecruiting
- Memorial Medical CenterRecruiting
- Southwest Illinois Health Services LLP
- Carle Cancer CenterRecruiting
- The Carle Foundation HospitalRecruiting
- Northwestern Medicine Cancer Center WarrenvilleRecruiting
- Illinois CancerCare - WashingtonRecruiting
- Rush-Copley Healthcare CenterRecruiting
- IU Health North HospitalRecruiting
- Northwest Cancer Center - Main CampusRecruiting
- Northwest Oncology LLCRecruiting
- Northwest Cancer Center - HobartRecruiting
- Saint Mary Medical CenterRecruiting
- Indiana University/Melvin and Bren Simon Cancer CenterRecruiting
- Sidney and Lois Eskenazi HospitalRecruiting
- Community Cancer Center EastRecruiting
- Community Cancer Center SouthRecruiting
- Community Cancer Center NorthRecruiting
- Saint Catherine HospitalRecruiting
- Community Howard Regional HealthRecruiting
- The Community HospitalRecruiting
- Women's Diagnostic Center - MunsterRecruiting
- Baptist Health FloydRecruiting
- Reid HealthRecruiting
- Northwest Cancer Center - ValparaisoRecruiting
- Mary Greeley Medical CenterRecruiting
- McFarland Clinic PC - AmesRecruiting
- McFarland Clinic PC-BooneRecruiting
- Saint Anthony Regional HospitalRecruiting
- Mercy HospitalRecruiting
- Oncology Associates at Mercy Medical CenterRecruiting
- Medical Oncology and Hematology Associates-West Des MoinesRecruiting
- Mercy Cancer Center-West LakesRecruiting
- Alegent Health Mercy HospitalRecruiting
- Greater Regional Medical CenterRecruiting
- Genesis Medical Center - East CampusRecruiting
- Genesis Cancer Care InstituteRecruiting
- Iowa Cancer SpecialistsRecruiting
- Iowa Methodist Medical CenterRecruiting
- Medical Oncology and Hematology Associates-Des MoinesRecruiting
- Broadlawns Medical CenterRecruiting
- Mercy Medical Center - Des MoinesRecruiting
- Mission Cancer and Blood - LaurelRecruiting
- Iowa Lutheran HospitalRecruiting
- McFarland Clinic PC-Trinity Cancer CenterRecruiting
- Trinity Regional Medical CenterRecruiting
- McFarland Clinic PC-JeffersonRecruiting
- McFarland Clinic PC-MarshalltownRecruiting
- Methodist West HospitalRecruiting
- Mercy Medical Center-West LakesRecruiting
- Cancer Center of Kansas - ChanuteRecruiting
- Cancer Center of Kansas - Dodge CityRecruiting
- Cancer Center of Kansas - El DoradoRecruiting
- Central Care Cancer Center - Garden CityRecruiting
- Central Care Cancer Center - Great BendRecruiting
- Cancer Center of Kansas-IndependenceRecruiting
- Cancer Center of Kansas-KingmanRecruiting
- Cancer Center of Kansas-LiberalRecruiting
- Cancer Center of Kansas-ManhattanRecruiting
- Cancer Center of Kansas - McPhersonRecruiting
- Cancer Center of Kansas - NewtonRecruiting
- Cancer Center of Kansas - ParsonsRecruiting
- Cancer Center of Kansas - PrattRecruiting
- Cancer Center of Kansas - SalinaRecruiting
- Cancer Center of Kansas - WellingtonRecruiting
- Cancer Center of Kansas-Wichita Medical Arts TowerRecruiting
- Ascension Via Christi Hospitals WichitaRecruiting
- Cancer Center of Kansas - WichitaRecruiting
- Cancer Center of Kansas - WinfieldRecruiting
- King's Daughter's Medical CenterRecruiting
- Flaget Memorial HospitalRecruiting
- Baptist Health CorbinRecruiting
- Commonwealth Cancer Center-CorbinRecruiting
- Baptist Health LexingtonRecruiting
- Saint Joseph HospitalRecruiting
- Saint Joseph Radiation Oncology Resource CenterRecruiting
- Saint Joseph Hospital EastRecruiting
- University of Kentucky/Markey Cancer CenterRecruiting
- Saint Joseph LondonRecruiting
- Jewish Hospital
- Baptist Health LouisvilleRecruiting
- Saints Mary and Elizabeth Hospital
- UofL Health Medical Center Northeast
- Baptist Health Madisonville/Merle Mahr Cancer CenterRecruiting
- Saint Joseph Mount SterlingRecruiting
- Baptist Health PaducahRecruiting
- Mercy Health - Paducah Medical Oncology and HematologyRecruiting
- Jewish Hospital Medical Center South
- Ochsner Hematology Oncology North Shore - Covington (West Region)Recruiting
- Louisiana State University Health Science CenterRecruiting
- University Medical Center New OrleansRecruiting
- Ochsner Medical Center JeffersonRecruiting
- LSU Health Sciences Center at ShreveportRecruiting
- Harold Alfond Center for Cancer CareRecruiting
- Waldo County General HospitalRecruiting
- MaineHealth/SMHC Cancer Care and Blood Disorders-BiddefordRecruiting
- Lafayette Family Cancer Center-EMMCRecruiting
- Maine Center for Cancer Medicine-KennebunkRecruiting
- Penobscot Bay Medical CenterRecruiting
- MaineHealth/SMHC Cancer Care and Blood Disorders-SanfordRecruiting
- Maine Center for Cancer Medicine-ScarboroughRecruiting
- Maine Medical Center- Scarborough CampusRecruiting
- Maine Medical Partners - South PortlandRecruiting
- Maine Center for Cancer Medicine-TopshamRecruiting
- Anne Arundel Medical CenterRecruiting
- Sinai Hospital of BaltimoreRecruiting
- Kaiser Permanente-Woodlawn Medical CenterRecruiting
- Johns Hopkins University/Sidney Kimmel Cancer CenterRecruiting
- Kaiser Permanente-Gaithersburg Medical CenterRecruiting
- Kaiser Permanente - Kensington Medical CenterRecruiting
- Kaiser Permanente - Largo Medical CenterRecruiting
- Kaiser Permanente Lutherville - Timonium Medical CenterRecruiting
- Northwest Hospital Center
- William E Kahlert Regional Cancer Center/Sinai Hospital
- Beverly HospitalRecruiting
- Tufts Medical CenterRecruiting
- Boston Medical CenterRecruiting
- Beth Israel Deaconess Medical CenterRecruiting
- Dana-Farber Cancer InstituteRecruiting
- Lahey Hospital and Medical CenterRecruiting
- Dana-Farber Cancer Institute at FoxboroughRecruiting
- Addison Gilbert HospitalRecruiting
- Lowell General HospitalRecruiting
- Dana Farber-Merrimack ValleyRecruiting
- Dana-Farber/Brigham and Women's Cancer Center at Milford RegionalRecruiting
- Lahey Medical Center-PeabodyRecruiting
- Dana-Farber/Brigham and Women's Cancer Center at South ShoreRecruiting
- Baystate Medical CenterRecruiting
- Winchester HospitalRecruiting
- UMass Memorial Medical Center - University CampusRecruiting
- University of Michigan Comprehensive Cancer CenterRecruiting
- Bronson Battle CreekRecruiting
- University of Michigan - Brighton Center for Specialty CareRecruiting
- Wayne State University/Karmanos Cancer InstituteRecruiting
- Weisberg Cancer Treatment CenterRecruiting
- Helen DeVos Children's Hospital at Spectrum HealthRecruiting
- Spectrum Health at Butterworth CampusRecruiting
- Trinity Health Grand Rapids HospitalRecruiting
- Bronson Methodist HospitalRecruiting
- West Michigan Cancer CenterRecruiting
- Ascension Borgess Cancer CenterRecruiting
- Borgess Medical CenterRecruiting
- Trinity Health Muskegon HospitalRecruiting
- Lakeland Hospital NilesRecruiting
- Cancer and Hematology Centers of Western Michigan - Norton ShoresRecruiting
- Ascension Providence Hospitals - NoviRecruiting
- Spectrum Health Reed City HospitalRecruiting
- Lakeland Medical Center Saint JosephRecruiting
- Marie Yeager Cancer CenterRecruiting
- Ascension Providence Hospitals - SouthfieldRecruiting
- Munson Medical CenterRecruiting
- Metro Health HospitalRecruiting
- Riverwood Healthcare CenterRecruiting
- Essentia Health - Baxter ClinicRecruiting
- Sanford Joe Lueken Cancer CenterRecruiting
- Essentia Health Saint Joseph's Medical CenterRecruiting
- Fairview Ridges HospitalRecruiting
- Minnesota Oncology - BurnsvilleRecruiting
- Cambridge Medical CenterRecruiting
- Mercy HospitalRecruiting
- Essentia Health - Deer River ClinicRecruiting
- Essentia Health Saint Mary's - Detroit Lakes ClinicRecruiting
- Essentia Health Cancer CenterRecruiting
- Essentia Health Saint Mary's Medical CenterRecruiting
- Miller-Dwan HospitalRecruiting
- Fairview Southdale HospitalRecruiting
- Essentia Health - Ely ClinicRecruiting
- Lake Region Healthcare Corporation-Cancer Care
- Essentia Health - FosstonRecruiting
- Unity HospitalRecruiting
- Essentia Health Hibbing ClinicRecruiting
- Essentia Health - International Falls ClinicRecruiting
- Fairview Clinics and Surgery Center Maple GroveRecruiting
- Minnesota Oncology Hematology PA-MaplewoodRecruiting
- Saint John's Hospital - HealtheastRecruiting
- Abbott-Northwestern HospitalRecruiting
- Hennepin County Medical CenterRecruiting
- Health Partners IncRecruiting
- Monticello Cancer CenterRecruiting
- Essentia Health - Moose Lake ClinicRecruiting
- New Ulm Medical CenterRecruiting
- Essentia Health - Park RapidsRecruiting
- Fairview Northland Medical CenterRecruiting
- North Memorial Medical Health CenterRecruiting
- Mayo Clinic in RochesterRecruiting
- Coborn Cancer Center at Saint Cloud HospitalRecruiting
- Park Nicollet Clinic - Saint Louis ParkRecruiting
- Regions HospitalRecruiting
- United HospitalRecruiting
- Essentia Health SandstoneRecruiting
- Saint Francis Regional Medical CenterRecruiting
- Lakeview HospitalRecruiting
- Sanford Thief River Falls Medical CenterRecruiting
- Essentia Health Virginia ClinicRecruiting
- Ridgeview Medical CenterRecruiting
- Rice Memorial HospitalRecruiting
- Minnesota Oncology Hematology PA-WoodburyRecruiting
- Fairview Lakes Medical CenterRecruiting
- Baptist Memorial Hospital and Cancer Center-Golden TriangleRecruiting
- Baptist Cancer Center-GrenadaRecruiting
- Gulfport Memorial HospitalRecruiting
- University of Mississippi Medical CenterRecruiting
- Baptist Memorial Hospital and Cancer Center-Union CountyRecruiting
- Baptist Memorial Hospital and Cancer Center-OxfordRecruiting
- Singing River Hospital
- Baptist Memorial Hospital and Cancer Center-DesotoRecruiting
- Saint Louis Cancer and Breast Institute-BallwinRecruiting
- Central Care Cancer Center - BolivarRecruiting
- Cox Cancer Center BransonRecruiting
- Saint Francis Medical CenterRecruiting
- Southeast Cancer CenterRecruiting
- Saint Luke's HospitalRecruiting
- University of Missouri - Ellis FischelRecruiting
- Siteman Cancer Center at West County HospitalRecruiting
- Parkland Health Center - FarmingtonRecruiting
- Capital Region Southwest CampusRecruiting
- Freeman Health SystemRecruiting
- Mercy Hospital JoplinRecruiting
- Delbert Day Cancer Institute at PCRMCRecruiting
- Mercy Clinic-Rolla-Cancer and HematologyRecruiting
- Heartland Regional Medical CenterRecruiting
- Saint Louis Cancer and Breast Institute-South CityRecruiting
- Washington University School of MedicineRecruiting
- Mercy Hospital SouthRecruiting
- Siteman Cancer Center-South CountyRecruiting
- Missouri Baptist Medical CenterRecruiting
- Siteman Cancer Center at Christian HospitalRecruiting
- Mercy Hospital Saint LouisRecruiting
- Siteman Cancer Center at Saint Peters HospitalRecruiting
- Sainte Genevieve County Memorial HospitalRecruiting
- Mercy Hospital SpringfieldRecruiting
- CoxHealth South HospitalRecruiting
- Missouri Baptist Sullivan HospitalRecruiting
- Missouri Baptist Outpatient Center-Sunset HillsRecruiting
- Mercy Hospital WashingtonRecruiting
- Community Hospital of AnacondaRecruiting
- Billings Clinic Cancer CenterRecruiting
- Bozeman Deaconess HospitalRecruiting
- Benefis Healthcare- Sletten Cancer InstituteRecruiting
- Great Falls ClinicRecruiting
- Kalispell Regional Medical CenterRecruiting
- Saint Patrick Hospital - Community HospitalRecruiting
- Community Medical HospitalRecruiting
- Nebraska Medicine-BellevueRecruiting
- CHI Health Saint Francis
- CHI Health Good SamaritanRecruiting
- Saint Elizabeth Regional Medical CenterRecruiting
- Cancer Partners of Nebraska - Pine LakeRecruiting
- Southeast Nebraska Cancer Center - 68th Street PlaceRecruiting
- Nebraska Medicine-Village PointeRecruiting
- Alegent Health Immanuel Medical CenterRecruiting
- Alegent Health Bergan Mercy Medical CenterRecruiting
- Alegent Health Lakeside HospitalRecruiting
- Creighton University Medical CenterRecruiting
- University of Nebraska Medical CenterRecruiting
- Midlands Community HospitalRecruiting
- Carson Tahoe Regional Medical CenterRecruiting
- Cancer and Blood Specialists-HendersonRecruiting
- Comprehensive Cancer Centers of Nevada - HendersonRecruiting
- Comprehensive Cancer Centers of Nevada-Horizon RidgeRecruiting
- Las Vegas Cancer Center-HendersonRecruiting
- OptumCare Cancer Care at Seven HillsRecruiting
- Comprehensive Cancer Centers of Nevada-Southeast HendersonRecruiting
- GenesisCare USA - HendersonRecruiting
- Las Vegas Urology - Green ValleyRecruiting
- Las Vegas Urology - PebbleRecruiting
- Urology Specialists of Nevada - Green ValleyRecruiting
- Las Vegas Urology - PecosRecruiting
- Desert West Surgery
- OptumCare Cancer Care at CharlestonRecruiting
- University Medical Center of Southern NevadaRecruiting
- Hope Cancer Care of NevadaRecruiting
- Cancer and Blood Specialists-Shadow
- Radiation Oncology Centers of Nevada CentralRecruiting
- Urology Specialists of Nevada - CentralRecruiting
- GenesisCare USA - Las VegasRecruiting
- HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
- Sunrise Hospital and Medical CenterRecruiting
- HealthCare Partners Medical Group Oncology/Hematology-San Martin
- Las Vegas Prostate Cancer CenterRecruiting
- Las Vegas Urology - SunsetRecruiting
- Urology Specialists of Nevada - SouthwestRecruiting
- Radiation Oncology Centers of Nevada SoutheastRecruiting
- Ann M Wierman MD LTDRecruiting
- Cancer and Blood Specialists-Tenaya
- Comprehensive Cancer Centers of Nevada - NorthwestRecruiting
- GenesisCare USA - Vegas TenayaRecruiting
- HealthCare Partners Medical Group Oncology/Hematology-Tenaya
- Las Vegas Urology - Cathedral RockRecruiting
- Las Vegas Urology - Smoke RanchRecruiting
- OptumCare Cancer Care at MountainViewRecruiting
- Urology Specialists of Nevada - NorthwestRecruiting
- Alliance for Childhood Diseases/Cure 4 the Kids FoundationRecruiting
- Comprehensive Cancer Centers of Nevada - Town CenterRecruiting
- Comprehensive Cancer Centers of Nevada-SummerlinRecruiting
- Summerlin Hospital Medical CenterRecruiting
- Las Vegas Cancer Center-Medical CenterRecruiting
- Comprehensive Cancer Centers of NevadaRecruiting
- GenesisCare USA - Fort ApacheRecruiting
- OptumCare Cancer Care at Fort ApacheRecruiting
- HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
- Comprehensive Cancer Centers of Nevada - Central ValleyRecruiting
- University Cancer CenterRecruiting
- Hope Cancer Care of Nevada-PahrumpRecruiting
- Renown Regional Medical CenterRecruiting
- Saint Mary's Regional Medical CenterRecruiting
- Radiation Oncology AssociatesRecruiting
- New Hampshire Oncology Hematology PA-ConcordRecruiting
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer CenterRecruiting
- Elliot Hospital
- Solinsky Center for Cancer CareRecruiting
- Memorial Sloan Kettering Basking RidgeRecruiting
- Trinitas Hospital and Comprehensive Cancer Center - Williamson Street CampusRecruiting
- Hackensack University Medical CenterRecruiting
- The Cancer Institute of New Jersey HamiltonRecruiting
- Jersey City Medical CenterRecruiting
- Monmouth Medical Center Southern CampusRecruiting
- Saint Barnabas Medical CenterRecruiting
- Monmouth Medical CenterRecruiting
- Memorial Sloan Kettering MonmouthRecruiting
- Memorial Sloan Kettering BergenRecruiting
- Morristown Medical CenterRecruiting
- Inspira Medical Center Mullica HillRecruiting
- Rutgers Cancer Institute of New JerseyRecruiting
- Rutgers New Jersey Medical SchoolRecruiting
- Newark Beth Israel Medical CenterRecruiting
- Sidney Kimmel Cancer Center Washington TownshipRecruiting
- Robert Wood Johnson University Hospital SomersetRecruiting
- Overlook HospitalRecruiting
- Holy Name HospitalRecruiting
- Community Medical CenterRecruiting
- Inspira Medical Center VinelandRecruiting
- Lovelace Medical Center-Saint Joseph SquareRecruiting
- University of New Mexico Cancer CenterRecruiting
- Lovelace Women's HospitalRecruiting
- Presbyterian Kaseman Hospital
- Memorial Medical Center - Las CrucesRecruiting
- Presbyterian Rust Medical Center/Jorgensen Cancer Center
- Hematology Oncology Associates of Central New York-AuburnRecruiting
- Montefiore Medical Center-Einstein CampusRecruiting
- Montefiore Medical Center-Weiler HospitalRecruiting
- Montefiore Medical Center - Moses CampusRecruiting
- New York-Presbyterian/Brooklyn Methodist HospitalRecruiting
- Maimonides Medical CenterRecruiting
- Mount Sinai BrooklynRecruiting
- Roswell Park Cancer InstituteRecruiting
- Memorial Sloan Kettering CommackRecruiting
- Cancer Institute at Saint Francis HospitalRecruiting
- Hematology Oncology Associates of Central New York-East SyracuseRecruiting
- The New York Hospital Medical Center of QueensRecruiting
- Glens Falls HospitalRecruiting
- Memorial Sloan Kettering WestchesterRecruiting
- NYU Winthrop HospitalRecruiting
- Mount Sinai ChelseaRecruiting
- Laura and Isaac Perlmutter Cancer Center at NYU LangoneRecruiting
- Mount Sinai WestRecruiting
- Mount Sinai HospitalRecruiting
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer CenterRecruiting
- Memorial Sloan Kettering Cancer CenterRecruiting
- NYP/Weill Cornell Medical CenterRecruiting
- Upstate Cancer Center at OneidaRecruiting
- Upstate Cancer Center at OswegoRecruiting
- University of RochesterRecruiting
- Stony Brook University Medical CenterRecruiting
- State University of New York Upstate Medical UniversityRecruiting
- Hematology Oncology Associates of Central New York-Onondaga HillRecruiting
- SUNY Upstate Medical Center-Community CampusRecruiting
- Memorial Sloan Kettering NassauRecruiting
- South Nassau Cancer CenterRecruiting
- Dickstein Cancer Treatment CenterRecruiting
- Atrium Health Stanly/LCI-AlbemarleRecruiting
- Rex Hematology Oncology Associates-CaryRecruiting
- UNC Lineberger Comprehensive Cancer CenterRecruiting
- Carolinas Medical Center/Levine Cancer InstituteRecruiting
- Novant Health Presbyterian Medical CenterRecruiting
- Novant Health Carolina Surgical - RandolphRecruiting
- Atrium Health Pineville/LCI-PinevilleRecruiting
- Atrium Health University City/LCI-UniversityRecruiting
- Southeastern Medical Oncology Center-ClintonRecruiting
- Atrium Health Cabarrus/LCI-ConcordRecruiting
- Levine Cancer Institute - RutherfordRecruiting
- Rex Hematology Oncology Associates-GarnerRecruiting
- Southeastern Medical Oncology Center-GoldsboroRecruiting
- Novant Health Breast Surgery - GreensboroRecruiting
- Margaret R Pardee Memorial HospitalRecruiting
- University of North Carolina-Hillsborough CampusRecruiting
- Novant Health Cancer Institute - HuntersvilleRecruiting
- Novant Health Presbyterian Medical Center HuntersvilleRecruiting
- Southeastern Medical Oncology Center-JacksonvilleRecruiting
- Novant Health Cancer Institute - KernersvilleRecruiting
- Atrium Health Lincoln/LCI-LincolntonRecruiting
- Levine Cancer Institute - Union WestRecruiting
- Matthews Radiation Oncology CenterRecruiting
- Novant Health Cancer Institute - MatthewsRecruiting
- Atrium Health Union/LCI-UnionRecruiting
- Novant Health Cancer Institute - MooresvilleRecruiting
- Novant Health Cancer Institute - Mount AiryRecruiting
- FirstHealth of the Carolinas-Moore Regional Hospital
- Rex Hematology Oncology Associates-Blue RidgeRecruiting
- UNC Rex HealthcareRecruiting
- UNC Rex Cancer Center of WakefieldRecruiting
- Novant Health Cancer Institute - RowanRecruiting
- Rowan Regional Medical CenterRecruiting
- Atrium Health Cleveland/LCI-ClevelandRecruiting
- Novant Health Cancer Institute - StatesvilleRecruiting
- Novant Health Cancer Institute - ThomasvilleRecruiting
- Novant Health Cancer Institute - WilkesboroRecruiting
- Novant Health Forsyth Medical CenterRecruiting
- Sanford Bismarck Medical CenterRecruiting
- Essentia Health Cancer Center-South University ClinicRecruiting
- Sanford South University Medical CenterRecruiting
- Southpointe-Sanford Medical Center FargoRecruiting
- Sanford Medical Center FargoRecruiting
- Sanford Broadway Medical CenterRecruiting
- Sanford Roger Maris Cancer CenterRecruiting
- Essentia Health - Jamestown ClinicRecruiting
- Aultman Alliance Community HospitalRecruiting
- Indu and Raj Soin Medical CenterRecruiting
- Saint Elizabeth Boardman HospitalRecruiting
- Aultman Health FoundationRecruiting
- Dayton Physicians LLC-Miami Valley SouthRecruiting
- Miami Valley Hospital SouthRecruiting
- The Christ HospitalRecruiting
- Good Samaritan Hospital - CincinnatiRecruiting
- Oncology Hematology Care Inc-KenwoodRecruiting
- Bethesda North HospitalRecruiting
- TriHealth Cancer Institute-WestsideRecruiting
- TriHealth Cancer Institute-AndersonRecruiting
- MetroHealth Medical CenterRecruiting
- Cleveland Clinic Cancer Center/Fairview HospitalRecruiting
- Ohio State University Comprehensive Cancer CenterRecruiting
- Dayton Blood and Cancer CenterRecruiting
- Miami Valley HospitalRecruiting
- Dayton Physician LLC-Miami Valley Hospital NorthRecruiting
- Miami Valley Hospital NorthRecruiting
- Armes Family Cancer CenterRecruiting
- Blanchard Valley HospitalRecruiting
- Orion Cancer CareRecruiting
- Atrium Medical Center-Middletown Regional HospitalRecruiting
- Dayton Physicians LLC-AtriumRecruiting
- Dayton Physicians LLC-WayneRecruiting
- Wayne HospitalRecruiting
- Cleveland Clinic Cancer Center IndependenceRecruiting
- Greater Dayton Cancer CenterRecruiting
- First Dayton Cancer Care
- Kettering Medical CenterRecruiting
- Cleveland Clinic Cancer Center MansfieldRecruiting
- Hillcrest Hospital Cancer CenterRecruiting
- North Coast Cancer CareRecruiting
- Springfield Regional Cancer Center
- Springfield Regional Medical Center
- Trinity's Tony Teramana Cancer CenterRecruiting
- Cleveland Clinic Cancer Center StrongsvilleRecruiting
- ProMedica Flower HospitalRecruiting
- ProMedica Toledo Hospital/Russell J Ebeid Children's HospitalRecruiting
- Dayton Physicians LLC - TroyRecruiting
- Upper Valley Medical CenterRecruiting
- South Pointe HospitalRecruiting
- Saint Joseph Warren HospitalRecruiting
- Cleveland Clinic Wooster Family Health and Surgery CenterRecruiting
- Wright-Patterson Medical CenterRecruiting
- Saint Elizabeth Youngstown HospitalRecruiting
- Cancer Centers of Southwest Oklahoma ResearchRecruiting
- University of Oklahoma Health Sciences CenterRecruiting
- Mercy Hospital Oklahoma CityRecruiting
- Saint Alphonsus Medical Center-Baker CityRecruiting
- Saint Charles Health SystemRecruiting
- Clackamas Radiation Oncology CenterRecruiting
- Providence Cancer Institute Clackamas ClinicRecruiting
- Bay Area HospitalRecruiting
- Legacy Mount Hood Medical CenterRecruiting
- Providence Newberg Medical CenterRecruiting
- Saint Alphonsus Medical Center-OntarioRecruiting
- Providence Willamette Falls Medical CenterRecruiting
- Legacy Good Samaritan Hospital and Medical CenterRecruiting
- Providence Portland Medical CenterRecruiting
- Providence Saint Vincent Medical CenterRecruiting
- Saint Charles Health System-RedmondRecruiting
- Legacy Meridian Park HospitalRecruiting
- UPMC AltoonaRecruiting
- UPMC-Heritage Valley Health System BeaverRecruiting
- Bryn Mawr HospitalRecruiting
- UPMC Hillman Cancer Center at Butler Health SystemRecruiting
- UPMC Camp HillRecruiting
- Carlisle Regional Cancer CenterRecruiting
- Christiana Care Health System-Concord Health CenterRecruiting
- Chambersburg HospitalRecruiting
- WellSpan Medical Oncology and HematologyRecruiting
- Main Line Health Center-CollegevilleRecruiting
- UPMC Hillman Cancer Center - Passavant - CranberryRecruiting
- Geisinger Medical CenterRecruiting
- Fox Chase Cancer Center - East Norriton Hospital Outpatient CenterRecruiting
- Ephrata Cancer CenterRecruiting
- UPMC Hillman Cancer Center ErieRecruiting
- Saint Vincent HospitalRecruiting
- Main Line Health Center-ExtonRecruiting
- UPMC Cancer Center at UPMC HorizonRecruiting
- Adams Cancer CenterRecruiting
- UPMC Cancer Centers - Arnold Palmer PavilionRecruiting
- Oncology Hematology AssociatesRecruiting
- Cherry Tree Cancer CenterRecruiting
- UPMC Pinnacle HarrisburgRecruiting
- UPMC Pinnacle Cancer Center/Community Osteopathic CampusRecruiting
- Geisinger Medical Center-Cancer Center HazletonRecruiting
- Penn State Milton S Hershey Medical CenterRecruiting
- IRMC Cancer CenterRecruiting
- Jefferson HospitalRecruiting
- UPMC-Johnstown/John P. Murtha Regional Cancer CenterRecruiting
- Lancaster General Ann B Barshinger Cancer InstituteRecruiting
- Lancaster General HospitalRecruiting
- Sechler Family Cancer CenterRecruiting
- Geisinger Medical Oncology-LewisburgRecruiting
- Lewistown HospitalRecruiting
- UPMC Cancer Center at UPMC McKeesportRecruiting
- Yolanda G Barco Oncology InstituteRecruiting
- UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer PavilionRecruiting
- Riddle Memorial HospitalRecruiting
- Forbes HospitalRecruiting
- UPMC Hillman Cancer Center - MonroevilleRecruiting
- UPMC Hillman Cancer Center in CoraopolisRecruiting
- UPMC Hillman Cancer Center - Part of Frick HospitalRecruiting
- Arnold Palmer Cancer Center Medical Oncology NorwinRecruiting
- UPMC Cancer Center-Natrona HeightsRecruiting
- UPMC Hillman Cancer Center - New CastleRecruiting
- Bryn Mawr Health CenterRecruiting
- Paoli Memorial HospitalRecruiting
- University of Pennsylvania/Abramson Cancer CenterRecruiting
- Thomas Jefferson University HospitalRecruiting
- Fox Chase Cancer CenterRecruiting
- Jefferson Torresdale HospitalRecruiting
- Temple University HospitalRecruiting
- Jefferson Methodist HospitalRecruiting
- Phoenixville HospitalRecruiting
- Allegheny General HospitalRecruiting
- UPMC-Magee Womens HospitalRecruiting
- Oncology Hematology AssociationRecruiting
- UPMC-Saint MargaretRecruiting
- UPMC-Mercy HospitalRecruiting
- West Penn HospitalRecruiting
- University of Pittsburgh Cancer Institute (UPCI)Recruiting
- UPMC-Passavant HospitalRecruiting
- UPMC-Saint Clair Hospital Cancer CenterRecruiting
- Geisinger Cancer Services-PottsvilleRecruiting
- Penn State Health Saint Joseph Medical CenterRecruiting
- Community Medical CenterRecruiting
- Geisinger Medical Oncology-SelinsgroveRecruiting
- UPMC Cancer Center at UPMC NorthwestRecruiting
- Geisinger Medical GroupRecruiting
- UPMC Cancer Center-UniontownRecruiting
- UPMC Uniontown Hospital Radiation OncologyRecruiting
- UPMC Cancer Center-WashingtonRecruiting
- UPMC Washington Hospital Radiation OncologyRecruiting
- Chester County HospitalRecruiting
- UPMC West Mifflin-Cancer Center JeffersonRecruiting
- Reading HospitalRecruiting
- Wexford Health and Wellness PavilionRecruiting
- Geisinger Wyoming Valley/Henry Cancer CenterRecruiting
- Divine Providence HospitalRecruiting
- Asplundh Cancer PavilionRecruiting
- Lankenau Medical CenterRecruiting
- Cancer Care Associates of YorkRecruiting
- WellSpan Health-York Cancer CenterRecruiting
- WellSpan Health-York HospitalRecruiting
- UPMC MemorialRecruiting
- Women and Infants HospitalRecruiting
- Kent HospitalRecruiting
- Smilow Cancer Hospital Care Center - WesterlyRecruiting
- Saint Joseph's/Candler - Bluffton CampusRecruiting
- Saint Francis HospitalRecruiting
- Saint Francis Cancer CenterRecruiting
- South Carolina Cancer Specialists PCRecruiting
- Levine Cancer Institute-Rock HillRecruiting
- Avera Cancer Institute-AberdeenRecruiting
- Avera Cancer Institute at PierreRecruiting
- Avera Cancer InstituteRecruiting
- Bristol Regional Medical CenterRecruiting
- Baptist Memorial Hospital and Cancer Center-ColliervilleRecruiting
- Vanderbilt-Ingram Cancer Center Cool SpringsRecruiting
- Ballad Health Cancer Care - KingsportRecruiting
- Wellmont Holston Valley Hospital and Medical CenterRecruiting
- Baptist Memorial Hospital and Cancer Center-MemphisRecruiting
- Vanderbilt Breast Center at One Hundred OaksRecruiting
- Vanderbilt University/Ingram Cancer CenterRecruiting
- Saint Joseph Regional Cancer Center
- Parkland Memorial HospitalRecruiting
- UT Southwestern Simmons Cancer Center - RedBirdRecruiting
- UT Southwestern/Simmons Cancer Center-DallasRecruiting
- Tarrant County Hospital District/JPS Health NetworkRecruiting
- UT Southwestern/Simmons Cancer Center-Fort WorthRecruiting
- Baylor College of Medicine/Dan L Duncan Comprehensive Cancer CenterRecruiting
- Ben Taub General HospitalRecruiting
- Doctor's Hospital of LaredoRecruiting
- UT Southwestern Clinical Center at Richardson/PlanoRecruiting
- Farmington Health CenterRecruiting
- University of Utah Sugarhouse Health CenterRecruiting
- Huntsman Cancer Institute/University of UtahRecruiting
- South Jordan Health CenterRecruiting
- Norris Cotton Cancer Center-NorthRecruiting
- Wellmont Medical Associates-BristolRecruiting
- Kaiser Permanente-Burke Medical CenterRecruiting
- Cancer Specialists of Tidewater Limited
- Peninsula Cancer Institute-Gloucester
- Sovah Health MartinsvilleRecruiting
- Kaiser Permanente Tysons Corner Medical CenterRecruiting
- Bon Secours Memorial Regional Medical CenterRecruiting
- Bon Secours Westchester Emergency CenterRecruiting
- Bon Secours Saint Francis Medical CenterRecruiting
- Peninsula Cancer Institute-Newport News
- Bon Secours DePaul Medical Center
- Southwest VA Regional Cancer CenterRecruiting
- Bon Secours Maryview Medical Center
- Bon Secours Richmond Community HospitalRecruiting
- Bon Secours Saint Mary's HospitalRecruiting
- Bon Secours Cancer Institute at Reynolds CrossingRecruiting
- VCU Massey Cancer Center at Stony Point
- Virginia Commonwealth University/Massey Cancer Center
- VCU Community Memorial Health Center
- Bon Secours Health Center at Harbour View
- Cancer Specialists of Tidewater-Suffolk
- Peninsula Cancer Institute-Cancer Specialists of Tidewater
- Peninsula Cancer Institute-Williamsburg
- Providence Regional Cancer System-AberdeenRecruiting
- Overlake Medical Center
- PeaceHealth Saint Joseph Medical CenterRecruiting
- Harrison HealthPartners Hematology and Oncology-BremertonRecruiting
- Harrison Medical Center
- Highline Medical Center-Main Campus
- Providence Regional Cancer System-CentraliaRecruiting
- Swedish Cancer Institute-EdmondsRecruiting
- Saint Elizabeth Hospital
- Providence Regional Cancer PartnershipRecruiting
- Saint Francis Hospital
- Swedish Cancer Institute-IssaquahRecruiting
- Kadlec Clinic Hematology and OncologyRecruiting
- Providence Regional Cancer System-LaceyRecruiting
- Saint Clare Hospital
- PeaceHealth Saint John Medical CenterRecruiting
- Jefferson HealthcareRecruiting
- Harrison HealthPartners Hematology and Oncology-Poulsbo
- Valley Medical CenterRecruiting
- Pacific Gynecology Specialists
- Swedish Medical Center-Ballard CampusRecruiting
- Swedish Medical Center-Cherry HillRecruiting
- Swedish Medical Center-First HillRecruiting
- PeaceHealth United General Medical CenterRecruiting
- Providence Regional Cancer System-SheltonRecruiting
- Franciscan Research Center-Northwest Medical Plaza
- Northwest Medical Specialties PLLC
- PeaceHealth Southwest Medical CenterRecruiting
- Legacy Cancer Institute Medical Oncology and Day TreatmentRecruiting
- Legacy Salmon Creek HospitalRecruiting
- Providence Saint Mary Regional Cancer CenterRecruiting
- North Star Lodge Cancer Center at Yakima Valley Memorial HospitalRecruiting
- Providence Regional Cancer System-YelmRecruiting
- West Virginia University Charleston DivisionRecruiting
- Langlade Hospital and Cancer CenterRecruiting
- ThedaCare Regional Cancer CenterRecruiting
- Ascension Saint Elizabeth HospitalRecruiting
- Duluth Clinic AshlandRecruiting
- Northwest Wisconsin Cancer CenterRecruiting
- ThedaCare Cancer Care - BerlinRecruiting
- Ascension Southeast Wisconsin Hospital - Elmbrook CampusRecruiting
- Aurora Cancer Care-Southern Lakes VLCCRecruiting
- Ascension Calumet HospitalRecruiting
- Marshfield Clinic-Chippewa CenterRecruiting
- Aurora Saint Luke's South ShoreRecruiting
- HSHS Sacred Heart HospitalRecruiting
- Marshfield Medical Center-EC Cancer CenterRecruiting
- Mayo Clinic Health System-Eau Claire ClinicRecruiting
- Mayo Clinic Health System Eau Claire Hospital-Luther Campus
- Ascension Saint Francis - Reiman Cancer CenterRecruiting
- Ascension Southeast Wisconsin Hospital - FranklinRecruiting
- Aurora Health Care Germantown Health CenterRecruiting
- Aurora Cancer Care-GraftonRecruiting
- Saint Vincent Hospital Cancer Center Green BayRecruiting
- Saint Vincent Hospital Cancer Center at Saint Mary'sRecruiting
- Aurora BayCare Medical CenterRecruiting
- Essentia Health-Hayward ClinicRecruiting
- UW Cancer Center Johnson CreekRecruiting
- Aurora Cancer Care-Kenosha SouthRecruiting
- Gundersen Lutheran Medical CenterRecruiting
- Mayo Clinic Health System-Franciscan HealthcareRecruiting
- Marshfield Clinic - Ladysmith CenterRecruiting
- University of Wisconsin Carbone Cancer CenterRecruiting
- Aurora Bay Area Medical Group-MarinetteRecruiting
- Marshfield Medical Center-MarshfieldRecruiting
- Aspirus Medford HospitalRecruiting
- Ascension Columbia Saint Mary's Hospital OzaukeeRecruiting
- Aurora Cancer Care-MilwaukeeRecruiting
- Ascension Southeast Wisconsin Hospital - Saint Joseph CampusRecruiting
- Ascension Columbia Saint Mary's Hospital - MilwaukeeRecruiting
- Ascension Saint Francis HospitalRecruiting
- Aurora Saint Luke's Medical CenterRecruiting
- Aurora Sinai Medical CenterRecruiting
- Marshfield Clinic-Minocqua CenterRecruiting
- ThedaCare Regional Medical Center - NeenahRecruiting
- Cancer Center of Western WisconsinRecruiting
- Saint Vincent Hospital Cancer Center at Oconto FallsRecruiting
- Ascension Mercy HospitalRecruiting
- Vince Lombardi Cancer Clinic - OshkoshRecruiting
- Ascension All Saints HospitalRecruiting
- Aurora Cancer Care-RacineRecruiting
- Ascension Saint Mary's Hospital
- Marshfield Medical Center-Rice LakeRecruiting
- Vince Lombardi Cancer Clinic-SheboyganRecruiting
- Essentia Health-Spooner ClinicRecruiting
- Ascension Saint Michael's HospitalRecruiting
- Marshfield Medical Center-River Region at Stevens PointRecruiting
- Saint Vincent Hospital Cancer Center at Sturgeon BayRecruiting
- Aurora Medical Center in SummitRecruiting
- Essentia Health Saint Mary's Hospital - SuperiorRecruiting
- Vince Lombardi Cancer Clinic-Two RiversRecruiting
- Aspirus Regional Cancer CenterRecruiting
- Marshfield Clinic-Wausau CenterRecruiting
- Ascension Medical Group Southeast Wisconsin - Mayfair RoadRecruiting
- Aurora Cancer Care-Milwaukee WestRecruiting
- Aurora West Allis Medical CenterRecruiting
- Marshfield Medical Center - WestonRecruiting
- Aspirus Cancer Care - Wisconsin RapidsRecruiting
- Marshfield Clinic - Wisconsin Rapids CenterRecruiting
- Cheyenne Regional Medical Center-WestRecruiting
- Billings Clinic-CodyRecruiting
- Welch Cancer CenterRecruiting
- Cancer Center-Metro Medical Center BayamonRecruiting
- HIMA San Pablo Oncologic Hospital
- Doctors Cancer CenterRecruiting
- Instituto Oncologia Moderna Ponce
- San Juan Community Oncology GroupRecruiting
- Primary Care Physician Group
- Centro Comprensivo de Cancer de UPRRecruiting
- PROncologyRecruiting
- San Juan City HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Arm A (pCR after surgery)
Arm B (residual invasive disease after surgery)
PRE-OPERATIVE/NEOADJUVANT THERAPY: Patients receive either paclitaxel or nab-paclitaxel IV on days 1, 8 and 15, or docetaxel IV on day 1 at the discretion of the treating oncologist. Patients also receive trastuzumab IV on day 1 or days 1, 8, and 15, and pertuzumab IV on day 1. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity. SURGERY: Within 42 days after last dose of neoadjuvant therapy, patients undergo standard of care lumpectomy and/or mastectomy. POST-OPERATIVE.ADJUVANT THERAPY: Patients with pCR after surgery receive trastuzumab and pertuzumab IV on day 1. Treatment repeats every 21 days for up to 13 cycles in the absence of disease progression or unacceptable toxicity. Patients may also undergo standard of care radiation therapy and receive hormone therapy if appropriate.
PRE-OPERATIVE/NEOADJUVANT THERAPY: Patients receive either paclitaxel or nab-paclitaxel IV on days 1, 8 and 15, or docetaxel IV on day 1 at the discretion of the treating oncologist. Patients also receive trastuzumab IV on day 1 or days 1, 8, and 15, and pertuzumab IV on day 1. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity. SURGERY: Within 42 days after last dose of neoadjuvant therapy, patients undergo standard of care lumpectomy and/or mastectomy. POST-OPERATIVE/ADJUVANT THERAPY: Patients with remaining tumor after surgery receive standard of care trastuzumab emtansine for 14 doses in the absence of disease progression or unacceptable toxicity. Patients may also receive additional standard of care chemotherapy, as well as hormone therapy if appropriate.