Covert Saccade Triggers in Bilateral Vestibular Hypofunction (CS-TRIGGER)
Reflex, Abnormal, Bilateral Vestibulopathy, Healthy Volunteers
About this trial
This is an interventional basic science trial for Reflex, Abnormal focused on measuring Saccadic Eye Movements, Bilateral Vestibulopathy, Bilateral Vestibular Hypofunction
Eligibility Criteria
Inclusion Criteria:
For all :
- Age from 18 to 90
- Understanding of the experimental instructions
- Informed Consent
- For Patients :
Bilateral vestibular hypofunction with regards to the criteria of the of the Barany Society A. Chronic vestibular syndrome with at least three of the following symptoms
- Postural imbalance
- Unsteadiness of gait
- Movement-induced blurred vision or oscillopsia during walking or quick head/body movements
Worsening of postural imbalance or unsteadiness of gait in darkness and/or on uneven ground B. No symptoms while sitting or lying down under static conditions C. Bilaterally reduced or absent angular VOR function documented by
- bilaterally pathological horizontal angular VOR gain < 0.6, measured by the video-HIT5or scleral-coil technique and/or
- reduced caloric response (sum of bithermal max. peak SPV on each side < 6°/sec7)and/or
- reduced horizontal angular VOR gain < 0.1 upon sinusoidal stimulation on a rotatorychair (0.1 Hz, Vmax = 50°/sec).
D. Not better accounted for by another disease
* For Healthy control No ENT or neurological disorders
Exclusion Criteria:
- Corrected Visual Acuity lower than 5/10
- Other conditions leading to oscillopsia or ataxia
- Oculomotor palsy, ocular instability in primary position
- Treatment that may affect ocular motility (psychotropes)
- Cervical rachis pathology with instability
- Cochlear Implants
- Non-stabilized medical disease
- Pregnant women
- Patients under tutelage
- Patient without social security
Sites / Locations
- Hospices Civils de Lyon
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Patients
healthy subject group
Patients suffering from chronic bilateral vestibular hypofunction