Transcutaneous Direct Current Stimulation of the Spinal Cord for Treatment of Spasticity in Multiple Sclerosis
Spastic Parapareses
About this trial
This is an interventional treatment trial for Spastic Parapareses
Eligibility Criteria
Inclusion Criteria:
-Patients diagnosed with Multiple Sclerosis according to the 2010 Mc Donald criteria with spasticity in the lower extremities
Exclusion Criteria:
- Cardiac pacemakers
- Patients with prior exposure to tDCS
- Metallic hardware in the spine
- Eczema or skin abrasion at the intended site of stimulation
- Currently pregnant or plan for pregnancy in the next 6 months
- Heart or respiratory failure resulting in activity impairment
- Walking impairment due to orthopaedics condition such as deformity or recent fracture.
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Experimental
Sham Comparator
Active tSDCS
Sham tSDCS
Anodal tSDCS will be administered through a pair of conductive rubber electrodes covered by saline soaked sponges (35 cm2). The current will be delivered continuously at 2 mA for 30 min through a battery-driven constant-current stimulator (designed by Sooma). The anode will be positioned over the spinal cord area at the level of the spinous processes of 10th-11th thoracic vertebra.
Sham stimulation will be delivered to the same spinal cord area using a sham tSDCS device that delivers a direct current for 10 seconds at the beginning and end of tSDCS to provide sensory experiences similar to active stimulation.