Effectiveness of Regenerative Endodontics Therapy for Single-rooted Mature Permanent Tooth With Pulp Necrosis
Pulp Necrosis
About this trial
This is an interventional treatment trial for Pulp Necrosis focused on measuring Pulp Necrosis, Regenerative Endodontics Therapy, Platelet Rich Fibrin
Eligibility Criteria
Inclusion Criteria:
- Intended to participate with this study, and provide informed assent/consent.
- Aged 10 and 59 years.
- At least one mature permanent teeth diagnosed as pulp necrosis with or without periapical lesion, and CBCT showed the teeth has single root and single root canal.
Exclusion Criteria:
- Allergic to any medications or materials necessary to complete the procedures.
- The teeth with severe coronal defect, of which pulp space is needed for post/core final restoration.
- Non-restorable teeth.
- The teeth with root fracture or vertical root fractures.
- Concurrent signs of other pathological root resorption.
- Patients with periodontitis.
- Patients with dental dysplasia or other oral genetic disorders.
- Women who are pregnant or lactating, or women who plan to become pregnant in the subsequent 2 years.
- Patients with dental phobia.
- Patients with mental disorders.
- Patients with a history of systemic diseases that may alter immune function.
- Patients with medical conditions and/or receiving medications that would affect patients' body's ability of healing or blood clotting.
- Participants who are participating in or had participated in other clinical studies within the prior 3 months.
Sites / Locations
- Nanfang Hospital, Southern Medical UniversityRecruiting
- Stomatological Hospital, Southern Medical UniversityRecruiting
- Shenzhen Hospital, Southern Medical UniversityRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Regenerative endodontics therapy with PRF
Regenerative endodontics therapy with BC
In the procedures of regenerative endodontics therapy, K-files were intentionally used to violate the periapical tissues via overinstrumentation up to 2-3mm past the apical foramen to induce bleeding. Only the apex 1/3 of the root canal need to be filled with blood. PRF was injected into the root canal to a level below the CEJ, then wait for 10-15min to coagulate.
In the procedures of regenerative endodontics therapy, K-files were intentionally used to violate the periapical tissues via overinstrumentation up to 2-3mm past the apical foramen to induce bleeding. The adequate blood need to be full with canal space and below the CEJ, then wait for 10-15min to coagulate.