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Power Training on Muscle Quality and Functional Capacity in Women Aged 65-75.

Primary Purpose

Muscle Weakness, Muscle Loss

Status
Unknown status
Phase
Not Applicable
Locations
Colombia
Study Type
Interventional
Intervention
Muscle power training with velocity loss (VL) of 10%
Muscle power training with velocity loss (VL) of 30%
Sponsored by
Universidad del Valle, Colombia
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Muscle Weakness focused on measuring Muscle quality, Functional capacity, Power training

Eligibility Criteria

65 Years - 75 Years (Older Adult)FemaleAccepts Healthy Volunteers

Inclusion Criteria:

  • Women 65 to 75 years.
  • Healthy volunteers.
  • Have not perform muscle power training in the last six months.

Exclusion Criteria:

  • History of asthma.
  • History of uncontrolled diabetes.
  • History of uncontrolled hypertension.
  • History of cardiovascular disease.
  • History of coronary heart disease.
  • Smoker.
  • Arrhythmias.
  • Personal history of surgical procedures in the last three months.
  • Uncontrolled non-communicable diseases.
  • Psychological, sensitive, cognitive, neuromotor and/or osteo-muscular conditions that may affect participation in an exercise program.
  • Under medical treatment with anticoagulants, bronchodilators, and/or steroids.

Sites / Locations

  • Universidad del Valle

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Active Comparator

Arm Label

Muscle power training with velocity loss (VL) of 10%

Muscle power training with velocity loss (VL) of 30%

Arm Description

Subjects followed a muscle power training for 8 weeks (2 sessions per week on alternate days) using the leg extension exercise, with similar relative intensity (50% 1RM). Between weeks one and four two series will be performed per session. Then the number of series will increase to three per session. The inter-set recovery period will be always of 2-min. Velocity loss will be of 10% (VL10) in each set.

Subjects followed a muscle power training for 8 weeks (2 sessions per week on alternate days) using the leg extension exercise, with similar relative intensity (50% 1RM). Between weeks one and four two series will be performed per session. Then the number of series will increase to three per session. The inter-set recovery period will be always of 2-min. Velocity loss will be of 30% (VL30) in each set.

Outcomes

Primary Outcome Measures

Change on muscle quality: obtained by measuring mean leg extension power divided by muscle mass of thighs
The muscle quality will be obtained by measuring mean leg extension power divided by muscle mass of thighs (measured by dual-energy x-ray absorptiometry)

Secondary Outcome Measures

Change on chair stand test
Participants stand up straight as quickly as they can five times, without stopping in between. After standing up each time, subjects will sit down and then stand up again. They will keep their arms folded across their chest. The examiner will be timing with a stopwatch.
Change on time up go test with cognitive task
The participant stands up from a chair, walks to the mark 3 m away, turns around, returns to the chair, and sits down again. The participants walk safely, as fast as possible. While walking, the participant counts backward in threes from a randomly chosen start number between 60 and 100 to avoid a learning effect.
Change on gait speed test
Participants walk a 4-m marked course at their usual walking pace, with the examiner timing their walk with a stopwatch.

Full Information

First Posted
March 9, 2020
Last Updated
March 17, 2020
Sponsor
Universidad del Valle, Colombia
Collaborators
Universidad de Antioquia
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1. Study Identification

Unique Protocol Identification Number
NCT04315662
Brief Title
Power Training on Muscle Quality and Functional Capacity in Women Aged 65-75.
Official Title
Effects of a Power Training at Two Different Loads on Muscle Quality and Functional Capacity in Women Aged 65-75.
Study Type
Interventional

2. Study Status

Record Verification Date
March 2020
Overall Recruitment Status
Unknown status
Study Start Date
May 1, 2020 (Anticipated)
Primary Completion Date
November 30, 2020 (Anticipated)
Study Completion Date
February 11, 2021 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Universidad del Valle, Colombia
Collaborators
Universidad de Antioquia

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No

5. Study Description

Brief Summary
Muscle power training has proven to be an effective intervention to prevent sarcopenia and frailty in old people. In the last decade, new concepts related to the functionality of old people have been generated, such as muscle quality and functional capacity. The power training consists of rapid movements of short duration that imply a more specialized neuromuscular response and that improve the functional response reflected in activities of daily life that demand a certain manifestation of muscular power (stand up of a chair, climbing stairs, rebalance, accelerate suddenly, among others). Therefore, it is important to investigate the dose-response relationships in power training in older people and establish how possible improvements in muscle quality can be reflected in functional capacity. The aim of this study is to compare the effects of power training at two different loads on muscle quality and functional capacity in women aged 65-75
Detailed Description
Fifty-six women will be randomly assigned to one of two muscle power training supervised for a physical activity instructor with different velocity loss (VL) thresholds: 10% (VL10) and 30% (VL30). Subjects followed a muscle power training for 8 weeks (2 sessions per week on alternate days) using the leg extension exercise, with similar relative intensity (50% 1RM). Between weeks one and four two series will be performed per session. Then the number of series will increase to three per session. The inter-set recovery period will be always of 2-min. Before and after the muscle power training the following tests will be performed: 1) measure of body composition with dual-energy x-ray absorptiometry for determining the lean mass of thighs; 2) three functional test (chair stand test, time up go test with cognitive task and gait speed test); 3)Progressive loading test in a leg extension machine until finding the mean muscle power corresponding to 50% of 1RM (speed of concentric phase of 6.67 ± 0.04 m/s measured using a camera-based optoelectronic system).

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Muscle Weakness, Muscle Loss
Keywords
Muscle quality, Functional capacity, Power training

7. Study Design

Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
Outcomes Assessor
Allocation
Randomized
Enrollment
56 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
Muscle power training with velocity loss (VL) of 10%
Arm Type
Experimental
Arm Description
Subjects followed a muscle power training for 8 weeks (2 sessions per week on alternate days) using the leg extension exercise, with similar relative intensity (50% 1RM). Between weeks one and four two series will be performed per session. Then the number of series will increase to three per session. The inter-set recovery period will be always of 2-min. Velocity loss will be of 10% (VL10) in each set.
Arm Title
Muscle power training with velocity loss (VL) of 30%
Arm Type
Active Comparator
Arm Description
Subjects followed a muscle power training for 8 weeks (2 sessions per week on alternate days) using the leg extension exercise, with similar relative intensity (50% 1RM). Between weeks one and four two series will be performed per session. Then the number of series will increase to three per session. The inter-set recovery period will be always of 2-min. Velocity loss will be of 30% (VL30) in each set.
Intervention Type
Other
Intervention Name(s)
Muscle power training with velocity loss (VL) of 10%
Intervention Description
Subjects followed a muscle power training for 8 weeks (2 sessions per week on alternate days) using the leg extension exercise, with similar relative intensity (50% 1RM). Between weeks one and four two series will be performed per session. Then the number of series will increase to three per session. The inter-set recovery period will be always of 2-min. Velocity loss will be of 10% (VL10) in each set.
Intervention Type
Other
Intervention Name(s)
Muscle power training with velocity loss (VL) of 30%
Intervention Description
Subjects followed a muscle power training for 8 weeks (2 sessions per week on alternate days) using the leg extension exercise, with similar relative intensity (50% 1RM). Between weeks one and four two series will be performed per session. Then the number of series will increase to three per session. The inter-set recovery period will be always of 2-min. Velocity loss will be of 30% (VL30) in each set.
Primary Outcome Measure Information:
Title
Change on muscle quality: obtained by measuring mean leg extension power divided by muscle mass of thighs
Description
The muscle quality will be obtained by measuring mean leg extension power divided by muscle mass of thighs (measured by dual-energy x-ray absorptiometry)
Time Frame
Baseline and after 8 weeks
Secondary Outcome Measure Information:
Title
Change on chair stand test
Description
Participants stand up straight as quickly as they can five times, without stopping in between. After standing up each time, subjects will sit down and then stand up again. They will keep their arms folded across their chest. The examiner will be timing with a stopwatch.
Time Frame
Baseline and after 8 weeks
Title
Change on time up go test with cognitive task
Description
The participant stands up from a chair, walks to the mark 3 m away, turns around, returns to the chair, and sits down again. The participants walk safely, as fast as possible. While walking, the participant counts backward in threes from a randomly chosen start number between 60 and 100 to avoid a learning effect.
Time Frame
Baseline and after 8 weeks
Title
Change on gait speed test
Description
Participants walk a 4-m marked course at their usual walking pace, with the examiner timing their walk with a stopwatch.
Time Frame
Baseline and after 8 weeks

10. Eligibility

Sex
Female
Minimum Age & Unit of Time
65 Years
Maximum Age & Unit of Time
75 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: Women 65 to 75 years. Healthy volunteers. Have not perform muscle power training in the last six months. Exclusion Criteria: History of asthma. History of uncontrolled diabetes. History of uncontrolled hypertension. History of cardiovascular disease. History of coronary heart disease. Smoker. Arrhythmias. Personal history of surgical procedures in the last three months. Uncontrolled non-communicable diseases. Psychological, sensitive, cognitive, neuromotor and/or osteo-muscular conditions that may affect participation in an exercise program. Under medical treatment with anticoagulants, bronchodilators, and/or steroids.
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Santiago A Arboleda, Ph.D.
Phone
+573164459690
Email
santiago.arboleda@correounivalle.edu.co
First Name & Middle Initial & Last Name or Official Title & Degree
Fredy A Patiño, Ph.D.
Phone
+573167849453
Email
fredy.patino@udea.edu.co
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Santiago A Arboleda, Ph.D.
Organizational Affiliation
Universidad del Valle, Cali, Colombia.
Official's Role
Principal Investigator
Facility Information:
Facility Name
Universidad del Valle
City
Cali
State/Province
Valle Del Cauca
Country
Colombia
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Santiago A Arboleda, Ph.D.
Phone
+573164459690
Email
santiago.arboleda@correounivalle.edu.co
First Name & Middle Initial & Last Name & Degree
Fredy A Patiño, Ph.D.

12. IPD Sharing Statement

Plan to Share IPD
No

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Power Training on Muscle Quality and Functional Capacity in Women Aged 65-75.

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