The Human Stress Response in a Simulated ED Setting
Stress Physiology, Stress Reaction, Substance Use Disorders
About this trial
This is an interventional other trial for Stress Physiology focused on measuring Stress Response
Eligibility Criteria
Inclusion Criteria:
- Healthy adult
- 21-55 years of age
- Self-reported recent history of meth use that meets DSM-5 criteria for current meth use disorder
- Have been previously inside an ED as either a patient or visitor
- Able to construct a stressful mental script of ED experiences
- Body mass index (BMI) < 30
- Ability to read and understand English
- If matched control, no lifetime history of any recreational or non-prescribed drug use.
Exclusion Criteria:
- Eating/drinking/taking drugs or alcohol the morning before the experiment
- If smoker, not smoking the morning before the experiment
- Subjective or objective signs of intoxication or withdrawal from any substance
- History of any serious medical condition such as cardiovascular, endocrine, neurologic (seizures), or hepatic disease
- Pregnancy
- History of any mental illness
- Hypertensive (>150/90) or abnormal EKG at screening
- Use of any daily medication
- Any recent night shift work in the last 4 weeks
- Any travel across time zones in the last 14 weeks
- Participation in a similar study in the past year
- Refusal to allow videotaping
Sites / Locations
- University of Arkansas for Medical SciencesRecruiting
Arms of the Study
Arm 1
Arm 2
Other
Other
Standard social stress task
Stressful experience in the ED
Participants will be given 4.5 minutes to prepare a 4.5-minute public speech on three standard scenarios presented in counterbalanced order. This will involve approximately 30 minutes of public speaking stress given expected transitions. The public speeches will be presented in front of 1-2 individuals who are evaluating their presentations. Immediately after the public speaking task, participants will be asked to complete a mental arithmetic task for 15 minutes.
Participants will be given 4.5 minutes to prepare a 4.5-minute public speech on three experiences surrounding their most stressful ED visit. These experiences are presented in counterbalanced order. This will involve approximately 30 of public speaking stress given expected transitions. The public speeches will be presented in front of 1-2 individuals who are evaluating their presentations. Immediately after the public speaking task, participants will be asked to complete a mental arithmetic task for 15 minutes.