Treatment of Complex Anal Fistulas Using Centrifuged Adipose Tissue Containing Progenitor Cells (CAT)
Anal Fistula
About this trial
This is an interventional treatment trial for Anal Fistula focused on measuring complex fistula-in ano, adipose tissue, stem cell therapy
Eligibility Criteria
Inclusion Criteria:
Patients aged 18 years or older with complex perianal fistulas
Exclusion Criteria:
Inflammatory bowel diseases, Crohn's Disease (CD) or Ulcerative Colitis (UC) Hepatitis B or C virus Infection with Human immunodeficiency virus Surgery for a malignant tumor during the previous 5 years (excluding in situ carcinoma) Previous pelvic radiotherapy Autoimmune disease Active tuberculosis Symptoms of septicemia Breastfeeding or pregnant women Women unwilling to use contraception during the study Psychiatric disorders Alcoholism Drug dependency Allergy to local anesthetics
Sites / Locations
- Simona Ascanelli
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
CAT injection group
No CAT injection group
After fistulectomy for complex anal fistula, CAT (harvested from abdominal subcutaneous adipose tissue by Coleman's procedure) was injected into the tissue surrounding the internal opening, and inside the perianal wound obtained after fistulectomy.
Patients of this group were treated with anal fistulectomy without CAT injection.