The Effect of a Healthy Snack on Radiance, Aging and Inflammation of the Skin (AlmondSkin)

This is an interventional other trial for Skin Laxity focused on measuring skin, aging, almonds Read More

Inclusion Criteria:

• Healthy Asian females age 18-50 years' old (inclusive)
• Typically consume low fiber/polyphenol diet (beige diet)
• In good health with a BMI of 22 to 30 kg/ m2 (inclusive)
• Non-smokers
• Fitzpatrick Skin type II-IV
• Willing to maintain their normal skin care pattern for the duration of the study
• Willing to maintain their normal diet for the duration of the study but avoid almonds and pretzels.
• Subjects must read and sign the Institutional Review Board-approved written informed consent prior to the initiation of any study specific procedures or enrollment. A subject will be excluded for any condition that might compromise the ability to give truly informed consent.

Exclusion Criteria:

• Eating a high fiber/polyphenol diet or taking any medication or dietary supplement which interfere with the absorption of polyphenols.
• Women who are pregnant, lactating or trying to become pregnant.
• Currently taking any skin related prescription medication or supplements for less than 3 months.
• Currently consuming >14 alcoholic drinks (1 drink = 12 fl oz beer, 4 fl oz wine or 1.5 fl oz liquor) per week and/or unwilling to limit intake to less than 3 drinks per week during study participation or history of alcohol dependency.
• Screening laboratory value outside of the laboratory normal range that is considered clinically significant for study participation by the investigator.
• History or current diagnosis of serious medical condition such as Type I or Type II diabetes, major surgery, thyroid disease, heart problems (e.g. angina, bypass surgery, myocardial infarction, etc.), presence of implanted cardiac defibrillator or pacemaker, uncontrolled hypertension/high blood pressure, gastrointestinal disorders including chronic malabsorptive conditions, peptic ulcer disease, Crohn's disease, chronic diarrhea or active gallbladder disease, inflammatory bowel disease, fatty liver or cancer.
• Known allergy to almonds.
• Participation in another clinical trial within 30 days prior to enrollment.
• Any known clinically significant food allergy or intolerance.
• Currently taking any prescription medication or supplements for less than 3 months.
• Is unable or unwilling to comply with the study protocol.
• Subjects who cannot avoid excessive exposure to either natural or artificial sunlight.
• Received a nasally-delivered steroid, antibiotics within the past 14 days.
• Used topical antibiotic or topical steroid on the face,currently taking any prescription medications that increase the risk of photosensitivity or history of taking such medications in the less than 3 months (e.g. alpha-hydroxy acids in cosmetics, antibiotics (ciprofloxacin, doxycycline, levofloxacin, ofloxacin, tetracycline, trimethoprim), antifungals (flucytosine, griseofulvin, voriconazole), antihistamines (cetirizine, diphenhydramine, loratadine, promethazine, cyproheptadine)
• Subjects with a significant medical history or concurrent condition that the investigator(s) feel is not safe for the study
• Is unable or unwilling to comply with the study protocol.