D-cycloserine Augmented Treatment for Youth With Tic Disorders
Tourette Syndrome
About this trial
This is an interventional treatment trial for Tourette Syndrome focused on measuring habit reversal training, Comprehensive Behavioral Intervention for Tics, d-cycloserine, behavior therapy
Eligibility Criteria
Inclusion Criteria:
- 8-17 years
- Meet Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 criteria for Tourette's Disorder, Persistent Motor Tic Disorder, or Persistent Vocal Tic Disorder
- Have moderate tic severity or greater as evidenced by a Yale Global Tic Severity Scale (YGTSS) total score greater than 13 (>9 for children with motor or vocal tics only)
- Be fluent in English
Exclusion Criteria:
- Current diagnosis of substance abuse/dependence
- Lifetime diagnosis of autism spectrum disorder, mania or psychosis
- History of a seizure disorder, kidney disease, or liver disease
- Four or more previous sessions of behavior therapy
Sites / Locations
- Johns Hopkins University School of Medicine
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Behavior Therapy + DCS
Behavior Therapy + Placebo
Youth with TD will receive four, 2-hour long sessions of evidence-based behavior therapy delivered in an intensive format. Participants will arrive an hour early for each session to take the d-cycloserine pill prior to starting each session of behavior therapy. Participants, therapists, and outcome assessors will be masked to pill condition.
Youth with TD will receive four, 2-hour long sessions of evidence-based behavior therapy delivered in an intensive format. Participants will arrive an hour early for each session to take the placebo pill prior to starting each session of behavior therapy. Participants, therapists, and outcome assessors will be masked to pill condition.