The Study to Evaluate the Safety and Efficacy of Spinal Cord Stimulation on Progressive Supranuclear Palsy
Progressive Supranuclear Palsy, Spinal Cord Stimulation
About this trial
This is an interventional treatment trial for Progressive Supranuclear Palsy
Eligibility Criteria
Inclusion Criteria:
- Clinical diagnosis is Progressive Supranuclear Palsy according to International Movement Disorder society criteria for Progressive Supranuclear Palsy (2017).
2.18FDG-PET imaging was completed within three months before the operation, and the imaging results were consistent with characteristics of Progressive Supranuclear Palsy, supporting the clinical diagnosis of Progressive Supranuclear Palsy.
3. The clinical manifestation is prominent gait balance disorder with "freezing gait", "turn difficulties" and "feet like a stick on the ground", "instabillity" and a fall history in the nearly 6 months (fall number less than or equal to 3 times).Or the researchers observe the existence of gait balance disorder, but patients can still walk without using external things with new freezing gait questionnaire survey more than 1 minute.
4.Those who fully understand the research and sign the informed consent.
Exclusion Criteria:
- Severe mental symptoms or depression state.
- Severe cognitive dysfunction with MMSE less than 20.
- Severe loss of postural reflexes (inability to stand and work independently) and depend on a walker or wheelchair.
- Depend on nasal feeding tube.
- Female in pregnant state when grouped.
- Clear and definite history of neurological diseases (stroke, trauma, tumor, hydrocephalus.
- Complicated with severe heart, liver or renal diseases.
- Clear and definite contraindications for surgery, electrical stimulation and PET examination.
- Unsuitable for surgery according to evaluation before the surgery.
- Other conditions that researchers think unsuitable surgery.
- Those who participant in other clinical trials at the same time.
Sites / Locations
- Huashan HospitalRecruiting
Arms of the Study
Arm 1
Experimental
spinal cord stimulation
the spinal cord stimulation was performed and operated